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マルチブラケット装置装着時におけるフッ化物洗口法によるう蝕予防効果
Get PDFapplication/pdfMany investigators have reported that orthodontic patients with braces have a high risk of dental caries. The purpose of this study was to investigate the effect of a fluoride mouth-rinsing program for orthodontic patients with braces during active treatment. The subjects were 25 orthodontic patients with braces ranging from 11 to 17 years old. Fifteen patients were subjected to the fluoride mouth-rinsing program and 10 patients were not. As a result of the analysis, the increase in the DMFT index in the fluoride mouth-rinsing program group was significantly smaller than that in the non-fluoride mouth-rinsing program group. In conclusion, the fluoride mouth-rinsing program appears effective for orthodontic patients with braces during active treatment.journal articl
破骨細胞の分化と機能を調節するシグナル伝達系
Get PDFapplication/pdfThe recent discovery of receptor activator of NF-kB ligand (RANKL)-RANK interaction confirms the well-known hypothesis that osteoblasts play an essential role in osteoclast differentiation. Osteoblasts express RANKL, a tumor necrosis factor α(TNF-α) family member, as a membrane-associated factor. Osteoclast precursors that express RANK, a receptor for RANKL, recognize RANKL through the cell-cell interaction and differentiate into osteoclasts. Recent studies have shown that lipopolysaccharide and inflammatory cytokines such as TNF-α and interleukin 1 directly regulate osteoclast differentiation and function through a mechanism independent of the RANKL-RANK interaction. Interferon-γ and β are also shown to be important negative regulators in osteoclastogenesis. These findings have opened new areas for exploring the regulatory mechanisms of osteoclast differentiation and function. This review article describes the current knowledge of signal transduction which regulates osteoclast differentiation and function.journal articl
う蝕歴と各カリエスリスク項目との関係について
Get PDFapplication/pdfIt has been reported that orthodontic patients with braces have a high risk of caries. We thus studied which factors are important for caries risk in an orthodontic patient with malocclusion. The caries risk factors investigated were 1) secretion velocity of saliva, 2) pH level of saliva, 3) viscosity of saliva, 4) streptococcus mutans and 5) lactobacilli. As a result, relatively high correlations were found in caries risk factors of pH level of saliva and lactobacilli. Digital processing of photographic-slides in the lactobacilli test was the most effective method of analysis for detecting caries risk factors.journal articl
女子骨格性上顎前突症例における下顎骨の成長変化 : A点重ね合わせ法の応用
Get PDFapplication/pdfIt is important in clinical orthodontics to develop a simple and precise method for prediction of mandibular growth from data of lateral cephalograms. The purpose of this study was 1) to develop a basic template for mandibular growth registered at the A-point and 2) to analyze not only direction but also distance of mandibular growth in the same way. A converted profilogram superimposed at Point A using the FH plane as a reference axis was made from the conventional data of Sakamoto as the first step in this study. Next, the direction and distance of mandibular growth were measured between mandibular points of Pog on the converted profilogram at the initial and these at the retaining stage of orthodontic treatment. For this purpose, 20 sets of tracings of lateral cephalograms of 20 female orthodontic patients with maxillary protrusion were used. In summary, the mean value of the direction of the mandibular growth was 63.84 degrees (s. d. 50.11) and that the distance was 5.08mm (s. d. 3.40), indicating an annual increment of 0.91mm (s. d. 0.62). The correlation factors between the growth direction and the mandibular characteristic angles were analyzed, and the correlation factor to the value of the mandibular plane angle added to the Y axis angle was highest (r=0.739). The correlation factors between the growth distance and the mandibular characteristic lengths were also analyzed, and the mandibular ramus length (Ar-Go) divided by the mandibular length (Ar-Me) was highest (r=0.409). Simple and accurate prediction of mandibular growth in an orthodontic patient can be performed when the retrogression formula of the growth direction and distance from data in this study is applied.journal articl
Serial Changes in pH and Sustained; Fluoride Release in Various Types of Condensation and Filling Materials
Get PDFapplication/pdfフッ素徐放性を有する各種填塞・修復材のpHおよびフッ素徐放量の経時的変化を検討するために,pHメーターおよびイオンメーター使用し,各条件下で検討した結果以下の結論を得た.1.試験片を生理食塩水50ml中に浸漬させたものは,填塞材の中でpH値が著しく低下するものがみられ,フッ素も継続して徐放される傾向にあった.2.照射5日後に試験片をフッ素イオン濃度1000 ppmの溶液に浸漬させたものは試験片を生理食塩水に浸漬したものに比べフッ素徐放量が増加する傾向にあった.3.試験片を照射直後から1日毎に4℃ と60℃ の温度変化を与えたものは,生理食塩水50ml中に浸漬させたものに比べpHの値が低く,フッ素徐放量も増加する傾向にあった.4.生理食塩水50ml中に浸漬させ,照射5日後に試験片にサンドブラスト処理を行ったものは,フッ素徐放量が著しく上昇する傾向にあった.以上の結果より,フッ素徐放性を有する材料は,温度負荷や表面構造の変化により,フッ素の取り込みと放出を繰り返していることが示唆された.また,口腔内において温度やpH変化がみられる条件下でも同様な影響を受けることが推測できた.journal articl
表層拡大型腫瘍の臨床病理学的および分子生物学的特徴 : 大腸腫瘍の側方増殖型腫瘍
Get PDFapplication/pdfLaterally spreading tumor (LST) of colon and rectum shows unique characteristics of horizontal-dominant intramucosal growth over 10mm in diameter, although polypoidtype tumor reveals vertical dominant growth. It was divided into two subtypes such as granular and non-granular or flat types. The former shows small-granular surface consisting of granules, measuring 1.2±0.3mm, that are mostly less than 3mm in diameter. So we prefer the name of granule aggregating tumor (GAT) to nodule aggregating tumor. While the latter has a strikingly unique margin, which protrudes outside like amoebase's pseudopodia, called as "pseudopodial-like appearance". Interestingly, histological investigations seldom reveal carcinomatous components involving the submucosa of GATs even if it is more than 20mm in size, in contrast to relatively frequent submucosal invasion in the nongranular or flat type. Microsatellite instability (MSI) was detected in only one case of our LST series. More than 80% of LSTs over-expressed β-catenin protein, accompanied by p 53 expression that correlated with atypia. Considering mutations of many oncogenes and tumor suppressor genes investigated in polypoid-type tumors, results of β-catenin and p 53 expressions seem to be consistent with "adenoma-carcinoma sequence theory". The apoptosis index of the lower part of granule-aggregating tumors was significantly higher than that of the lower part (4.44±1.81 vs. 1.21±1.47 in TUNEL). Acceleration of apoptosis in cells of lower part of granule aggregating tumors may inhibit the vertical growth and result in its characteristic morphogenesis.journal articl
試作水酸化カルシウム系糊剤根管充填材に対する組織反応
Get PDFapplication/pdfThe aim of this study was the histopathological evaluation of the subcutaneous tissue reaction to a newly developed root canal filling material (HP paste). We injected HP paste and a control paste using a calcium hydroxide/water mixed paste as a control subcutaneously into the dorsal area of 6-week-old anesthetized male ddY mice. Two days, 1 week, 3 and 12 weeks after injection, the tissue surrounding the injection sites was removed from mice in each group and examined. We found necrotic and degeneration changes due to the pastes, as well as foreign body reactions or granulation tissue proliferation in each group, until 3 weeks after injection. No inflammatory cell infiltration was observed in the experimental group, although there was some in the control group in the 12-week specimens. In conclusion, our data leads us to believe the HP paste is safely usable as a root canal filling material.journal articl
視覚的教材とパソコン学習の現状
Get PDFapplication/pdfMany dental colleges and schools have developed recently the education systems utilizing computers for efficient clinical training and lectures. CD-ROM as visual education material can provide, through simple manipulation, clear images consisted of huge information data such as radiogram, pictures of the cranial bones and anatomical findings, can contain question-answer systems, and, by starting software such as a movie player, can show moving images accompanied with sound. In this paper, I introduce briefly visual education material developed at the Department of Oral Radiology, Matsumoto Dental University, and interpret the present situation of learning by personal computers. I intend to provide useful and effective information in the dental education and clinical training, through making visual education material and constructing the system of learning by personal computer, reflecting the idea and desire of the students. I expect to start the on-demand instruction in near future, as a part of promotion of information-oriented our University, by repletion of visual education material, network system teaching and construction of data base of scientific studies.journal articl