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Purification and Partial Characterization of Leucine Aminopeptidase from Actinomyces viscosus
Get PDFapplication/pdfLeucine aminopeptidase was purified from cell-free extracts of Actinomyces viscosus ATCC 19246 and some properties were investigated. The enzyme had a molecular weight of 65,000 and its isoelectric point was 4.0. Optimum pH was found at 7.0. The enzyme was quite labile over 40℃. It was sensitive to inhibition by diisopropylfluorophosphate, phenylmethane sulfonylfluoride, or tosyl-L-lysine chloromethyl ketone. Inhibition by urea was also obvious and this inhibition was found to be irreversible. Ca^, Mg^, Mn^ or Co^ had no no effect on the activity. Leucine-P-nitroanilide was the most suitable substrate among the tested synthetic substrates.journal articl
カエル口腔反射の神経機構 : 1.閉口反射および舌反射でみられる単シナプス性反射
Get PDFapplication/pdfIn order to reveal neural mechanism of oral reflexes in the frog, we studied the reflex discharges of jaw-closing muscles or efferent nerves, and of the hypoglossal nerve elicited by electrical stimulation of the trigeminal, facial and glossopharyngeal nerves, and found that the main reflex discharges were sometimes preceded by a reflex discharge with short latency. Since the central delay of the reflex discharges with short latency, obtained by reducing conduction times in both the efferent and afferent nerves from the reflex latency, were less than 1 msec, the pathway of the reflex seemed to be monosynaptic. To make sure of this possibility, we studied unit discharges of trigeminal motoneurons by means of glass microelectrode recording, and found that some motoneurons elicit an action potential or an EPSP with short latency. These results indicate that some of the jaw-closing and tongue reflex pathways are monosynaptic.journal articl
Studies on Administration of Antibiotics in Children -Application of Persistant Cephalexin in Dentistry for Children
Get PDFapplication/pdf口腔内に急性化膿性炎症症状を呈していた小児患者48例に持続性セファレキシン(L-CEX)を投与し,その臨床成績を検討するとともに,彼らの母親に対しても「お薬についてのアンケート調査」を実施した.結果を要約すると下記のようであった.1.L-CEXの有効率は,採点法では3日連用で70.8%,5日連川で91.7%,主治医の主観的評価では93.7%と優れた効果があることが認められた.2.消炎酵素剤の併用により,著効例が増加する傾向が認められた.3.副作用については,軽度の下痢4例,鼻出血,嘔吐,腹部不快感各1例で,特に重篤なものはなく,投与を中止するにはいたらなかった.4.各種の口腔内化膿性疾患に対して,短期間に高い有効率を示した.安全性も比較的高いことから,この領域での第一選択剤として位置づけてよいと考えられた.5.在来の抗生物質では6時間毎に投与するため,夜間睡眠中や昼の通園・通学中の服用もれが生じやすいが,本剤は1日2回,朝夕食後の投与で十分な血中濃度を維持でき,家庭内で親の手から直接に投与できることは,「服ませ忘れ」を防ぐ上でも大きな利点になると考えられた.また,大多数の小児患者がそれほど嫌がらずに,むしろ喜んで服用し,拒否した者は皆無であったことから,本剤は幼児にも服みやすい薬であると考えられた.journal articl
耳下腺唾石症の1例
Get PDFapplication/pdfParotid calculi are found in approximately 5% of salivary gland calculi. A case of parotid calculius was reported, and the diagnostic features and treatment were discussed. Totally 38 cases of parotid calculi were reported in Japan.journal articl
Effects of Sodium Fluoride on Frog Heart Motility
Get PDFapplication/pdfEffects of sodium fluoride (NaF) on the bullfrog heart were investigated. NaF (10 mM) inhibited the autonomic heart contraction, reducing the heart rate. This inhibitory action was recovered by per fusion with 2-Ca^ Ringer's solution. The twitch tension of auricular muscle was reduced by 2 mM NaF as well as 1 mM sodium oxalate and low-Ca^ Ringer, but the latter two were less effective than the former. However, NaF (5 mM) induced a rise in resting tension similar to that in the case of DNP application. ATP, adrenaline, and theophylline all reversed the inhibitory action of NaF, while both DNP and iodo acetic acid promoted it. NaF (5 mM) decreased the tension of Na^+-deficient contracture. The results obtained suggest that the reduction in the heart motility by NaF might be caused by the following mechanism : Inhibition of Ca^ influx into the myocardial cell as a result of both decrease in the extracellular Ca^ concentration and inhibition of ATP production and the Na^+-Ca^ exchange.journal articl
ヨードホルム加水酸化カルシウム系根管充塡剤(材)応用後の根端付近組織の治癒変化に関する臨床病理学的研究
Get PDFapplication/pdfTwo root canal filling materials, consisted chiefly of calcium hydroxide and iodoform, "Calvital" and "Vitapex" were used to the teeth of a 78-year-old man and an 82-year-old woman respectively. One or two years later these teeth with alveolar bone were resected from the patients died, and observed histopathologically. 1. These human materials especially periapical tissues to which applied "Calvital" and "Vitapex" were thought to be the first cases examined histopathologically. 2. In 6 "Calvital" cases, 3 cases with enlargement and cleaning of the root canals before filling showed a good healing, and 1 case with the same treatment was nearly good, but 2 cases without this root canal treatment showed not so good. 3. The "Vitapex" case was only one, in which the root canal filling was carried out after the pulp extripation. The apical foramen was closed by an osteoid hard tissue, meaning a success healing. 4. In this "Vitapex" case, the patient was old and laid up with illness soon after the filling. Therefore this success healing may be suggested that "Vitapex" is excellent for root canal filling and that the cells in periodontal ligament of such an aged patient still have a capacity of differentiation to osteoblasts or.cementoblasts. 5. Clinically it may be noticed that in the radiograph the disappear of radiopaque materials in the root canal does not mean disappear of calcium hydroxide but of iodoform.journal articl
Thomas BartholinのAnatomia Reformataにおける顎骨と歯牙の記載について
Get PDFapplication/pdfThomas Bartholin revised his father's anatomical treatise "Anatomicae Institiones" , it was called "Anatomia Reformata" which was used widely as typical textbook of anatomy in Europe during 17th century. Recently, as it was reproduced in Japan, the anthor translated into Japanese about chapters of maxillary bone and teeth in "Anatomia reformata". In views of these chapters, the anthor had a knowledge regarding level of anatomical study on the maxillary bone and teeth in the mid 17th century, especially payed attention to that he quoted from new findings of tooth-growth by famous anatomists Fallopio and Eustachio.journal articl