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Distribusi Jenis Batu Ginjal pada Penderita Urolithiasis serta Hubungannya dengan Jenis Kelamin dan Usia
No full textInsiden urolitiasis di Jakarta meningkat setiap tahun dari 2016 - 2019, namun distribusi komposisi batu pada penderita urolithiasis serta hubungan distribusi komposisi batu ginjal dengan jenis kelamin dan usia belum diketahui. Tujuan penelitian ini adalah mengetahui karakteristik komposisi batu ginjal dan hubungan batu ginjal dengan jenis kelamin dan usia. Penelitian cross-sectional ini dilakukan di Laboratorium Biokimia dan Biologi Molekuler Fakultas Kedokteran Universitas Indonesia menggunakan 160 sampel data hasil laboratorium analisis komposisi batu ginjal. Data dianalisis dengan SPPS tipe 20, setelah itu dilakukan uji chi square untuk mengetahui hubungan antara jenis kelamin dan usia terhadap komposisi batu ginjal. Uji Mann Whitney dilakukan pada data yang tidak memenuhi syarat untuk uji chisquare. Batu ginjal terbanyak terdapot pada laki – laki dibandingkan perempuan dengan perbandingan (3:1) dan batu ginjal terbanyak pada kelompok usia 45 – 64 tahun (49,4%). Komposisi jenis batu ginjal terbanyak adalah campuran kalsium, oksalat, karbonat, amonia. Terdapat hubungan komposisi batu ginjal dengan jenis kelamin (p<0,05) untuk komposisi kalsium, amonia dan magnesium. Tidak terdapat hubungan antara usia terhadap komposisi batu ginjal. Disimpulkan komposisi batu ginjal terbanyak adalah oksalat. Terdapat hubungan antara komposisi batu ginjal dengan jenis kelamin namun tidak berhubungan dengan usia. Distribution of Kidney Stones Type in Urolithiasis Patients: Association with Gender and AgeThe incidence of urolithiasis in Jakarta has increased every year from 2016 to 2019. However, the distribution of stone composition in urolithiasis patients and the relationship between the distribution of kidney stone composition with gender and age is unknown. This study aimed to determine the characteristics of kidney stones’ composition and the relationship of kidney stones with gender and age. This cross-sectional study was conducted at the Laboratory of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia. The data were collected from the laboratory result of 160 samples of kidney stone composition analysis. Data were analyzed using SPPS ver. 20, additionally, the chi-square test was performed to determine the relationship between sex and age on kidney stones’ composition. The Mann-Whitney test was performed on data that did not meet the requirements for the Chi-square test. Most kidney stones were found in males than females (3: 1) and the most kidney stones were in the 45-64 years age group (49.4%). Most types of kidney stones are a mixture of calcium, oxalate, carbonate, ammonia. There was a relationship between the composition of kidney stones and gender (p <0.05) for the composition of calcium, ammonia, and magnesium. There is no relationship between age and the composition of kidney stones. It is concluded that the composition of most kidney stones is oxalate. There is a relationship between the composition of kidney stones and gender. However, there is no relationship between the composition of kidney stones and age
Karakteristik Klinis Tumor Intrakranial pada Dua Rumah Sakit Rujukan Nasional Tahun 2018
No full textTumor intrakranial adalah massa abnormal di kranium yang dapat berasal dari sel sistem saraf pusat atau dari tipe histopatologi lain. Gejala yang paling sering adalah nyeri kepala, kejang, penurunan kesadaran, dan defisit neurologis. Meskipun telah diketahui tanda dan gejala tumor intrakranial, belum ada penelitian di Indonesia yang mempelajari karakteristik tumor. Penelitian ini bertujuan untuk mengetahui karakteristik tumor intrakranial di RSUPN Dr. Cipto Mangunkusumo (RSCM) dan RS Kanker Dharmais (RSKD). Desain penelitian ini adalah potong lintang dengan subjek pasien tumor intrakranial dewasa yang dirawat di RSCM dan RSKD, pada bulan Oktober- Desember 2019. Data yang diambil meliputi data demografi, klinis, dan jenis tumor intrakranial, lalu disajikan secara deskriptif dan analitik. Terdapat 85 subjek dengan mayoritas perempuan (65,9%), letak tumor di supratentorial (86,3%), keluhan nyeri kepala (63,5%), dan median usia 49 (18-65) tahun. Jenis tumor terbanyak adalah tumor primer (62,4%), terutama meningioma, serta glioma derajat tinggi dan derajat rendah. Tumor metastasis terbanyak berasal dari kanker payudara, kanker paru, dan melanoma maligna. Meningioma adalah tumor intrakranial primer terbanyak (22,4%) dan kanker payudara merupakan sumber metastasis intrakranial paling sering. Clinical Characteristics Of Intracranial Tumors In Two National Referral Hospitals, 2018Intracranial tumor is an abnormal mass inside cranium. Those mass come from central nervous system cell or from other histopathological types. The symptoms commonly found are headache, seizure, decreased consciousness, along with various neurological deficits. Although the sign and symptoms of intracranial tumor has been known, there were no study in Indonesia that describe those characteristics. This purpose of this study is to know intracranial tumor characteristics in Cipto Mangunkusumo General Hospital and National Cancer Referral Dharmais hospital. This is a cross sectional study towards adults diagnosed with intracranial tumor consulted to Neurology Department in both hospital, October-December 2019. Data acquired were demography and clinical characteristics of intracranial tumor. Data were presented descripteively and analytically. There were 85 subjects in this study. Majority of subjects were female (65.9%), with supratentorial tumor (86.3%), had headache (63.5%) with median age of 49 (18-65) years old. The most common tumor was primary intracranial tumor (62.4%) consisted mainly of meningioma, high-grade glioma, and low-grade glioma. The most common metastatic tumor comes from breast cancer, lung cancer, and melanoma. Meningioma was the most commonprimary intracranial tumor found in 22.4% patients. The most common metastasis was breast cancer
Survival after Minimally Invasive Surgery versus Abdominal Radical Hysterectomy for Early-Stage Cervical Cancer in dr. Cipto Mangunkusumo National Hospital, Jakarta
No full textstract Cervical cancer is one of the most frequent cancer among women in the world. Indonesian’s gynecologic oncologists have started using laparoscopic approach for radical hysterectomy for early stage cervical cancer. There are still limited data and studies reporting survival outcomes after laparoscopic or open abdominal radical hysterectomy, thus we would like to compare the survival outcomes between laparoscopic and open technique of radical hysterectomy in early stage cervical cancer. A retrospective study included 415 early stage cervical cancer was conducted in dr. Cipto Mangunkusumo Hospital. Patient were treated with radical hysterectomy, laparotomy, or laparoscopy, and followed for 3 years period. Survival outcome was reported in univariate and multivariate design, to know the effect of age, parity, tumor size, free margin, and lymph nodal status on overall survival. From 415 patients, 268 patients fulfilled the inclusion criteria. A total of 44 patients underwent laparoscopy radical hysterectomy and 224 to open surgery. Positive resection margins rate for laparoscopic patient was lower than open group (25,9% versus 12.5%). The mean survival of laparoscopic patient was 30 months while open surgery patient was 34 months. The overall 3-year survival rate in open surgery group was 90.2% and 81.8% among those who underwent minimally invasive surgery (hazard ratio 1.7; 95% confidence interval 0.9 to 3.1; p=0.11 by the log-rank test). Laparoscopic approach for radical hysterectomy is a feasible method for early stage cervical cancer other than laparotomy.Sintasan Bedah Invasif Minimal Dibandingkan Radikal Abdominal Histerektomi pada Kanker Serviks Stadium Awal di RSUPN dr. Cipto Mangunkusumo Jakarta Kanker serviks adalah kanker yang paling sering pada perempuan di dunia. Onkologi ginekologis Indonesia telah menggunakan pendekatan laparoskopi untuk melakukan histerektomi radikal pada kanker serviks stadium awal. Data dan penelitian yang melaporkan hasil sintasan laparoskopi atau radikal abdominal histerektomi, masih terbatas sehingga perlu penelitian untuk membandingkan kesintasan laparoskopi dan radikal abdominal histerektomi pada kanker serviks stadium awal. Studi dilakukan secara retrospektif dengan menginklusi 415 data pasien kanker serviks stadium awal di RSUPN dr. Cipto Mangunkusumo. Pasien ditatalaksana dengan histerektomi radikal, laparotomi atau laparoskopi, dan ditindaklanjuti selama 3 tahun. Kesintasan dilaporkan dalam data univariat dan multivariat, untuk mengetahui hubungan usia, paritas, ukuran tumor, batas tumor, dan status kelenjar getah bening pada seluruh sintasan. Dari 415 pasien, sebanyak 268 pasien memenuhi kriteria inklusi. Sebanyak 44 pasien menjalani laparoskopi histerektomi radikal dan 224 menjalani laparotomi. Angka kejadian batas reseksi positif untuk pasien laparoskopi lebih rendah dari laparotomi (25,9% versus 12,5%). Rerata kesintasan pasien laparoskopi adalah 30 bulan dan laparotomi adalah 34 bulan. Seluruh sintasan pasien laparotomi dalam 3 tahun adalah 90,2%, dan 81,8% pada pasien operasi invasif minimal (hazard ratio 1,7; 95% confidence interval 0,9-31; p=0,11 dengan tes log-rank). Disimpulkan metode laparoskopi untuk histerektomi radikal dapat dikerjakan untuk pasien kanker serviks stadium awal
Flutter Atrium Tipikal Menyerupai Blok Atrioventrikuler Derajat Tinggi
No full textFlutter atrium adalah jenis takiaritmia atrium yang paling sering dijumpai setelah atrial fibrilasi. Flutter atrium adalah bentuk takiaritmia berupa denyut atrium yang meningkat dan teratur, akibat aktivitas listrik atrium berlebihan ditandai dengan denyut atrial rerata 250 - 350 kali per menit. Risiko flutter atrium dikaitkan dengan berbagai kondisi medis tertentu dan hanya 2% kasus flutter atrium yang dapat timbul spontan. 90% kasus flutter atrium merupakan jenis tipikal dengan anticlockwise re-entry. Dilaporkan seorang laki-laki, 61 tahun dengan flutter atrium tipikal clockwise re-entry disertai pola disosiasi atrioventrikuler yang nyata dan bervariasi tanpa gambaran gelombang P sinusoid/gigi gergaji yang khas, sehingga hasil elektrokardiografi (EKG) pasien awalnya dianggap sebagai blok atrioventrikuler derajat tinggi. Gelombang P yang sinusoid khas flutter atrium baru terlihat jelas setelah pemberian salbutamol dan teofilin. Flutter atrium berhasil kembali menjadi irama sinus setelah salbutamol dan teofilin dihentikan dilanjutkan dengan pemberian digoksin. Disimpulkan bahwa diagnosis flutter atrium dapat didiagnosis hanya berdasarkan EKG sehingga untuk penatalaksaan kasus di runah sakit diperlukan pengalaman dan pemahaman komprehensif mengenai patofisiologi takiaritmia dan EKG. Typical Atrial Flutter Mimicking High Degree Atrioventricular Block Atrial flutter is one of the most common types of atrial tachyarrhythmias after atrial fibrillation. Atrial flutter is a form of tachyarrhythmias with a regular and increased atrial pulses, due to the activity of excessive atrial electrical activity characterized by an atrial pulse averaging 250 to 350 times per minute. The risk of atrial flutter always associated with a variety of certain medical conditions and only 2% of cases of atrial flutter can occur spontaneously. 90% of cases of atrial flutter are typical atrial flutter with anticlockwise re-entry. Here we present, a 61 years old male with a typical clockwise re-entry atrial flutter presenting a promienent and varied atrioventricular dissociation pattern without showing a sinusoidal / typical sawtooth P wave image, hence the patient’s electrocardiographic results were initially regarded as a high degree atrioventricular block. A typical sinusoid P waves of atrial flutter were then observed after administration of salbutamol and theophylline. In the end, the atrial flutter was succesfully converted into sinus rhythm after cessation of salbutamol and theophylline and administration of digoxin. In conclusion, the diagnosis of atrial flutter based solely on electrocardiography is a challenge that requires experience and a comprehensive understanding of the pathophysiology of the tachyarrhythmia and electrocardiography.  
Quaternary Ammonium Compound Disinfectant Efficacy Test on The Patients’ Environment in dr. Cipto Mangunkusumo General Hospital
No full text The increasing prevalence of hospital-acquired infection continues to be a global concern until today. The purpose of this study is to determine the efficacies of Caviwipe® and 70% alcohol tissue in the prevention of hospital-acquired infection. This experimental study was conducted on 36 equipment samples in dr. Cipto Mangunkusumo Hospital during April–August 2015. A total of 144 surface samples were collected before and after the disinfection process by both the disinfectants. The sample equipment used and placed in the agar plate for a short period of time; the plates were then incubated. The colony numbers of grown bacteria and fungi were calculated. The data were numerically reported as the microbial colony count. Data were analyzed by using SPSS for Windows. Paired t-test was used for the statistical analysis. The mean colony counts before disinfection by 70% alcohol tissue and Caviwipe® were 11.75 and 17.58, respectively. Meanwhile, the average colony counts after disinfection with 70% alcohol tissue and Caviwipe® were 0.138 and 0.222, respectively. Statistical analysis showed no significant difference between the mean of the colony count before and after disinfection with both disinfectants (p>0.05). Separately, a significant difference of colony count between before and after the disinfection process for each disinfectant was seen (p<0.05). The mean reduction in the colony counts after disinfection by both disinfectants indicates that there is no significant difference (p>0.05) in the efficacies between the Caviwipe® and 70% alcohol tissue in reducing the amount of bacteria and fungi present on the surfaces of the equipment placed close to the patients in a hospital environment. Keywords: disinfectant, environment, hospital, alcohol, Caviwipe®. Uji Efikasi Disinfektan Quaternary Ammonium Compound Disinfectant di Lingkungan Pasien di RSUPN dr. Cipto Mangunkusumo Abstrak Peningkatan prevalensi infeksi yang didapat di rumah sakit masih menjadi perhatian hingga saat ini. Penelitian ini bertujuan membandingkan efektivitas Caviwipe® dan tisu alkohol 70% dalam upaya pencegahan infeksi yang didapat di rumah sakit. Penelitian eksperimental ini dilakukan pada bulan April–August 2015 dengan 36 sampel peralatan di rumah sakit dr. Cipto Mangunkusumo (RSCM). Terdapat 144 titik pengambilan sampel permukaan lingkungan dan peralatan, sebelum dan sesudah disinfeksi dengan kedua disinfektan. Sampel diambil dengan contact agar lalu diinkubasi, kemudian dihitung jumlah koloni bakteri dan jamur yang tumbuh. Data jumlah koloni mikroba dilaporkan sebagai data numerik dan dianalisis dengan perangkat lunak SPSS untuk Windows. Analisis statistik menggunakan paired-t-test. Hitung koloni sebelum disinfeksi dengan tisu alkohol 70% dan Caviwipe® adalah 11,7 dan 17,58. Rerata jumlah koloni sesudah disinfeksi dengan tisu alkohol 70% dan Caviwipe® adalah 0,138 dan 0,222. Analisis statistik menunjukkan tidak ada perbedaan bermakna antara rerata jumlah koloni sebelum dan sesudah disinfeksi dengan kedua jenis disinfektan (p>0,05). Masing-masing disinfektan menunjukkan perbedaan bermakna antara jumlah koloni sebelum dan sesudah disinfeksi (p<0,05). Penurunan rerata jumlah koloni sesudah disinfeksi antara kedua disinfektan tidak berbeda bermakna (p>0,05). Efikasi antara Caviwipe® dan tisu alkohol 70% dalam menurunkan jumlah bakteri dan jamur di lingkungan rumah sakit yang dekat dengan pasien juga tidak berbeda bermakna. Kata kunci: disinfektan, lingkungan, rumah sakit, alkohol, Caviwipe® 
Dementia Risk Reduction in Cognitively Normal Elderly Receiving Mediterranean Diet
No full textStudies showed cognitive health improvement with mediterranean diet (MD). It is important to find out the benefit in dementia prevention. Relevant meta-analysis and randomised controlled trials pertaining to MD impact on dementia risk reduction in cognitively normal elderly were collected. The comprehensive search relied on databases Pubmed and Cochrane with keywords MD and dementia. Results of methodological quality assessment of three studies utilising Oxford Centre for Evidence Based Medicine year 2011 tools, showed that the studies were valid and applicable. Neuroprotective effect was different in group with the highest adherence to the diet in study 1 with adjusted hazard ratio (HR) of 0.67 (95% CI 0.52-0.88, p=0.004). In study 2 none were diagnosed with dementia in all three groups receiving MD with extravirgin olive oil (EVOO), diet with nuts, and control group. In comparison with the control group in study 3, number needed to treat (NNT) was 13.29 for group with EVOO (absolute risk reduction/ ARR = 7.5% [95%CI 1.09%-13.95%]) and was 10.79 for group with nuts (ARR = 9.2% [95%CI 2.88%-15.65%]). Long-term MD may be beneficial to reduce dementia rate. Neuroprotective effect is achievable only with the highest adherence (p=0.004). Gado-gado modification in Indonesian diet is desirable. Keywords: dementia, mediterranean diet, risk reduction, prevention. Penurunan Risiko Demensia pada Usia Lanjut Berfungsi Luhur Normal dengan Diet Mediterania Abstrak Diet mediterania dapat mempertahankan fungsi kognitif berdasarkan beberapa penelitian. Manfaatnya terhadap pencegahan demensia perlu diketahui. Studi ini mengumpulkan meta-analisis dan uji acak dengan kontrol mengenai pengaruh diet mediterania terhadap penurunan risiko demensia pada usia lanjut (lansia) dengan fungsi luhur normal. Sumber data elektronik Pubmed dan Cochrane digunakan dengan kata kunci mediterranean diet dan dementia. Hasil dari penilaian kualitas studi dengan metode Oxford Centre for Evidence Based Medicine 2011 terhadap tiga studi terpilih menunjukkan bahwa studi tersebut valid dan dapat diterapkan. Efek neuroprotektif berbeda signifikan pada kelompok dengan tingkat ketaatan tertinggi pada diet mediterania dalam penelitian pertama dengan hazard ratio (HR) 0,67 (95% CI 0,52-0,88, p= 0,004). Pada penelitian kedua, tidak ada yang terdiagnosis demensia pada akhir penelitian pada ketiga kelompok, yakni kelompok diet dengan tambahan minyak zaitun ekstravirgin, kelompok dengan tambahan kacang-kacangan (kelompok 2), serta kelompok kontrol. Mekipun demikian penelitian ketiga menunjukkan number needed to treat (NNT) 13,29 pada kelompok minyak zaitun ekstravirgin (absolute risk reduction/ ARR = 7,5% [95%CI 1,09% - 13,95%]) dan pada kelompok 2 NNT 10,79 (ARR = 9,2% [95%CI 2,88%-15,65%]) dibandingkan kontrol. Diet mediterania jangka panjang dapat menurunkan angka demensia. Efek neuroprotektif hanya dapat dicapai dengan ketaatan tinggi terhadap diet (p=0,004). Pada diet Indonesia, modifikasi gado-gado dapat dipertimbangkan. Kata kunci: demensia, diet mediterania, penurunan risiko, pencegahan
The Use of Vaginal Pessary for Pelvic Organ Prolapse’s Treatment
No full textPelvic organ prolapse (POP) is the descent of the anterior and/or posterior vaginal wall or vagina apex (uterus or vaginal apex after a hysterectomy) and has negative effects on woman’s daily activities and reduces her quality of life. One of the treatments of POP is pessary that has limited evidence but still commonly used for treatment of genital prolapse and considered as the first line treatment by the American Urogynecologic Society (AUGS). This evidence-based case report (EBCR) is made to critically analyze from the current studies whether the use of pessary improves the symptoms of pelvic organ prolapse or not. A search of literature was performed in two databases, MEDLINE and Cochrane. Eligible articles were observational studies, clinical trials, systematic reviews, or meta-analyses that published within the last 5 years. All studies showed symptoms improvement with four studies using Pelvic Organ Prolapse Distress Inventory (POPDI) score and one study using International Consultation on Incontinence Questionnaire – Vaginal Symptoms (ICIQ-VS). Keywords: pelvic organ prolapse, pessary, treatment. Penggunaan Pesarium Vagina untuk Penatalaksanaan Prolaps Organ Pelvik Abstrak Prolaps organ pelvik (POP) adalah penurunan dinding anterior dan atau posterior vagina atau apeks vagina (uterus atau apeks vagina setelah histerektomi) yang memiliki dampak negatif terhadap aktivitas sehari-hari dan menurunkan kualitas hidup. Salah satu tata laksana POP adalah pesarium yang memiliki bukti ilmiah terbatas tetapi masih digunakan untuk tata laksana prolaps genitalia dan dipertimbangkan sebagai terapi utama menurut American Urogynecologic Society (AUGS). Evidence-based case report (EBCR) dibuat untuk menganalisis secara kritis dari studi yang sudah ada apakah penggunaan pesarium dapat memperbaiki gejala dari prolaps organ pelvik atau tidak. EBCR ini dilakukan dalam dua databases, MEDLINE dan Cochrane. Artikel yang memenuhi syarat merupakan studi observasional, percobaan klinis, ulasan sistematis, atau meta-analisis yang telah dipublikasi pada 5 tahun terakhir. Semua studi menunjukan bahwa terdapat perbaikan dari gejala (POP) dengan empat studi menggunakan pelvic organ prolapse distress inventory (POPDI) score dan satu studi lainnya menggunakan International Consultation on Incontinence Questionnaire – Vaginal Symptoms (ICIQ-VS). Kata kunci: prolapse organ pelvik, pesarium, penatalaksanaan
Limb Salvage Surgery untuk Meningkatkan Fungsi Ekstremitas dan Psikologis Pasien Osteosarkoma pada Era Jaminan Kesehatan Nasional
No full textHubungan Ekspresi miR-21 dan miR-200c dengan Respons Terapi Sistemik Neoajuvan Pasien Kanker Payudara Stadium Lanjut
No full textKegagalan terapi pada kanker payudara stadium lanjut dihubungkan dengan ekspresi mikroRNA antara lain miR-21 dan miR-200c. Untuk mengetahui hubungan respons terapi sistemik neoajuvan serta ekspresi miR-21 dan miR-200c pada pasien kanker payudara, dilakukan studi potong lintang di RS Kanker Dharmais dan RSUPN dr. Cipto Mangunkusumo (RSUPNCM) pada bulan Juli 2015 hingga April 2016. Subjek yang memiliki spesimen jaringan segar dan blok parafin serta telah mendapat pengobatan adekuat, dilakukan pengukuran MiR-21 dan miR-200c dengan qRT-PCR. Hasil dinyatakan sebagai perbedaan cycle thresholds (ΔCt) terhadap U6 snRNA. Ekspresi relatif dihitung sebagai perbedaan dua nilai ΔCt (ΔΔCt) dan fold change (2-ΔΔCt). Sebanyak 31 dari 60 subjek mendapat kemoterapi dan 29 mendapat terapi hormonal. Setelah terapi neoajuvan, hanya 46 orang subjek yang dapat menjalani mastektomi. Respons terapi dinilai dengan kriteria Miller Payne dari sediaan operasi. Sebanyak 23 (50%) subjek tidak respons (Miller Payne grade 1). ΔCt miR21 dan ΔCt miR-200c tidak berbeda bermakna pada subjek yang responsif dan tidak responsif, namun subjek yang tidak responsif memperlihatkan peningkatan ekspresi miR-200c (FC=2,375). Berdasarkan jenis terapi neoajuvan ekspresi miR21 maupun miR-200c lebih tinggi pada kelompok tidak respons dengan kemoterapi, sedang pada pemberian hormonal ekspresi miR-21 lebih rendah dan miR-200c cenderung lebih tinggi. Disimpulkan ekspresi miR-21 dan miR-200c tidak dapat digunakan untuk memprediksi respons terapi. Association of Expression of miR-21, miR-200c and response of Neoadjuvan Systemic Therapy in Patients with Breast Cancer Treatment failure in advanced stage breast cancer has been associated with expression of microRNA e.g. miR-21 and miR-200c. To know the association between response neoadjuvant systemic therapy and the expressions of miR-21 and miR-200c in breast cancer patient, a cross-sectional study has been conducted in Dharmais Cancer Hospital and dr. Cipto Mangunkusumo Hospital National (CMHN) from July 2015 to April 2016. Patients had fresh and paraffin-embedded tissues from biopsy specimens and have been treated adequately. MiR-21 and miR-200c were measured using qRT-PCR on fresh tissues. Results were expressed as cycle thresholds difference (ΔCt) against U6 snRNA. Relative expression was calculated as difference of two ΔCt values (ΔΔCt) and fold change (2-ΔΔCt). Treatment response was evaluated histopathologically using Miller-Payne criteria on mastectomy specimens. A total of 60 patients were enrolled, 31 had chemotherapy and 29 had hormonal therapy. After treatment, only 46 patients were eligible for mastectomy. Twenty-three (50%) patients showed no response (Miller-Payne grade 1) after treatment. ΔCt miR-21 and ΔCt miR-200c were not significantly different between responsive and not responsive patients. However, patients with no response showed increased expression of miR-200c (FC=2.375). Based on type of neoadjuvant , in chemotherapy group expression of miR-21 and miR-200c were high(FC=3.67 and 6.16 respectively) but in hormonal group expression miR-21 FC=0.11 and miR-200c FC=1.25). In conclusion, expressions of miR-21 and miR-200c cannot be used to predict treatment response
Semen Parameter Profile of Infertile Men Visiting Andro-Urology Clinic
No full textInfertility is the inability of a sexually active, non-contracepting couple to achieve spontaneous pregnancy in one year. Male infertility is found in about 7% of couples globally and one of the factors associated with it is impaired semen parameter. This study aimed to understand the semen parameter profile of infertile male patients in andro-urology clinics. This is a retrospective-descriptive study from medical records of patients in Dr. Cipto Mangunkusumo Hospital from 2010 to 2020. About 1656 infertile males went to the clinic and. 81 (4.9%) were found to have normal semen parameter, 879 (53%) had azoospermia, and 777 (46%) have at least one impaired parameter (sperm concentration, motility, and morphology). The mean spermatozoa concentration was 16.74 + 29.17 mil/ml, total motility rate was 27.87 + 24.3 %, and normal morphology was 13.19 + 19.50 %. In conclusion, most of the patients came to the clinic with azoospermia, and the percentage was above other studies. Therefore, further research is needed to ascertain the reason for the high percentage of azoospermia patients. Profil Parameter Semen pada Laki-laki Infertil yang Berkunjung ke Klinik Andro-Urologi Infertiltas laki-laki merupakan masalah pada 7 % pasangan yang menikah dan melakukan sanggama secara teratur tanpa alat kontrasepsi selama lebih dari satu tahun, namun belum memiliki keturunan. Salah satu penyebab infertiltas laki-laki adalah gangguan pada parameter semen. Penelitian ini bertujuan untuk mengetahui profil parameter semen pada laki-laki infertil yang berkunjung ke klinik andro-urologi. Penelitian retrospektif dan deskriptif ini menggunakan data rekam medis pasien infertilitas laki-laki yang mengunjungi klinik andro-urologi Rumah Sakit dr. Cipto Mangunkusumo (RSCM) tahun 2010 hingga 2020 dan terdapat 1656 pasien infertiltas laki-laki. Sebanyak 81 (4,9%) pasien memiliki parameter semen normal, azoospermia 879 (53%) dan 777(46%) dengan gangguan pada salah satu atau lebih parameter semen (jumlah, gerakan, bentuk spermatozoa). Rerata konsentrasi spermatozoa 16,74 + 29,17 juta/ml; Rerata motilitas spermatozoa 27,87 + 24,3% dan rerata morfologi normal 13,19 + 19,50%. Disimpulkan sebagian besar pasien infertilitas laki-laki yang datang ke klinik andro-urologi RSCM dalam keadaan azoospermia. Pasien infertilitas laki-laki dengan azoospermia jauh lebih tinggi dibandingkan dengan kepustakaan sehingga diperlukan penelitian lebih lanjut untuk mencari penyebab tingginya angka azoospermia.