Jurnal Ilmiah Manuntung
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No full textHypertension is one of the deadliest diseases in the world. As many as 1 billion people in the world or 1 in 4 adults suffer from this disease. In fact, it is estimated that the number of hypertension sufferers will increase to 1.6 billion by 2025. Measuring the quality of life of hypertensive patients using the Indonesian version of the EQ5D questionnaire. The purpose of this study was to determine the quality of life of hypertensive patients at RSUD Ulin Banjarmasin using the EQ5D instrument. This study is an observational study conducted prospectively. Data were collected by filling out the EQ5D questionnaire by all hypertensive patients at the Internal Medicine Department at Ulin Hospital Banjarmasin. The research sample is part of the population that meets the inclusion and exclusion criteria with the simple random method. The inclusion criteria were patients aged 18-65 years and willing to take part in the study. Meanwhile, the exclusion criteria were pregnant, blind and deaf, only the patient's family and absent at the second visit. This research was conducted at the Internal Medicine Polyclinic of Ulin Hospital from March-June 2020. Based on the research that has been done, it was found that the average value of the quality of life of hypertension patients at Ulin Banjarmasin Hospital, the average value of quality of life was 0.792, with a quality of life value ≥ 0.792 as many as 19 patients (63.33%) in the category of good quality of life and value quality of life ≤ 0.792 as many as 11 patients (36.67%) in the poor quality of life category
No full textAsthma is a non-communicable respiratory disease that can pose a risk of mortality and morbidity. Asthma is a long-term disease that carries the risk of drug-related problems (DRP). This study aims to analyze drug-related problem (MTP) in outpatient asthma treatment. This study used a cross-sectional analysis method using purposive sampling technique, carried out at a Pratama pharmacy in Wonokromo district, Surabaya City. The research sample was adult outpatient asthma patients who underwent treatment at the pharmacy from November 2018 to January 2019. Data were analyzed using GINA and Classification for Drug related problems. The results showed that of the 40 respondents the DRP was 34 respondents (85.00%). The domain related to the effectiveness is that the drug effect is not optimal (88.24%) and other drugs are not needed (11.76%) and the cause of drug selection is the improper combination of drugs (2.87%). And the associated therapy was most involved in DRP events. Outpatient asthma drug use was the most associated therapy for the short acting beta 2 agonist class of drugs. Therefore, inpatient asthma treatment requires monitoring by a pharmacist to achieve optimal treatment
No full textThis research identified lead (Pb) contaminants in vegetables. The measurement method used was anodic stripping voltammetry (ASV) with a working electrode of carbon paste modified acid-activated natural zeolite. The stages of the research were formulation of the working electrode, validation of the measurement method and measurement of lead levels in vegetables. The result showed that the optimum formulation of working electrode gave the highest measurement peak current. The optimum formulation with composition of graphite: liquid paraffin: acid activates zeolite is 100:35:10. This electrode was used for determination linear range concentration, limit of detection, percent recovery, and repeatability. The measurement of Pb using electrode by ASV method which gave valid results. It can be seen from a wide concentration range from 50-3000 ppb, a low detection limit of 55.28 ppb, good accuracy and precision. The application of this method is to measure Pb levels in vegetables, and the result is 1.43 mg/Kg
No full textShip sanitation is one of the efforts aimed at environmental health risk factors on board. The results obtained from the Port Health Office (KKP) Class II Samarinda, there are several types of ships that are routinely carried out sanitary inspections of ships, one of which is a passenger ship. Therefore, researchers want to examine the Sanitary Relationship of Ships With Signs of The Presence of Cockroaches On Passenger Ships Leaning in The Port of Class II Samarinda. The design of this study is an observational analytical method with cross sectional study design. The instruments in this study used the ship's sanitation inspection form and the cockroach inspection form on the passenger ship. The data is processed using Fisher Exact Test. Based on the results of the study, where the 5 vessels that were examined have met the sanitary requirements (100%) in accordance with The Minister of Health Regulation No. 40 of 2015 concerning Certificate of Ship Sanitation. The results of the study found signs of the presence of cockroaches on the ship as many as 4 units of ships (80%). The results of statistical tests processed by Fisher Exact Test obtained the following results, p-value count = 0.20 > from p-value α = 0.05 so that the conclusion H0 received, which means "No Relation to Ship Sanitation with Signs of The Presence of Cockroaches On Ships Leaning in Samarinda Port". 
No full textPandan leaves have the effect of increasing the immune system so that it is necessary to develop the potential of pandan leaves as a medicinal preparation in the form of a suspension. The purpose of this study was to determine the secondary metabolites contained in pandan leaves and the best suspension formula in terms of the physical properties of the pandan leaf juice suspension (Pandanus amaryllifolius Roxb.). Three formulas for the suspension of Pandan leaf juice were made, the formula I used CMC suspending agent, formula II used cassava starch, formula III used CMC: cassava starch then carried out a physical test for the suspension of Pandan leaf juice including organoleptic test, pH, specific gravity, viscosity, and sedimentation. The next step is to determine the best formula in terms of the physical properties of the pandan leaf juice suspension. The secondary metabolites contained in pandan leaves through qualitative tests are flavonoids, alkaloids, saponins, tannins, and terpenoids. Formula I have a pH of 7, a specific gravity of 1.043, a viscosity of 20.57, and a sedimentation volume of 0, formula II has a pH of 7, a specific gravity of 1.049, a viscosity of 10.58, and a sedimentation volume of 0.75, while formula III has a pH of 8, specific gravity 1.053, viscosity 26.27, and sedimentation volume 0.975. The best formula in terms of the physical properties of the pandan leaf juice suspension (Pandanus amaryllifolius Roxb.) Is formula I with Carboxy Methyl Cellulose (CMC) as a suspending agent
No full textJackfruit (Artocarpus heterophyllus Lam.) leaves have medicine potential, such as an antibacterial in anti-acne treatment contain flavonoids, tannins and saponins. The study aims to determine whether the ethanol extract of jackfruit leaves 96% can be formulated and determined the effectiveness of concentration preparation in inhibiting the Propionibacterium acnes bacteria. The preparation of cream preparations used a concentration of 20%, 30% and 40% jackfruit leaf ethanol extract. Then carried out the evaluation test of the preparation including the organoleptic test, homogeneity test, spreadability test, and pH test. Furthermore, the antibacterial effectiveness test was carried out by using the diffusion method. The results of evaluation test for cream preparations which included organoleptic tests with the results of three concentrations meeting the requirements, the homogeneity test and the dispersion test of the preparations, the results meet the specified conditions and the results of the pH test with the three concentrations of preparations that met the specified pH requirements. And it can inhibit the growth of Propionibacterium acnes bacteria with an inhibition zone of 7.5 mm at a concentration of 20%, 11 mm at a concentration of 30%, and 11.7 mm at a concentration of 40%. Antibacterial effectiveness test using positive control had an inhibition zone of 25.9 mm. The conclusion of this study is that the ethanol extract of jackfruit leaves can be formulated into anti-acne cream preparations
No full textHyperglycemia is a condition where blood glucose levels increase above normal. Hyperglycemia is a manifestation of diabetes mellitus (DM). Chronic hyperglycemia in diabetes mellitus has an important role in the damage to various organism, including the heart, gynecological eye, nervous and vascular system, which in turn causes complications of diabetes mellitus. Dragon tail leaf extract (Rhaphidophora pinnata (L.f) Schott) contains several compounds that function to reduce glucose in the blood including flavonoids, alkaloids, saponins, steroids and tanins which can inhibit the action of the enzyme α- glucosidase. The purpose of this study was to determine the effect of giving ethanol extract of dragon tail leaves in blood glucose levels and determine the best dose of ethanol extract of dragon tail leaves in reducing blood glucose levels. The samples used were ethanol extract of dragon tail leaves, acarbose as positive control. The study design used was a completely randomized design (CRD) with 5 treatments in which each treatment consisted of 7 mice. The treatment groups are K + acarbose solution at a dose of 50 mg / kgBB, P1 extract dose 125 mg / kgBB, P2 extract dose 250 mg / kgBB, and P3 extract dose 375 mg / kgBB. The testing method used is the Oral Glucose Tolerance Test (OGTT), which is a standard method in the testing antihiperglycemic effect. Observations were carried out for 120 minutes in the time span of 10; 30; 60; 100 and 120 minutes. The research data were analyzed descriptively and One Way ANOVA test. Based on the analysis of the One Way ANOVA test it was found that there were significant differences for each study treatment (p <0.05). Based on Duncan's further tests it was found that the results of the dragon tail leaf extract had antihiperglycemic effect. The best dose of ethanol extract of dragon tail leaves in percent reduction is dose III 375 mg / KgBB with a percent decrease (38,79%). Then followed by dose II 250 mg/KgBB with a percent decrease (17,01%) anf dose I 125 mg/KgBB with percent decrease (5,325%). So it can be concluded that the ethanol extract of dragon tail leaves has effectiveness as an antihiperglycemia
No full textThis study aims to determine the content of flavonoid and the effect of ethanol extract of moringa seeds on the regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes. This study method used has total flavonoid equivalent quercetin by spectrophotometry uv-vis and to regeneration of pancreatic β cells in male white rats used 30 test animals,namely male white rats divided into 6 groups, each group consisted of 5 male white rats with details of group I as normal control, Group II as negative control given 0.5% Na-CMC suspension, Group III as positive control given glibenclamide suspension and in Groups IV, V, and VI were given with each dose of 100 mg/kg BW, 200 mg/kg BW and 400 mg/kg BB. Histopathological damage picture of the pancreas was observed by staining HE using a 400x magnification olympus Cx21 microscope. The results showed that the ethanol extract of moringa seeds contained secondary metabolites, namely flavonoids, alkaloids, saponins and tannins. The results showed has total flavonoid equivalent quercetin of moringa seeds is 1,26% and regeneration of pancreatic β cells in male white rats streptozotocin induced diabetes of Moringa seed ethanol extract at a dose of 400 mg/kg BB can have an effect on the regeneration of β cells in the pancreas of white diabetic male rats.
 
No full textDental caries and bad breath are oral health problems that are complaints by teenagers and children caused by Streptococcus mutans which is normal flora bacteria in the oral cavity but in large numbers, these bacteria can trigger the formation of dental plaque. This study aims to compare the antibacterial effectiveness of a single extract and extracts combination formulated in mouthwash. Basil and madeira-vine leaves are known to have antibacterial activity against several bacteria, one of them is Streptococcus mutans. Simplicia of madeira-vine and basil leaves were extracted by maceration using 70% ethanol and phytochemical screening tests has done on the extracts produced. Mouthwash formulation is performed using the bottle method and antibacterial activity test and its effectiveness are carried out using the agar diffusion method. Phytochemical screening result shows that basil leaves extract contains alkaloid and flavonoid, while madeira-vine leaves extract contains alkaloid and phenolic compounds. A single extract at a concentration of 7% had the most optimal inhibition of Streptococcus mutans while in the combination of extracts, the most optimal concentration ratio was shown at an extracts combination of madeira-vine : basil leaves 70:30. Mouthwash preparations are formulated in several formulas namely F1, F2, F3. Tests carried out before and after storage were expedited showing that F3 (a combination formula of madeira vine leaves extract : basil leaves 70:30) is the most stable and effective formula in inhibiting Streptococcus mutans.
 
No full textGewang (Corypha utan Lamk) is a member of a palm tree that grows wild in most parts of Indonesia. The gewang plant is rich in starch which is thought to be used as an additional ingredient in making Paracetamol tablets with wet granulation methods. This study aims to determine the effect of starch supplementation on the physical properties of Paracetamol tablets. This research is a type of experimental research. Tablets are made in three formulas based on variations in the ratio of starch gewang intragranular and extragranular. Comparison of three formulas intragranular and extragranular, namely: FI (100%: 0%), FII (75%: 25%), FIII (0%: 100%). Tablets are made in wet granulation method with starch binder. Homogeneous dry granules then tested for physical properties of granules include: flow time, stationary angle, and tapping. Furthermore, pressing and tablets obtained were tested for the physical and chemical properties of tablets including weight uniformity and hardness. Statistical analysis of the physical quality of tablets was carried out by the Kolmogorov-Smirnov data normality test, followed by the dendan One Way Anova. The results showed that the use of starch gewang intragranular, extragranular and intragranular and extragranular combinations affected the physical properties of tablets. The method of adding extragranular starch starch to formula 3 produced tablets with effective tablet fragility, which was to meet the physical properties of tablets.