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    Pengaruh Pendidikan Kesehatan Metode Demonstrasi terhadap Tingkat Pengetahuan dan Motivasi Penggunaan Alat Pelindung Diri (APD) pada Petani Desa Wringin Telu Kecamatan Puger Kabupaten Jember (The Effect of Health Education of Demonstration Methods to the

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    Knowledge and motivation are factors influencing the using of PPE for farmers to protect them from injured or disease due to chemical fertilizers, insects, worm, sunlight, sharp objects, grinding machines, etc. Health education by demonstration method is one of learning method purposed to improve knowledge and motivation of using PPE of farmers. The purpose of this research was to find out the effect of health education by demonstration method toward the levels of knowledge and motivation in using PPE of farmers in Wringin Telu village. This research was a quasy experiment with two groups pretest-posttest treatment design. The population was 875 farmers with 30 respondents as sample, conducted by purposive sampling, and divided into two groups: 15 respondents as treatment group and 15 respondents as control group. Data were analyzed used t- test dependent and t- test independent with 95% CI. The result showed that there were significant defferences of knowledge levels (k) and motivation (m) before and after health education by demonstration methode in treatment group (pVk: 0,000; pVm: 0,000;α: 0,05). Meanwhile, there were no defferences of knowledge levels (k) and motivation (m) in control group (pVk: 0,418; pVm: 0,467;α: 0,05). Moreover, there were significant defferences of knowledge level and motivation between treatment grup and control group after health education by demonstration methode (pVk: 0,000, pVm: 0,000;α: 0,05). Overall, health education by demonstration method can improve both knowledge levels and motivation of using PPE. It is recommended for nurses to do health education by demonstration method to improve knowledge level and motivation of using PPE for farmers when they are working on the field   Keywords: Health Education demonstration method, knowledge, motivation, personal protective equipment

    Perbedaan Tingkat Kecacatan Klien Kusta yang Aktif dan Tidak Aktif Mengikuti Kegiatan Kelompok Perawatan Diri (KPD) di Kabupaten Jember (The Difference in Impairment Level of Leprosy Clients who were Active and Inactive participating Self Care Group ( S

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    Leprosy is an infectious disease caused by Mycobacterium leprae due to problems quite complex involve physical, psychological, social, economic, cultural, and spiritual problems. Physical problems such as impairment experienced by clients leprosy generally occur in the feet, hands, and eyes. Self-care group is a group of leprosy patients who come together to support each other primarily in prevention and reduction disabilities, also to find solutions for problems related to leprosy. The aim of this research was to analyze the difference in impairment levels of leprosy clients who were active and inactive participating Self Care Group (SCG) activities in Jember. This research used historical cohort study. The sampling collection technique used was total sampling involving 44 individuals, divided into 23 active leprosy clients and 21 inactive leprosy clients who participate SCG. Data analysis used Mann Whitney U-test with the significance level of 95% (α = 0.05). The research result showed that the average value of the active leprosy clients in impairment degree was 0.83 while the impairment degree of the inactive leprosy clients was 2.57. Data analysis showed that there was significant difference in impairment levels of leprosy clients who were active and inactive in participate Self Care Group (SCG) activities in Jember (p value 0.042, α = 0.05). Nurses are expected to create new innovations in the implementation of the SCG to increase participation of leprosy client's in the activities of the SCG then the impairment of leprosy client can be prevented and treated. Keywords: Leprosy, Impairment levels, Self Care Group (SCG

    Daya Antibakteri Infusa Daun Asam Jawa (Tamarindus indica Linn) terhadap Streptococcus mutans (Antibacterial Activity of Asam Jawa Leaf Infuse (Tamarindus indica Linn) against Streptococcus mutans

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    Background: Dental caries is a mouth diseases caused by the interaction of host, microorganisms, substrate and time. One of the microorganisms that had played a role in occurrence dental caries is Streptococcus mutans bacteria. Infection caused by S. mutans can be treated with an natural antibacterial or synthetic antibacterial, but synthetic antibacterial has side effects in long term use so we need to do some research to find out natural materials that can be used as an antibacterial to minimize the side effects. Asam jawa leaf (Tamarindus indica L) is one of medicinal plants that have been known contains antibacterial compound namely flavonoid, saponin, alkaloid, vitamin C, chlorine and tanin. Objective: Determined the antibacterial activity of asam jawa leaf infuse against S. mutans. Methods: Laboratories experimental with post test only control group design research. Samples in this research divided into 2 control groups that is negative control (sterile aquadest), positive control (chlorhexidine) and 3 treated groups that is 25%, 50% and 100% asam jawa leaf infuse with 5 total samples for each groups. The antibacterial test was paper disc diffusion method. Antibacterial activity showed by the inhibition zone around the paper disc that indicated there is no bacterial growth. Result and Conclusion: Asam jawa leaf infuse had antibacterial activity against S. mutans and the effective concentration of the asam jawa leaf infuse which had antibacterial activity was 100%. Keywords : Antibacterial, asam jawa leaf infuse, S. mutans

    Pengaruh Lama Distres Kronis Terhadap Perubahan Jumlah Sel Osteoklas Pada Tulang Alveolar Tikus Sprague dawley (The Effect of Chronic Distres Duration on Osteoclast Changes in Alveolar Bone of Sprague dawley Rats)

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    Chronic distress is a psycho-physiological reaction of stimuli that disrupt homoestasis which cause damage to the body, one of kind is an electrical shock stressor. The distress can increase catecholamines level in considerable amounts and allegedy it produce pro-inflamatory cytokines. Cytokine will affect the Hypoyhalamic pituitary adrenal (HPA) axis to produce cortisol and also act as negative control of cytokines. In this assumption, cytokines can increase bond of osteoclast formation key mediator which is RANKL with its receptor (RANK) to produce osteoclasts. This study was an experimental laboratories research using 8 weeks old Sprague dawley rats with body weight 200-250 gram as samples to observe increase of the number of osteoclasts in the alveolar bone. A total of 32 samples were divided into 4 groups: the rats group exposed with electrical shock stressor  for 0, 7, 14, and 28 days. Then samples were processed by tissue processing  until it’s ready to observe using an electron microscope with 400x magnification. The results showed  that there were significant differences (p <0.05) between groups. It is concluded that the number of osteoclasts alveolar bone osteoclast were increased in Sprague dawley rats that experienced chronic distress. Keywords: stress/distress, cathecolamines, cytokine, cortisol,osteoclas

    Hubungan antara Pola Sidik Bibir dengan Jenis Kelamin pada Mahasiswa Fakultas Kedokteran Gigi Universitas Jember (The Correlation between Lip Prints Pattern and Sexual Dimorphism on Students of Faculty of Dentistry, The University of Jember)

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    Background:Cheiloscopyisaforensicidentificationtechniquesbasedonpatternsofwrinklesandgroovesonthe mucosalsurface ofthelip, calledlipprints. Theunique characteristicsoflipprintsanditsdifferentamonghumanbeingcouldbeusedinidentifypeople.Objective:Theaimofthisstudyistoidentifywhetherthereisacorrelationbetweenlipprintsinsexualdimorphismof studentsofFacultyofDentistry,TheUniversityofJember,ornot.Method:Thedescriptiveobservationalstudyiscrosssectionalapproach.Thesubjectsofthisstudyare80students,comprisingof40malesand40females.Result:Theresultshowedthatthereweredifferenceslipprintspatternbetweenmaleandfemale. Themostdominantlipprint patternin malewastipeIII 16 (40%), whereasthemostdominantlipprintpatterninfemalewastipeI’14(35%).Conclusion:Thedifferencesoflipprintspatternbetweenmaleandfemaleshowedthatlipprintspatterncouldbeused inforensicidentification.Keywords:forensicidentification,lipprintspattern,sexualdimorphis

    Uji Aktivitas Fraksi Diklorometana Ekstrak Metanol Bangle (Zingiber cassumunar Roxb.) sebagai Terapi Komplementer Malaria secara In Vivo (The Activity Test of Dichloromethane Fraction of Bangle (Zingiber cassumunar Roxb.) Methanolic Extract as Complement

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    World Malaria Report reported that Malaria threats 40% of world population in six regions and ninety seven endemic countries. This study aimed to investigate the activity of dichloromethane fraction of Bangle as a complementary therapy of malaria in vivo. This was true experimental laboratories study using 28 mice of Balb/c, divided into seven groups. Five treatment groups were given five dose of dichloromethane fraction of Bangle methanolic extracts as imunostimulant before malaria infection and during malaria therapy by combining with malaria standard therapy. K(+) group was given malaria standard therapy. K(-) group was not given any therapy after infection. Inhibition percentage of malaria parasite in K(-) was 0 and K(+) was 24,74%. The treatment group of 0,09 mg/grBW had the highest inhibition percentage, as many as 88,19%. It declined by decreasing dose of fraction. The result of pearson correlation showed very strong correlation (r=0,880). The Ic50 value of dichloromethane fraction of Bangle methanolic extract as a complementary therapy was 0,008 mg/grBW. In conclusion, dichloromethane fraction of Bangle methanolic extract had immunostimulant effect and antimalarial activity in vivo.   Key words: bangle, complementary therapy, inhibition percentage, malari

    Optimasi Hydroxypropyl Methylcellulose dan Xanthan Gum pada Tablet Floating-Mucoadhesive Gliclazide Metode Desain Faktorial (Optimization of Hydroxypropyl Methylcellulose and Xanthan Gum on Floating-Mucoadhesive Gliclazide Tablet using Factorial Design)

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    Gliclazide is one of the drugs used for type 2 diabetes mellitus treatment. It requires frequent dosing which is why gliclazide need to be formulated into preparations using a controlled release drug delivery system. This study aimed to determine the optimum composition of hydroxypropyil methylcellulose (HPMC K4M) and xanthan gum polymer combination for gliclazide tablet. Tablets that have been produced were evaluated for tablets physical characterization, homogenity test, dissolution test, floating lag time, and mucoadhesive test. Tablets were optimized using a factorial design and the data were analyzed using design expert trial 9.0.6. The results showed that the optimal formulation for polymer combination in gliclazide tablet was 122.267-140.000 mg for HPMC K4M and 80.659-90.000 mg for xanthan gum.   Keywords: gliclazide, HPMC K4M, xanthan gum, floating-mucoadhesive system, factorial design

    Peran dan Fungsi Kader, Dukungan Sosial Suami, dan Pengetahuan Tentang Budaya Keluarga pada Pelaksanaan Keluarga Sadar Gizi (Roles and Functions of Cadre, Husband Social Support, and Knowledge of Family Culture on the Implementation of Nutrition Conscious

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    Family that is aware of nutrients is family that all members having good nutrition behavior. Pesanggaran was first place in Banyuwangi which has the lowest of implementation nutrition conscious family, it was 43,3%. The purpose of this study was to analyze the correlation between roles and functions of cadre, husband social support, and knowledge of family culture with the implementation of nutrition conscious family which was held July-August 2015 and used cross sectional approach. The research sample consists of 80 families. The result showed implementation of nutrition conscious family in region of Pesanggaran Public Health Centre was 35%. Based on bivariate analysis, it was found that roles and functions of cadre in the increasing in maternal health, baby, toddler, and socialization Kadarzi, husband social support (emotional, award, instrumental, infoemative), and knowledge of family culture had a significant relationship with the impleentation of Knutrition conscious family.The role and function of cadre in a socialization Kadarzi was the most dominant factor related to implementation of Knutrition conscious family on the family of toddler. Keywords: Kadarzi, toddler, risk facto

    Identifikasi Pelayanan Promotif pada Fasilitas Kesehatan Tingkat Pertama Program Jaminan Kesehatan Nasional (Identification of Promotive Services In Primary Health Care Facility of National Health Insurance Program)

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    Promotive services is important to support the enactment of the National Health Insuranceprogram, for any medical expenses that are collected through dues, it will run out if notaccompanied by increased promotional efforts. Based on preliminary studies were conductedto the Primary Health Care Facility in Jember district, data obtained 6 (40%) Primary HealthCare Facility who carry out services Promotive, It indicate that Primary Health Care Facilitydoing promotive still low in Jember district, The purpose of this study was to identify Promotiveservices in Primary Health Care Facility of the National Health Insurance Program. Thisresearch is descriptive. This study was conducted in Primary Health Care Facility in Jemberdistrict in November 2015. The samples were 30 Primary Health Care Facility. The resultsshowed a large majority has not made promotive, Input Element, human resources PrimaryHealth Care Facility no one had a special officer to promotive services. The level of knowledgeof the entire head Primary Health Care Facility had a high level of knowledge. No PrimaryHealth Care Facility that allocate costs to promotive services. Funds used for service prolanisof funds claim to the Social assurance agency. Most goals Primary Health Care Facility thatindividuals and groups using the method of counseling and lectures as well as the majority useprint media that leaflet. While the place promotive services carried out in the institution building.Most of the elements of the process had not been doing.Keywords: Promotive services, National Health Insurance

    Optimasi Suhu dan Lama Pemanasan dalam Pembentukan Kompleks Inklusi Glibenklamid-β-Siklodekstrin dengan Metode Sealed-Heating (Optimization Temperature and Heating Time Formation of Inclusion Complexes Glibenclamide-β-Cyclodextrin by Sealed-Heating Metho

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    Glibenclamide is a second-generation sulfonylurea that used for type II diabetes mellitus. Glibenclamide is included in the biopharmaceutical classification system (BCS) class II, which has a low solubility and high permeability. One effort that can be done to improve the solubility of drug is inclusion complexation. The aims of the study was to determine temperature and heating time on inclusion complexation of glibenclamide-β-cyclodextrin using sealed-heating method. Optimization done using a factorial design for two factors with 22 number of experiments. Inclusion complexes were determined its miosture content, solubility and in vitro dissolution. Moisture content study showed that F1> FB > FA > FAB. The results of solubility study were analyzed statistically using One-Way ANOVA and least significantly different (LSD). Statistical analysis showed that each formula had a significant difference solubility with FAB > FB > FA > F1>Control. Optimization on in vitro dissolution showed that FAB was an optimum formula with drug release of 87.24% within 180 min. This formula was characterized by DSC to observed for broadening, shifting and appearance of new peaks or disappearance of certain peaks. DSC analysis was indicated that inclusion complexation between glibenclamide and β-cyclodextrin was formed.   Keywords: glibenclamide, β-cyclodextrin, inclusion complexe, sealed-heating &nbsp

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