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Evaluation of Antioxidant Activity of Ethanol Extract from Phyllospongia lamellosa Obtained in Parentek Beach, Minahasa Regency
No full textSponges are one of the components of coral reef biota that are quite widespread. Almost 75% of the sponge species found in the waters are classes of Demospongiae. Asymmetrical in shape, demospongiae grow in various sizes from small to more than 2 meters. This study aims to determine the antioxidant activity of ethanol extract of Phyllospongia lamellosa obtained using DPPH method. The results of data analysis of % inhibition values are 20 ppm concentration (41.80%), 40 ppm concentration (43.78%), 60 ppm concentration (46.65%), 80 ppm concentration (47.25%), 100 ppm concentration (48.42%). This shows that the Phyllospongia lamellosa sponge sample obtained from Parentek Beach, Minahasa Regency has antioxidant effectiveness but is not active because the highest percent inhibition value at a concentration of 100 ppm is only 48.42%
EVALUATION OF PINEAPPLE PEEL ETHANOL EXTRACT CAPSULES AS A NATURAL IMMUNOMODULATOR
No full textImmunomodulators are drugs that can modify immune responses and stimulate natural defense mechanisms. Natural immunomodulator preparations are an alternative solution to using synthetic immunomodulators, because they are safer and have minimal side effects. The immunomodulatory in this research was made from underutilized pineapple skin. This research is focused on finding out the best formulation with varying concentrations of starch as a filler for immunomodulatory preparations from pineapple peel ethanol extract. Research methods include: pineapple peel preparation, extraction of secondary metabolite compounds from pineapple peel with ethanol solvent, phytochemical testing, capsule preparation formulation, and evaluation. Evaluation of capsule preparations: weight uniformity test, disintegration time test, flow velocity test, angle of repose test, and moisture content test. Phytochemical test results show that pineapple peel ethanol extract contains terpenoids, phenolics, flavonoids, alkaloids, steroids and tannins which have potential as immunomodulators. Formulation 1 has test results for angle of response, flow time, stable humidity, uniform weight, and does not break easily. Therefore, formulation 1 (starch 59.58 mg) is the best natural immunomodulator preparation from pineapple peel
Evaluation of Drug Prescription Appropriateness for BPJS Kesehatan Patients Against the National Formulary at Noongan Regional General Hospital
No full textThe prescription of medication in healthcare facilities that collaborate with health social security administering agency refers to the National Formulary. Writing prescriptions that do not comply with the National Formulary can affect the quality of pharmaceutical services in hospitals and may result in rejected prescriptions for patients. The aim of this study was to determine the percentage of drug prescription compliance among BPJS Health patients with the National Formulary during the period of January to June in 2021 and 2022 at noongan regional general hospital, as well as to compare the percentage of prescription compliance between the years 2021 and 2022 during the same period. This research employed a descriptive design with retrospective data collection. The results of the study revealed an average percentage of prescription compliance with the National Formulary of 69.25% during the period of January to June 2021. However, during the period of January to June 2022, there was a decrease in the percentage to 67.22%. Therefore, it can be concluded that the compliance of prescription writing with the National Formulary has not yet reached the established standard
ANTIDIABETIC ACTIVITY TEST OF ETHANOL EXTRACT OF YELLOW PUMPKIN LEAVES (Cucurbita moschata) ON MALE WHITE RATS (Rattus norvegicus)
No full textPumpkin is a plant that contains many natural phenolic compounds, making it potential as an antioxidant, antidiabetic and antihyperglycemic. The aims of this study was to determine the antidiabetic activity of ethanol extract of pumpkin leaves on blood glucose levels and body weight on male white rats induced by alloxan at a dose of 120 mg/kgBW. The type of research used in this study was an experimental laboratory using the pre test and post test with control group design methods. Rats was divided into 5 groups, each group consisting of 3 rats. Group I as the positive control was given metformin, group II as the negative control was given 0,5% CMC Na, groups III, IV and V as the treatment group were given extract doses of 150 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW. The results showed that the ethanol extract of pumpkin leaves had a significant effect on decreasing blood glucose levels of rats P(< 0,05) and had no significant effect on the body weight of rats P(> 0,05) and the dose of the extract was the best in reducing glucose levels blood of rats is a dose of 600 mg/kgB
ANTIBACTERIAL ACTIVITY TEST OF Liosina paradoxa SPONGE EXTRACT FROM POOPOH COASTAL WATERS, MINAHASA REGENCY
No full textLiosina paradoxa sponge contains an active compound that can act as an antibacterial. This study aims to determine the antibacterial activity of the ethanol extract of Liosina paradoxa on the growth of Staphylococcus aureus and Pseudomonas aeruginosa. The research was conducted using an experimental method. Extraction uses the maceration method to extract the active compounds from the Liosina paradoxa sponge. The extraction results were tested to determine whether there was antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa; the test used the Kirby-Bauer agar diffusion method. The results of the test showed that there was antibacterial activity marked by the presence of an inhibition zone around the disc paper of the extract test solution on Staphylococcus aureus bacteria with a medium inhibition zone diameter of 7.25 mm and Pseudomonas aeruginosa bacteria with a medium inhibition zone diameter of 8.25 mm
ANTIPYRETICS EFFECT OF ETHANOL EXTRACT OF PARE LEAVES (Momordica charantia L.) ON MALE WHITE RAT (Rattus norvegicus)
No full textBitter melon (Momordica charantia L.) is a plant that contains flavonoids. Based on previous studies, it has been reported that flavonoid compounds have antipyretic activity. The aim of this study is to test the antipyretic effect of bitter melon leaf extract (Momordica charantia L.). This study uses a laboratory experimental research design employing male white rats (Rattus norvegicus) as the test subjects. Bitter melon leaf extract was administered at different doses, namely 3.6 mg, 7.2 mg, and 14.4 mg. Each rat was induced to have a fever with a 0.2 ml intramuscular dose of the DPT vaccine. Temperature measurements were taken before and after induction for 2-3 hours and every 30 minutes until the 180th minute. The data obtained were analyzed using ANOVA and LSD tests. The research results indicate that the ethanol extract of bitter melon leaves (Momordica charantia L.) has an antipyretic effect that can lower the body temperature in male white rats (Rattus norvegicus) at a dose of 3.6 mg
ANTIOXIDANT ACTIVITY TEST OF ETHANOL EXTRACT (Polycarpa aurata) OBTAINED FROM THE WATERS OF POOPOH VILLAGE, MINAHASA REGENCY
No full textOne of the potential marine ingredients that are needed in the fields of food, cosmetics and health is as a source of antioxidants. Antioxidants inhibit the decay of certain substances, reduce oxidative stress, inhibit cell aging, and ward off free radicals. One marine organism that has potential as a natural antioxidant is Tunikata Polycarpa aurata. This study aims to test the antioxidant activity of Polycarpa aurata ethanol extract obtained from the coast of Poopoh Village, Minahasa Regency. The test uses the DPPH method with concentrations of 25 ppm, 50 ppm, 75 ppm, and 100 ppm to analyze antioxidant activity using a spectrophotometer. The results obtained the greatest antioxidant activity in Polycarpa aurata with a concentration of 100 ppm with an average percent inhibition of 80.744%. The results of this study showed the antioxidant activity of Polycarpa aurata from the waters of Poopoh Village, Minahasa Regency has good antioxidant activity.
Keywords: Polycarpa aurata, Antioxidant, DPPH, Poopoh Village, Minahasa Regency
Hubungan HOT (Human, Organization, Technology) terhadap Benefit pada Penggunaan Sistem Informasi Manajemen Rumah Sakit X Kota Manado
Full text linkPenerapan Sistem Informasi Manajemen di Instalasi Farmasi RS. X Kota Manado masih mengalami kendala dimana yang paling sering terjadi ialah perbedaan informasi data dalam sistem dengan kondisi yang sebenarnya. Penelitian ini bertujuan untuk mengetahui apakah Human, Organization dan Technology berpengaruh terhadap Benefit pada penggunaan SIMRS di Instalasi Farmasi. Penelitian dilakukan menggunakan metode kuantitatif dengan rancangan cross sectional berdasarkan kerangka Human, Organization, Technology–Fit. Hasil penelitian ini menunjukkan uji T variabel human, organization dan technology tidak berpengaruh terhadap Benefit. Berdasarkan kategorisasi variabel, human, organization dan technology telah memberikan hasil yang baik ditunjukkan dengan nilai kategorisasi sebesar 80%, dimana benefit yang diperoleh memiliki nilai lebih rendah dengan nilai 69,37%, hal ini disebabkan karena implementasi sistem oleh pegawai masih kurang optimal sehingga kebermanfaatan sistem belum terasa maksimal oleh pengguna. Kesimpulan dari penelitian ini ialah tidak terdapat pengaruh antara human, organization dan technology terhadap benefit pada penggunaan sistem informasi manajemen Rumah Sakit X Kota Manado
Identifikasi Medication Discrepancies Pada Proses Rekonsiliasi Obat Di Instalasi Rawat Inap Bedah Prof. Dr. R. D. Kandou Manado
Full text linkRekonsiliasi merupakan proses yang dapat dilakukan untuk mencegah terjadinya kesalahan pengobatan. Penelitian ini bertujuan untuk mengidentifikasi perbedaan pengobatan berdasarkan hasil rekonsiliasi obat pada 56 pasien periode penelitian Januari – Maret 2020. Penelitian ini merupakan jenis penelitian kuantitatif dengan rancangan deskriptif dengan pengambilan data secara prospektif di Instalasi Rawat Inap Bedah RSUP Prof. Dr. R. D. Kandou Manado. Hasil penelitian berdasarkan karakteristik pasien menunjukkan mayoritas pasien adalah laki-laki yaitu sebanyak 43 pasien (76,79%) dan jumlah pasien terbanyak pada kelompok usia dewasa (18-44) sebanyak 26 pasien (46,43%). Berdasarkan karakteristik jumlah obat pada data BPMH (Best Possible Medication History) menunjukan bahwa mayoritas pasien mengkonsumsi <5 jenis obat sebanyak 55 pasien (98,21%), di IGD sebagian besar mengkonsumsi <5jenis obat yaitu sebanyak 45 pasien (80,36%), pada karakteristik jumlah obat di instalasi mayoritas mengkonsumsi <5 jenis obat (53,57%) dan saat keluar rumah sakit mayoritas pasien diberikan <5 jenis obat yaitu 46 pasien (82,14%). Persentase Medication Discrepancies yaitu Incomplete prescription sebesar (28,57%), Omission medication (14,29%), dan perbedaan yang disengaja (100%).
Kata Kunci : Rekonsiliasi obat, medication discrepancies
PENGARUH VARIASI TRIETANOLAMIN DAN ASAM STEARAT TERHADAP STABILITAS FISIK SEDIAAN KRIM EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.)
Full text linkKestabilan suatu sediaan emulsi dipengaruhi oleh beberapa faktor yaitu emulgator, suhu serta waktu. Pembuatan krim membutuhkan penambahan emulsifier atau massa pengemulsi, karena dapat mempengaruhi kualitas dan stabilitas produk krim, misalnya triethanolamine dan asam stearat digunakan sebagai emulsifier. Tujuan dari penelitian ini yaitu untuk melihat efek dari variasi trietanolamin dan asam stearat terhadap stabilitas fisik dari formula sediaan krim ekstrak etanol daun sirsak yang mempunyai perbandingan trietanolamin dan asam stearat 2%: 16%, 2,5%:15,5%, 3%:15%, dan 3,5%:14,5%. Daun sirsak diekstrak dengan pelarut etanol 96% kemudian dibuat krim M/A. Dilakukan pengujian stabilitas sediaan krim dengan cara menyimpan sediaan krim pada suhu kamar (25º±2C) selama 4 minggu. Pengujian fisik seperti uji daya lekat, uji daya sebar, uji pH, uji homogenitas dan uji organoleptik dilaksanakan tiap minggunya. Hasilnya, variasi konsentrasi trietanolamin dan asam stearat tidak memiliki dampak pada pengujian homogenitas, tetapi variasi konsentrasi trietanolamin dan asam stearat memiliki dampak pada pengujian daya lekat, pengujian daya sebar, pengujian pH, dan pengujian organoleptic darri sediaan krim ekstrak etanol daun sirsak. Kesimpulannya F1 (asam stearat 16% : trietanolamin 2%) merupakan formulasi yang paling stabil secara fisik.
Kata Kunci: Krim, Trietanolamin, Asam Stearat, Emulgator, Stabilitas Fisi