Jurnal Ilmiah Manuntung
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No full textBreast cancer is a disease of malignant neoplasm which is an abnormal growth of tissue that is different from the surrounding tissue. Various used of chemotherapy in the process of achieving management in cancer that causes the use of benefits and costs. This study aims to determine a more effective therapy in breast cancer patients at RSPAD Gatot Soebroto in 2017. This study was non experimental with comparative study into two group chemotherapy is single group (chemotherapy bondronat) and combination group (chemotherapy doxorubicin-paclitaxel). This study use secondary data from medical records patients on retrospectively. The results showed a decrease in the scale of single chemotherapy (Bondronat) was 82,61% with an average direct medical cost of IDR 9,3 million where as in combination chemotherapy (Doxorubicin-Paclitaxel) 95,65% with an average direct medical cost of IDR 7,6 million. The ACER value in single chemotherapy was IDR 11,3 million and combination chemotherapy was IDR 7,9 million. The ICER value in the two treatment groups was IDR 13,5 million. The conclusion is the combination of chemotherapy of Doxorubicin-Paclitaxel is the most cost-effective than Bondronate single chemotherapy
No full textIndonesia biodiversity has the second highest number of indigenous medical plants after the amazon rain forest, meanwhile Indonesian people usually used plants as a medicine source and some medicine plants have been developed as modern drugs. One of medicine plant in Indonesia that usually used as a refreshment was grass jelly (Stephania capitata (Blume) Spreng). This plant frequently found in Sumatra, Borneo and Java island and the leaf of grass jelly has been reported as a medicine against stomach complaint (diarrhea) and fevers. This research was designed to investigate the secondary metabolites and the efficacy of leaf extract of grass jelly as anti diarrhea. The leaves extraction was done by using maceration with ethanol solvent at room temperature. Meyer reagent, dagendroff reagent, methanol, magnesium band, hydrochloric acid, iron (III) chloride, anhydrous acetic acid, sulfuric acid, chloroform were used for identification of secondary metabolites from grass jelly leaves. For potency anti diarrhea, animals were divided into six group: diarrhea group, treatment group with loperamid HCl and treatment group of leaf extract of grass jelly. The results showed that the leaf extract of grass jelly contain saponin, phenol, sterol and triterpen and the treatment with leaf extract of grass jelly significantly decreasing time duration of diarrhea
No full textJengkol (Archidendron jiringa (Jack).I.C. Nielsen) skin for this belongs to the organic wastes that do not provide economic value. Compounds of natural ingredients on the Jengkol Skin among others, alkaloids, flavonoids, tannins, saponins, and triterpenoids. Some of the molecular structures of the compound are thought to potentially in inhibiting the growth of cancer cells. This research aimed to determine the cytotoxicity effect of 70% ethanol extract of Jengkol Skin as anticancer. Jengkol Skin was macerated in ethanol 70% then extract was concentrated with a rotary vacuum evaporator and water bath. Cytotoxicity test was carried out using cells MCF-7 (breast cancer) and HeLa cells (cervical cancer) based upon the method of MTT assay. The parameter was the value measured inhibition concentration (IC50). Extracts of the Jengkol Skin showed activity against cytotoxicity MCF-7 cells with IC50 values of 51.76 μg/mL and for the IC50 value of HeLa cells 39.618 μg/mL. IC50 values of the cell were less than 100 μg/mL, indicated categories of potential cytotoxicity. The Jengkol Skin extract could be used as anticancer agents
No full textPurple sweet potato rind has content of flavonoid and inhibitory activity against Staphylococcus aureus bacteria. This study aims to determine the content of flavonoid and difference between variations in the concentration of purple sweet potato rind ointment as inhibitory capacity to produce the physical quality of ointment that is in accordance with Indonesian Pharmacopoeia requirements and to know the difference in activity of inhibition of purple sweet potato rind ointment between variations in concentration on Staphylococcus aureus. The research method used has total flavonoid equivalent quercetin by spectrophotometry uv-vis and to inhibitory activity was used the paper disk method, namely by applying Staphylococcus aureus bacteria culture using sterile cotton sticks and then placed paper discs which had been soaked for 15 minutes with purple sweet potato rind extract ointment. Purple sweet potato rind extract was obtained by maceration using 96% ethanol solvent until the ethanol extract of purple sweet potato rind was obtained. It was then formulated into ointment dosage forms with variations in concentrations of 20%, 25%, 30%. The results showed has total flavonoid equivalent quercetin of purple sweet potato rind is 8,36% and the variation of the concentration of purple sweet potato rind ointment influential in producing the physical quality of the ointment, the ointment the concentration of 30% produced a distinctive aroma and brighter colors from concentrations of 20% and 25%. The inhibitory activity of purple sweet potato rind extract ointment showed a significant value of < 0,05 (p=0,000) at a concentration of 30% having a strong inhibitory activity against the Staphylococcus aureus bacteria
No full textBitter melon fruit (Momordica charantia L.) can be used as traditionally to reduce blood sugar levels. Avicel PH 101 and corn starch are efficacious as fillers, disintegration excipient and binders. The combination of Avicel PH 101 with corn starch is expected to be able accelerate the tablet disintegration time of tablet. This research was aimed to get the optimum formula tablets of bitter melon extract tablets using combination of corn starch and avicel PH 101. Bitter melon extract was formulated in tablet with wet granulation method. Bitter melon extract was obtained by maceration with ethanol 70% as solvent. Tablet formula based on the Simplex Lattice Desaign method uses Design Expert software version 11 with parameters that are used weight uniformity, hardness, friability and disintegration time. The results obtained from the simplex lattice design compared with the results of testing using the SPSS 18 program using the One Sample T-Test with a confidence level of 95%. The result of this research indicate bitter melon extract was made by tablets with wet granulation method with a combination of Avicel PH 101and corn starch, a formula with a ratio of 51% : 49% selected as the optimum formula with weight uniformity, hardness, friability and disintegration time meeting the requirements.
Keywords : bitter melon extract, tablets, corn starch, avicel PH 101, simplex lattice design  
No full textThe leaf of kedondong hutan (Spondias pinnata (L.F.) Kurz.) Contain of flavonoid compound, which capable as antioxidants that function for preventing free radicals. The purpose of this study was to determine the antioxidant activity profile of ethanol extract of kedondong hutan leaf with DPPH, ABTS radical and iron reduction methode (FRAP). This study used experimental research with stages of sample collection, plant determination, simplicia preparation, maceration with 70% ethanol, phytochemical screening and antioxidant activity assay with UV-Vis spectrophotometry. The results obtained from the ethanol extract of kedondong hutan leaves had antioxidant activity on DPPH and ABTS with IC50 of 32.83 ppm and 45.84 ppm respectively. In FRAP method kedondong hutan leaves had antioxidant activity which is equivalent to quarcetin of 2936.7 µmol QR /g sample. Ethanol extract of kedondong hutan leaves has very strong antioxidant power against DPPH, ABTS radical and iron reduction
No full textAccording to Riskesdas (2013) the prevalence of hypertension in South Kalimantan Province is 30.4%, this means around 1,145,536 people. Risk factors are occupation of less physical activity 26.1% and residents> 10 years consuming less vegetables and fruits. The government invites the entire community to carry out a movement of healthy living people by doing physical activities, consuming vegetables and fruits and checking health regularly. The purpose of this study was to determine the effect of Brief Counseling of Pharmacists on Physical Activity and Therapeutic Results of Hypertensive Patients Outpatient in the Internal Medicine Polyclinic of Ulin Hospital, Banjarmasin.The quasi-experimental study used a prospective two-group pretest and posttest design. Patients were grouped randomly into two groups, namely the group that received the intervention in the form of a pharmacist / researcher briefing and group without intervention (control) followed for one month. Sampling using co-executive sampling method that meets the inclusion and exclusion criteria. The study was conducted at the internal medicine clinic at Ulin Banjarmasin Public Hospital in the period January-March 2018. The instrument used is International Physical Activity Questionnaire (IPAQ).The results of physical activity data analysis in the control group with the Wilcoxon Test which showed data had a significant difference (p <0.05), while in the treatment group with the Wilcoxon Test which showed data did not have a significant difference (p> 0.05). Analysis of blood pressure data in the control group with the Wilcoxon Test which showed data had a significant difference (p <0.05), while in the treatment group with the Wilcoxon Test which showed data had a significant difference (p <0.05)
No full textClove and lemongrass are agricultural commodities that have high economic value. One of the natural compounds produced from both and is usually obtained by distillation is essential oil. The use of clove oil and citronella oil that has often been used by the public is as an analgetics. The purpose of this study was to make an analgetics gel from a combination of essential oils of clove and citronella oil with variations in the concentration of CMC-Na as a gelling agent and to determine the gel that wasmost preferred by respondents. This research is an experimental research, the method of document collection uses qualitative and quantitative data from laboratory experiments. The resulting gel is then tested for physical properties of the preparation which includes organoleptic test, homogeneity, pH, clarity, dispersion , protection power, and adhesion. Test of preference for 10 respondents to determine the most preferred gel. The results showed that the gel combination of clove and citronella oil with 2% CMC-Na concentration was the best formula seen from the physical test and preference test
No full textActivated carbon is defined as carbon that has a great absorptive capacity of anions, cations, and molecules in the form of organic and inorganic compounds, either in the form of solutions or gases. Activated carbon has been highly used for various things, mainly to absorb dirt or toxins. The pores formed on this activated carbon will bind the impurities on the tooth surface. Therefore, cleaning the yellowish substances on the teeth will be easier. The aim of this research is to make dentifrice formulation with variety of activated carbon concentrate as the active substance and Virgin Coconut Oil (VCO) as the basis to get best tooth paste formula, or to meet toothpaste quality requirement.The concentrate of activated carbon used was12.5%, 15%, 17.5%, 20% and the Virgin Coconut Oil (VCO) concentrate used was 10%, 12.5%, 15%, 17.5% , 20%. Other additives that were also used were calcium carbonate, sorbitol, glycerol, Na.CMC, saccharin, sodium benzoate, sodium lauryl sulphate, menthol and aquades. The result of research indicated that the nifty basis of VCO was F3 with 15% VCO concentrate and 15% of F1 activated carbon toothpaste formula, which fulfilled toothpaste quality requirement. This formula was used to test gray organoleptic test, delicate texture, and homogeneous. It also had a pH of 8 which was corresponding to the pH value requirement for dentifrice preparations according to SNI 12-3524-1995 ie 4.5 -10.5 and typical menthol odor and fresh taste. The toothpaste does not contain of air bubbles, separated lumps and particles, and foreign objects are not visible
No full textThalassemia is a group of congenital hemoglobinopathy characterized by deficiency or absence of one (or more) of the globin chains that constitute hemoglobin. Thalassemia major is inherited through autosomal recessive pattern by marriage between carriers of the thalassemia gene known as thalassemia minor. Beta-thalassemia is the most common type of thalassemia. It is estimated that 10% of Indonesia's population carries the beta-thalassemia gene. However, there has been no routine screening for thalassemia gene carriers. Several recognized methods of thalassemia screening are available. One of them is screening of prospective brides using several hematology parameters such as Mentzer index and red blood cells fragility; both are relatively straightforward and inexpensive compared to hemoglobin analysis or genetic testing. This study aimed to determine the frequency of beta-thalassemia minor suspects among students in the Medical Faculty of Mulawarman University. This study was a descriptive quantitative study with cross sectional approach that involved 160 participants. Participant's blood sample was collected for complete blood count and one tube osmotic fragility test (OTOFT). Mentzer index is calculated by dividing MCV values with erythrocyte count. Participants were determined as beta-thalassemia minor suspects if they met following criterias: (1) MCV < 80 fL; (2) Mentzer index < 13; and (3) positive OTOFT result. This study demonstrated that 1.25% (n=2) of 160 participants were beta-thalassemia minor suspect. Further examination of hemoglobin electrophoresis or genetic testing is needed to further confirm this finding