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PENGARUH SUHU TERHADAP STABILITAS BERBAGAI PRODUK TABLET NIFEDIPIN
Full text linkDrug storage at heat air condition, high humidity room, and exposed with light lead todrug degradation. Temperature changes is one of external factor cause unstability ofpharmaceutical product.The purpose of this research is to examine the effect of temperature onnifedipin stability. The method using in this research is factorial Complete Random design.There are two factors. Factor A is temperature(40oC, 50 oC, and 60 oC) and factor B are period(60, 120 and 180 minutes). There are three samples in this research research. Analysis ofnifedipin content using Spectrophotometer UV-Vis. Obtained data were analyzed using spss ver.20. The differences between variable were statistical analyzed. The results shows that sample Aat temperature 60 oC, after 180 minutes treatment decrease to 86,47%, Sample B 86,43%, andsample C 85,66%, respectively. Temperature significantly effect on the stability of nifedipin(p<0,05).Keywords: temperature, stability, Nifedipi
PENGARUH SUHU TERHADAP STABILITAS SERTA PENETAPAN KADAR TABLET FUROSEMIDA MENGGUNAKAN SPEKTROFOTOMETER UV-VIS
Full text linkStability is the ability of product to maintain its nature and characteristics similar to itsorigin during storage and use period. Furosemide is one of drugs product that works as diuretic.The aim of this research was to study the effect of temperature on furosemide stability. Themethod using in this research is factorial Complete Random design. There are two factors in thisresearch,factor A is temperature (40oC, 50 oC, and 60 oC) and factor B are period (60, 120 and180 minutes). There are three samples in this research. Analysis of furosemide content usingSpectrophotometer UV-Vis at λ = 271 nm. Obtained data were analyzed using spss ver. 20. Thedifferences between variable were statistical analyzed. The result shows that the decreasing offurosemide in tablet starts at temperature 50°Cafter60minutes heating for sample A and C.Sample B decrease at temperature 50°C after 120 minutes heating.Keywords: stability, furosemide, spectrophotometry UV-Vi
EFEK ANTIHIPERGLIKEMIA DARI EKSTRAK KULIT BUAH MANGGIS (Garcinia mangostana L.) TERHADAP TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) YANG DIINDUKSI SUKROSA
Full text linkThis study aims to determine the effects of pericarp extracts of mangosteen antihiperglikemia inwistar strain male mice induced sucrose and compare its effectiveness with glibenclamide. Themethod used is a laboratory experiment using a Completely Randomized Design. Subjects in the formof 15 male white rats tail with weight ranging from 100g-210g are divided into 3 groups of eachgroup as much as 5 tails. The treatment begins with administration of sucrose solution is adjusted tothe weight of each rat. On the second day evening, the test animals fasted for twelve hours, and thethird day in the morning followed by blood glucose level measured sucrose solution, after thirtyminutes of administration of sucrose solution was measured blood glucose level, the first group weregiven distilled water, the second group were given mangosteen rind extract 20%, The third group wasgiven glibenclamide and 0.3030 mg/g weight had made suspension in 1% CMC solution is thenmeasured blood sugar test animals one, two, three, and four hours. Data were analyzed with spssver.17, the real difference between treatments was tested by one way ANOVA. The results ofstatistical analysis gave a significant difference p-value=0.00 (p <0.05) in which the extract cansuppress the KBM 20% increase in KGD in mice and provide similar effectiveness withglibenclamide.Key Word : Garcinia mangostana L., Rattus norvegicus L., Sucrose, CM
FORMULASI DAN UJI KRIM EKSTRAK UMBI SINGKONG (Manihot esculenta) TERHADAP LUKA BAKAR PADA KELINCI (Oryctolagus cuniculus)
Full text linkCrops Cassava (Manihot esculenta) contains carbohydrates, phosphorus, calcium, vitaminC, protein, iron and vitamin B1 can provide a healing effect on wounds. The content contained incassava able to give effect to the skin re-epithelialization of damaged tissues due to burns. Thisstudy aims to determine the effectiveness of the test extract tubers Cassava (Manihot esculenta) inthe dosage form of a cream with the concentration level of 2%, 4%, and 8% for burn woundhealing in rabbits (Oryctolagus cuniculus). Making cream formulation using cassava tuber extractoil phase in water and used as test animals 10 rabbits, divided into 5 treatment groups, namely, testthe cream treatment group, negative control group (basic cream) and a positive control group(Bioplacenton). Burns in the back with a diameter of 1.5 cm were treated and observed the healingeffects for 7 days. The results showed that from day-1 to day-7 observations burns suffereddiminution in diameter. It was concluded that the concentration of 2% cassava extract cream hashealing effect and increasing the concentration of 4% and 8% contained showed more effectiveand speed up the healing process.Keywords: cream, extract, cassava tubers, healing burns, rabbi
EVALUASI PENGGUNAAN OBAT ANTITUBERKULOSIS PADA PASIEN TUBERKULOSIS PARU DI INSTALASI RAWAT INAP BLU RSUP PROF. DR. R. D. KANDOU MANADO PERIODE JANUARI – DESEMBER 2010
Full text linkThis study aims to examine the patterns of the use of antituberculosis drugs (OAT) and to evaluate thesuitability of the use of OAT based on the Guidelines for Tuberculosis Control 2009 by Ministry ofHealth RI, in hospitalized patients with pulmonary tuberculosis in BLU RSUP Prof. Dr. R. D. KandouManado period January to December 2010. This study is a descriptive survey research and datacollection carried out retrospectively. Data was analyzed with descriptive analysis. The resultsshowed patients with category 1 of an intensive phase is given the alloy HRZE or 4FDC andcontinoum phase patients is given the alloy HR. Category 2 patients, the 2-month intensive phase isgiven the alloy HRZES and for category 2 patients at 1-month intensive phase is given the alloyHRZE. A total of 97.7% of patients prescribed a single drug dosage OAT (generic) and 2.3% ofpatients prescribed OAT FDC. Based on the suitability of the selection of alloys OAT, for thetreatment of category 1 have met the suitability of 94.7% and category 2 is 66.7%, compliance withthe standards of the Guidelines for Tuberculosis Control 2009 by Ministry of Health RI.Keywords: OAT, pulmonary tuberculosis, hospitalized patient
UJI EFEKTIVITAS EKSTRAK KULIT BUAH SALAK (Salacca zalacca (Gaertn.) Voss) TERHADAP PENURUNAN KADAR GULA DARAH TIKUS PUTIH JANTAN GALUR WISTAR (Rattus norvegicus L.) YANG DIINDUKSI SUKROSA
Full text linkThis study aimed at finding out the effectivity of Salacca (Salacca zalacca [Gaertn]Voss) rind extract on blood sugar decrease of white male wistar (Rattus norvegicus L.)induced with sucrose. Completely randomized design method was used in this experiment.The subject of the experiment were 15 white male wistar which were divided into 3 (three)groups namely negative control group, treatment group with the dose of 150 mg extract/kgbody weight, and positive control group using glibenclamide 0.45 mg/kg body weight. Dataobtained from the examination of the fasting blood sugar were 30 minutes after inductionwith sucrose and at minute 15, 30, 60, and 120 after treatment was given. The data isprocessed using ANOVA and LSD test to compare between the negative control group,treatment, and a positive control. The analysis revealed a significant difference betweennegative control and treatment, negative control and positive control, but did not show asignificant difference between treatment groups with the positive control. The conclusion ofthis study is Salacca rind extract has an effect on blood sugar levels decrease of white malewistar induced with sucrose.Keywords: Salacca zalacca (Gaertn.) Voss, Salacca rind extract, blood sugar level, sucros