Jurnal Gizi dan Pangan
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Torbangun Leaves (Coleus amboinicus Lour) Powder Capsules Supplementation Improve Lipid Profile and Blood Pressure in Men with Hypercholesterol
Get PDFThe aim of this study was to analyze the effect of torbangun leaves powder capsules supplementation on lipid profile and blood pressure in men with hypercholesterol. This study was a single blind randomized control trial design with 26 male subjects. The inclusion criterias for subject were adults (age 25-55 years), blood total cholesterol levels ≥200 mg/dl, and signed the informed consent. Subjects were divided into two groups of one intervention (torbangun capsules) and one control (amylum) group. The intervention of 750 mg/day torbangun powder for the intervention group and 300 mg/day amylum for control group were administered for 28 days. The analysis of lipid profile results showed that the trygliseride, LDL, and HDL were not significantly affected by the torbangun intervention but it significantly decreased the total cholesterol level. The supplementation of torbangun capsules also decreased the sistolic blood pressure significantly. but not in diastolic pressure
Aktivitas antihiperglikemia ekstrak kulit dan daun surian (Toona sinensis) pada tikus diabetes (Sprague-dawley) yang diinduksi streptozotocin
Get PDFThis study aimed to examine the antihyperglycemia activity of ethanol extract of 70% on surian bark and leaves on diabetic rats induced with streptozotocin based on body weight, and fasting blood glucose level. Consist of 28 rats are grouped into 7 groups namely normal, negative control, positive control which given glybenclamide with a dose of 3.22 mg/kg bw, bark extract with dose of 150 mg/kg bw, bark extract with a dose of 300 mg/kg bw, leaf extract with dose 150 mg/kg bw and leaf extract with dose 300 mg/kg bw. Diabetogenic mechanisms was conducted with intraperitoneal injection of streptozotocin at dose of 50 mg / kg bw. This research was conducted experimentally using complete randomized design (RAL) to analyze the results obtained. Bark extract with a dose of 150 mg/kg bw had a better antihyperglycemia activity compared to the other groups which was showed by the decrease of blood glucose level percentage of 72.83% and this group also had ability to maintain body weight was better than the other groups as well as stable feed consumption during research process
Aktivitas antioksidan ekstrak sulur buah naga putih (Hylocereus undatus) dengan metode DPPH dan Rancimat
Get PDFThe objectives of this study were to analyze phytochemical components, to determine total phenol and flavonoid content, and to test the antioxidant activity of dragon fruit vine extract. The results of phytochemical analysis showed acetone and ethyl acetate extracts contain alkaloids, flavonoids and steroids, while methanol extracts contained alkaloids, flavonoids and triterpenoids. Total phenol and flavonoid content determination results showed the highest concentration in acetone extract of 460.01 GAE mg / 100 g sample and 229.27 RUE mg/100 g sample. Extract of dragon fruit vine has a potencial as antioxidant by inhibition of free radical of DPPH with best IC50 value on acetone extract 25.32 mg / L. The results of antioxidant testing in lipid system using rancimat method obtained the highest protection factor on methanol extract of 1.64
Potensi selada air (Nasturtium officinale R. Br) sebagai antioksidan dan agen anti proliferasi terhadap sel MCF-7 secara in vitro
Get PDFThis study aimed to determine the potential of watercress extract as an antioxidant and antiproliferation against cancer cells in vitro. Cells used in this study were breast cancer culture cells (MCF-7) and vero cells. Watercress was extracted using water solvent and 70% ethanol. Phytochemical test was performed on both types of extract. Toxicity test was measured using BSLT method, assessment of antioxidant activity was measured using DPPH method and inhibitory proliferation in cancer cell was measured using MTT Assay method. Analysis of the data using ANOVA, if there is a significant difference between treatments will be followed up with Duncan test. The results of phytochemical tests showed that watercress extracts had bioactive content namely flavonoids, tannins, saponins, and steroids. The result of BSLT test showed that the strongest extract toxicity was 70% ethanol extract with LC50 value of 406.02 ppm and had the highest antioxidant activity with IC50 value of 102.26 ppm, while proliferation inhibitory test found in MCF-7 breast cancer cells had IC50 value of 1.696 μg / ml and not toxic to vero cells. Result showed that the ethanolic extract of Nasturtium Officinale gave a significant effect on MCF-7 breast cancer cells inhibition (p=0,015) at concentration 50, 400, 800 and 1000 ppm. The mechanism of proliferative inhibition was associated with phytochemical content present in watercress.
Intervensi tahu ungu mampu memperbaiki profil lipid darah subjek penderita diabetes melitus tipe-2
Get PDFThis study aimed to determine the effect of purple tofu intervention made from black soybean seeds in improving blood lipid profile of diabetics. Intervention of purple tofu was performed for 28 days and 20 subjects selected purposively and divided into two groups, control and treated. Tofu was served in soup form as much as 85 g. Significant improvement was identified in blood lipid profile of subjects after intervention (p<0.05). Decreased lipid profile occurred in triglycerides, low density lipoprotein (LDL), total cholesterol, and high density lipoproteins (HDL) (175.60±72.61 mg/dl to 123.70±29.50 mg/dl; 133.76±47.00 mg/dl to 98.96±13.81 mg/dl; 207.00±52.26 mg/dl to 154.40±50.89 mg/dl; 48.90±3.24 mg/dl to 30.80±7.09 mg/dl, respectively). Overall, black soy improves blood lipid profile of type 2 diabetes mellitus subjects, involving decreased triglycerides, LDL, and total cholesterol levels, but has not been able to increase HDL levels
Risk Factors of Hypertension among Adult in Rural Indonesia
Get PDFThe aim of this study was to analyse the risk factors of hypertension among adult in rural Indonesia. This cross-sectional study included 112 married couples (112 men and 112 women) aged 45-59 years old and was conducted in Cianjur District, West Java, Indonesia. The measurement of body weight and fat composition used Bioelectrical Impedance Analysis (BIA) monitor (OMRON® Karada Scan Body Composition Monitor HBF-358-BW). Body height was measured by stadiometer, meanwhile waist circumference was measured by measuring tape. Data on the blood pressure measured by an automatic blood pressure monitor (OMRON® Automatic Blood Pressure Monitor Model HEM-7200). All measurement were done twice in repetition. Chi-square was used to analysed the association between variables and logistic regression was used to analyse the risk factors. The prevalence of hypertension was 49.1% (women 54.5%; men 43.7%). Women had a higher proportion of overweight, obesity, abdominal obesity, and hypertension stage 2 than men. BMI (p<0.05), waist circumference (p<0.05), total body fat (p<0.05), and visceral fat (p<0.05) were significantly higher in hypertension subject than not hypertension. Nonetheless, only waist circumference became the risk factor for hypertension (OR=4.005; 95%CI:1.47-10.914 for high risk). There is high prevalence of hypertension among adult in rural area. Adult, particularly women need to pay attention on their body fat to reduce the risk of hypertension
Teh putih (Camellia sinensis) dan kelor (Moringa oleifera) sebagai antihiperglikemia pada tikus Sprague dawley yang diinduksi streptozotocin
Get PDFThis study aims to examine the antihyperglycemic effect of white tea (Camellia sinensis) and Moringa oleifera when administered as a single component and as mixture in streptozotocin-induced diabetic rats. The study design was experimental. The first step was to analyze epigallocathecingallat (EGCG) content as standard with High Performance Liquid Chromatography (HPLC) method. The second step was intervention in Sprague dawley rats induced by streptozotocin 40 mg/kgBW. Intervention held for 21 days with given white tea (WT), M. oleifera (MO), mixture of white tea and M. oleifera (WT+MO) and green tea (GT) as positive control with reference dose 100 mg/kgBW EGCG. Rats blood glucose and body weight were measured. The results are WT having the highest content of EGCG (4.46%). MO and WT+MO only have 2.42% and 2.46% of EGCG while GT as control is the lowest (1.29%). Measurements of blood glucose and body weight in group that given WT or MO as single component showed no significant difference with control negative group (p>0.05). Blood glucose decreased significantly in group WT+MO (p<0.05). Administration of WT+MO was able to maintain a stable body weight during the intervention period (p>0.05). The combination of white tea and M. oleifera has better ability as an antihiperglycemic agent compared to single component
Potential of Bioactive Components in Tempe for the Treatment of Obesity
Get PDFObesity has become a global health issue and is one of the factors that trigger degenerative diseases. The correct food consumption management could be a solution for treating obesity. Soybean is a food that is rich in bioactive components and has antiobesity properties through various mechanisms. In Indonesia, nearly 60% of the soybeans are consumed in the form of tempe. The process of fermenting soybeans into tempe causes a bioconversion of nutrients and bioactive components, improving the active physiological abilities. The bioactive components that play a role in the treatment of obesity are isoflavones, proteins, and peptides. These bioactive components help in reducing body weight, lowering the body fat ratio and improve lipid profile. Thus, optimation and popularization of tempe as a functional food in the daily menu supported with correct tempe processing could be a solution in treating obesity
EFEK INTERVENSI BUAH TAKOKAK (Solanum torvum Swartz) TERHADAP KADAR SUPEROKSIDA DISMUTASE ERITROSIT DAN 8-ISOPROSTAN SERUM PADA WANITA DEWASA GEMUK
Get PDFThis study aimed to assess the effect of polyphenols in turkey berry fruits on level of antioxidant enzyme (erythrocyte superoxide dismutation [SOD]) and oxidative stress marker (serum 8-isoprostane) in obese adult women. The study was quasi experimental trial with cross-over design. Eight obese women subjects in Benteng Village-Ciampea, Bogor District, West Java were randomly assigned to a control group (n=4), and a turkey berry group (n=4) for 2 x 1 week daily treatment with a one week wash-out period between treatment periods. Turkey berry group consumed home diet and ±160 g of cooked turkey berry (as a side dish or snack) while the control group consumed only home diet. A food record consumption data was collected twice each week. Blood samples were obtained in the morning at day 1, 8, 15, and 22 of interventions and analyzed for the level of erythrocyte SOD and serum 8-isoprostane. The results showed that the different levels of erythrocyte SOD between post and pre intervention on turkey berry groups was not significantly different compared to the control group (p=0.607). Whereas, the different level of serum 8-isoprostane between post and pre intervention on turkey berry group in which decreasing was significantly different from the level on control group which was increasing (p<0.05). It seems that daily consumption of cooked turkey berry fruits can improve oxidative stress condition