JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan"
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IDENTIFIKASI GENUS BAKTERI KLEBSIELLA DAN CITROBACTER HASIL ISOLASI DARI AIR MINUM ISI ULANG KOTA JAMBI
ABSTRACT
Background: Refill drinking water are in great demand by the public. The selection is not careful, resulting in consumers can consume drinking water contaminated with bacteria. Drinking water contaminated with bacteria can cause waterborne disease. The purpose of this study was to identify the presence of the genus Klebsiella and Citrobacter bacteria at Refill Drinking Water Depots and to determine the distribution of the number of Refill Drinking Water Depots in Jambi City which were contaminated with Klebsiella and Citrobacter bacteria.
Methods: This type of research is a descriptive research with a laboratory approach and cross-sectional research design. The samples was taken from refill drinking water depot in Jambi City which was identified by MPN Test, Gram Staining and Biochemical Test.
Result: Of the 83 total samples examined, it was found that 4 samples were contaminated with the Klebsiella genus of bacteria (4.8%) and 17 samples (20.5%) were contaminated with the Citrobacter bacterial genus..
Keywords: Klebsiella Bacteria, Citrobacter Bacteria and Refillable Drinking Water Depots in Jambi City
ABSTRAK
Pendahuluan: Air Minum isi ulang sangat diminati oleh masyarakat. Pemilihan yang tidak cermat, mengakibatkan konsumen dapat mengkonsumsi Air Minum yang terkontaminasi bakteri. Air minum yang terkontaminasi bakteri dapat mengakibatkan waterborne disease. Tujuan dari penelitian ini untuk mengidentifikasi keberadaan Genus Bakteri Klebsiella dan Citrobacter pada Depot Air Minum Isi Ulang dan untuk mengetahui distribusi jumlah Depot Air Minum Isi Ulang di Kota Jambi yang terkontaminasi bakteri Klebsiella dan Citrobacter.
Metode: Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan laboratorium dan desain penelitian cross-sectional. Sampel diambil dari Depot Air Minum isi ulang di Kota Jambi yang diidentifikasi dengan Uji MPN, Pewarnaan Gram dan Uji Biokimia.
Hasil: Dari 83 total sampel yang diperiksa, ditemukan jumlah sampel yang terkontaminasi Genus Bakteri Klebsiella sebanyak 4 sampel (4,8%) serta 17 Sampel (20,5%) terkontaminasi Genus Bakteri Citrobacter.
Kesimpulan: Terdapat bakteri Klebsiella pada 4 sampel (4,8%) dan Citrobacter 17 sampel (20,5%) pada Depot Air Minum Isi Ulang di Kota Jambi.
Kata Kunci: Genus Bakteri Klebsiella, Genus Bakteri Citrobacter dan Depot Air Minum Isi Ulang di Kota Jambi
 
ANALISIS PEMETAAN DAN DETERMINANT PENYAKIT BERBASIS LINGKUNGAN DI KABUPATEN MUARO JAMBI TAHUN 2020
ABSTRACT
Introduction: Environmental health problems are a problem for all groups, including the government, health workers and the wider community. One effort to solve this problem is to increase knowledge about environmental health so as to avoid the occurrence of infectious and non-communicable diseases, which are often related to human behavior, namely water and sanitation. The purpose of this research is to Mapping and Determinant of Environmental Diseases in Muaro Jambi Regency.
Methods: This type of research is descriptive research with a spatial analytic approach, this research was conducted in September – November 2021 in Muaro Jambi Regency. These variables were analyzed using a spatial analytic approach using a GIS (Geographic Information System) program.
Results: The determinants of households using PHBS have a relationship with diarrhea in North Bahar District, filariasis in Taman Rajo District, Malaria in Kumpeh and Kumpeh Ulu and DHF in North Bahar District. Determinants Place of food management that meets the requirements has an influence on diarrheal disease in Taman Rajo sub-district, , Determinant population density has an influence on filariasis in Taman Rajo sub-district, tuberculosis in Kumpeh sub-district and DHF in North Bahar. Determinants of healthy homes in Tuberculosis in Kumpeh District. Determinants of village coverage Stop open defecation on diarrheal disease in North Bahar District, STBM (Community-Based Total Sanitation) on Diarrhea in North Bahar and Kumpeh Districts and the determinants of healthy latrines affect diarrheal disease in Kumpeh Ulu.
Conclusion: Some areas such as Kumpeh, Kumpeh Ulu, North Bahar and Sungai Bahar still have prevalence of environmental-based diseases in Muaro Jambi District after being analyzed with the existing determinants.
Keywords: Spatial Analysis, Environmental-Based Disease
ABSTRAK
Pendahuluan: Masalah kesehatan lingkungan merupakan masalah semua kalangan baik pemerintah, tenaga kesehatan serta masyarakat luas. Salah satu upaya untuk menyelesaikan masalah ini adalah dengan meningkatkan pengetahuan tentang kesehatan lingkungan sehingga dapat menghindari terjadinya penyakit menular maupun penyakit tidak menular, yang sering kali berhubungan dengan perilaku manusia yaitu terkait air dan sanitasi. Tujuan penelitian ini adalah untuk Pemetaan dan Determinant Penyakit Akibat Lingkungan di Kabupaten Muaro Jambi.
Metode: Jenis penelitian ini adalah penelitian deskriptif dengan pendekatan spasial analitik, penelitian ini dilakukan pada bulan September – November 2021 di Kabupaten Muaro Jambi. Variable-variabel tersebut dianalisis dengan pendekatan spasial analytic menggunakan program GIS (Geographic Information System).
Hasil: Pada determinan Rumah tangga yang ber-PHBS memiliki hubungan dengan Diare pada Kecamatan Bahar Utara, Filariasis pada Kecamatan Taman Rajo, Malaria pada Kumpeh dan Kumpeh Ulu dan DBD pada Kecamatan Bahar Utara. Determinan Tempat pengelolaan makanan yang memenuhi syarat memiliki pengaruh pada penyakit Diare pada Kecamatan Taman Rajo, , Determinant kepadatan Penduduk memiliki pengaruh pada penyakit Filariasis di Kecamatan Taman Rajo, Tuberkulosis di Kecamatan Kumpeh dan DBD pada Bahar Utara. Determinant rumah sehat pada penyakit Tuberculosis di Kecamatan Kumpeh. Determinant cakupan desa Stop BAB sembarangan pada penyakit pada penyakit barbarslot Diare di Kecamatan Bahar Utara, STBM (Sanitasi Total Berbasis Masyarakat) pada penyakit Diare pada Kecamatan Bahar Utara dan Kumpeh dan Determinatn Jamban sehat berpengaruh pada penyakit Diare di Kumpeh Ulu.
Kesimpulan: Beberapa daerah seperti Kumpeh, Kumpeh Ulu, Bahar Utara dan Sungai Bahar masih memiliki prevalensi penyakit berbasis lingkungan di Kabupaten Muaro Jambi setelah dianalisis dengan determinant-determinant yang ada.
Kata Kunci: Analisis Spasial, Penyakit Berbasis Lingkunga
THE EVALUATION OF THE COMPARISON ANTITUBERCULOSIS DRUGS INTERACTIONS TO THE TEENAGER AND ADULT INPATIENT AT LABUANG BAJI HOSPITAL MAKASSAR IN 2019
ABSTRACT
Background : The drugs interaction is a changes of the drugs due effect because of the combination with another drugs or the consumtion of the drugs in the same time. The drugs interaction will make a reduction of the drugs effect so that the result of the therapy is not as good as the expectation. The research of the drug interaction is to reduce and prevent the treatment fo the tuberculosis patient with a right treatment so it will reduce the drugs interaction during the therapy and also can increase a good therapy which is can effective, safe and efficient. The aim of the research was to known the interaction antituberculosis drugs to the teenager and adult inpatient in the RSUD Labuang Baji Makassar 2019.
Methods : The method of the research was used non-experimental (observational) descriptive analysis (qualitative) and retrospective data collection. In this research, there were 62 samples by used Slovin's formula technique. The drugs interaction in terms of Drug interaction of Stockley's book in 9th edition. Checker drugs interaction application and Medscape application.
Result : The result of the research showed the interaction of the antituberculosis drugs and non antituberculosis drugs ware 62 cases (100%). The evaluation of the interaction antituberculosis drugs : The severity or the significance highest level were 34 cases (75.6%), based on the data collection in the patient who consumed Isoniazid. That medicine was used for tuberculosis treatment therapy category 1, category 2 and multi drugs resistant. Based on mechanism showed pharmacodynamics were 24 cases (53.3%). Then based on the data collection showed the most of pharmacodynamics level interaction was Moxifloxacin doe to used for the treatment of multi drug resistant of tuberculosis. In this research, the most patient was multi drug resistance of tuberculosis. Based on the interaction of pharmacodynamics level showed that antagonist was the highest level with 22 cases (91.7%).
Conclusion : Based on the data collection showed the most interaction of the highest antagonist was Moxifloxacin due to used as multi drug resistant of tuberculosis.
Keywords: Antituberculosis, Drug Interaction, Labuang Baji Hospital
GAMBARAN INFEKSI Klebsiella pneumoniae PENGHASIL Extended-spectrum β-lactamase (ESBL) PADA PASIEN COVID-19 DI RSUP DR. MOHAMMAD HOESIN PERIODE JANUARI 2021-JUNI 2021
ABSTRACT
Background: ESBL-producing Klebsiella pneumoniae infection can make medical costs increase, patients become longer in the hospital, and a worse prognosis in Covid-19 patients. Therefore, this study aims to find out the prevalence, characteristics of age, gender, specimen type, inpatient room, and pattern of antibiotic sensitivity of ESBL-producing Klebsiella pneumoniae in Covid-19 patients so as to help patients in the prevention and control of HAIs in Dr. Mohammad Hoesin Hospital.
Method: This observational research used secondary data in the form of the status of Covid-19 patients identified as ESBL-producing Klebsiella pneumoniae at the Central Laboratory Installation of Mohammad Hoesin Hospital Palembang during the period January 2021-June 2021. The samples in this study were all medical records of Covid-19 patients who met the inclusion criteria. Data was processed and analyzed by univariate to determine the frequency distribution of each variable studied.
Result: Prevalence of ESBL-producing Klebsiella pneumoniae in Covid-19 patients at Dr. Mohammad Hoesin Hospital is 48,6%. Based on Age, prevalence of ESBL-producing Klebsiella pneumoniae in Covid-19 patients are often found in elderly (41,2%). Based on gender, prevalence of ESBL-producing Klebsiella pneumoniae in Covid-19 patients are often found in female (64,7%). Based on specimen type, prevalence of ESBL-producing Klebsiella pneumoniae in Covid-19 patients are often found in sputum (47,1%). Based on the inpatient room, prevalence of ESBL-producing Klebsiella pneumoniae in Covid-19 patients are often found in non-intensive care unit (79,5%). Based on sensitivity patterns, isolates ESBL-producing Klebsiella pneumoniae are resistance to ampicilin/AMP (100%), cefazoline (100%), ceftriaxon (100%), aztreonam (91,2%), ceftazedim (85,3%), ampisilin/Sulbaktam (76,5%), ciprofloxacin (76,5%), trimethoprim/ sulfamethoxazole (58,8%) and gentamicin (55,9%).
Conclusion: Prevalence of ESBL-producing Klebsiella pneumoniae in Covid-19 patients at the Central Laboratory Installation of Mohammad Hoesin Hospital Palembang during the period January 2020-June 2020 is 48,6%. Antibiotics that resistance to ESBL-producing Klebsiella pneumoniae in Covid-19 patients are ampicilin/AMP, cefazoline, ceftriaxon, aztreonam, ceftazdim, ampisilin/sulbaktam, ciprofloxacin, trimethoprim/sulfamethoxazole and gentamicin.
Keywords: ESBL, Covid-19, HAIs
ABSTRAK
Pendahuluan: Infeksi Klebsiella pneumoniae penghasil ESBL bisa membuat biaya pengobatan menjadi bertambah, pasien menjadi lebih lama di rumah sakit, dan prognosis yang lebih buruk pada pasien Covid-19. Oleh karena itu, penelitian ini bertujuan untuk mengetahui prevalensi, karakteristik berdasarkan usia, jenis kelamin, jenis spesimen, asal ruang rawat inap, dan pola sensitivitas antibiotik Klebsiella pneumoniae penghasil ESBL pada pasien Covid-19 sehingga dapat membantu pasien dalam pencegahan dan pengendalian HAIs di RSUP Dr. Mohammad Hoesin.
Metode: Penelitian deskriptif observasional ini menggunakan data sekunder berupa status pasien Covid-19 yang teridentifikasi Klebsiella pneumoniae penghasil ESBL di instalasi laboratorium sentral RSUP Dr. Mohammad Hoesin Palembang selama periode Januari 2021-Juni 2021. Sampel pada penelitian ini adalah seluruh data rekam medik pasien Covid-19 yang memenuhi kriteria inklusi. Data diolah dan dianalisis secara univariat untuk mengetahui distribusi frekuensi setiap variabel yang diteliti.
Hasil: Prevalensi Klebsiella pneumoniae penghasil ESBL pada pasien Covid-19 di RSUP Dr. Mohammad Hoesin sebesar 48,6%. Berdasarkan usia, Klebsiella pneumoniae penghasil ESBL pada pasien Covid-19 banyak ditemukan pada lansia (41,2%). Berdasarkan jenis kelamin, Klebsiella pneumoniae penghasil ESBL pada pasien Covid-19 banyak ditemukan pada perempuan (64,7%). Berdasarkan jenis spesimen, Klebsiella pneumoniae penghasil ESBL pada pasien Covid-19 banyak ditemukan pada sputum (47,1%). Berdasarkan ruang rawat inap, Klebsiella pneumoniae penghasil ESBL pada pasien Covid-19 banyak berasal dari ruang rawat non intensif (79,5%). Berdasarkan pola sensitivitas, Klebsiella pneumoniae penghasil ESBL resisten terhadap ampisilin/ AMP (100%), sefazolin (100%), seftriakson (100%), aztreonam (91,2%), seftazdim (85,3%), ampisilin/ sulbaktam (76,5%), siprofloksasin (76,5%), trimetoprim/ sulfametoksazol (58,8%), dan gentamisin (55,9%)
Kesimpulan: Prevalensi Klebsiella pneumoniae penghasil ESBL pada pasien Covid-19 di Instalasi Laboratorium Mikrobiologi RSUP Dr. Mohammad Hoesin Palembang selama periode Januari 2021-Juni 2021 sebesar 48,6%. Antibiotik yang resisten pada Klebsiella pneumoniae penghasil ESBL yaitu ampisilin/AMP, sefazolin, seftriakson, aztreonam, seftazdim, ampisilin/sulbaktam, siprofloksasin, trimetoprim/sulfametoksazol dan gentamisin.
Kata kunci: ESBL, Covid-19, HAI
THE ART OF ANATOMY: PENGEMBANGAN MEDIA ATLAS ANATOMI DAN EVALUASI MELALUI PENILAIAN PEMBELAJARAN SECARA DARING DAN LURING PADA MAHASISWA KEDOKTERAAN UNIVERSITAS JAMBI
ABSTRACT
Backgound: The medical study program in Universitas Jambi implements competency-based curriculum that emphasizes learning anatomy in the first year of education. In learning anatomy, lecture and practice are using as a method, and an assessment will be carried out in the form of an anatomy exam or often called OSPE (Objective Structural Practice Examination) anatomy. Due to the Covid-19 pandemic, the Minister of Education and Culture of the Republic of Indonesia issued a regulation that enforces a distance learning system as a substitute for the face-to-face learning system. Objective: The purpose of the study was to compare the average scores of the anatomy exams in offline learning and online learning at the Faculty of Medicine and Health Sciences, Universitas Jambi.
Methods: This study is a retrospective quantitative study design involving all students from the 2019 class that match with inclusion criteria that taking all of the anatomy practicum exams in block 1.1 to block 2.3.
Result: 155 students are being included as the sample based on the inclusion criteria. Data recapitulation of anatomy test scores was carried out from June to September 2021. The score for offline learning is 63.05 and for online learning is 70.84 and statistically different (p-Value = 0.000).
Conclusion: There is a significant difference between the anatomy exam scores during offline and online learning for the 2019 batch of medical students.
Keywords: Anatomy, Online learning, Offline learning
ABSTRAK
Latar Belakang: Program studi kedokteran di Universitas Jambi menerapkan pembelajaran kurikulum berbasis kompetensi yang menekankan pembelajaran anatomi pada tahun pertama pendidikan. Dalam pembelajaran anatomi digunakan metode perkuliahan dan praktikum, penilaian akan dilakukan dalam bentuk ujian anatomi atau sering disebut dengan OSPE (Objective Structural Practice Examination) anatomi. Di tengah pandemi Covid-19, Menteri Pendidikan dan Kebudayaan Republik Indonesia mengeluarkan Surat Edaran yang memberlakukan sistem pembelajaran jarak jauh atau online sebagai pengganti sistem pembelajaran tatap muka. Tujuan: Penelitian ini bertujuan untuk membandingkan rerata nilai ujian anatomi mahasiswa tahun 2019 pada pembelajaran luring dan pembelajaran daring di Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi.
Metode: Penelitian ini merupakan penelitian retrospektif. Penelitian ini merupakan penelitian kuantitatif yang melibatkan seluruh mahasiswa angkatan 2019 yang memenuhi kriteria inklusi yaitu mengikuti seluruh ujian praktikum anatomi blok 1.1 sampai blok 2.3.
Hasil: 155 mahasiswa dimasukkan sebagai sampel berdasarkan kriteria inklusi. Rekapitulasi data nilai ujian anatomi dilakukan pada bulan Juni sampai September 2021. Median skor untuk pembelajaran offline adalah 63,05 dan untuk pembelajaran online adalah 70,84 dan berbeda secara statistik (p-Value = 0,000).
Kesimpulan: Terdapat perbedaan yang signifikan antara nilai ujian anatomi saat pembelajaran offline dan online untuk mahasiswa kedokteran angkatan 2019.
Kata kunci: Anatomi, Pembelajaran Daring, Pembelajaran Lurin
THE EFFECT OF NITROGLYCERIN ON RADIAL ARTERY OCCLUSION AFTER TRANSRADIAL CATHETERIZATION : A SYSTEMATIC REVIEW
Background : Transradial access is preferred approach for coronary angiography and PCI. Although, access site-related complications can occur following transradial access. RAO is the most common postprocedural complication. It has been reported that nitroglycerin can dilate radial artery in patients undergoing transradial coronary catheterization without affecting blood pressure.
Objective: This study aimed to evaluate the effect of nitroglycerin on RAO after transradial catheterization.
Methods : We searched RCT from Cochrane, PubMed, Science Direct, NCBI, and BMJ. Titles, abstracts, and full texts were screened using inclusion criteria to filter out irrelevant studies. Quality assessment were undertaken using Jadad scale and the results have been presented as a narrative overview with figures.
Results : Three studies were included after screening 206 records. Two studies demonstrated statistically significant results that giving nitroglycerin reduced the risk of RAO after transradial catheterization, compared with the comparator groups (p < 0.05). These studies were Chen Y et al 2018 (95% CI 0.116 - 0.998; p = 0.04) and Dharma S et al 2015 (OR : 0.62; 95% CI: 0.44 – 0.87; p = 0.006).
Conclusions : This study demonstrated benefit of using nitroglycerin for reducing incidence of RAO after transradial catheterization
GAMBARAN PARENTAL INVOLVEMENT ORANGTUA YANG MENJALANI WORK FROM HOME (WFH) DALAM PENDIDIKAN ANAK LATE CHILDHOOD SELAMA MASA PANDEMI COVID-19
ABSTRACT
Background: Indonesia is currently being hit by a pandemic that raises policies Large-Scale Social Restrictions (PSBB). This policies makes office workers work from home (WFH), and students have to do school from home (SFH). The pandemic that gave rise to the SFH and WFH policies made both children and parents spend much time together at home and also made parents have more time to directly or indirectly supervise children's learning which will more or less affect children's academic performance due to the presence of parents at home.
Methods: This study aims to provide an overview of the parental involvement of parents who undergo work from home in the education of late childhood children during the Covid-19 pandemic. This research uses a qualitative method with a descriptive research type. The data collection method used for this research is to conduct semi-structured qualitative interviews. The research instrument used for this research is an interview guide compiled using the theory of Parental Involvement in children's education. The data analysis method used was to perform qualitative data analysis methods.
Results: The results of this study explain that all participants are fully involved in carrying out parental involvement in children's education as long as children carry out SFH. The form of parental involvement to their respective children also has the same goal but only has a different focus. Some limitations require that participants cannot carry out parental involvement functions in this study due to school rules that both parents and children must follow.
Keywords: parental involvement, work from home, working parents, covid-19
ABSTRAK
Pendahuluan: Indonesia saat ini sedang dilanda pandemi yang memunculkan kebijakan Pembatasan Sosial Berskala Besar (PSBB). Hal ini membuat para pekerja kantoran harus melakukan work from home (WFH) dan para pelajar harus melakukan school from home (SFH). Pandemi yang memunculkan kebijakan SFH dan WFH membuat baik anak maupun orangtua banyak menghabiskan waktu bersama dirumah dan kebijakan pandemi ini membuat orangtua jadi memiliki waktu yang lebih banyak untuk secara langsung maupun tidak langsung mengawasi anak belajar yang sedikit banyaknya akan berpengaruh pada performa akademik anak dikarenakan adanya orangtua dirumah. Penelitian ini bertujuan untuk memberikan gambaran mengenai parental involvement orangtua yang menjalani work from home dalam pendidikan anak late childhood selama masa pandemi Covid-19.
Metode: Penelitian ini menggunakan metode kualitatif dengan jenis penelitian deskriptif. Metode pengumpulan data yang digunakan untuk penelitian ini adalah dengan melakukan wawancara kualitatif yang bersifat semi-structured. Instrumen penelitian yang akan digunakan untuk penelitian ini adalah panduan wawancara yang disusun dengan menggunakan teori Parental Involvement pada pendidikan anak serta metode analisis data yang digunakan adalah dengan melakukan metode analisis data kualitatif.
Hasil: Hasil dari penelitian ini menjelaskan bahwa seluruh partisipan terlibat penuh dalam melakukan parental involvement pada pendidikan anak selama anak menjalankan SFH. Bentuk dari parental involvement yang diberikan partisipan kepada anaknya masing- masing juga memiliki tujuan yang sama, namun hanya berbeda fokusnya saja. Terdapat keterbatasan yang mengharuskan partisipan tidak dapat menjalankan beberapa fungsi parental involvement dalam penelitian ini, dikarenakan adanya aturan sekolah yang harus diikuti oleh pihak orangtua maupun anak.
Kata kunci: parental involvement, work from home, orangtua bekerja, covid-1
PENGGUNAAN MEDIA AJAR DALAM STATISTIK KEDOKTERAN
ABSTRACT
Introduction: Statistics have an important role in the world of education, one of which is in the field of medicine. Medical students in the final stages who are undergoing thesis often experience difficulties in data processing. The purpose of this study was to determine the relationship between statistical learning videos and students' statistical abilities.
Methods: This study was conducted on 140 students who were divided into a control group and an intervention group. Both groups received modules and lectures. Only the intervention group received the learning video. The data was taken from the students' pretest and posttest scores, which were then processed using IBM SPSS version 25.
Results and Conclusions: The results of data processing showed that the score in the intervention group was higher than the control group, however the Mann-Whitney test showed that there was no relationship between learning videos and students' statistical scores.
Keywords: Teaching Media, Medical Statistics
ABSTRAK
Pendahuluan: Statistik memiliki peranan yang penting dalam dunia pendidikan, salah satunya di bidang kedokteran. Mahasiswa kedokteran di tahap akhir yang sedang menjalani skripsi sering kali mengalami kesukaran dalam pengolahan data. Tujuan penelitian ini adalah untuk mengetahui hubungan antara video pembelajaran statistik terhadap kemampuan statistik mahasiswa.
Metode: Penelitian ini dilakukan pada 140 mahasiswa yang dibagi menjadi kelompok kontrol dan kelompok intervensi. Kedua kelompok tersebut mendapatkan modul dan perkuliahan. Hanya kelompok intervensi yang mendapatkan video pembelajaran. Data diambil dari nilai pretest dan posttest mahasiswa, yang kemudian diolah menggunakan IBM SPSS versi 25.
Hasil dan Kesimpulan: Hasil pengolahan data menunjukkan bahwa nilai pada kelompok intervensi lebih tinggi daripada kelompok kontrol, namun demikian uji Mann-Whitney menunjukkan bahwa tidak terdapat hubungan antara video pembelajaran dengan nilai statistik mahasiswa.
Keywords: Media Ajar, Statistik Kedoktera
KORELASI AMBANG NYERI TEKAN OTOT DENGAN DERAJAT NYERI DAN DISABILITAS PADA PENGENDARA OJEK ONLINE YANG MENDERITA NYERI PUNGGUNG BAWAH MIOFASIAL
Background: Online taxi rider is one of the jobs that requires the rider to be in a sitting or flexed position for a long time. An ergonomic position at work affects the pressure and tension of the lower back muscles. Continuous muscle pressure and strain has the risk of causing myofascial low back pain (LBP) in Online taxi riders.
Objectives: This study aims to determine the correlation between the pressure threshold and the degree of pain and degree of disability in online motorcycle taxi drivers who suffer from LBP.
Methods: This study is an observational study with a cross-sectional design. All samples were examined for muscle pressure at trigger points at paraspinal mucle in the lower back area using an Algometer. Assessment of the degree of pain was carried out using the Numeric Pain Scale instrument and the degree of disability was assessed by the Oswetri Disability Index.
Results: In this study, 30 online Online taxi riders were found with complaints of myofascial low back pain with an average pressure threshold that causes pain at the trigger point of 5.03 ± 1.3 kgf. After conducting bivariate analysis with the Pearson test, no significant correlation was found between the threshold of muscle tension and the degree of pain and degree of disability of Online taxi riders who suffer from LBP (p>0.05).
Conclusion: There is no correlation between the threshold of muscle pressure and the degree of pain and disability of Online taxi rider.
Keywords: threshold of tenderness, myofacial lower back pain, online taxi rider
VARIASI GEN METHYLENETETRAHYDROFOLATE REDUCTASE PADA PREEKLAMPSIA; SEBUAH STUDI PENDAHULUAN PADA POPULASI JAMBI
ABSTRACTBackground: Pre-eclampsia is a major cause of maternal and neonatal mortality and morbidity. The pathogenesismechanism of pre-eclampsia involves the interaction of genetic and environmental factors. Genetic variation in thegene MTHFR C677T (C> T transition) alter activity of MTHFR enzyme and predictrisk for pre-eclampsia but withconflicting results in worldwide population. This study aimed to investigate the association between gene variationof MTHFR C677T with pre- eclampsia in Jambi malay population.Method: This study was a case-control design. We compared the two subject groups; 30 pregnant women withpre-eclampsia and 30 normal pregnant women. Pre-eclampsia was diagnosed by elevated blood pressure (systolicbloodpressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg) after 20 weeks of gestation.All samples wereethnic malay living in Jambi. The two groups were matched by age, gravida and parity. The Amplification RefractoryMutation System - Polymerase Chain Reaction was used for genotyping.Result and Conclusion: Association between the gene variation of MTHFR C667T and preeclampsia wasassessed using bivariate analysis with p<0,05. Statistical analysis of the additive model showed that the frequencyof TT genotype in thepre-eclamptic group was higher than normal pregnant women but did not show a significantdifference (OR = 0,833; 95% CI = 0,170 – 4,088; p= 0,568). Our study resultsuggest that the MTHFR C677T genevariation is not a risk factor for pre-eclampsia in theJambi malay population.Keywords: gene variation, Methylenetetrahydrofolate Reductase gene, MTHFR C677T, preeclampsiaABSTRAKPendahuluan: Mekanisme patogenesis preeklampsia melibatkan interaksi faktorgenetik dan lingkungan. Variasigenetik pada gen Methylenetetrahydrofolate Reductase (MTHFR) C677T (C>T transisition) menyebabkanpenurunan aktivitas enzim MTHFR yang berpengaruh pada peningkatan homosistein dan berkaitan dengankejadian preeklampsia. Penelitian ini bertujuan untuk mengetahui asosiasi antara variasi gen MTHFR C667Tdengan preeklampsia pada populasi melayu Jambi.Metode: Penelitian ini menggunakan rancangan kasus-kontrol. Kamimembandingkan dua subyek grup; 30 wanitahamil dengan preeklampsia dan 30 wanita hamil normal. Diagnosis preeklampsia ditentukan dengan adanyapeningkatan tekanan darah (tekanan darah sistolik ≥140 mmHg atau tekanan darah diastolik ≥90mmHg) setelah 20minggu kehamilan. Seluruh sampel merupakan etnis melayu yang berdomisili di provinsi Jambi. Kedua grup telahdicocokan berdasarkan usia ibu, gravida dan paritas. Pemeriksaan genotyping menggunakan metodeAmplification Refractory Mutation System - Polymerase Chain Reaction.Hasil: Asosiasiantara variasi gen MTHFR C677T dengan preeklampsia dinilai menggunakan analisis bivariatdengan p<0,05. Analisis statistik model additive menunjukkan frekuensi genotype TT pada kelompok hamil denganpreeklampsia lebih tinggi dibandingkan wanita hamil normal namun tidak menunjukkan perbedaan bermakna(OR=0,833; 95% CI=0,170 – 4,088; p=0,568).Kesimpulan: Hasil penelitian memberikan kesan variasi gen MTHFR C677T bukan sebagai faktor risiko terhadapkejadian preeklampsia pada populasi melayu Jambi.Kata kunci: variasi genetik, gen Methylenetetrahydrofolate Reductase, MTHFR C677T, preeklampsi