Jurnal Ilmiah Manuntung
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No full textType 2 diabetes mellitus (insulin-dependent diabetes or adult-onset diabetes) is a condition caused by the ineffective use of insulin in the human body. This disease is also often accompanied by hypertension, where these comorbidities can spur severe cardiovascular complications such as heart attacks, strokes and kidney failure. Hospitalised diabetic patients with comorbid hypertension, have the potential to experience drug-related problems / Drug-Related Problems (DRPs), especially Drug-Drug Interactions (DDIs) due to a combination of therapies during the treatment period. The results obtained from the data tracking of 52 patients showed that 21 patients (40%) had the potential to experience DDIs. The types of potential DDI found in this study had 71 kinds variation with 124 events, 5% were major and 95% were moderate. The prevalence of potential interactions between drugs is quite high and varied. Inpatient monitoring of the risk is essential to avoid potential dangers inflicts on patients.
 
No full textIllipe butter and cacao butter have alike physical characteristic. Hence, illipe butter is one of CBS (cacao butter substitute) in food industry. The studi aims to compare the physical properties of illipe butter based lipstick with cacao butter based lipstick. Illipe butter in the study is a vegetable fat from the nut of Shorae mecistopteryx, it has a melting point of 29 ° C. The study was conducted at Pharmaceutical Technology Laboratory of Stikes Samarinda. Lipstick bases consist of illipe butter, cacao butter, carnauba wax, beeswax, lanolin and castor oil. Physical evaluation of lipstick includes homogeneity test, pH test, meting point test, hardness test, patch test, and sensory evaluation. The results showed that all lipstick formulas were homogeneous, stable, and no discoloration during 14 days. The average pH of all lipstick formulas is 5.9. Melting point of illipe buteer based lipstick is 58-59 ° C and 59-60° on cocoa butter based lipstick. Illipe butter brown fat base. Hardness level of illipe butter based lipstick is 433-833 grams, while cocoa butter based lipstick has a hardness level more than 1000 grams. Panelists in sensory evaluation preferred illipe butter based lipstick.
 
No full textMeasuring the quality dimensions of health service is essential and should be done along with patient satisfaction surveys. The level of patient satisfaction with hospital health services may use the five-dimensional Service Quality (ServQual) method, that is, reliability, responsiveness, assurance, concern and tangible form. The study was conducted to determine the level of outpatient satisfaction with the quality of services provided by The Cilandak Marinir Hospital Pharmacy Installation. The research design is Observational by survey methods, conducted on JKN outpatients, with a total sample of 106 respondents. Inclusion criteria; patients who redeem a prescription at a hospital pharmacy installation at least 2 times; patients who are willing to fill out the questionnaire, sign the questionnaire, and approve the informed consent; patients aged ≥ 15 years. Exclusion criteria are patients who are hospital employees; HIV / AIDS patients. This study was also complemented with data collection permits from the hospital and ethical approval from the ethics research committee of the Universitas Pembangunan Veteran Jakarta. The instrument used is in the form of a questionnaire to measure patient satisfaction about pharmacy services at the pharmacy. The results of the validity test of 0.383-0.950 (components of expectations) and 0.362-0.928 (components of performance) are declared valid. The reliability test results are 0.954-0.961 (expectation component) and 0.951-0.960 (performance component); these results indicate that the questionnaire can be used because all questions are reliable (> 0.60 Cronbach Alpha scores). Data analysis uses the Service Quality method (Service Quality score = Performance - Expectation). A positive score indicates that customer expectations are met so that services on specific dimensions can be perceived as high quality and vice versa. Ideally, the value of the gap between expectations and perceptions is zero. ServQual analysis results based on the gap showed that the most significant value of the gap in the dimensions of reliability -0.18, responsiveness (responsiveness) -0.12, awareness (empathy) -0.08, assurance -0, 07, and tangible form (tangible) -0.03. Based on these results, It can be concluded that pharmaceutical services still need improvement because they still have a negative gap value for the five dimensions.
 
No full textKeladi tikus (Typhonium divaricatum Decne) is one of Aracaceae family which a plant that’s very popular in Indonesian society because it contains anti-cancer substances. Nowadays, keladi tikus plants have been cultivated in tissue culture widely. The simplicia used in this study was keladi tikus from tissue culture which was separated into the upper part (leaves and petioles) and the bottom (tubers) dried in the sun. Dry simplicia was extracted with methanol at a temperature of 60-70 oC and the methanol extract was partitioned with ethylacetate then with n-BuOH solvents, and all extracts were tested for cytotoxic tests using the Brine Shrimp Lethality test (BSLT) method. The active fraction of ethylacetate extract, which is the tuber parts was carried out by column chromatography (SiO2; i). n-hexane: ethylacetate = 10: 1 ~ 1: 1; ethylacetate; MeOH; ii). n-hexane-ethylacetate = 5: 1) give one pure isolate. The results of identification based on Infrared (IR) spectra, and gas chromatography-mass spectra (GC-MS) are b-sitosterol which LC50 is 76.2 pp
No full textMekai leaves (Pycnarrhena cauliflora Diels.) (P. cauliflora). Are known to contain flavonoid compounds, tannins and phenolics that act as antibacterial agents and are used in the treatment of eye pain. Staphylococcus aureus (S. aureus) is one of the examples of bacterial diseases of eye pain and also a major cause of many infections in communities and health facilities with cases of resistance to various antimicrobial agents. The purpose of this study was to prove the antibacterial activity of mekai leaves ethanol extract against S. aureus bacteria. This research is an experimental research. The stages of this research began by extracting mekai leaves using maceration method with 96% ethanol solvent. Antibacterial activity was tested by the disc method (Kirby-Bauer) using ethanol extract concentrations of mekai leaves (EPC) 20%, 30%, 40%, 50%, 60%, 70%, and 80%, positive control using 25 μg amoxicillin and negative control using DMSO 10%. The measurement results of inhibition zones of mekai leaf ethanol extract 20%, 30%, 40%, 50%, 60%, 70% and 80% respectively were 8.32 mm, 8.32 mm, 8.32 mm, 8.67 mm, 9.00 mm, 8.67 mm, and 8.33 mm. While the positive control measurement of 25 μg amoxicillin against S. aureus is 28.67 mm and the measurement of 10% negative DMSO control does not produce inhibitory zones, so it can be concluded that the ethanol extract of mekai leaves has antibacterial activity, but the area of inhibition zone produced is smaller than amoxicillin 25 µg. The results of statistical tests using Mann Whitney between negative controls with all EPC concentrations obtained significant differences with p values <0.05, it can be concluded that there is antibacterial activity produced at all EPC concentrations
No full textPharmacists are one of the health workers who play a role in providing information related to explanations of how to use inhaler preparations to asthma patients. This study aims to determine the effectiveness of providing educational videos on how to use several types of inhalers (MDI, MDI with spacers, Diskus®, and Bodyaler® given to pharmacist students. This research is a pre-post design (experimental) study. Sampling was conducted using the method non random sampling using purposive technique, normality test using Shapiro-Wilk and continued.From the results of the data obtained, each assessment verbally (as explained by the subject) and motoric assessment (as demonstrated by the subject) is seen from the pre- and post-intervention Comparing the completeness of explanations both verbally and motorically, showing significant differences compared to before education, with P values for MDI (P (0,000) ≤0.05), MDI with spacers (P (0,000) ≤0.05) Diskus® (P (0,000) ≤0.05), and Turbuhaler® (P (0,000) ,00.05), therefore video education has proven to be effective in increasing student proficiency. self-pharmacist to explain how to use inhalers.Apoteker merupakan salah satu tenaga kesehatan yang berperan dalam memberikan informasi terkait penjelasan cara penggunaan sediaan inhaler kepada pasien asma. Penelitian ini bertujuan untuk mengetahui efektivitas pemberian edukasi video cara penggunaan beberapa jenis inhaler (MDI, MDI dengan spacer, Diskus®, dan Tubuhaler® yang diberikan kepada mahasiswa apoteker. Penelitian ini merupakan penelitian pre-post design (eksperimental). Pengambilan sampel dilakukan dengan metode non random sampling yang menggunakan teknik purposive. Uji normalitas menggunakan Shapiro-Wilk dan dilanjutkan. Dari hasil data yang diperoleh, masing-masing penilaian secara verbal (yang dijelaskan oleh subjek) dan penilaian secara motorik (yang diperagakan oleh subjek) dilihat dari pre- dan post-intervensi. Membandingkan kelengkapan penjelasan baik secara verbal dan motorik, menunjukkan perbedaan bermakna dibandingkan dengan sebelum diedukasi, dengan nilai P untuk MDI (P(0,000)≤0,05), MDI dengan spacer (P(0,000)≤0,05). Diskus® (P(0,000)≤0,05), dan Turbuhaler® (P(0,000)≤0,05). Oleh karena itu edukasi video terbukti efektif dalam meningkatkan kemampuan mahasiswa apoteker untuk menjelaskan cara penggunaan inhaler.
Kata kunci: teknik inhaler, asma, mahasiswa apoteker, video edukas
No full textLeaves Sepat (Mitragynaspeciosa) is a plant of Kalimantan. These plants are often used traditionally to reduce blood sugar and antibacterial. The effectiveness is related with strong antioxidant activity in flavonoid compounds. Flavonoid compounds work through the mechanism of capturing free radicals, reducing oxidative stress. The purpose of this study was to measure the percentage of free radical inhibition in the hand sanitizer of methanol extract of leaves Sepat (Mitragynaspeciosa). Sample extraction by maceration method using methanol. Qualitative analysis of chemical compounds with certain eluents using Thin Layer Chromatography (TLC). The antioxidant activity test using the DPPH immersion method (1,1-Diphenyl-2-picryl Hidrazil) measured absorption at a wavelength of 517 nm. The largest percentage of free radical inhibition was obtained in a hand sanitizer concentration of 80 ppm, which is 51.07 ppm.
 
No full textFoot deodorizing products currently circulating include anti-bacterial soaps, foot soaking powders, anti-prespirants, creams, and foot odor powders. However, these preparations have not been sold freely in Indonesia. In terms of use, it is considered impractical, because they have to use water when used. The product is considered ineffective, so there is a need for an innovation to remove foot odor that is healthy, more practical, and effective, namely Footsanitizer Spray. However, Footsanitizer Spray preparations in the market contain 70-95% alcohol. Excessive use of alcohol and chemicals can have health effects and irritant effects on the skin. Coffee has properties that are known to get rid of bad odors. Ginger rhizome (Zingiber officinale Roscoe) has been known to have antibacterial activity because it contains phenols, flavonoids, terpenoids, and essential oils. So that the combination of coffee bean extract and ginger rhizome is taken into consideration in making Footsanitizer Spray. Footsanitizer Spray in this study was made into 3 formulas. The difference in the formula is based on the comparison of the concentration of coffee bean extract and ginger root. Formula 1 with 25%: 45% coffee bean and ginger extract. Formula 2 with a ratio of 35%: 35% coffee bean extract and ginger rhizome. Formula 3 with a ratio of 45%: 25% coffee bean extract and ginger root. Based on the results of organoleptic testing and homogeneity, all formulas have a light brown color liquid with a distinctive aromatic smell. And soft taste. All formulas also produce homogeneous preparations. The results of the specific gravity test of the three formulas have not much different density. Namely, formula 1, formula 2 and formula 3 respectively are 1.064 gr / ml, 1.065 gr / ml, and 1.062 gr / ml. while the viscosity values were 1.56 cp, 1.6 cp, and 1.61 cp, respectively. Formula 2 with a concentration of 35%: 35% has better antibacterial activity than other formulas. And it is included in the moderate barrier response category
No full textThe incidence of infections in the gastrointestinal tract is increasing every year. Some bacteria that often cause infections in the gastrointestinal tract are Salmonella typhi, which is a bacterium that causes typhoid fever, and Shigella dysenteriae which is a bacterium that causes dysentery. Handling of infection can only be done by using antibiotics. Improper use of antibiotics can lead to resistance, so it is necessary to look for alternative treatments that come from nature to overcome resistance levels. One of them is raw Kepok banana peel (Musa paradisiaca formatypica) which has secondary metabolites such as flavonoids, alkaloids, tannins, and saponins, where these compounds have many antibacterial activities unknown to the public. This research was an experimental research. The extraction method was using the maceration method with 96% ethanol solvent. Antibacterial activity test for Salmonella typhi and Shigella dysenteriae was using diffusion method therefore the wells were divided into 7 treatment groups, namely extract concentration 0.3125%; 0.625%; 1.25%; 2.5%; 5.0%; positive control (Chloramphenicol dose 30 mg / ml for Salmonella typhi, Ciprofloxacin dose 100 mg / ml for Shigella dysenteriae), and negative control (ethanol 96%). The diameter of the inhibitory zone formed was then measured using a caliper. From the results of the research that has been done, it was found that the ethanol extract of raw Kepok banana peel (Musa paradisiaca forma typica) had inhibitory effect on the growth of Salmonella typhi and Shigella dysenteriae bacteria with the highest inhibition zone diameter of 11.36 mm and the lowest 6.45 mm for Salmonella typhi, and the highest inhibition zone for Shigella dysenteriae was 17.99 mm and the lowest was 15.13 mm. The minimum concentration of banana skin ethanol extract which had inhibitory power was 0.3125%
No full textCimetidine is an H2 receptor antagonist which can be used to reduce acid secretion in the stomach by inhibiting selective binding of histamine to H2 receptors so that it can reduce the concentration of cyclic-adenosine monophosphate (c-AMP) which plays a role in the proton pump mechanism. The combination of floating and mucoadhesive systems is used to increase drug retention in the stomach so that it can reduce the drug interval and increase bioavailability of the drug. The purpose of this study was to make floating-mucoadhesive cimetidine tablets using Hydroxypropyl Methylcellulose (HPMC) as a floating polymer and chitosan as a mucoadhesive polymer. Tablets are expected to have the ability to maintain the dosage form in the stomach for approximately 12 hours. The evaluations carried out included the flow characteristics and the angle repose of the powder mixture, tablet weight uniformity, tablet hardness, tablet friability, floating lag time, floating duration time and tablet mucoadhesive strength. The responses observed were the ability to float and the mucoadhesive strength of tablets. The tablet release test (dissolution) for the optimum formula was performed to determine the character of tablet release. The optimum amount for HPMC is 146,686 mg and chitosan are 50 mg. The combination of polymers with this amount produces a floating lag time of 43,458 seconds, floating duration time >12 hours and the strength of mucoadhesive is 100 grams. The release of the optimum formula in the 720th minute is about 73,180% following the Higuchi release model with dissolution efficiency (DE720) about 67,855%