Matsumoto Dental University Repository
Not a member yet
2206 research outputs found
Sort by
シリコーンラバー応用スポーツマウスガードの基礎的研究─物性ならびに適合・吸水試験による評価─
Get PDF松本歯科大学大学院歯学独立研究科博士（歯学）学位申請論文application/pdfothe
スポーツマウスガードの新規材料に関する基礎的研究─シリコーンラバーのマイクロ波加硫による物性と結晶石英フィラーの配合─
Get PDF松本歯科大学大学院歯学独立研究科博士（歯学）学位申請論文application/pdfothe
高齢者における年齢，食物輸送時の粘性および二相性食物の咀嚼時の呼吸─嚥下機能の相互関係への影響
Get PDF松本歯科大学大学院歯学独立研究科博士（歯学）学位申請論文application/pdfothe
【骨リモデリングの制御機構】 第10章 オステオプロテゲリンによる骨リモデリング制御
Get PDFapplication/pdfオステオプロテゲリン(OPG)は、骨(オステオ)を護る(プロテクトする)という意味から命名されたサイトカインである。OPGは、破骨細胞分化因子であるRANKL分子のデコイ受容体として破骨細胞の分化と骨吸収機能を抑制する。骨組織においては、骨芽細胞および骨細胞がOPGの産生細胞であるが、近年、骨のリモデリングを制御する因子としてOPGが生体内において重要な役割を果たすことを示す実験結果が蓄積されてきた。journal articl
Notch as a Possible Cell Differentiation Factor in Pleomorphic Adenomas
Get PDF松本歯科大学博士（歯学）2015甲第183号application/pdfThe expression of Notch in 30 cases of pleomorphic adenoma was examined by immunohistochemistry.Comparing the results of our study with previous literatures, from the partial CK7 expression and substantial Notch expression in ductal epithelial cells as well as the Notch expression in solid tumor nests, it can be inferred that Notch is involved in cell differentiation. CK13 expression was observed in cells undergoing squamous metaplasia and Notch expression was seen in the nucleus of basal and squamous cells. The intense Notch expression in basal cells and weak expression in squamous cells suggests that Notch is involved in the differentiation from basal to squamous cell. Moreover, the loss of nuclear expression on the inner layer would signify that differentiation is about to end or has been terminated. Notch was expressed in the cytoplasm of cartilage cells and in the cell membrane of mucous cells but not in the nucleus indicating that differentiation has been concluded. Notch involvement is suspected in cell differentiation in areas showing ductal structures and squamous metaplasia. In summary, Notch is involved in cell differentiation of ductal cells in PA. Nuclear expression was shown in tumor cells in solid nests and surrounding structures. Moreover, Notch is expressed by basal cells undergoing squamous metaplasia suggesting the participation of Notch in cell differentiation in PA.doctoral thesi