JAMBI MEDICAL JOURNAL "Jurnal Kedokteran dan Kesehatan"
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AT Genotype of FTO rs9939609 Enhances Risk for Central Obesity Under Obesogenic Lifestyle
Full text linkBackground: Central obesity is a major risk factor for cardiovascular diseases, influenced by both genetic and lifestyle factors. The rs9939609 variant of Fat Mass and Obesity-Associated (FTO) gene has been associated with increased risk of central obesity, potentially modulated by dietary intake and physical activity. Objective: This study aimed to investigate the association between the FTO rs9939609 variant and central obesity, and its interaction with dietary intake and physical activity among adults in Jambi, Indonesia.
Method: A cross-sectional study was conducted on 175 adults. Central obesity was defined using NCEP ATP III criteria. Dietary intake and physical activity were assessed using 24-hour food recall and the IPAQ, respectively. Genotyping was performed using the Tetra ARMS-PCR. Bivariate analysis was used to assess associations.
Results: Individuals with the AT genotype had a significantly increased risk of central obesity (OR= 3.29; 95% CI: 1.30–8.35; p= 0.01). Under the dominant model (AAAT), the association remained significant (OR= 2.90; 95% CI: 1.17-7.16; p= 0.02). The risk was higher among individuals with high caloric intake (OR= 4.64) and low to moderate physical activity (OR= 4.77).
Conclusion: The FTO rs9939609 variant is associated with increased central obesity risk, and in the presence of obesogenic lifestyle factors
The Importance of Exercise: The Effectiveness of the Buerger Allen Exercise in Increasing Lower Limb Peripheral Circulation and Perfusion in Type II Diabetes Mellitus Patients
No full textBackground: Type 2 diabetes mellitus can cause venous and arterial blood circulation disorders. Buerger Allen Exercise (BAE) is a modality therapy that uses active posture movements. This study aimed to assess the effect of BAE on increasing the Ankle Brachial Index (ABI) value.
Methods: This study used a pre-experimental, pretest and posttest design. Sampling was carried out using consecutive sampling techniques of 54 respondents with type 2 DM. The Wilcoxon test was performed to analyze the data. Measurement of ABI values was carried out to assess increased blood circulation in the legs. BAE exercises were carried out 2 times a day with a duration of 10 to 15 minutes for 3 days. In the intervention group and the control group.
Results: The results showed that there was a significant difference between before and after the intervention with a p value of 0.001 (p <0.005). BAE is effective in improving blood circulation, peripheral perfusion and ABI values. Based on the results of the statistical test, it is known that p value = 0.067> 0.05 so it can be concluded that Ho: is rejected, thus it can be said that there is no difference in ABI scores in the control group. In contrast to the 10-minute BAE intervention, the test results look different with a p value = 0.0005 so it can be concluded that there is a difference between 3-minute exercise (control group) and 10-minute exercise (intervention group).
Conclusion: BAE had an effect on the ABI score and had the effect of reducing peripheral vascular disease in the extremities of the legs and improving blood circulationin the legs
The Perception Of Health Cluster Student’s On Health Promoting University In Jambi University
No full textBackground : Health promoting university is a comprehensive health approach by using universities as a place to create a learning environment that can improve health and well-being in a sustainable manner for academic community, the purpose of this study is to provide an overview related to the perception of jambi university health cluster student to health promoting university.
Methods: This research was quantitative research with cross sectional design research. Sampling techniques using purposive sampling. The population in this study was students of faculty of medicine and health sciences of year 2018 and year 2019.
Result: The results showed a significant association between students perception of the benefit of health promoting university and the intention of supporting the health promoting university (p=0,000) and there was also a significant relationship between students perception of the barriers to health promoting university and the intention of supporting the health promoting university (p=0,011).
Conclusion: This shows that according to Jambi University Health Cluster students, the perception of benefit and perception of barriers on health promoting university is required in order to embody the policies related to health promoting university program
Water, Sanitation, Hygiene (Wash) Interventions To Reduce Open Defecation Habit: A Structural Equation Modeling (SEM) Approach
No full textBackground: Open defecation and other poor sanitation and hygienic practices create major public health problems in many developing nations. Improving community health and well-being depends on attending to these problems. Using partial least squares structural equation modeling (PLS-SEM), this study aims to investigate the links between Water, Sanitation, and Hygiene (WASH) parameters and open defecation behavior in riverbank villages.
Method: Environmental observations combined with structured questionnaires was used in a cross-sectional survey. Convenience sampling helped participants to be gathered; PLS-SEM data analysis was used to investigate the intricate connections between WASH factors and open defecation behavior.
Result: results show that there is no statistically significant relationship between open defecation practices and water (coefficient = -0.128, p = 0.355), sanitation (coefficient = -0.493, p = 0.861), income (coefficient = -0.030, p = 0.675), or education (coefficient = 0.067, p = 0.377). Furthermore, there is no significant link between open defecation practices and water (coefficient = -0.009, p = 0.911) and sanitation (coefficient = 0.058, p = 0.479) moderating effects of hygiene.
Conclusion: Effective reduction of open defecation hinges on comprehensive WASH interventions that combine improved sanitation infrastructure with hygiene promotion and community involvement. Prioritizing hygiene education and fostering community ownership are essential for sustainable public health improvements. (rekomendasi dari hasil untuk future persepective
The Relationship Of Work Stress With Lower Back Pain Complaints In Dentists In Jambi City
No full textBackground: Work stress is one of the factors causing complaints of lower back pain. Work stress has a negative impact on a person's physical and psychological health. Dentists who experience ongoing stress will usually experience complaints of low back pain. Pain can increase during prolonged activities. Increased pain can be felt due to psychological conditions and an unsupportive environment. The aim of this research is to determine the relationship between work stress and complaints of lower back pain among dentists in Jambi City
Method: This research is a quantitative study using an analytical observational design with a cross sectional approach. Respondents in this study were 134 dentist taken randomly. Data collection used the Oswestry Dissability Index (ODI) questionnaire to measure complaints of low back pain, the Perceive Stress Questionnaire (PSQ) to measure work stress. Data analysis uses statistical correlation tests.
Results: The results of the statistical correlation test show that the work stress variable (p= 0.006)
Conclusion: There is a positive correlation between the work stress variable and the lower back pain complaint variable among independent practicing general dentists in Jambi City
Correlation of IL-10 Levels with the Bacterial Index in Multibacillary Leprosy
No full textBackground: Multibacillary (MB) leprosy is characterised by a high bacillary burden and a tolerogenic immune profile. Interleukin-10 (IL-10) is a key immunoregulatory cytokine that may reflect bacillary load. Objective: To compare bacillary burden and IL-10 between MB patients and controls and to examine the correlation between the Bacterial Index (BI) and IL-10 among MB patients.
Methods: A comparative cross-sectional study included 68 participants (MB n=34; controls n=34). Categorical variables were analysed using Chi-square tests, and medians were used with Mann–Whitney U tests. Spearman’s rank correlation was used to assess the BI–IL-10 relationship in MB.
Results: Age distribution was similar between groups (p=0.451), whereas occupation (p=0.040) and education (p=0.027) differed. BI was markedly higher in MB than in controls (median 2.5 [IQR 4] vs 0 [0]; p<0.001). IL-10 concentrations were also higher in MB (1.96 [4.03] pg/mL) than in controls (1.12 [1.94] pg/mL; p=0.029). Among MB patients, BI correlated positively with IL-10 (ρ = 0.358; p = 0.038).
Conclusion: MB leprosy shows substantially greater bacillary burden and elevated IL-10 relative to controls. The positive association between BI and IL-10 supports the role of an immunoregulatory milieu linked to bacillary load. These findings highlight IL-10 as a potential biomarker for disease burden in MB leprosy and warrant validation in larger, adjusted cohorts
Mycobacterium Tuberculosis Identification on Suspected Extra Pulmonary Tuberculosis Patients
Full text linkBackground: Extra Pulmonary Tuberculosis (EPTB) is Tuberculosis infection in organs other than the lungs, like pleura, lymph nodes, abdomen, genitourinary tract, skin, joints and bones, or meninges. The Diagnosis of EPTB is still challenging because symptoms of EPTB is vary, location EPTB is an inaccessible site, and paucibacillary smear. We wanted to know the Mycobacterium tuberculosis identification using the qPCR method on samples of EPTB suspects.
Methods: This research was a descriptive research with laboratory experiments. Subjects in this study were all cases of suspected EPTB with clinically diagnosed, thoraks radiographs, colonoscopy, and formalin fixed paraffin embedded (FFPE). DNA extraction was carried out according to PureLink® Genomic dna extraction kit instructions. The PCR volume 20 ul with 2x QuantiNova SYBR Green PCR Kit, M.tuberculosis Primer IS 6110, and DNA Sample. QPCR temperatures was done with predenaturation at 95 °C for 3 minutes, and followed 45 cycles, consist of denaturation at 95 °C for 15 seconds, annealing at 60 °C for 30 seconds dan extenstion at 72 °C for 30 seconds. PCR was performed with positive and negative controls, and data analysis was based on positive and negative ct controls.
Results: From 30 suspect EPTB samples, there are males (56,67%), with age 36-55 yo (50%), site of samples most from gastrointestines (70%), and there are 6 samples (20%) with positive qPCR.
Conclusion: qPCR methods can be used for EPTB diagnosis
Evaluating HbA1c as a Predictive Biomarker for Depression in the Elderly: A Cross-Sectional Analysis
Full text linkIntroduction: Depression in the elderly is a significant public health concern and is linked to elevated HbA1c, a marker of long-term glucose control. Persistent hyperglycemia may impair neurogenesis, disrupt brain networks, and reduce neurotransmitter activity, making HbA1c a potential biomarker for depression.
Purpose: This study aims to explore the potential of HbA1c as a biomarker for predicting depression severity in the elderly.
Methods: This cross-sectional study examined 93 elderly residents at Bina Bhakti Nursing Home, who exhibited varying levels of depression severity. Depression was assessed using the Geriatric Depression Scale (GDS), and HbA1c levels were analyzed using an automated clinical analyzer. To evaluate the predictive ability of HbA1c for depression severity, we used the area under the curve (AUC) from a receiver operating characteristic (ROC) analysis. A GDS score of 4 or higher was used to indicate severe depression.
Results: The AUC for HbA1c was 0.692, with a p-value of 0.049, indicating a statistically significant relationship between HbA1c levels and depression severity.
Conclusion: Elevated HbA1c levels may serve as a potential biomarker for depression risk in the elderly. Routine HbA1c monitoring could support early detection and timely intervention. Further research is needed to clarify its clinical relevance
Literature Review: The Iceberg Phenomenon in Hyperthyroidism and Mental Disorders
No full textBackground: Elevated thyroid hormone levels have a high prevalence this year. It has a long-term impact on the cognitive and productivity of sufferers, leading to a decrease in the quality of life of individuals and an increase in social and economic burden. Previous studies have shown a direct link between hyperthyroidism and mental disorders, but the impact on cognitive and emotional functioning still needs to be clarified. Early detection and management are the main challenges in preventing and treating this condition.
Methods: Our study was a literature review of medical journal for the last 10 years through NCBI, Google Scholar, Clinicalkey, Semantic Scholar, Sciencedirect, and Springer.
Result: Hyperthyroidism caused by dysregulation of the Hypothalamic-Pituitary-Thyroid axis that disrupts the balance of triiodothyronine and thyroxine hormones, leading to emotional and cognitive impairment. The brain and thyroid tissue are also affected by the FDPS, PPIL3, MMAB, and ALDH2 genes, which are characterized by significant expression in areas of brain function that are involved in cognitive, emotional, and social behaviour.
Conclusion: A multidisciplinary approach, including pharmacological therapy, cognitive therapy, and community education, is an important step in reducing the impact of hyperthyroidism on mental health as well as social and economic aspects
Ultrasound Assessment of Fetal Biometry at Raden Mattaher Hospital
No full textBackground: Fetal biometry is the cornerstone of modern prenatal care. This study aims to assess fetal size (fetal biometry at a given time point compared to normal charts) and estimate fetal weight (EFW) using the Hadlock formula.
Methods: A descriptive retrospective study in order to establish fetal biometry in the third trimester of pregnancy and incorporated into Hadlock's formula to estimate fetal weight. Four fetal biometry measurements (BPD, HC, AC and FL) were collected from ultrasonography examination results in Raden Mattaher General Hospital. Data were documented using case report form and being tabulated using Microsoft Excel 2011 Version 14.7.0 (161029). All data were analyzed using SPSS 25.0.
Results: There were 100 data of pregnant women who underwent fetal biometry ultrasound examinations from February 2021 to April 2023, 100 data samples were obtained that met the criteria for inclusion in the study. The data was distributed based on gestational age from 9 weeks to 41 weeks of gestation. Data on four biometric parameters were collected and calculated using Hadlock formula to obtain an estimate of fetal weight. In the study, it was estimated the weight of the fetus at the 33rd week of pregnancy was 1800 grams, which was in the 10-50 percentile on Hadlock curve.
Conclusion: Assessment of fetal biometry is one of the main components of modern prenatal care. Accurate pregnancy dating is essential for further interpretation of both fetal size and growth. Measuring biometrics parameters, including Head Circumference (HC), Biparietal Diameter (BPD), Abdominal Circumference (AC), and Femur Length (FL), and combining them into an estimated fetal weight should be part of the routine ultrasound exam