JSFK (Jurnal Sains Farmasi & Klinis)
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Efek Ekstrak Etanol Kulit Batang Sirsak Terhadap Penurunan Kadar Gula Darah dan Kolesterol
No full textThis study aims to determine effect of the ethanolic extract of soursop stembarks in the increasing of blood glucose and cholesterol levels. Maceration technique has been used to extract the soursop stembarks with ethanol 96% as a solvent extraction. Furthermore, the ethanolic extract of soursop stembarks was prepared in a suspension form with Na CMC 0.5 % as a suspending agent. The suspension was administered orally at dose of 50, 100, 300, 1000 mg/kg BW daily to white male mice for seven days. The level of blood sugar and cholesterol were measured at 8th day using digital tools Nesco®Multicheck. The result showed that the blood glucose level in mice at dose of 50, 100, 300, 1000 mg/KgBW were 123.25, 129.75, 132.25, 121.25 mg/dl. The cholesterol level mice at dose of 50, 100. 300, 1000 mg/kg BW were 156.5, 118.5, 149.75, 156.75 mg/dl respectively. Biostatistically, the ethanolic extract of soursop stembark showed the decreasing of cholesterol level significantly (p 0.05).Penelitian ini bertujuan untuk mengetahui efek ekstrak etanol kulit batang sirsak dalam menurunkan kadar glukosa darah dan kolesterol. Pengekstrakan kulit batang sirsak dilakukan dengan metoda maserasi menggunakan etanol 96%. Selanjutnya ekstrak etanol kulit batang sirsak dibuat dalam bentuk suspensi menggunakan Na CMC 0,5% dan diberikan kepada mencit putih jantan secara oral satu kali sehari selama 7 hari dengan dosis 50, 100, 300, 1000 mg/kg BB. Kadar gula darah dan kolesterol diukur pada hari ke delapan menggunakan alat digital Nesco®Multicheck. Hasil penelitian memperlihatkan kadar glukosa darah mencit putih jantan pada kelompok dosis ekstrak 50, 100, 300, 1000 mg/kg BB adalah 123,25, 129,75, 132,25, 121,25 mg/dl. Kadar kolesterol darah rata-rata mencit putih jantan pada kelompok dosis ekstrak 50, 100, 300, 1000 mg/kg BB adalah 156,5, 118,5, 149,75, 156,75 mg/dl. Analisa statistik menunjukkan bahwa pemberian ekstrak etanol kulit batang sirsak berpengaruh signifikan terhadap penurunan kadar kolesterol (p0,05)
Karakterisasi Fisikokimia Sistem Biner Siprofloksasin HCl – PEG 4000
No full text"Physicochemical Characterization of Binary Systems Ciprofloxacin HCl - PEG 4000" has been reseach. This study aimed to characterize ciprofloxacin HCl formula that was developed to 9, with a comparison between ciprofloxacin - PEG 4000 following formula I (1: 9), formula II (2: 8), formula III (3: 7), formula IV (4: 6), formula V (5: 5), formula VI (6: 4), formula VII (7: 3), formula VIII (8: 2) and formula IX (9: 1). Binary system made by the manufacture of solid dispersion by melting method. The results of the binary System were characterized by analysis Differential Thermal Analysis (DTA), X-ray diffraction, IR spectrophotometry, and Scanning Electron Microscope (SEM). The results of this analysis have results of the binary solid dispersion systems a good formula this VII.Telah dilakukan penelitian dengan judul "Karakterisasi Fisikokimia Sistem Biner Siprofloksasin HCl – PEG 4000". Penelitian ini bertujuan untuk mengkarakterisasi siprofloksasin HCl yang dikembangkan menjadi 9 formula, dengan perbandingan antara siprofloksasin – PEG 4000 sebagai berikut formula I (1 : 9), formula II (2 : 8), dan formula III (3 : 7), formula IV (4 : 6), formula V (5 : 5), formula VI (6 : 4), formula VII (7 : 3), formula VIII (8 : 2) dan formula IX (9 : 1). Sistem biner dibuat dengan cara pembuatan disperi padat dengan metoda peleburan. Hasil sistem biner ini dikarakterisasi dengan analisa Differensial Thermal Analysis (DTA), Difraksi Sinar X, Spektrofotometri Infra Red dan Scanning Electron Microscope (SEM). Hasil analisa tersebut menunjukkan bahwa sistem biner dispersi padat yang paling baik terdapat pada formula VII
An Assay of Antioxidant Power of Methanolic Extract Various Type of Soybean
No full textThis study aimed to examine the antioxidant activity of methanolic extract of various type of soybean (Glycine max L.Merill) i.e Argomulyo, Burangrang, Ijen, and Kaba by using DPPH (1,1-Diphenyl-2-picryhydrazyl) method. The soybean was crushed, defatted using n-hexan, and extracted using methanol 90%. The processes of defatting and extracting were conducted by kinesthetic maceration. Identification of flavonoid content using KLT and an assay of the antioxidant power of soybean were carried out qualitatively and quantitavely. Qualitative analysis, the color of DPPH solution was fading from violet into yellowish. Quantitative analysis showed that the maximum wave-length of DPPH in methanol was 516,00 nm within 15-minute reaction time. The effective concentration 50% (EC50) of each extract was alsa determined. Results of this study revealed that the methanolic extract of soybean taken from varieties of Argomulyo, Burangrang, Ijen, and Kaba contained flavonoid, with EC50 value of each variety subsequently ranging from 3620.22 bpj; 5290.71 bpj; 4145.99 bpj; and 4253.50 bpj. Argomulyo variety showed the highest antioxidant power
Protection Effect of Ethyl Acetate Fraction of Toona sureni (Blume) Merr. Against Atherosclerosis
No full textStudi tentang efek proteksi fraksi etil asetat daun surian (Toona sureni (Blume) Merr.) terhadap aterosklerosis pada burung puyuh hiperkolesterol sudah dilakukan. Metoda yang digunakan adalah metoda hispatologi. Hiperkolesterol di induksi dengan pemberian makanan lemak tinggi (MLT) dan profil tio urasil (PTU). Parameter yang diamati adalah adanya perbaikan tebal dinding pembuluh darah aorta, perubahan luas lumen aorta dan keadaan sel endothelia. Hasil penelitian menunjukan pemberian fraksi etil asetat daun surian dosis 50 mg/ kgBB memberikan efek proteksi yang terbaik, ditandai dengan tebal dinding pembuluh darah aorta, luas lumen dan tingkat kerusakan sel endotelia aorta tidak berbeda nyata dengan kontrol negatif (p>0,05) dan berbeda nyata dengan hewan kelompok positif (p0.05), but significantly different with positive control group (p<0.05)
Efek Analgetik Ekstrak Etanol Daun Tampa Badak (Voacanga foetida (Bl.) K. Schum) Pada Mencit Putih Jantan
No full textA study on the analgesic activity ethanolic extract of Voacanga foetida leaves has been conducted on male mice by using Writhing test. The mice were induced with 0.1 mL of glacial acetic acid 1%. The extract was administered orally in the doses of 250, 500, and 1000 mg/kg, suspended with NaCMC 1%, while 65 mg/kg acetosal was used as positive control. The data was analyzed with two way ANOVA. The study revealed that the extract exhibited analgesic effect insignificantly different with acetosal at the doses of 250, 500, and 1000 mg/kg. This effect was different with negative control (p<0.05).Telah dilakukan penelitian tentang uji efek analgetik ekstrak etanol daun tampa badak (Voacanga foetida (BI.) K. Schum) pada mencit putih (Mus musculus) jantan, menggunakan Metoda Writhing Test. Sebagai kontrol positif digunakan asetosal 65 mg/kgBB yang diinduksi dengan asam asetat glasial 1% sebanyak 0,1 mL. Rute pemberian ekstrak etanol daun tampa badak secara oral dengan dosis 250, 500 dan 1000 mg/kgBB, yang disuspensi dengan NaCMC 1%. Data yang diperoleh diolah dengan menggunakan Analysis Of Varian (ANOVA) dua arah. Hasil penelitian menunjukkan bahwa ekstrak etanol daun tampa badak mempunyai efek sebagai analgetik yang sama dengan asetosal (kontrol positif) pada dosis 250, 500 dan 1000 mg/kgBB dan berbeda secara nyata dengan kontrol negatif (p<0,05)