JSFK (Jurnal Sains Farmasi & Klinis)
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Comparison Method Wet Granulation and Direct Compression of Physical Properties and Disintegration Time of Orally Disintegrating Tablets Piroxicam
No full textTelah dilakukan penelitian mengenai perbandingan penggunaan metode granulasi basah dan kempa langsung terhadap sifat fisik dan waktu hancur orally disintegrating tablets (ODTs) piroksikam. Penelitian ini bertujuan untuk membandingkan metode pembuatan ODTs piroksikam yang menghasilkan sifat fisik tablet dan waktu hancur yang paling baik. Komposisi formula pada metode granulasi basah dan cetak langsung sama tiap tabletnya yaitu Piroksikam 20 mg, Primellose® 5%, PVP K30 1%, Mg stearat 1%, Manitol 10%, dan Comprecel® ad 175 mg. Tablet ODTs kemudian dievaluasi sifat fisiknya yang meliputi keseragaman bobot, keseragaman ukuran, kekerasan, friabilitas dan friksibilitas, waktu hancur, rasio penyerapan air, waktu pembasahan dan penetapan kadar serta uji disolusi. Hasil penelitian menunjukkan bahwa kedua metode menghasilkan sifat fisik tablet yang baik. Namun metode kempa langsung memberikan waktu hancur yang lebih cepat yaitu 55,51 detik dibandingkan dengan metode granulasi basah. Hasil uji statistik menggunakan metode independent sample T test menunjukkan terdapat perbedaan bermakna waktu hancur (P<0,05) antara formula dengan metode kempa langsung dengan granulasi basah.Study on comparison of wet granulation and direct compression method of physical properties and disintegration time of orally disintegrating tablets piroxicam has been done. This study aims to comparison which method gives better results of physical properties and disintegration time between wet granulation and direct compression method. Both methods are made with the same composition formula of each tablets is Piroxicam 20 mg, Primellose® 5%, 1% PVP K30, magnesium stearate 1%, Mannitol 10%, and Comprecel® up to 175 mg. ODTs then evaluated physical properties which include weight variation, thickness, hardness, friability and friksibility, disintegration time, ratio of water absorption, wetting time, drug content and dissolution test. The results showed that both methods produce the physical properties of a good tablets. However, the method of direct compression provides a disintegrating faster 55.51 seconds compared with the wet granulation method. Statistical test using independent sample T test showed that there were significant differences in the disintegration time (P <0.05) between the formula with the method of direct compression and wet granulation
The Effect of Ethanolic Extract of Vernonia amygdalina, Del Leaves on Serum Creatinin Level of Male White Mice
No full textDaun Vernonia amygdalina yang dikenal sebagai daun Afrika Selatan digunakan sebagai obat-obatan tradisional untuk mengobati diabetes, demam, hipertensi dan asam urat. Penelitan tentang efek ekstrak etanol daun ini terhadap kadar kreatinin dalam serum mencit putih jantan telah dilakukan. Dua puluh ekor mencit putih jantan dikelompokkan ke dalam empat kelompok yaitu satu kelompok kontrol dan tiga kelompok hewan uji (A, B, C) yang diberikan ekstrak etanol dengan dosis 100 mg/kg BB, 200 mg/kgBB dan 400 mg/kgBB. Kelompok uji diberikan ekstrak secara oral selama 21 hari. Leher mencit dipotong dan darah dikumpulkan pada hari ke 7, 14 dan 21. Kadar kreatinin dalam serum darah diukur menggunakan Spektrofotometer UV-Visibel pada panjang gelombang 492 nm. Hasil menunjukkan bahwa semua dosis sampel uji memberikan perbedaan yang signifikan terhadap kadar kreatinin dalam serum darah (p<0,05). Ekstrak etanol dengan dosis 400 mg/kgBB menunjukkan dosis paling efektif menurunkan kadar kreatinin dalam serum darah.Vernonia amygdalina, Del leaves which are locally known as Afrika Selatan leaves used as traditional medicine for diabetes, fever, hypertension and uric acid. A study on the effect of their ethanolic extract on serum creatinin level of male white mice has been done. A twenty of male white mice were divided into four groups which were control group and three test group (A, B, C) which given extract with dose 100 mg/kg BW, 200 mg/kgBW and 400 mg/kgBW respectively. Test group were given extract orally for 21 days. The mice neck was cut and their blood collected at 7th, 14th and 21st day. The serum creatinin level was measured by using spectrophotometer UV-Visible at 492 nm. The result showed all doses of ethanolic extract gave statistically difference on the serum creatinin level (p<0.05). The doses at 400 mg/kgBW showed the most effective in reducing serum creatinin level
Formulasi Pasta Gigi Gel Ekstrak Etanol Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.)
No full textDental caries is a disease of tooth decay that starts from the surface and evolve in the direction of the tooth, beginning with the process of tooth demineralization. Tooth decay is usually caused by the bacterium Streptococcus mutans. Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) has antibacterial activity due to its compound i.e. flavonoid, fenol, triterpenoid, dan antrakuinon. This study aims to formulate the bawang dayak ethanol extract into a stable gel toothpaste. Bawang dayak ethanol extract 2,5% was formulated in 5 formulas with varying degree of sorbitol (5 - 50%) and carboxymethyl cellulose (3 - 7%). Physical stability of bawang dayak ethanol extract gel toothpastes were evaluated including organoleptic and homogeneity test, pH measurement, viscosity measurement, spreading test, and freeze-thaw cycling test. The result showed bawang dayak ethanol extract gel toothpastes have pH range of 5.50 - 5.80, spreading area 4.61 - 5.82, viscosity value 17066 - 99877 mPas. Organoleptic and homogeneity in 7 days showed two layers color of gel toothpaste. Consistency test and Freeze-thaw cycling test results showed no change in organoleptic, homogeneity, pH, and viscosity of gel toothpastes.Karies gigi adalah suatu kerusakan gigi yang dimulai dari permukaan dan berkembang ke arah dalam pada gigi, diawali dengan proses demineralisasi gigi. Karies gigi biasanya disebabkan oleh bakteri streptococcus mutans. Bawang dayak (Eleutherine bulbosa (Mill.) Urb) dapat menghambat pertumbuhan bakteri karena mengandung metabolit sekunder seperti flavonoid, fenol, triterpenoid, dan antrakuinon. Penelitian ini bertujuan memformulasikan ekstrak etanol bawang dayak (Eleutherine bulbosa) ke dalam bentuk sediaan pasta gigi gel. Ekstrak bawang tiwai dengan konsentrasi 2,5% diformulasi menjadi pasta gigi gel dengan variasi sorbitol 5% - 50% dan CMC 3% - 7%. Evaluasi yang dilakukan meliputi organoleptis, homogenitas, pH, viskositas, daya sebar dan freeze-thaw cycling test. Hasil pengamatan organoleptik menunjukan adanya perubahan warna pasta gigi gel menjadi terbentuk 2 lapisan gel. Rentang pH pasta gigi gel 5,50 - 5,80, rentang uji daya sebar 4,61 – 5,82 cm, rentang viskositas 17066 - 99877 mPas. Hasil sentrifugasi dan cycling test menunjukkan tidak terjadi perubahan organoleptis, homogenitas, pH, dan viskositas pasta gigi gel
Antidiabetes dari Fraksi Air Daun Karamunting (Rhodomyrtus tomentosa (Ait.) Hassk.) Terhadap Kadar Glukosa Darah Mencit Diabetes
No full textKaramunting is one of the plants used in traditional medicine of diabetes mellitus. The antidiabetic effect of aqueous fraction of Rhodomyrtus tomentosa (Ait.) Hassk leaves has been investigated on male white mice that were induced with alloxan dose 200 mg/kgBW intraperitoneally. The fraction was given orally at dose 10, 20, 40 mg/KgBW for 15 days. Parameters that were measured are decrease concentration of blood glucose, body weight, urin output and water intake. Result showed that the aqueous fraction of Rhodomyrtus tomentosa (Ait.) Hassk leaves at dose 10, 20, 40 mg/KgBW has effect on decreasing blood glucose level on diabetic mice induced alloxan (P<0.05). This fraction also improved body weight, urine output dan reduced water intake (P<0.05).Karamunting salah satu tumbuhan yang digunakan sebagai obat tradisional penyakit diabetes mellitus. Penelitian telah dilakukan terhadap uji efek antidiabetes fraksi air daun karamunting (Rhodomyrtus tomentosa (Ait.) Hassk.) pada mencit putih jantan diabetes yang diinduksi dengan aloksan dosis 200 mg/kgBB secara intraperitonial. Fraksi air diberikan secara oral dengan dosis 10, 20 dan 40 ml/kgBB selama 15 hari. Parameter yang diukur adalah kadar glukosa darah, berat badan, volume urin, dan volume air minum. Hasil penelitian menunjukkan bahwa fraksi air daun Rhodomyrtus tomentosa (Ait.) Hassk oral dengan dosis 10, 20 dan 40 mg/kgBB mampu menurunkan kadar glukosa darah mencit diabetes yang diinduksi aloksan secara bermakna (P<0,05), dapat memperbaiki berat badan, volume urin, dan konsumsi air minum mencit diabetes (P<0,05)
Kajian Penggunaan Antibiotik pada Pasien Sepsis dengan Gangguan Ginjal
No full textProspective observational study was conducted to investigate antibiotic using, by evaluating clinical pharmacokinetic and antibiotic quality on septic patient with kidney disorder in Interne Department at Hospital X. Septic patients with kidney disorder treated with antibiotic for 4 months. The evaluated antibiotic are excreted by kidney mainly. The clinical aspects of evaluation are kinds of antibiotic, dosage, frequency, period of treatment, and clinical drug interaction. The evaluation of antibiotic quality used Gyssens method. Total respondens were 40 patients, treated with 8 kinds of antibiotic. Among 8 of them, there were 5 antibiotic which were excreted mainly by kidney. From five antibiotics, it was found that the accurate dosage adjustment on 29 patients (74,3%), and unproperly adjustment in 10 patients (10,25%) that adjust upper individual dosage that calculate pharmacokinetically. There were five interactions that clinically significant. The evaluation of antibiotic using qualitatively by Gyssens method found that 4 patients (10%) as incomplete therapy/VI category, two patients (5%) were ineffective category IVa, 1 patient (2,5%) as unsafe category IVb, 9 patients (22,5%) as inappropriate dosage adjustment, and 23 patients (57,5%) as appropriate antibiotic category 0. Conclusion: Using antibiotic that mainly excreted by kidney in septic patients with kidney disorder, generally doesn’t show bad impact in kidney of patient.Telah dilakukan kajian observasional secara prospektif terhadap penggunaan antibiotik meliputi aspek farmakokinetika klinik dan kualitas antibiotik secara kualitatif pada pasien sepsis dengan gangguan ginjal di Rawat Inap Penyakit Dalam Rumah Sakit X. Pasien sepsis dengan gangguan ginjal ini diterapi dengan antibiotik selama 4 bulan. Antibiotik yang dievaluasi adalah yang ekskresi utamanya di ginjal meliputi jenis antibiotik, dosis, frekwensi, lama penggunaan, dan interaksi yang bermakna klinis. Evaluasi antibiotik secara kualitatif menggunakan metode Gyssens. Total pasien berjumlah 40 orang, diterapi dengan 8 jenis antibiotik dan diantaranya ada 5 antibiotik diekskresi utama melalui ginjal. Dari 5 jenis tersebut, ditemukan penyesuaian dosis dengan tepat pada (n=29;74,3%) dan penyesuaian dosis yang tidak tepat (n=10;25,7%) yang melebihi dosis individual yang dihitung secara farmakokinetik. Terdapat 5 jenis interaksi yang bermakna secara klinik. Evaluasi pemakaian antibiotik secara kualitatif dengan metode Gyssens, diperoleh kategori pasien tidak lengkap/VI (N=4; 10%), kategori tidak efektif/IVa (n=2; 5%), kategori tidak aman/IVb (n=1; 2,5%), kategori spektrum tidak sempit/IVd (n=1; 2,5%), kategori dosis tidak tepat/IIa (n=9; 22,5%), dan kategori bijak/tepat/0 (n=23; 57,5%). Dari penelitian ini dapat disimpulkan bahwa secara umum penggunaan antibiotik yang diekskresikan sebagian besar melalui ginjal tidak memperlihatkan dampak yang buruk pada fungsi ginjal pasien.ABSTRACT: Prospective observational study was conducted to investigate antibiotic using, by evaluating clinical pharmacokinetic and antibiotic quality on septic patient with kidney disorder in Interne Department at Hospital X. Septic patients with kidney disorder treated with antibiotic for 4 months. The evaluated antibiotic are excreted by kidney mainly. The clinical aspects of evaluation are kinds of antibiotic, dosage, frequency, period of treatment, and clinical drug interaction. The evaluation of antibiotic quality used Gyssens method. Total respondens were 40 patients, treated with 8 kinds of antibiotic. Among 8 of them, there were 5 antibiotic which were excreted mainly by kidney. From five antibiotics, it was found that the accurate dosage adjustment on 29 patients (74,3%), and unproperly adjustment in 10 patients (10,25%) that adjust upper individual dosage that calculate pharmacokinetically. There were five interactions that clinically significant. The evaluation of antibiotic using qualitatively by Gyssens method found that 4 patients (10%) as incomplete therapy/VI category, two patients (5%) were ineffective category IVa, 1 patient (2,5%) as unsafe category IVb, 9 patients (22,5%) as inappropriate dosage adjustment, and 23 patients (57,5%) as appropriate antibiotic category 0. Conclusion: Using antibiotic that mainly excreted by kidney in septic patients with kidney disorder, generally doesn’t show bad impact in kidney of patient.
Potential of Red Spinach Leaves Ethanolic Extract (Amaranthus tricolor L.) as a Complementary Therapy For Hiperlipidemia: Study in Vivo of Histopathologic and Activity of Alanin Aminotransferase (ALT)
No full textThis study was conducted to determine the potential of ethanolic extract of red spinach leaves (Amaranthus tricolor L.) with control quality as a complementary treatment of hyperlipidemic based on histopathology and activity of alanin aminotrasferase (ALT). A total of 24 male Wistar rats were randomized in 6 groups: normal group; positive control group were given the drug simvastatin; negative control group; 1st treatment group was given extract at dose of 400mg/kgBW rat, 2nd group was given extract at dose of 400mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat; 3rd treatment groups were given extract at dose of 800mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat. Induction hyperlipidemic using high fat diet and poloxamer. The data obtained were tested normality with the Shapiro-Wilk test. Statistical analysis using Oneway ANOVA and Post-Hoc Tukey HSD to determine the significance of differences between groups for ALT parameter. Result show the use of ethanolic extract of red spinach leaves can reduce fatty liver condition based on decreased level of ALT and liver histopathologic. It is concluded that the ethanolic extract of red spinach leaves dose 400mg/kgBW rat combine with simvastatin can reduce activity of ALT until 31.57 U1-1.This study was conducted to determine the potential of ethanolic extract of red spinach leaves (Amaranthus tricolor L.) with control quality as a complementary treatment of hyperlipidemic based on histopathology and activity of alanin aminotrasferase (ALT). A total of 24 male Wistar rats were randomized in 6 groups: normal group; positive control group were given the drug simvastatin; negative control group; 1st treatment group was given extract at dose of 400mg/kgBW rat, 2nd group was given extract at dose of 400mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat; 3rd treatment groups were given extract at dose of 800mg/kgBW rat and simvastatin dose 0.18 mg/kgBW rat. Induction hyperlipidemic using high fat diet and poloxamer. The data obtained were tested normality with the Shapiro-Wilk test. Statistical analysis using Oneway ANOVA and Post-Hoc Tukey HSD to determine the significance of differences between groups for ALT parameter. Result show the use of ethanolic extract of red spinach leaves can reduce fatty liver condition based on decreased level of ALT and liver histopathologic. It is concluded that the ethanolic extract of red spinach leaves dose 400mg/kgBW rat combine with simvastatin can reduce activity of ALT until 31.57 U1-1
Pengembangan dan Validasi Metode KLT-Densitometri untuk Analisis secara simultan Parasetamol, Asam Mefenamat dan Ibuprofen dalam Jamu “Pegel Linu”
No full textJamu is a traditional or herbal medicine that is widely used by Indonesian people for prevention, maintenance and treatment of diseases. Traditional medicines contain plants or extracted plant material, or combinations thereof. The adulteration practice violates the laws. However, the presence of undeclare synthetic chemical drugs in the herbal products are still often found, among others, analgesic and anti-inflammatory drugs. The purpose of this study is to obtain a validated, simpler and lower operational cost of TLC-densitometric method to analyze paracetamol, mefenamic acid and ibuprofen in herbal medicines in “pegel linu” herbal medicines. The samples were extracted with ethanol, then separated over silica gel GF254 TLC plate with mixture of chloroform-ethanol (8:1) as mobile phase and analyzed using TLC-densitometry. The method has a satisfactorily specificity and linearity, and met the precision and accuracy criteria at the concentration of 1500 ng/spot for paracetamol, 1250 ng/spot for mefenamic acid, and 2000 ng/spot for ibuprofen. The results of the determination of eight samples showed that four of them were positive containing paracetamol with the concentration of 337.12 - 505.55 mg/single dosage.Jamu merupakan obat tradisional yang banyak digunakan oleh masyarakat Indonesia untuk pencegahan, pemeliharan dan pengobatan penyakit. Obat tradisional mengandung bahan tumbuhan atau hasil sarian atau campurannya. Praktek penambahan bahan kimia obat (BKO) adalah perbuatan melawan hukum. Namun masih banyak ditemukan BKO dalam produk jamu, antara lain obat analgetika dan anti inflamasi. Penelitian ini bertujuan memperoleh metode KLT-densitometri yang tervalidasi, lebih sederhana dan lebih rendah biaya pelaksanaannya untuk menganalisis parasetamol, asam mefenamat dan ibuprofen dalam jamu “pegel linu”. Sampel diekstraksi dengan etanol, kemudian dipisahkan di atas lempeng KLT silika gel GF254 dengan fase gerak campuran kloroform-etanol (8:1) dan dianalisis dengan menggunakan KLT-densitometri. Metode mempunyai spesifisitas, dan linieritas yang memuaskan, dan memenuhi kriteria presisi dan akurasi pada konsentrasi 1500 ng/bercak untuk parasetamol, 1250 ng/bercak untuk asam mefenamat, dan 2000 ng/bercak untuk ibuprofen. Hasil analisis delapan sampel menunjukkan empat diantaranya positif mengandung parasetamol dengan kandungan 337,12-505,55 mg/dosis tunggal pemakaian.
Perbandingan Dosis Warfarin terhadap Durasi Tercapainya Target INR pada Pasien CHF dengan Fibrilasi Atrial
No full textA study of comparison between warfarin dose with achieving target INR in patients with CHF and atrial fibrillation at RSUP. DR. M. Djamil Padang has been investigated. This study analyzed using one-way ANOVA and if the result is significant then followed by post hoc test. Of the total 27 patients, all the patients suffering from CHF and 11 patients suffering from hypertension. There were 15 patients aged <60 years, 11 patients aged between 60-74 years, and 1 patient aged ≥75 years. The number male and female patients are 11 and 16 people. The mean duration of achieving the target INR at dose 2 mg, dose (2 mg and 4 mg) and dose 5 mg are 38.22, 29.33, and 6.56 days. There is a significant difference in the mean duration of achieving the target INR in the dose group. 5 mg dose had a mean duration of achieving the target INR which significantly different compared to the other doses. A study of comparison betweenwarfarin dose with achieving target INR in patients with CHF and atrial fibrillation at RSUP. DR. M. Djamil Padang has been investigated. This study analyzed using one-way ANOVA and if the result is significant then followed by post hoc test. Of the total 27 patients,all the patients suffering fromCHF and11 patients suffering from hypertension. There were 15 patients aged <60 years, 11 patients aged between 60-74 years, and 1 patient aged ≥75 years. The number male and female patients are11 and 16 people. The mean duration of achieving the target INR at dose 2 mg, dose (2 mg and 4 mg) and dose 5 mg are 38.22, 29.33, and 6.56 days. There is a significant difference in the mean duration of achieving the target INR in the dose group. 5 mg dose had a mean duration of achieving the target INRwhich significantly different compared to the other doses.Telah dilakukan penelitian mengenai perbandingan dosis warfarin terhadap durasi tercapainya target INR pada pasien CHF dengan fibrilasi atrial di RSUP DR. M. Djamil Padang. Penelitian ini dianalisis menggunakan metode anova satu arah yang jika bermakna dilanjutkan dengan uji post hoc. Dari total 27 pasien, seluruhnya menderita penyakit CHF dan 11 orang menderita hipertensi. Pasien dengan umur <60 tahun sebanyak 15 orang, 60-74 tahun sebanyak 11 orang, dan ≥75 tahun sebanyak 1 orang. Pasien berjenis kelamin laki-laki dan perempuan masing-masing berjumlah 11 dan 16 orang. Rata-rata durasi tercapainya target INR pada dosis 2 mg adalah 38,22 hari; dosis (2 mg dan 4 mg) adalah 29,33 hari; dan dosis 5 mg adalah 6,56 hari. Terdapat perbedaan rerata durasi tercapainya target INR secara bermakna pada kelompok dosis. Dosis 5 mg memiliki rerata durasi tercapainya target INR yang berbeda signifikan dibandingkan dengan dosis lainnya
Pengaruh Kehadiran Apoteker Terhadap Pelayanan Kefarmasian di Apotek di Kota Padang
No full textStandard pharmacy services is measure used especially in implementing pharmacist pharmacy services. This study examines effect of presence of Pharmacists to pharmacy services, is crosssectional study using questionnaires in February - August2015. The research sample 90 Pharmacists in pharmacies taken random. results Showed the percentage of the presence of the pharmacist in the pharmacy Padang city 58.67% and Pharmaceutical Services Categorized less (inspection recipe 57.06%, 55.12% prescription preparation, and delivery prescriptions 51.89%) with average percentage 54,69%. Linear regression analysis of test results can be known effect X on Y positive. Testing shows the product moment correlation coefficient X to Y Strong where: r=0.910, in testing the coefficient of determination shows X higher influence on Y equal to 82.8% and 17.2% influenced other factors. Based on the F test 422,579 with significance of 0.000. Due significant levels <0.05, can concluded that the presence of Pharmacists have influence on Pharmaceutical Services.Standar pelayanan kefarmasian merupakan tolok ukur yang digunakan khususnya apoteker dalam melaksanakan pelayanan kefarmasian. Penelitian ini bertujuan melihat pengaruh kehadiran apoteker terhadap pelayanan kefarmasian, bersifat cross sectional menggunakan kuisioner bulan Febuari – Agustus 2015. Sampel penelitian 90 apoteker di Apotek diambil secara random. Hasil penelitian menunjukkan bahwa Persentase kehadiran apoteker di apotek kota Padang sebesar 58,67% dan Pelayanan Kefarmasian dikategorikan kurang (pemeriksaan resep 57,06%, penyiapan resep 55,12%, dan penyerahan resep 51,89%) dengan persentase rata-rata 54,69%. Hasil pengujian analisis regresi linear dapat diketahui pengaruh X terhadap Y positif. Pengujian Koefisien Product moment menunjukkan hubungan X terhadap Y kuat dimana : r=0,910, dalam pengujian koefisen determinasi menunjukkan bahwa X mempunyai pengaruh tinggi terhadap Y yaitu sebesar 82,8% dan 17,2% dipengaruhi oleh faktor lain. Berdasarkan tabel uji F test sebesar 422.579 dengan signifikansi 0,000. Karena tingkat signifikan < 0,05, maka dapat disimpulkan bahwa variabel Kehadiran Apoteker mempunyai pengaruh terhadap Pelayanan Kefarmasian
Pola Penggunaan Antibiotik Profilaksis pada Pasien Bedah Caesar (Sectio Caesarea) di Rumah Sakit Pekanbaru Medical Center (PMC) Tahun 2014
No full textThe research has been done on the use of prophylactic antibiotics in caesarean section at Pekanbaru Medical Center (PMC) hospital in 2014. The aim of this study was to overview the use of prophylactic antibiotics caesarean section. Type of research was an observational study designed a descriptive by conducting a review of the medical records of patients that using prophylactic antibiotics in cesarean section during Januari until December 2014. The samples used were 73 patients who met the inclusion criteria with purposive sampling. The results of this study suggest that the use of prophylactic antibiotics in cesarean section at Pekanbaru Medical Center hospital is a single-dose Ceftriaxone 1g (58.9%) and a combination of gentamicin (80 mg) with Ceftriaxone (1g) (41.1%), where all the form generic drugs (100%) with the time of prophylactic antibiotics for the majority that is 0-2 hours before surgery (100%) with the intravenous route (100%).Telah dilakukan penelitian pola penggunaan antibiotik profilaksis pada pasien bedah caesar (Seksio Sesare) di Rumah Sakit Pekanbaru Medical Center (PMC) tahun 2014. Tujuan penelitian ini untuk mengetahui pola penggunaan antibiotik profilaksis bedah sesar. Jenis penelitian yang dilakukan adalah penelitian observasional yang dirancang dengan studi deskriptif dengan cara melakukan kajian terhadap rekam medis pasien yang menggunakan antibiotik profilaksis pada bedah sesar selama bulan Januari sampai dengan bulan Desember 2014. Sampel yang digunakan adalah 73 pasien yang memenuhi kriteria inklusi dengan teknik purposive sampling. Hasil penelitian ini menyatakan bahwa penggunaan antibiotik profilaksis bedah sesar di Rumah Sakit Pekanbaru Medical Center adalah Seftriakson tunggal dengan dosis 1g (58,9%) dan kombinasi Gentamisin (80 mg) dengan Seftriakson (1g) (41,1%), dimana semuanya dalam bentuk obat generik (100%) dengan waktu pemberian antibiotik 0-2 jam sebelum operasi (100%) dengan rute pemberian secara intravena (100%)