Sains Medika: Jurnal Kedokteran dan Kesehatan
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EFFECTS OF TOPICAL TOMATO (LYCOPERSICON LYCOPERSICUM L) EXTRACT ON MALONDYALDEHYDE LEVEL AND THE NUMBER OF MELANIN IN SKIN CAUSED BY ULTRAVIOLET-B RADIATION
Get PDFINTRODUCTION: UVB radiation on skin may increase reactive oxygen species (ROS) level and cause hyperpigmentation. Polyphenol, an antioxidant contained in tomato, is able to quench ROS and inhibit tyrosinase activity.OBJECTIVE: This study aims to evaluate the effect of topical tomato lotion on Malondyaldehide (MDA) level and the amount of melanin in skin following UVB radiation.METHODS: In this experimental study, 28 female Balb/c mice are randomly divided into 4 groups: control group (C-G) are given with base lotion, and Lycopersicum groups 0.14 (L-014), 0.7 (L-07) and 1.4 (L-14) are given with tomato lotion of concentration of 0.14%, 0.7% and 1.4% daily, respectively. All of the mice are exposed to UVB at 1MED once every two days for two weeks before lotion application. On day 16, all mice are terminated, and their skin tissues are prepared for MDA level and the amount of melanin assessment.RESULTS: The ANOVA statistical analysis shows a significant difference in the MDA level and the number of melanin of the groups, (p0.05. The correlation between MDA level and the amount of melanin shows a strongly positive correlation value (r2) = 0.648CONCLUSION: Topical administration of tomato extract lotion significantly decreases the MDA level and the number of melanin in the mice’s skin following UVB radiation.BACKGROUND: UVB radiation on skin may increase reactive oxygen species (ROS) level and cause hyperpigmentation. Polyphenol, an antioxidant contained in tomato, is able to quench ROS and inhibit tyrosinase activity. OBJECTIVE: This study aims to evaluate the effect of topical tomato lotion on Malondyaldehide (MDA) level and the amount of melanin in skin following UVB radiation.METHODS: In this experimental study, 28 female Balb/c mice are randomly divided into 4 groups: control group (C-G) are given with base lotion, and Lycopersicum groups 0.14 (L-014), 0.7 (L-07) and 1.4 (L-14) are given with tomato lotion of concentration of 0.14%, 0.7% and 1.4% daily, respectively. All of the mice are exposed to UVB at 1MED once every two days for two weeks before lotion application. On day 16, all mice are terminated, and their skin tissues are prepared for MDA level and the amount of melanin assessment. RESULTS: The ANOVA statistical analysis shows a significant difference in the MDA level and the number of melanin of the groups, (p0.05. The correlation between MDA level and the amount of melanin shows a strongly positive correlation value (r2) = 0.648CONCLUSION: Topical administration of tomato extract lotion significantly decreases the MDA level and the number of melanin in the mice’s skin following UVB radiation.Keywords: UVB, tomato extract, MDA, melani
THE EFFECTS OF HYPERTENSION STAGES ON N-TERMINAL-PRO BRAIN NATRIURETIC PEPTIDE (NT-PRO-BNP) LEVEL AND LEFT VENTRICULAR EJECTION FRACTION
Get PDFIntroduction: Hypertension is the most common risk factor for heart failure causing an increase in N-Terminal-Pro Brain Natriuretic Peptide (NT-proBNP) level and a decrease in left ventricular ejection fraction (LVEF). Objective: To investigate the effect of hypertension on NT-proBNP level and LVEF in patients with chronic heart failure.Methods: This cross sectional study takes 29 people with hypertension stage-1 (HTD-1) and 27 people with hypertension stage-2 (HTD-2) as sample. The left ventricular ejection fraction and NT-proBNP level obtained from medical records are analyzed using independent t test and Mann Withney test, followed with Spearmen correlation between NT-proBNP level and LVEF.Results: Mann-Whitney test indicates that the mean value of NT-proBNP level of HTD-2 is significantly higher compared to that of HTD-1, p = 0,000. On the contrary, the independent t test shows that LVEF in HTD-2 is lower than that of HDT-1, p = 0.001. The Spearman correlation analysis conducted on the NT-proBNP level and the LVEF results in value of -0.651, p = 0.000. The cut-off-point value of NT-proBNP level is 1511pg/ml (sensitivity 0.82% and specificity 0.80%) and the value of area under the ROC curve > 0.7. The left ventricular ejection fraction has an area under the ROC curve > 0.7 with a cut-off-point value of 39% (sensitivity 0.67% and specificity 0.69%).Conclusion: The NT-proBNP level and the LVEF of HTD-2 are significant higher and lower respectively compared to those of HTD-1. The NT-proBNP level and LVEF also show a strong negative correlation. The cut-off-point value of NT-proBNP level and LVEF can be utilized to compare the stages of hypertension in patients with chronic heart failure.Background: Hypertension is the most common risk factor for heart failure causing an increase in N-Terminal-Pro Brain Natriuretic Peptide (NT-proBNP) level and a decrease in left ventricular ejection fraction (LVEF). Objective: To investigate the effect of hypertension on NT-proBNP level and LVEF in patients with chronic heart failure.Method: This cross sectional study takes 29 people with hypertension stage-1 (HTD-1) and 27 people with hypertension stage-2 (HTD-2) as sample. The left ventricular ejection fraction and NT-proBNP level obtained from medical records are analyzed using independent t test and Mann Withney test, followed with Spearmen correlation between NT-proBNP level and LVEF.Results: Mann-Whitney test indicates that the mean value of NT-proBNP level of HTD-2 is significantly higher compared to that of HTD-1, p = 0,000. On the contrary, the independent t test shows that LVEF in HTD-2 is lower than that of HDT-1, p = 0.001. The Spearman correlation analysis conducted on the NT-proBNP level and the LVEF results in value of -0.651, p = 0.000. The cut-off-point value of NT-proBNP level is 1511pg/ml (sensitivity 0.82% and specificity 0.80%) and the value of area under the ROC curve > 0.7. The left ventricular ejection fraction has an area under the ROC curve > 0.7 with a cut-off-point value of 39% (sensitivity 0.67% and specificity 0.69%).Conclusion: The NT-proBNP level and the LVEF of HTD-2 are significant higher and lower respectively compared to those of HTD-1. The NT-proBNP level and LVEF also show a strong negative correlation. The cut-off-point value of NT-proBNP level and LVEF can be utilized to compare the stages of hypertension in patients with chronic heart failure.Keywords: Hypertension stage, NT-proBNP, left ventricular ejection fraction, chronic heart failure
HIGH DOSE VITAMIN C ADMINISTRATION EFFECT IN LEYDIG CELLS, SERTOLI CELLS NUMBER, AND SPERM QUALITY ON MALE WISTAR RATS
Get PDFIntroduction: Most infertile male are associated with poor spermatogenesis due to oxidative stress, and can be prevented with vitamin C. However, excessive amount of high dose of vitamin C can hindered and lower the sperm quality. Objective: To prove that high dose vitamin C is capable to decrease the number of leydig cells, sertoli cells, and sperm quality on male wistar rats.Methods: This research was using experimental method with Post Test Only Controlled Group Design. Of 24 male Wistar rats, divided randomly to 4 groups. Normal groups (Nor -G), only given 2 ml/day distilled water; vitamin C group (VC18-G, VC36-G, and VC72-G) given 18 mg/day, 36 mg/day and 72 mg/day vitamin C respectively, dissolved in 2 ml of distilled water. Sperm, the number of Leydig cells and Sertoli cells were taken from the epididymis and left right testicle on day 21. Sperm analysis using WHO standard, while the number of Leydig cells and Sertoli cells with HE staining.Results: Mann Whitney analysis indicated that the number of sperm in VC36-G and VC72-G are lower compared to that of Nor-G and VC18-G groups, p <0.05. Post-Hoc LSD analysis showed that the lowest number of Leydig and Sertoli Cell, and the weakest sperm motility and morphology in VC36-G and VC72-G groups, compared to that of Nor-G and VC18-G groups, p <0.05 .Conclusion: Vitamin C 36 and 72 mg/day were capable of reducing Leydig and Sertoli cells number, and worsen sperm quality, characterized by decreased in sperm concentration, motility and morphology in Wistar male- rats.Introduction: Most infertile male are associated with poor spermatogenesis due to oxidative stress, and can be prevented with vitamin C. However, excessive amount of high dose of vitamin C can hindered and lower the sperm quality. Objective: To prove that high dose vitamin C is capable to decrease the number of leydig cells, sertoli cells, and sperm quality on male wistar rats.Methods: This research was using experimental method with Post Test Only Controlled Group Design. Of 24 male Wistar rats, divided randomly to 4 groups. Normal groups (Nor -G), only given 2 ml/day distilled water; vitamin C group (VC18-G, VC36-G, and VC72-G) given 18 mg/day, 36 mg/day and 72 mg/day vitamin C respectively, dissolved in 2 ml of distilled water. Sperm, the number of Leydig cells and Sertoli cells were taken from the epididymis and left right testicle on day 21. Sperm analysis using WHO standard, while the number of Leydig cells and Sertoli cells with HE staining.Results: Mann Whitney analysis indicated that the number of sperm in VC36-G and VC72-G are lower compared to that of Nor-G and VC18-G groups, p <0.05. Post-Hoc LSD analysis showed that the lowest number of Leydig and Sertoli Cell, and the weakest sperm motility and morphology in VC36-G and VC72-G groups, compared to that of Nor-G and VC18-G groups, p <0.05.Conclusion: Vitamin C 36 and 72 mg/day were capable of reducing Leydig and Sertoli cells number, and worsen sperm quality, characterized by decreased in sperm concentration, motility and morphology in Wistar male- rats
Low Molecular Weight Antioxidant versus Flavonoids in Combating Oxidative Stress: Which One is Superior?
Get PDFAccording to the free radical theory of aging, firstly proposed by Denham Harman, the most prominent cause of aging and degenerative diseases (DD) is continuously chemical reaction in cells and tissues. In this context aging and or DD is manifested as chemical composition, whilst aging process is reflected by chemical reaction affected by environment (Harman, 1981). Thus, both aging and DD have similar process, predisposed with oxidative stress and characterized by the progressive cellular alteration accumulation in line with time and account for increase in susceptibility to diseases and death. The most prevalent chemical reaction is between free radical reactive oxygen species (ROS) and reactive nitrogen species (RNS) with cellular biomolecules such as lipids, protein, carbohydrate, and DNA (Lamichhane et al., 2013). In order to prevent the deleterious effect of that chemical reaction, human’s body provides an antioxidant defense system to counterbalance the free radical dangerous effect. However, owing to inappropriate life style, eating style, physical activity, and poor environment, production of ROS and RNS may be increased and induce cellular damages. Numerous publications indicated that oxidative stress and cellular damages can be reduced even prevented by exogenous antioxidant, thus intake antioxidant from external sources is necessary. There are two type of exogenous antioxidant consisting of low molecular weight antioxidant (LMWA) and flavonoids. Unfortunately, the effect of LMWA on delaying aging and ameliorating DD remain inconsistent. On the other hand, numerous data indicate that flavonoids a botanical antioxidant was capable of improving oxidative stress and emerging as an alternative promising antioxidant (Sudhakaran et al., 2019). However, the effect of LMWA and flavonoids in combating oxidative stress remain unknown which one is better
RELATIONSHIP BETWEEN FAMILY HISTORY, BLOODY STOOL, PALPABLE MASS, ANEMIA, AND MSCT ABDOMEN AND KOLON CARSINOMA Cross-Sectional Study at Dr.Kariadi General Hospital in 2016
Get PDFBackground: Colon cancer, a colorectal cancer, is the third most common epithelial malignancy in the world. Family history, bloody stool, palpable mass, anemia, and abdominal MSCT are symptoms and signs of colon carcinoma.Objective: To determine the relationship between the 5 variables and the incidence of colon carcinoma at Dr. Kariadi Hospital, Semarang in 2016.Methods: a Cross-sectional observational analytical study using medical record (RM) and complementary primary data. The inclusion criteria werethe complete medical record, and clinical diagnosis of suspected colon carcinoma. Data obtained from the department of Anatomy Pathology/PA (11,794PA results) were traced to the medical record section (46 patients with suspected colon carcinoma). The incomplete data were confirmed by: contacting the patient/family, obtaining the archive in the laboratory and radiology resulting in 27 patients meeting the inclusion criteria. Analysis was done using chi-square test, Spearman-Kendall bivariate correlation, and logistic regression.Results: Abdominal MSCT was moderately associated with colon carcinoma (p = 0.003; r = 0.488), while family history, bloody stool, palpable mass, and anemia were not associated with colon cancer. Analysis between predictors of outcome: Bloody stool was moderately associated with anemia (p = 0.006; r = 0.411), and anemia was weakly associated MSCT (p = 0.035; r = 0.351). Abdominal MSCT was the predictive factor for colon carcinoma (p = 0.021).Conclusion: Abdominal MSCT was found to be associated with the incidence of colon carcinoma. Bloody stool was associated with anemia, and anemia was associated with abdominal MSCT. MSCT was the predictive factor for colon cancer.Background: Colon cancer, a colorectal cancer, is the third most common epithelial malignancy in the world. Family history, bloody stool, palpable mass, anemia, and abdominal MSCT are symptoms and signs of colon carcinoma. Objective: To determine the relationship between the 5 variables and the incidence of colon carcinoma at Dr. Kariadi Hospital, Semarang in 2016.Methods: a Cross-sectional observational analytical study using medical record (RM) and complementary primary data. The inclusion criteria were the complete medical record, and clinical diagnosis of suspected colon carcinoma. Data obtained from the department of Anatomy Pathology/PA (11,794 PA results) were traced to the medical record section (46 patients with suspected colon carcinoma). The incomplete data were confirmed by: contacting the patient/family, obtaining the archive in the laboratory and radiology resulting in 27 patients meeting the inclusion criteria. Analysis was done using chi-square test, Spearman-Kendall bivariate correlation, and logistic regression.Results: Abdominal MSCT was moderately associated with colon carcinoma (p = 0.003; r = 0.488), while family history, bloody stool, palpable mass, and anemia were not associated with colon cancer. Analysis between predictors of outcome: Bloody stool was moderately associated with anemia (p = 0.006; r = 0.411), and anemia was weakly associated MSCT (p = 0.035; r = 0.351). Abdominal MSCT was the predictive factor for colon carcinoma (p = 0.021).Conclusion: Abdominal MSCT was found to be associated with the incidence of colon carcinoma. Bloody stool was associated with anemia, and anemia was associated with abdominal MSCT. MSCT was the predictive factor for colon cancer
Soursop (Annona Muricata, Linn) Leaf Ethanol Extract Cream Application Affected the Expression of TNF-α and VEGF on Balb/C Mice Skin Exposed to Acute UVB
Get PDFBackground: Wound healing problems are often associated with TNF-α and VEGF expressions. However, the benefits and effects of ethanol extract cream from soursop leaves towards TNF-α and VEGF expression for burns healing process are yet to be known. Objective: To evaluate the benefits and influence of ethanol extract cream from soursop leaves in decreasing TNF-α expression and stimulate VEGF expression in BALB/c mice exposed to acute UVB radiation. Method: This study is a laboratory-based experimental study with post test only control group design. The subjects were 48 BALB/c female mice, divided into 24 subjects for TNF-α and 24 for the VEGF group, and were randomly distributed into 4 groups in each study, with each group containing 6 BALB/c mice. Group K was smeared with a base cream of 0.3 grams three times daily, while P1, P2 and P3 groups were each applied 0.3 grams of ethanol extract with consecutive consentrations of 2.5%, 5%, and 10% three times daily. On the sixth day, termination was performed on 24 mice to assess Tnf-α expression and on the eighth day also termination on 24 mice to assess VEGF expression. Preparation of substances was done using IHC method, analyzed using Kruskal Wallis test followed by Mann Whitney test.Results: The results of TNF-a and VEGF expression analysis based on Kruskal Wallis test obtained a p value of 0.0001 (p<0.05) showing that the mean expression of TNF-a and VEGF among the four groups ware significantly different. Mann Whitney test results revealed that the differences in expression of TNF-a and VEGF between the two groups were all significant differences (p<0.05). The mean TNF-a expression in the three treatment groups (PI, PII, PIII) ware significantly lower than the control group. The mean TNF-a expression in the PII and PIII treatment groups ware significantly lower than in the PI group, and the mean TNF-a expression in the PIII treatment group was significantly lower than the PII group. The mean VEGF expression in the three treatment groups (PI, PII, PIII) ware significantly higher than the control group. The mean VEGF expression in the PII and PIII treatment groups ware significantly higher than the PI group, and the mean VEGF expression in the PIII treatment group was significantly higher than in the PII group.Conclusion: Ethanol creams made of soursop leaves extract is proven to be useful and decreasing TNF-α expression and increase VEGF expression in BALB/c mice exposed to acute UVB rays.Keywords: Ethanol cream of soursop leaves extract, TNF-α expression, VEGF expressio
Administration of Mung Bean Extract (Phaseolus radiatus) in Increasing Hb and Ferritin Level and Decreasing Malondyaldehide (MDA) Level in Anaemic Rats
Get PDFBACKGROUND: Mung bean, not only contains protein, carbohydrates, and fats, but also contains iron and vitamin C which are proven to overcome anemia in pregnant woman. High iron levels are potential to increase ROS production through fenton reaction.OBJECTIVE: to prove the administration of mungbean can increase Hb and ferritin levels and decreasing malondihaldehyde (MDA) in anaemic rats.METHODS: This research uses Post Test Only Control Group Design. A total of 25 anaemic rats were divided into 5 groups: normal group (Nor-G);negative control group (Neg-G), were given low Fe diet; and treatment group with low Fe and mung bean extract at dose of 0,18g/200g/days (GP-0,18), 0,36g/200g/days (GP-0.36), dan 0,72g/200g/days (GP-0.72). Low Fe diet and mung bean extract were administered for 14 days. Hb levels were measured using Sahli method, ferritine level using Immulite Ferritine Kit, and MDA were measured using TBA.RESULTS: Compare to Nor-G and Neg-G, levels of ferritin and Hb on groups with mung bean extract 0,18g (75.56), 0,36g (90.98) and 0,72g (95.87) were significantly higher (p < 0.05). While MDA levels on groups with mung bean 0,18g (4.646), 0,36g (3.396) and 0,72g (1.92) were significantly lower than on Nor-G and Neg-G groups (p < 0.05).CONCLUSION: The administration of mung bean extract can increase Hb and ferritin, also lower MDA level on anaemic rats.BACKGROUND: Mung bean, not only contains protein, carbohydrates, and fats, but also contains iron and vitamin C which are proven to overcomeanemia in pregnant woman. High iron levels are potential to increase ROS production through fenton reaction. OBJECTIVE: to prove the administrationof mungbean can increase Hb and ferritin levels and decreasing malondihaldehyde (MDA) in anaemic rats.METHODS: This research uses Post Test Only Control Group Design. A total of 25 anaemic rats were divided into 5 groups: normal group (Nor-G);negative control group (Neg-G), were given low Fe diet; and treatment group with low Fe and mung bean extract at dose of 0,18g/200g/days (GP-0,18),0,36g/200g/days (GP-0.36), dan 0,72g/200g/days (GP-0.72). Low Fe diet and mung bean extract were administered for 14 days. Hb levels were measuredusing Sahli method, ferritine level using Immulite Ferritine Kit, and MDA were measured using TBA.RESULTS: Compare to Nor-G and Neg-G, levels of ferritin and Hb on groups with mung bean extract 0,18g (75.56), 0,36g (90.98) and 0,72g (95.87)were significantly higher (p < 0.05). While MDA levels on groups with mung bean 0,18g (4.646), 0,36g (3.396) and 0,72g (1.92) were significantly lowerthan on Nor-G and Neg-G groups (p < 0.05).CONCLUSION: The administration of mung bean extract can increase Hb and ferritin, also lower MDA level on anaemic rats
CORRELATIONS BETWEEN ATTITUDES AND RATIONAL USE OF ANTACID IN SELF MEDICATION (Study on Health Students of Universitas Muhammadiyyah Malang)
No full textIntoduction: Self-medication is the selection and use of modern drugs, herbs, and traditional medicines by individuals to overcome diseases or symptoms of disease. One mild disease that can be treated with self-medication is gastritis. The over-the-counter medication which is frequently used in treating gastritis in self- medication is antacid.Objective: To determine the correlation between attitudes and antacid rational use in self-medication among health students at the Universitas Muhammadiyah Malang.Methods: observational analytic method using questionnaire was used for this study. The sample consist of 97 people who met inclusion criteria. Sampling was done by purposive sampling method, then the data were analyzed using Rank Spearman analysis using SPSS. This research was conducted at the campus II, Universitas Muhammadiyah Malang.Results: The results showed that 97 students of health had negative attitudes of 42% (41) and positive attitude of 58 % (56). The rational use of antacid drugs as much as 60% (58), the irrational use of drugs is 40% (39). Results of analysis using Spearman rank correlation test values were rcount 0.680 > rtable 0.202.Conclusion: The results of this study indicated that there is a significant correlation between a positive attitude to the antacid rational use in self-medication on Health Students of Universitas Muhammadiyah Malan
The Effect of Moringa Oleifera. Lam Leaf Extract on Bcl2 and Bax Expression in Paracetamol-induced Renal Tubular Apoptosis in Rats
Get PDFBACKGROUND: Paracetamol may cause apoptosis in the renal tubules. Moringa leaf (Moringa oleifera. Lam) has been shown to have antioxidant effects due to its f lavonoids. In addition, f lavonoids also have biological effects to modulate the signal-transduction pathway.OBJECTIVE: to investigate the effect of Moringa oleifera Lam extract on Bcl-2 and Bax expression on paracetamol-induced renal tubular injury.METHODS: in this post-test only control group design study, 24 rats were divided into 4 groups: AqC-G (aquades), EtC-G (70% ethanol), MoL1-Gand MoL2-G (moringa leaf extract at the dose of 1.075 g/Kg BW and 2.150 g/Kg BW respectively). Expression of Bcl2 and Bax was determined using immunohistochemical staining. The data on the number of Bcl2 and Bax expressions tested with One Way Anova followed by the Post Hoc LSD test.RESULTS: Post Hoc LSD test showed that the expression of Bcl-2 in the experimental groups ((MoL1-G (9.1) and MoL2-G (13,683)) was significantly higher compared to that of controls (p<0.001). Bax expression in the experimental groups (MoL1-G (6,85) and MoL2-G (2,633)) was significantly lower compared to that of controls, p <0.001.CONCLUSION: The administration of Moringa leaf extract at the dose of 1,075 and 2,150 increases Bcl-2 expression and decreases Bax expression in paracetamol-induced renal tubular injury.BACKGROUND: Paracetamol may cause apoptosis in the renal tubules. Moringa leaf (Moringa oleifera. Lam) has been shown to have antioxidanteffects due to its flavonoids. In addition, flavonoids also have biological effects to modulate the signal-transduction pathway.OBJECTIVE: to investigate the effect of Moringa oleifera Lam extract on Bcl-2 and Bax expression on paracetamol-induced renal tubular injury.METHODS: in this post-test only control group design study, 24 rats were divided into 4 groups: AqC-G (aquades), EtC-G (70% ethanol), MoL1-Gand MoL2-G (moringa leaf extract at the dose of 1.075 g/Kg BW and 2.150 g/Kg BW respectively). Expression of Bcl2 and Bax was determined using immunohistochemical staining. The data on the number of Bcl2 and Bax expressions tested with One Way Anova followed by the Post Hoc LSD test.RESULTS: Post Hoc LSD test showed that the expression of Bcl-2 in the experimental groups ((MoL1-G (9.1) and MoL2-G (13,683)) was significantly higher compared to that of controls (p<0.001). Bax expression in the experimental groups (MoL1-G (6,85) and MoL2-G (2,633)) was significantly lower compared to that of controls, p <0.001.CONCLUSION: The administration of Moringa leaf extract at the dose of 1,075 and 2,150 increases Bcl-2 expression and decreases Bax expression inparacetamol-induced renal tubular injury
Strangulated Femoral Hernia With Perforated Jejunal Pseudodiverticula : a Case Report
Get PDFIntroduction: Sixty percent of femoral hernias are characterized by incarceration and strangulation. Jejunal pseudo diverticulum are rare and usually asymptomatic. It may cause chronic obstruction of small bowel and can lead to an acute perforation.Case presentation: An 85 – year – old woman presenting with 1 week history of generalized abdominal pain, with episodes of vomiting, fever, and history of 6 months of reponible femoral hernia and 2 weeks strangulated of femoral hernia. An abdominal X-ray displayed multiple dilated loops of the small bowel, coil spring sign and intra peritoneal free air. This  patient underwent a laparotomy and hernioraphy, which identified single perforated jejunal pseudo diverticulum 50 cm from ligamentum of treitz orally from strangulated of ileal on femoral hernia site, and associated fecal contamination. The management for this case was perforation repaired with diverticulectomy, simple closure, and extensive washout of intraperitoneal cavity. The non tension femoral hernia repair was performed with monofilament, macroporous MESH.Conclusion: chronic intestinal obstruction caused by femoral hernia in the elderly can lead a performed of intestinal pseudo diverticulum and lead to significant morbidity and mortality. This could be suspected in those presenting with cramping abdominal pain and altered bowel habits.Keywords: hernia, femoral, strangulated, pseudo diverticulum, perforated, managementIntroduction : Femoral hernia is usually presented as a flexible, round, domed shape lying on the medial side of the thigh about 2 – 3 cm below the inguinal ligament. Among the external hernias, femoral hernia is the second most common inguinal hernia. It’s prevalence reaches 20 %. Among all inguinal hernias, femoral hernias are characterized by a high level of incarceration and strangulation. This can be as high as 60 %. Jejunal psudodiverticula are rare and are usually asymptomatic. It may cause by chronic obstruction of small bowel and can lead to an acute perforation.Case presentation : We report the case of an 85 – year – old woman presenting with 1 week history of generalized abdominal pain, with episodes of vomiting, fever, and history of 6 months of reponible femoral hernia and 2 weeks strangulated of femoral hernia. An abdominal X-ray displayed multiple dilated loops of the small bowel, coil spring sign and intra peritoneal free air. Our patient underwent a laparotomy and hernioraphy, which identified single perforated jejunal pseudodiverticula 50 cm from ligamentum og treitz orally from strangulated of ileal on femoral hernia site, and associated fecal contamination. The perforation was repaired with diverticulectomi, simple closure, and extensive washout of intraperitoneal cavity. We performed non tension femoral hernia repaired with monofilament, macroporous MESH.Conclusion : chronic intestinal obstruction caused by femoral hernia in the elderly can lead a performed of intestinal pseudodiverticula and lead to significant morbidity and mortality. This should be suspected in those presenting with crampy abdominal pain and altered bowel habits