Jurnal Ilmiah Manuntung
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No full textCalotropis gigantea (Biduri) are plants that are widely used as herbal medicines by the community. Calotropis gigantea (Biduri) is used as a medicine for coughing, hives, medication for toothache, medicine for ear pain, epilepsy, wounds, sprains and diarrhea. The chemical content of Calotropis gigantea (Biduri) is in the form of glycosides, saponins, alkaloids, flavonoids, and tannins. The purpose of this study was to determine the presence or absence of tannin compounds and levels of tannin compounds in Calotropis gigantea (Biduri). The identification test used FeCl3 and gelatin reagent. Extraction was carried out by maceration using ethanol 96% solvent. Determination of tannin levels of. Calotropis gigantea (Biduri) by Uv-vis spectrophotometry method. The results of the identification test showed that Calotropis gigantea (Biduri) positively contained tannins with FeCl3 resulting in a blackish green color and gelatin causing deposits. The results of the average level of tannins in biduri leaf extract Calotropis gigantea (Biduri) at a concentration of 100 ppm of 1.16 µg / ml, a concentration of 200 ppm of 3.53 μg / ml and a concentration of 300 ppm of 7.12 μg / ml
No full textRecently, Traumatic Brain Injury (TBI) has high mortality in the world. In severe TBI, secondary brain injury can occur. ElectrSolyte disorders are the most common in secondary brain insult especially sodium disorders. It remains unclear whether hyponatremia or hypernatremia can cause worse clinical outcome in TBI patients. This study aimed to determine association between serum sodium level with clinical outcome in severe TBI patients at RSUD Abdul Wahab Sjahranie Samarinda. A cross sectional analytical study by taking samples to the patients with diagnosed severe TBI (GCS ≤ 8) which were hospitalized at RSUD Abdul Wahab Sjahranie Samarinda in the period of January-December 2018 that complied inclusion and exclusion criteria. Research variables are sodium serum level and clinical outcome that was assessed by structured interviews for Glasgow Outcome Scale (GOS). The relationship between variables was done using the Fisher's Exact test. A total of 41 severe TBI patients were administered. The characteristics of the sample were the most patients in 20s-40s (46.3%), patients were dominated by male (82.9%) and the most common CT scan characteristic were epidural hematoma (29.3%). The most of patients showed normonatremia in 25 patients (61%), 9 patients (22%) had hypernatremia and 7 patients (17.1%) had hyponatremia. The most clinical outcome on severe TBI patients were worse outcome with 70.7% while good outcome with 29.3%. Statistical result showed there’s no association between serum sodium level (hyponatremia and hypernatremia) with clinical outcome in severe TBI patients with p values, 1.000 and 0.225, respectively. There’s no association between serum sodium level with clinical outcome in severe TBI patients.
 
No full textGlibenclamide is a sulfonylurea drug compound used as oral antidiabetic. Solid Lipid Nanoparticles (SLN) are alternative carrier systems that can be used to increase the bioavailability of drugs with low solubility. The purpose of this study was to determine the effect of lipid concentration on the efficiency of Solid Lipid Nanoparticle (SLN) entrapment efficiency of glibenclamide, to determine the optimum concentration of lipids which had the best Solid Lipid Nanoparticle (SLN) efficiency parameter values of glibenclamide. This study varied between glyceryl monostearate and oleic acid as a lipid phase made in 12 formulas. The method of making solid lipid nanoparticles used by the solvent emulsion / evaporation method. The results of the study showed that the concentration variations between oleic acid lipids and glyceryl monostearate had a significant effect on percent entrapment efficiency in glibenclamide Solid Lipid Nanoparticle (SLN) preparations. The optimal formula is a formula with 1% oleic acid and 9% glyceryl monostearate which has particle size of 294.6 nm with a PI value (polydispersity index) of 0.465
No full text Cesarean section (Sectio Caesarea) is an attempt to remove the fetus through surgery on the abdominal wall and uterus. The use of inappropriate prophylactic antibiotics will lead to infection and resistance. The purpose of this study was to determine prophylactic antibiotic use, in cesarean section patients, to know prophylactic antibiotic use in cesarean section patients in accordance with antibiotic use guidelines (PPAB) Ulin Hospital in 2017, to know prophylactic antibiotic use in cesarean section patients in accordance with Permenkes RI Number 2406 / PER / XII / 2011. This research is a non-experimental type of descriptive study retrospectively by taking medical record data of cesarean section patients at Ulin Banjarmasin Hospital in 2017 with saturated sampling method, obtained a population of 99 medical records of cesarean section with a total sample of 99 medical records. The use of prophylactic antibiotics in Ulin Banjarmasin Public Hospital is a class of third generation cephalosporins namely ceftriaxone and cefotaxime with doses of 1-2 grams / day and duration of 3-5 days. Comparison of the percentage of prophylactic antibiotic use with the guidelines for drug use in Ulin Hospital in Banjarmasin in 2017 is the name and class of 100% is appropriate and 0% is not appropriate, the dose is 100% appropriate and 0% is not appropriate, the duration of administration is 69.70% is appropriate and 30.30% is not corresponding. Comparison of the percentage of prophylactic antibiotic use with Permenkes RI Number 2406 / PER / XII / 2011 is the name and class of 0% is appropriate and 100% is not appropriate, the dose is 0% is appropriate and 100% is not appropriate, the duration of giving 0% is appropriate and 100 % it is not in accordance with
No full textThe development of traditional plants as herbal medicines continues to be increased, especially in local use. Aloe vera (Aloe vera), bay leaf (Eugenia polyantha) and Turmeric Rhizome (Curcuma domestica Val) have compounds that function as antibacterial. Chicken claw bones play a role in accelerating the growth of skin cells, but it also has the potential as an antibacterial. This combination is expected to increase the work of medicinal ingredients in killing bacteria. The work method begins with the selection of herbal ingredients, dry sorting, wet sorting and slicing. Drying the sample using an oven at a temperature of 40 which is then pollinated and sieved with 100 mesh. Before macerated with 70% ethanol solvent 1:10 ratio, the sample was tested microscopically. The extract was made of three formulas and tested for antibacterial activity in Stapilococus aureus bacteria using the well method. The antibacterial activity in formula 1 was 7.1mm, Formula 2 was 8.7mm and formula 3 was 10.2mm. Experiments were also carried out on extracts without collagen extracts with better inhibitory results compared to polyherbal extract combinations of collagen extracts. This research proves that polyherbal extract from chicken claw collagen extract has the ability of antibacterial activity. Formula 3 has the best inhibition compared to formulas 1 and 2
No full textGel is a semisolid preparation that is clear, translucent containing active ingredients, can provide a cool effect on the skin and good spread of the skin. The use of gelling agent in gel formulations greatly affects the physical properties of the resulting gel preparations. HPMC is a gel forming material that is neutral and can form a clear gel and can maintain the viscosity of the resulting gel, while carbopol are easily dispersed in water and produce preparations with sufficient viscosity. The research conducted aims to determine the comparison of carbopol and HPMC in the optimal gel formula of betel leaf extract nanoparticles with Simplex Lattice Design method. The response used was pH, viscosity, spreadability, adhesion and antibacterial activity against Staphylococcus aureus. The results obtained by carbopol concentration of 80.9% and HPMC 19.1% was the optimal gel formula of betel leaf extract nanoparticle. Based on the verification, an insignificant difference was obtained between the predictions of the software and the results of the tests performed. This shows that the method used was valid or can be trusted
No full textEmpirically, one of the plants that are widely used by the Dayak tribe as a medicine is the bajakah tampala (Spatholobus littoralis Hassk.) This plant is claimed to be able to treat several diseases such as abdominal pain, diarrhea and dysentery. But until now studies on the antibacterial activity of bajakah tampala have never been done. This study studied the antibacterial activity of bajakah ethanol extract against the growth of Escherichia coli bacteria and minimum inhibitory value (MIC). This type of research is experimental research. The stem bajakah Tampala looks like it wastaken from the inland forest in Garung Village, Jabiren District, Pulang Pisau Regency, Central Kalimantan. The sample of this study was 70% ethanol extract of bajakah tampala stems obtained by maceration. Extract payment of antibacterial activity using a concentration of 3.12%; 6.25%; 12.5%; 25% and 50%. The positive control used is ampicillin 0.01 mg/ml and negative control using distilled water. Tests are carried out by the well method. The tested data were analyzed statistically by the One-Way ANOVA test method. The results of the study showed that the ethanol extract bajakah tampala could inhibit the growth of E. coli bacteria. The biggest inhibition of E. coli bacteria at a concentration of 50% with an average inhibition diameter of 20.32 mm. included in the category of very strong. The minimum inhibitory concentration of extract batang bajakah tampala is 6.25
No full textDayak onion (Eleutherine palmifolia Merr.) is a multifunctional medicinal plant for various diseases, one of which is an antibacterial. Dayak Onions (E. palmifolia Merr.) contains an alkaloid, flavonoid, triterpenoid, and saponin compound which has antibacterial properties. This study aims to determine the effect of the ethyl acetate extract of Dayak Onion tubers inhibits the growth of Staphylococcus aureus bacteria. Dayak onion tuber was extracted using ethyl acetate solvent by the maceration method until thick extract was obtained. The concentration extract used were 30 mg/ml;15 mg/ml;7,5 mg/ml;3,75 mg/ml; 1,875 mg/ml; and 0,9375 mg/ml tested for antibacterial effectivity against Staphylococcus aureus using Mueller Hinton Agar (MHA) with the wells method. The result showed that the ethyl acetate of Dayak onion with MEC (Minimum effective concentration) 3,75 mg/ml obtained inhibition zone of 10,367 mm while at the highest concentration of 30 mg/ml had the best antibacterial effectiveness. The effective concentration of ethyl acetate onion of Dayak tuber which is 30 mg/ml obtained inhibition zone of 18,404 mm even in the moderate category
No full textDisease in the liver caused by hypercholesterolemia is fatty liver. Fatty liver is one of the damages to the liver, a condition in which the liver experiences fat accumulation. Green kiwifruit (Actinidia deliciosa) is a plant that contains a lot of flavonoid compounds can be used as cholesterol-lowering. Flavonoids are able to release cholesterol found in the walls of blood vessels and organs in the body. The purpose of this study was to determine the presence or absence of anticholesterol activity and EC50 values in ethanol extracts of green kiwifruit (Actinidia deliciosa) with a concentration series of 2.5; 5.0; 7.5; 10.0; 12.5 ppm. Ethanol extract of green kiwifruit was tested for active substance content and quantitative analysis using UV-Vis spectrophotometry method at a wavelength of 668 nm and operating time of 15 minutes. The results showed ethanol extract of green kiwifruit contains phenols, flavonoids, saponins, vitamin C which can reduce cholesterol levels with an average EC50 value of 7.3 ppm with a coefficient of variation value of 1.12%.
Keywords : Cholesterol, Lieberman-burchard, Extract, Green kiwifruit (Actinidia deliciosa), UV-VIS spectrophotometry
No full textThe research was conducted on ethanol extract formulation of red betel leaves (Piper crocatum Ruiz & Prav.). This research aims to formulate the ethanol extract of red betel leaves (Piper crocatum Ruiz & Prav.) to be a dosage of good, effective, and safe sheet mask to use. This research was experimental, in which 12 women aged 18-25 years old were selected to test for irritation that was observed on the skin behind the ear. To test the effectiveness, the observed dosage was facial skin moisture in the T. The results obtained are in the form of an essence that is slightly thick, brown in color, having a distinctive smell of red betel leaf extract, homogeneous, and safe for the skin. For the effectiveness, the test showed that the sheet mask of red betel leaf extract in formula 1 (1%), formula 2 (3%) and formula 3 (5%) were able to increase facial skin moisture. The analysis results showed that there was a significant difference in the average measurement of water content on the volunteers' facial skin of 0.01 (α <0.05)