Jurnal Ilmiah Manuntung
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No full textAdverse Drug Reaction (ADR) is every adverse event related to the use of a drug in humans. Geriatrics have a 7 times greater risk of developing ADR. Hypertension is the most common disease suffered by geriatric patients. The purpose of this study was to analyze the risk of ADR occurrence in geriatric hypertension patients and also to analyze the relationship of demographic data with the incidence of ADR. This study was carried out in an observational manner which was descriptive analytic with a cross sectional approach in 88 medical record samples of geriatric hypertension patients in inpatient installations using gerontoNET scores. Based on the ADR risk variable according to the gerontoNET score, there was 1 patient with ≥4 comorbid, 45 patients had heart failure, 5 patients had liver disorders, 19 patients received 6-7 drugs and 37 patients received ≥8 drugs, no patients with ADR history, and 28 patients developed kidney problems. From the results of this study, there are 37 patients who have a high risk of ADR events which are marked by gerontoNET score ≥4. Based on the correlation analysis of gender and age range on ADR risk obtained a weak relationship and no significant correlation (r = 0.116, p = 0.116; r = 0.017, p = 0.847), so that gender and age in geriatric hypertension patients are not related to the risk of ADR
No full textTeripang pasir (Holothuria scabra) dan daun kersen (Muntingia calabura L.) digunakan sebagai obat tradisional yang memiliki aktivitas antiinflamasi. Penelitian ini bertujuan untuk mengetahui aktivitas antiinflamasi dari kombinasi ekstrak etanol teripang pasir dan daun kersen terhadap penurunan udem pada kaki tikus yang telah diinduksi dengan karagenan 1%. Tikus kemudian dibagi menjadi 5 kelompok dan masing-masing kelompok terdiri dari 3 ekor tikus. Kelompok 1 sebagai kontrol positif, kelompok 2 sebagai kontrol negatif, kelompok 3 sebagai kombinasi ekstrak 1:1 (200 mg/kgBB:200 mg/kgBB), kelompok 4 sebagai kombinasi ekstrak 1:2 (200 mg/kgBB:400 mg/kgBB), kelompok 5 sebagai kombinasi ekstrak 2:1 (400 mg/kgBB:200 mg/kgBB), dan masing-masing kelompok diberikan secara peroral. Pada EK 2:1 memiliki efek antiinflamasi yang sama dengan kontrol positif dengan %DAI, yaitu 4,84%. Sedangkan pada EK 1:2 dengan %DAI 4,24% dan EK 1:1 dengan %DAI 1,81%.Sea cucumber (Holothuria scabra) and Kersen leaf (Muntingia calabura L.) are used as traditional medicines that have anti-inflammatory activity. This study aims to determine the anti-inflammatory activity of a combination of ethanol extract of sea cucumber sand and Kersen leaves on the decrease of edema in the feet of rats that have been induced with 1% carrageenan. The rats were then divided into 5 groups and each group consisted of 3 rats. Group 1 as positive control, group 2 as negative control, group 3 as extract combination 1: 1 (200 mg / kg body weight: 200 mg / kg body weight), group 4 as extract combination 1: 2 (200 mg / kg body weight: 400 mg / kg body weight) ), group 5 as extract combination 2: 1 (400 mg / kgBB: 200 mg / kgBB), and each group is given orally. At 2: 1 EK has the same anti-inflammatory effect as positive control with% DAI, which is 4.84%. Whereas at EK 1: 2 with% DAI 4.24% and EK 1: 1 with% DAI 1.81%
No full textTiwai Onion (Eleutherine bulbosa (Mill.) Urb.) is an Iridaceae tribe which is a typical plant of Borneo. Its used by the Dayak community, among others, for colon cancer, breast cancer, diabetes mellitus, hypertension, lowering cholesterol, strokes, boils, anti-bleeding and abdominal pain. The purpose of this study was to determine the components of anticancer compounds of chloroform fraction by GC-MS method. The results of GC-MS spectrum analysis based on the base peak equation of the chloroform fraction contain 9,12-Octadecadienoic Acid, and 1- (2,3,5,6-Tetramethyl phenyl) Ethanone which has the potential as an anticancer
No full textThe development and improvement of pharmacy service has become consumer concern, since this quality of service will affect on consumer satisfaction. The study aimed at assessing the level of outpatient satisfaction at Department of Pharmacy X Hospital In Surakarta City. This study was a survey research, which was conducted using questionnaire by direct interview. A total of 323 respondent were recruited conveniently in the study. The obtained data was then analyzed using Gap analysis to assess the differences in level of quality services between customer perceptions and customer expectations. The study investigates the five dimensions of service quality and identifies the gap between the perception and expectation. The data was analyzed by using SPPS for windows. In general, the result shows that service quality was lower than the expectations of the patients in the studied hospital. The study finding indicated that gap or differences exist on various dimensions between perception and expectation in level quality services. The highest service quality gap was given to Responsiveness followed by Reliability, Empathy, Tangibles and Assurance with the value of - 0,129; - 0,125; - 0,115; - 0,114; and - 0,108 respectively. Patient satisfactions was influenced by health service quality, with the assurance and responsiveness dimensions as the greatest influence on patient satisfaction
No full textThe research on formulation and evaluation of lypholized tomato (Solanum lycopersicum L) as lip balm has been conducted. The objective of this research was to investigate the physical stability of lip balm formula from lypholized tomato that could enhance the lips’ humidity. The formulation of lip balm was made into three concentration i.e 1%, 3%, and 5%. The physical stability evaluations that were performed before and after stress condition. Which is included organoleptic, homogeneity, and melting point test. The stable formula was then evaluated as skin moisture enhancer using skin analyzer. The results of this research showed that all three formula was physically stable. On the third formula (lypholized concentration of 5%) had the highest percentation of moisture enhancement with the significant difference among the three formulas
No full textThe study about the effect of brief counseling on quality of life of diabetes mellitus patients were conducted at RSUD Dr. H. Moch. Ansari Saleh Banjarmasin. This study using a randomized controlled trial design. Subjects who met the inclusion criteria were 156 patients randomly into two groups, 78 patients who received the intervention and 78 patients did not receive the intervention. Exclusion criteria were pregnancy patients, deaf, illiterate and uncooperative. The data collected by questionnaires Euro-Qol EQ-5D. The quality of life data were analyzed by multivariate statistic test. The result showed that the quality of life scores in the control group and the intervention group were both significantly increased with p <0.05. Multivariate analysis both group at pre and median study were significant different, while at the post study was not significant different. There were improving quality of life of patients with diabetes mellitus who received the brief counseling is greater than patients who did not receive the interventio
No full textStaphylococcus aureus is a bacterial strain that causes acne. Linalool and limoneneis are the ingredients of Citrus bergamia essensial oil which has antibacterial activity Staphylococcus aureus. This research aimed to examine the effective consentration of Citrus bergamiaessensial oil as antibacterial Staphylococcus aureus ATCC 29213. Citrus bergamia essensial oil is made in series a concentration of 1%, 2% and 3% for testing of antibacterial activity using the pitting diffusion method. Based on the test results of antibacterial activity gained an average diameter of inhibitory zone Citrus bergamiaessensial oil in a row 1,151 cm; 1,529 cm; 1,683 cm. The statistically test results showed significant difference in the antibacterial activity of Citrus bergamiaessensial oil in concentrations 1%, 2% and 3% to the growth of Staphylococcus aureus ATCC 29213. Citrus bergamiaessensial oil has effective concentration 3% as stapgylocuccus aureus antibacterial and made peel-off gel mask formula. Test of antibacterial activity obtained resistibility zone diameter 1,259 cm. The result of t-test indicated that the Citrus bergamiaessensial oil peel-off gel mask has significant affect on antibacterial activity of Citrus bergamiaessensial oil
No full textThe importance of pharmacovigilance activity is the Adverse Drug Reaction (ADR) reporting system. Many pharmacists who do not report ADR incident and number of ADR indicated that more knowledge and good perception of ADR is needed. This study was aimed at investigating the knowledge and perception of pharmacists towards the ADR reporting system of Community Pharmacists in Yogyakarta City, Indonesia. Cross sectional study design was conducted to community pharmacists (n=275) in Yogyakarta City, Indonesia on the period of November 2016 to March 2017. All data were analysed by Statistical Package for Social Sciences (SPSS) software V.16.0. Results were reported as frequency, and we used cross tabulation. The questionnaire consisted of questions about the sociodemographic characteristics of the Pharmacists. Furthermore, questionnaire with nine and eight points for assessing knowledge and perception about ADR Reporting System in Indonesia was used. The response rate of community pharmacists reached 36% (n = 100). A majority of the respondent was female (81%) and respondents of age group 20–30 years were predominantly (55%). Most of the respondents was graduated as pharmacist (85%), in the graduation year of 2010-2016 (55%). Most of the pharmacist had 1-5 years of work experience (44%) and never get pharmacovigilance training (86%). Most of the pharmacists had fair knowledge ( 40%) and fair perception (65%) towards the ADR reporting system. Pharmacovigilance training and last education of community pharmacists could influence the pharmacists’ knowledge (p: 0.00 and 0.013, respectively). Moreover, there was no significant association between pharmacists’ knowledge and perception (p > 0.496)
No full textBad breath is usually caused by bacteria and leftovers in the mouth. Utilization of natural ingredients that can be used to overcome the problem of bad breath one of them by using basil leaves (Ocimum americanum L.), which has activity as an antibacterial. The development of the preparations was done on basil leaves to overcome bad breath is by formulating the basil leaves ethanol extract into the Orally Disintegrating Tablet (ODT) preparation. The purpose of this study was to investigate the effect of explotab® concentration variations on the physical properties of ODT and to determine the best of concentrations of Explotab® that fulfill the physical properties of ODT. The type of research conducted was an experimental study. Research object was basil leaves ethanol extract formulated into ODT with Explotab® 2% w/b, 4% w/w, 6% w/b and 8% w/w variation. Physical evaluations test then conducted including : the uniformity of weight evaluation, the hardness test, the friability test, and the dissolved time. The results showed that the explotab® concentration variations had an effect on the physical properties of tablets and the formula with the Explotab® 8% b/b concentration was the best formula that could produce the best ODT tablet with physical properties.
Keywords : Basil leaves (Ocimum americanum L.), Explotab®, Orally Disintegrating Tablet (ODT
No full textMore than two-thirds of patients with type 2 diabetes also experience hypertension whose development coincides with hyperglycemia, where each disease has a tendency to influence the increased risk of other diseases. Sundry new guidelines, such as the National Joint Committee 8, the American Diabetes Association recommend blood pressure targets in the diabetic population of <140/90 mmHg to reduce cardiovascular risk and prevent the progression of nephropathy. This study aims to determine whether there is a difference in achieving blood pressure target < 140/90 mmHg according to Join National Committee 8 between ACEi and ARB in patients with type 2 diabetes with hypertension. This research was conducted using a retrospective at internist clinic of Abdul Wahab Syahranie hospital, by taking secondary data from the medical record from blood pressure o 49 outpatients received a single antihypertensive either drug ACEi 29 people or ARB 34 people. This study showed that the achievement of target blood pressure by <140/90 mmHg (JNC 8 guideline) between ACEi 7 (28%) and ARB 5 (20,8%) group and it can be concluded that between ACEi and ARB drugs(P=0.5) there was no differsignificantly in achievement blood pressure target on type 2 diabetes with hypertension