Jurnal Ilmiah Manuntung
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No full textRhizopora mucronate is a typical mangrove plant that easly found on the coast of Muara Badak Beach, Kutai Kartanegara Regency, East Borneo, Indonesia. The purpose of this research is to know the activity of active compound from mangrove Rhizopora mucronate leaves that have the potencial as antidiabetic. Samples of R. mucronata mangrove leaves were taken at Muara Badak beach region. Leaf samples that have been dried, are extracted by maceration using methanol solvent and followed by a partition extraction process using n-hexane solvent. The methanol and n-hexane extracts from R.mucronata mangrove leaves were obtained, followed by phytochemical tests (alkaloid, flavonoid, steroid, terpenoid, phenolic compounds, tannin, and saponin) qualitatively. Then the antidiabetic activity was tested using an oral glucose tolerance test method. Phytochemical test results of methanol and n-hexane extracts of R.mucronata mangrove leaves are positive contained group compounds; alkaloids, flavonoids, tannins and phenolics. The percentage decrease in blood glucose levels of mice for positive control (Glibenclamide 0.05 mg / kgBB) was 21.81%, methanol extract for group III (dose 62.5 mg / kgBB) 67.86%, Group IV (dose 125 mg / kgBB) 58.74% and Group V (group V (dose 62.5 mg / kgBW) 67.86%, Group IV (dose 125 mg / kgBW) 58.74% and Group V (group V (dose 62.5 mg / kgBW) dose 250 mg / kg) 36.72%. Then the percentage decrease in blood glucose levels of mice for n-hexane extract; Positive control was 11.60%, Group III (dose 62.5 mg / kgBW) was 20.1%, Group IV (dose 125 mg / kgBW) 7.83% and Group V (dose 250 mg / kgBW) 42.7%. The methanol extract of R.mucronata mangrove leaves at a dose of 62.5 mg / kgBB has the best antidiabetic activity. Whereas n-hexane extract has the best antidiabetic activity at a dose of 250 mg / kgBW. Thus the methanol and n-hexane extract of Rhizopora mucronata mangrove leaves has the potential as an antidiabetic.
 
No full textThe study aims to identify the secondary metabolite compounds contained in the ethanol extract Propolis Tetragonula Iridipennis and determine the antioxidant activity. Propolis is extracted from the beehive of Kelulut (Tetragonula Iridipennis) with a method of maceration of ethanol 96% produce a yield of 66.73%. Propolis extract contains alkaloid compounds, flavonoids, triterpenoids, tannins and carbohydrates. Propolis extract tested its antioxidant activity using the DPPH method (1.1-diphenyl-2-picrylhydrazyl) with a wavelength of 514 nm. Results showed a percentage of propolis extract free radicals 59% in concentrations of 100 ppm with IC50 33.74 ppm so that propolis extract is potentially as an antioxidant.
 
No full textDiabetes mellitus is a chronic disease caused by insufficient insulin effectively. Compliance medication in patients diabetes mellitus is important to achieve treatment goals and effective to prevent complications in diabetes mellitus. The duration of suffering from DM is one of the factors that influences medication adherence. The purpose of this study is to compare the differences in adherence to taking medication between patients who have just been diagnosed with diabetes mellitus type II. Questionnaire instrument 4 indicators of compliance (right dose, right frequency, right interval, right time). Analysis statistical of the Mann-Whitney test. Total of 10 new patients and 20 old patients were diagnosed. The results study is patient to be compliant with right dose adherence 8 new patients (80%), 19 old patients (95%). Right frequency adherence 9 new patients (80%), 19 old patients (95%). Timely compliance 7 new patients (70%), 16 old patients (80%). Right interval adherence 4 new patients (40%), 13 old patients (65%). The results of data analysis showed p-value = 0.076> 0.05 there was no significant difference in adherence to taking medication between old patients and new patients with diabetes mellitus type II.
 
No full textMoringa oleifera leaf contains quercetin act as an analgesic by inhibiting cyclooxygenase and lipooxygenase. These enzymes interfere synthesis of prostaglandins by arachidonic acid and lead to reduce pain. This study aimed to obtain a physically stable M/A cream formula from the lyophilized ethanol extract of Moringa leaf and to determine the irritation effect. The cream prepared with variations of cetyl alcohol concentration F1 (2%), F2 (4%,) and F3 (6%). The cream stability was determined with organoleptic, homogeneity, type of emulsion, pH, viscosity, and spreadability parameters after accelerated condition. The Irritancy test was determined to the Albino Oryctolagus cuniculus. The results showed that F1 has the best stability than F2 and F3 and showed irritation index 0,5 classified as moderate irritation
No full textKaramunting (Rhodomyrtus tomentosa (Aiton) merupakan salah satu tanaman yang digunakan sebagai obat tradisional yang banyak tersebar diseluruh Indonesia khususnya berasal Toraja, yang berpotensi sebagai antioksidan dan antikanker dengan adanya kandungan senyawa fenolik dan flavanoid. Penelitian ini bertujuan untuk melihat flavonoid total serta aktivitas antioksidan dan toksisitas ekstrak daun karamunting. Simplisia daun karamunting diekstraksi dengan metode maserasi menggunakan etanol 70%, pengujian aktivitas antioksidan diukur menggunakan microplet reader dan diuji toksisitasnya dengan metode BSLT. Hasi penelitian fenolik total 3,496% , Perolehan aktivitas antioksidan nilai IC50 ekstrak etanol daun karamunting sebesar 24,451 bpj dan Perolehan uji toksisitas nilai IC50 ekstrak etanol daun karamunting sebesar 31,80 bpj terhadap larva udang. Berdasarkan hasil tersebut, ekstrak etanol daun karamunting masuk dalam kategori antivitas sangat kuat dengan range <50 % dan dinilai memiliki sifat toksisitas katogori sangant kuat.Karamunting (Rhodomyrtus tomentosa (Aiton) is one of the plants used as a traditional medicine that is widely spread throughout Indonesia, especially from Toraja, which has the potential as antioxidants and anticancers with the content of phenolic compounds and flavanoids. This study aims to look at total flavonoids as well as antioxidant activity and toxicity of karamunting leaf extract. Simplisia karamunting leaf research method is extracted by maceration method using ethanol 70%, testing antioxidant activity with ABTS method and toxicity test with BSLT method. The results of the study obtained a total phenolic 3.496% , The acquisition of antioxidant activity of ethanol extract of caramel leaves with ic50 value of 24,451 bpj and the acquisition of toxicity test of ethanol extract of caramel leaves with a value of LC50 of 31.80 bpj against shrimp larvae. Based on the results obtained ethanol extract of caramel leaves has antioxidant activity and has a very strong toxicity effect.Karamunting (Rhodomyrtus tomentosa (Aiton) merupakan salah satu tanaman yang digunakan sebagai obat tradisional yang banyak tersebar diseluruh Indonesia khususnya berasal Toraja, yang berpotensi sebagai antioksidan dan antikanker dengan adanya kandungan senyawa fenolik dan flavanoid. Penelitian ini bertujuan untuk melihat flavonoid total serta aktivitas antioksidan dan toksisitas ekstrak daun karamunting. Simplisia daun karamunting diekstraksi dengan metode maserasi menggunakan etanol 70%, pengujian aktivitas antioksidan diukur menggunakan microplet reader dan diuji toksisitasnya dengan metode BSLT. Hasi penelitian fenolik total 3,496% , Perolehan aktivitas antioksidan nilai IC50 ekstrak etanol daun karamunting sebesar 24,451 bpj dan Perolehan uji toksisitas nilai IC50 ekstrak etanol daun karamunting sebesar 31,80 bpj terhadap larva udang. Berdasarkan hasil tersebut, ekstrak etanol daun karamunting masuk dalam kategori antivitas sangat kuat dengan range <50 % dan dinilai memiliki sifat toksisitas katogori sangant kuat.Karamunting (Rhodomyrtus tomentosa (Aiton) merupakan salah satu tanaman yang digunakan sebagai obat tradisional yang banyak tersebar diseluruh Indonesia khususnya berasal Toraja, yang berpotensi sebagai antioksidan dan antikanker dengan adanya kandungan senyawa fenolik dan flavanoid. Penelitian ini bertujuan untuk melihat flavonoid total serta aktivitas antioksidan dan toksisitas ekstrak daun karamunting. Simplisia daun karamunting diekstraksi dengan metode maserasi menggunakan etanol 70%, pengujian aktivitas antioksidan diukur menggunakan microplet reader dan diuji toksisitasnya dengan metode BSLT. Hasi penelitian fenolik total 3,496% , Perolehan aktivitas antioksidan nilai IC50 ekstrak etanol daun karamunting sebesar 24,451 bpj dan Perolehan uji toksisitas nilai IC50 ekstrak etanol daun karamunting sebesar 31,80 bpj terhadap larva udang. Berdasarkan hasil tersebut, ekstrak etanol daun karamunting masuk dalam kategori antivitas sangat kuat dengan range <50 % dan dinilai memiliki sifat toksisitas katogori sangant kuat.Karamunting (Rhodomyrtus tomentosa (Aiton) merupakan salah satu tanaman yang digunakan sebagai obat tradisional yang banyak tersebar diseluruh Indonesia khususnya berasal Toraja, yang berpotensi sebagai antioksidan dan antikanker dengan adanya kandungan senyawa fenolik dan flavanoid. Penelitian ini bertujuan untuk melihat flavonoid total serta aktivitas antioksidan dan toksisitas ekstrak daun karamunting. Simplisia daun karamunting diekstraksi dengan metode maserasi menggunakan etanol 70%, pengujian aktivitas antioksidan diukur menggunakan microplet reader dan diuji toksisitasnya dengan metode BSLT. Hasi penelitian fenolik total 3,496% , Perolehan aktivitas antioksidan nilai IC50 ekstrak etanol daun karamunting sebesar 24,451 bpj dan Perolehan uji toksisitas nilai IC50 ekstrak etanol daun karamunting sebesar 31,80 bpj terhadap larva udang. Berdasarkan hasil tersebut, ekstrak etanol daun karamunting masuk dalam kategori antivitas sangat kuat dengan range <50 % dan dinilai memiliki sifat toksisitas katogori sangant kuat
No full textThe soil is one of the habitats for microorganisms, in one gram soil there are millions of microorganism. Population microorganism per gram the rich soil of covering bacteria, actinomycetes, fungi, algae and protozoa. Garden having the potential to do exploration of isolation microorganisms. This is because land contains many organic compounds and minerals that is one ecosystem fertile to life and growth microorganisms. Whenever a microorganisms have proven produce substance antimicrobe so organisms of its potential as producer antibiotics. Material research the land, taken from the soil Faculty of Pharmacy Plant Garden of UNJANI, we did dilution and cultivated in a media potato dextrose broth. The isolate from medium broth was cultivating in a media potato dextrose agar, to obtained isolates single. Isolates obtained seen features macroscopic and microscopic. The results obtained isolates isolation two of the four isolates that can give inhibition to Escherichia coli but does not inhibition to Staphylococcus aureus.
Keywords: isolation, microbe, soi
No full textThis study aims to determine the potential for glucose levels in the blood of ethanol extracts of the begonias (Begonia Sp.), the effect of the extract on the pancreatic histopathology of white rats (Rattus norvegicus) which was induced by streptozotocin, and the effective dose begonias’ extract leaves on the histopathological descriptions of pancreatic male white rats. This study was an experimental laboratory where the research group consisted of group I (the control group) as a normal control was given a standard feed, group II (negative control) was given a 0.5% Na CMC suspension, group III (positive control) was orally given glibenclamide and experimental groups IV, V, and VI (doses 50, 100, and 200 mg/kg BW). Were given ethanol extract of begonias leaves. The results showed that the ethanol extract of the begonias (Begonia Sp.) contained secondary metabolite compounds, namely flavonoids, alkaloids, saponins, polyphenols, and tannins. Ethanol extract of begonias leaves at adose of 50 mg/kg BW was an affective dose in reducing blood glucoselevels by an avarage of 101,8 mg/dL) and a dose of 50 mg/kg BW can affect the histopathological picture of the pancreas in STZ induuced rats with an average damage value of 2 from a maximum of 4
No full textDiabetic ulcers are a disease that is experienced by many people with diabetes mellitus, open wounds on the skin surface of the diabetic ulcer have the potential to develop into infection, to deal with the problem of infection needed the right treatment, one of them is by using antibiotics. The purpose of this study was to describe the use of diabetic ulcer patients In Installation Of Outpatient in RSUD Ulin Banjarmasin Period July-December 2018. This study is a non-experimental study with a descriptive type of study through a retrospective search for outpatient prescription for diabetic ulcers. This research was conducted in April-May 2019 in Installation Of Outpatient in RSUD Ulin Banjarmasin. Sampling is done by saturation sampling method, the population in this study were 254 prescrptions. While the sample in this study were 228 prescrptions that met the criteria of inclusion and exclusion. The data obtained is copied to the observation sheet, after the data collected is then entered into a computer and a calculation is carried out to find out the percentage of each factor studied and finally the data will be presented in table form. The results obtained from the study of 228 prescriptions of diabetic ulcer patients obtained the use of single antibiotics as much as 182 (79.82%) and combination antibiotics by 46 (20.18%). The single most prescribed group of antibiotics is the Makrolide group of 49.56%, the Makrolide group which is often prescribed namely Clindamycin 300 mg as much as 39.91%.While the most prescribed combination of 2 antibiotics is Clindamycin 300 mg + Metronidazole 500 mg 14.47%
No full textOsteoarthritis (OA) is a disorder affecting the diarthrodial joints that support the skeletal system and the axial causing joint symptoms. The effectiveness of NSAID pain therapy in osteoarthritis often results in inadequate response and prolonged use can cause unexpected side effects. The therapy offered is diclofenac sodium and piroxicam. This research used the design of Quasy Experimental Design type Non Equivalent Control Group Design. The research was conducted at Puskesmas Tenggilis Surabaya. The outcomes measured as the intensity of pre and post treatment pain, Drug Side Effects on pre and post-treatment kidney function, and side effects on pre and post-treatment blood pressure. The study sampled 42 patients consisting of 20 patients (piroxicam group) and 22 patients (sodium diclofenac group). There was a significant difference with the intensity of the pain scale in both post groups (p= 0.001). There were no significant differences in average creatinine and BUN in the post treatment of pyroclacycam group and post treatment group sodium diclofenac (p = 0.772) and (p = 0.801). This study shows that the piroxicam group is more effective in reducing the pain scale than sodium diclofenac and both groups have not been shown to be safety in renal function (Creatinine and BUN
No full textMahkota Dewa (Phaleria macrocarpa Boerl) is a medical plant of the Thymelaeaceae family originating from Indonesia, precisely from Papua. Phaleria macrocarpa Boerl the deity has been known in various treatments such as diabetes, cancer, liver, dysentery, allergic diabetes, eczema, or gout and others (Ratna & Wiwi, 2014). The purpose of this study is to find out whether extract ethanolic 96% of Phaleria macrocarpa Boerl can inhibit the growth of K. pneumoniae, and to know what concentration of extract ethanolic 96% of Phaleria macrocarpa goodnes to inhibit K. pneumoniae. The method used is the Kirby Bauer Method. With the average inhibition zone concentrations is 100%, 80%, 60%, 40%, 20% respectively 17.41mm, 15.37mm, 12.60mm, 11.10mm, 6.43mm