Indo. J. Chem. Res.
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Acid and Base modified Pectin from Orange Peel as an Effective Bio-adsorbent for Pb(II) and Cr(VI) from Textile Industry Wastewater
Full text linkModifying the methoxyl group on pectin from Siam orange peel (Citrus nobilis) has been done. Pectin was obtained from the peel of Siam orange by extraction method. The modified pectin obtained were analyzed using the FT-IR (Fourier Transform-Infra Red Spectroscopy) method, the XRD (X-Ray Diffractometry), and surface appearance images using SEM (Scanning Electron Microscopy). Pb(II) and Cr(VI) metals which can be adsorbed by the adsorbent then analyzed by UV-Visible Spectrophotometer. The results of the FT-IR analysis was found that the modification of the methoxyl group was successful. XRD analysis showed that the modified pectin adsorbent produced amorphous properties. The maximum pH for Pb(II) adsorption was obtained, namely pH = 6 and the maximum pH for Cr(VI) adsorption was pH =7. The best adsorption time variation for Pb(II) was 240 min and for Cr(VI) was 500 min. The best adsorbent for adsorption of Pb(II) was base-modified pectin adsorbent, while the best adsorbent for adsorption of Cr(VI) was base-modified pectin adsorbent. It could be proven that base-modified pectin was able to adsorb Pb(II) and acid-modified pectin was able to absorb Cr(VI) better (Pb(II) 80% adsorption percentage and 90% Cr(VI) adsorption percentage) than previous studies, namely pectin without modification (adsorption percentage obtained 60-70%)
The Effect of Fermentation on the Characteristics and Antioxidant Activity of Wuluh Starfruit Leaf Kombucha Tea (Avverhoa bilimbi Linn.)
Full text linkKombucha is a fermented drink that provides health effects. Wuluh starfruit leaves are one of the ingredients that can be used in making kombucha. This study was conducted to determine the effect of fermentation time on the physical, chemical, and antioxidant characteristics of wuluh starfruit leaf kombucha tea (Avverhoa bilimbi Linn.). This research is an experimental study with a completely randomized design (CRD) consisting of 4 treatments. Kombucha wuluh starfruit leaves are made with a fermentation time of 0, 4 8, and 12 days. The physical characteristics tested include an organoleptic test of scent, color, and taste. The chemical characteristics tested include pH, levels of titrated acids (tta), phenolic, and alcohols. The antioxidant activity is known by determining the value of IC50. Organoleptic, pH, tat, and phenolic assessment data were statistically analyzed using Kruskal Wallis and Mann Whitney. Alcohol content and antioxidant activity were analyzed descriptively. The best result of physical, and chemical characteristics and antioxidant activity are on the 12th day of fermentation with a pH of 3, TTA 0.11 0.070%, phenolic 87.33 1.140 mg/ml GAE and alcohol of 0.41% with an IC50 value of 3.65 ppm
Synthesis of 2-Amino-3-cyanopyridine Derivatives and Investigation of Their Antibacterial and Antifungal Properties
Full text linkThe aim of this study was to examine of antibacterial and antifungal activity of 2-amino-3-cyanopyridine derivatives against some microorganisms. The investigated compounds 2, 4, 6 exhibit promising antibacterial and antifungal activities. The high biological activities of the indicated compounds can be probably caused by the simultaneous presence of bromine atoms, nitro and amino groups in the molecules
Formulation of Watermelon Rind (Citrullus vulgaris schard) and Secang (Caesalpinia sappan L.) Jam as Functional Food Rich in Antioxidants
Full text linkThe body's immune system is one of the natural defenses in the human body, functioning to ward off various diseases, including those that emerged after the Covid-19 pandemic. One plant with potential as an antioxidant and easily found in the environment is watermelon. Jam made from watermelon rind and secang wood, with various formulations, namely 100% watermelon rind: 0% secang (F1), 90% watermelon rind: 10% secang (F2), 80% watermelon rind: 2% secang (F3), and 70% watermelon rind: 3% secang (F4), is expected to possess good antioxidant properties. A promising antioxidant formulation for watermelon rind jam and secang is the one with 70% watermelon rind and 30% secang (F4), having an IC50 value of 144.27 g/mL, which is classified as a moderate antioxidant. Among the four jam formulations, panelists preferred the jam formulation (F4) without the addition of sweetened condensed milk in terms of color and texture. However, for the jam formulation (F4) with the addition of sweetened condensed milk, panelists favored it in terms of aroma and taste. The jam formulation (F4) meets the quality standards for fruit jam based on INS 3746:2008, including total plate count, arsenic, and tin categories
Utilization of Secang Wood Ethanol Extract (Caesalpinia sappan L.) as an Additional Ingredient Antiseptic Hand Cream Preparations Instead of Hand Sanitizer
Full text linkSecang wood is a plant used in medicine. This study aims to find out that ethanol extract of secang wood can be formulated into a hand cream preparation and to determine the antibacterial activity against Staphylococcus aureus as an antiseptic. This study used the maceration method to produce ethanol extract, then made a hand cream dosage formula using 2, 4, and 6% ethanol extract of secang wood. Then a physical quality evaluation is carried out including organoleptic testing, homogeneity testing, pH measurement, viscosity testing, and dispersion power. After that, an antiseptic test of Staphylococcus aureus is carried out. Based on research, the results show that hand cream preparations meet the standards. The anti-bacterial activity test of the hand cream extract of wood ethanol extract can inhibit the growth of Staphylococcus aureus with a concentration of 2, 4, and 6% respectively by 13.1; 13.9 and 14.8 mm fall into the category of inhibitory solid zones
Antibacterial Activity and Toxicity of Honey Derived from Bone, South Sulawesi, Indonesia
Full text linkHoney is a sweet substance produced by honey bees from the nectar of flowers or other parts of plants. Honey obtained from Bone, in South Sulawesi, has been extracted and tested for antibacterial activity and toxicity. Honey was macerated with methanol to obtain a crude extract. Methanol crude extract was then partitioned successively with n-hexane and ethyl acetate to obtain ethyl acetate and methanol fraction. Antibacterial activity test was performed by agar diffusion method against Escherichia coli and Staphylococcus aureus. Methanol extract, ethyl acetate fraction, and methanol fraction showed an inhibition zone against E. coli at 10.10, 10.05, and 8.40 mm, respectively with amoxicillin as a positive control (20.05 mm). Also against S. aureus, inhibition zone was obtained at 11.90, 9.30, 8.60, and 13.70 mm for methanol extract, ethyl acetate fraction, methanol fraction, and amoxicillin, respectively. The greatest inhibition zone was obtained from methanol extract against E. coli and S. aureus, both including the strong category. The LC50 value of methanol extract and methanol fraction was 273.57 µg/ml and 765.66 µg/ml, respectively, categorized as toxic against Artemia salina, while ethyl acetate fraction was not toxic
Bioprospective screening and characterization of isolates from Pterocarpus osun leaf and stem bark extracts
Full text linkAntimicrobial resistance (AMR) ranks among the top 10 world health challenges of the 21st century, predicted that it will cause approximately 10 million deaths in 2050. Therefore, more investigation into identifying new antibiotics from natural sources is inevitable. Compounds from the leaf and stem bark of Pterocarpus osun were isolated using column chromatography, screened for their bioactivities, and characterized using the FTIR spectroscopy method in the ongoing search for novel antimicrobial therapies. The isolates were tested for antibacterial and antifungal activities against eleven pathogenic organisms. The zones of inhibition ranged in diameter from 22 to 30 mm. The minimum inhibitory concentrations were determined. Thin-layer chromatography was used to determine the purity of the compounds, and their retention factor was calculated. This ranged between 0.2424 and 0.8151. The melting points of the compounds were also recorded, as are FTIR spectra ranging from 4000 to 400 cm-1. Some of the peaks recorded are typical of single bond (4000-25000 cm-1), double bond (2000-1500 cm-1) with confirmation in the fingerprint (1500-400 cm-1) region but none in the triple bond (2500-2000 cm-1) region of the spectra. The antimicrobial screening results show that the identified compounds can potentially lead to the discovery of novel antibiotic medications
Synthesis and Characterization of Silver Nanoparticles from the Leaf Stalk Extract of Moringa oleifera
Full text linkThe exploitation of plant extract as a reducing agent for synthetic silver nanoparticles has become the main focus of researchers. This study aimed to synthesize silver nanoparticles (AgNPs) from Moringa oleifera leaf stalk extract via bio-reduction. The AgNPs were characterized through ultraviolet-visible absorption spectroscopy (UV-Vis), Fourier transforms infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The research results indicated that an increase in the initial AgNO3 concentration and incubation time had affected the absorption pattern of the surface plasmon resonance (SPR) trend of AgNPs. The results of the functional group analysis revealed the formation of the ketone group (1741 cm-1), which was derived from hydroxyl groups (3415 cm-1). The crystal structure of AgNPs was characterized using XRD. The estimation of the crystal measurement based on the Debye-Scherer equation was 15.59 nm, which was estimated as having a cube crystal form
Antioxidant Activity of Ethanol and n-hexane Extracts of Javanese Bark (Lannea coromandelica) Using the DPPH Method
Full text linkJavanese bark (Lannea coromandelica) contains secondary metabolites of saponins, tannins, phenolics, and flavonoids. Flavonoids include aromatic compounds that are antioxidants. Antioxidants can inhibit the oxidation process that arises due to free radical reactions to form unreactive compounds. The active flavonoid compounds in counteracting free radicals are determined by the presence of the –OH (hydroxy) functional group. Flavonoid compounds that have antioxidant properties include catechins, flavones, flavanones, flavonols, chalcones, and isoflavones. This study aims to determine the antioxidant activity of ethanol extract and n-hexane bark of Javan bark (Lannea coromandelica) using the DPPH method. The method used is DPPH using UV-VIS spectrophotometry. Ethanol extract has an IC50 of 3.996 mg/L and has a strong antioxidant activity while the antioxidant activity of N-Hexan is obtained IC50 2193.043 mg/L. has weak antioxidants weak antioxidants
Phytochemical Tests and Antioxidant Activities of the Rhips Ginger (Zingiber Officinale Var Amarum.)
Full text linkGinger is a traditional plant that thrives and has essential functions, including an antioxidant. This study aimed to determine the phytochemical content and test the antioxidant activity of fresh white ginger and powdered ginger (Zingiber officinale var. Amarum.). Two methods are used in this research: the phytochemical test and the antioxidant activity test using DPPH. Phytochemical tests, such as flavonoid, phenolic, steroid, and saponin, were conducted qualitatively. The antioxidant activity test was carried out using a UV-Vis spectrophotometer. Fresh white ginger and powdered ginger were extracted using the maceration method with water solvent. The study results showed that the effects of fresh white ginger extract obtained a yield of 64.08%. Meanwhile, powdered ginger extract was 58.68%. Phytochemical test results of fresh white ginger extract and powdered ginger (commercial) showed positive results for flavonoid, phenolic, and saponin compounds while adverse effects for steroids. Antioxidant activity test on fresh white ginger extract with water solvent showed an IC50 value of 25.41 ppm. The powdered ginger extract (commercial) has an IC50 value of 36.70 ppm. The results showed fresh white ginger and powdered ginger had relatively high antioxidant activity