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Evaluasi Pelaksanaan Manajemen Risiko di Instalasi Farmasi Rumah Sakit X Manado
Full text linkManajemen Risiko merupakan suatu cara dalam mengorganisir suatu risiko yang akan dihadapi dengan cara mengurangi risiko. Tujuan dalam penelitian ini adalah untuk mengetahui pelaksanaan manajemen risiko yang diterapkan di Instalasi Farmasi RS X Manado berdasarkan Peraturan Menteri Kesehatan Nomor 58 Tahun 2014 tentang Standar Pelayanan Kefarmasian terkait manajemen risiko yang meliputi menentukan konteks, mengidentifikasi, menganalisa, mengevaluasi, serta mengatasi risiko. Jenis penelitian yang digunakan adalah penelitian kualitatif. Hasil penelitian menunjukkan bahwa Manajemen Risiko di RS X belum berjalan dengan efektif. Terdapat 8 risiko yang teridentifikasi 2 diantaranya didapatkan dari laporan insiden dan 6 lainnya berdasarkan wawancara dan observasi, hal ini menunjukkan bahwa risiko belum dapat teridentifikasi secara menyeluruh. Instalasi Farmasi juga belum bisa menentukan tingkat dari keparahan risiko serta penanganan risiko yang hanya dilakukan saat risiko terjadi. Hal ini dikarenakan masih terdapat beberapa kendala diantaranya, tidak adanya monitoring, beban kerja tinggi serta tidak adanya pelatihan yang dilakukan. Kesimpulan dari penelitian ini yaitu pelaksanaan manajemen risiko di RS X Manado belum efektif secara keseluruhan
Evaluasi Penerapan Standar Pelayanan Kefarmasian di RSUD Dr. Sam Ratulangi Tondano
Full text linkPelayanan kefarmasian menjadi kegiatan yang bertujuan untuk mengidentifikasi, mencegah, dan menyelesaikan masalah terkait obat. Tujuan penelitian ini untuk mengevaluasi penerapan Standar Pelayanan Kefarmasian yang tertuang dalam Permenkes RI Nomor 72 Tahun 2016 di RSUD Dr. Sam Ratulangi Tondano. Jenis penelitian yang digunakan bersifat deskripstif kualitatif. Pengumpulan data yang dilakukan menggunakan metode wawancara dan observasi. Berdasarkan observasi dan wawancara dalam pengelolaan sediaan farmasi, alat kesehatan, dan bahan medis habis pakai di RSUD Dr. Sam Ratulangi diperoleh hasil sebagai berikut: pemilihan 100%, perencanaan 100%, pengadaan 71%, penerimaan 100%, penyimpanan 57%, pendistribusian 100%, pemusnahan dan penarikan 100%, pengendalian 100%, dan administrasi 100%. Pelayanan kefarmasian di rumah sakit ini dikategorikan sangat baik dengan skor persentase kesesuaian 92% dan telah memenuhi standar pelayanan kefarmasian yang tertuang dalam Permenkes RI Nomor 72 Tahun 2016
Antibacterial Efficay Test of Ethanol Extract of Yaki Areca Nut (Areca vestiaria) Against the Growth of Propionibacterium acnes, the Cause of Acne.
No full textA bacterial skin infection that is often experienced by everyone, especially in adolescence, is acne(Acne vulgaris). Acne is caused by the accumulation of excess oil in the skin, thus becoming a medium for bacterial growth, which causes acne. The use of natural antibiotics can be a therapeutic option in the treatment of acne. One of the plants that potentially has antbacterial activity is Pinang Yaki (Areca vestiaria). The purpose of this study was to determine the antibacterial activity of ethanol extract of areca nut fruit against the growth of Propionibacterium acnes that causes acne. The test of antibacterial activity of areca nut extract with the pitting method found that at a concentration of 10% the antibacterial activity was included in the weak group, 20% was included in the medium group, while those included in the strong group in inhibiting the growth of Propionibacterium acnes were extracts with concentrations of 40%, 60% and 80%.
Phytochemical Screening and Determination of Content Total Flavonoids Of Ethyl Acetate Extract Of Matoa Leaves Using UV-VIS Spectrophotometry
No full textExcessive amounts of free radicals will cause pathological effects that result in degenerative diseases. The free radical oxidation process can be neutralized by antioxidants. Antioxidants are compounds that have the ability to eliminate, clean and resist the effects of free radicals. Matoa leaf plants are used as traditional medicine to treat various diseases. The leaves of matoa contain active compounds in the form of saponins, flavonoids and tannins. Flavonoids can act as antioxidants because they can provide an electron to free radicals. The aim of this research was to determine the total flavonoid content and antioxidant activity of matoa (Pometia Pinnata) leaf ethyl acetate extract which was tested using the DPPH free radical reduction method. The extraction process was carried out using the maceration method using ethyl acetate solvent in a ratio of 1:5. Determination of total flavonoid levels was carried out by adding AlCl3 and sodium acetate reagents. The antioxidant activity test was carried out using the DPPH free radical reduction method with quercetin as a comparison. Analysis was carried out using a UV-Vis spectrophotometer. Research shows that the yield of matoa leaf ethyl acetate extract was 20.7161 grams. Ethyl acetate extract of matoa leaves contains chemical compounds in the form of saponins, flavonoids and tannins. The total flavonoid content obtained from the ethyl acetate extract of matoa leaves was 6.19% and the IC 50 value was 34.21 ppm, while quercetin as a comparison had an IC 50 value of 4.75 ppm. Ethyl acetate extract of matoa (Pometia Pinnata) leaves has a total flavonoid content of 6.19% and very strong antioxidant activity, the same as quercetin as a comparison
TOXICITY TESTING OF SOURSOP LEAF EXTRACT (Annona muricata l.) AS AN ANTICANCER CANDIDATE WITH THE BRINE SHRIMP LETHALITY TEST (BSLT) METHOD
No full textSoursop leaves (Annona muricata L.) contain several secondary metabolite compounds including alkaloids, flavonoids, tannins, saponins, steroids and is one of the plants used to prevent and treat cancer. This study was conducted with the aim of knowing whether the secondary metabolite compounds contained in soursop leaves and the potential of soursop leaves as anticancer candidates against Artemia salina Leach larvae. The extraction method used to extract soursop leaves is the maceration method using 96% ethanol solvent. Phytochemical screening tests in this study include examination tests for alkaloids, flavonoids, tannins, saponins, steroids and triterpenoids. Toxicity testing using the Brine Shrimp Lethality Test (BSLT) method using 4 concentrations (1000 ppm, 100 ppm, 10 ppm, 1 ppm) and carried out three replication. The results of research obtained in phytochemical screening tests, soursop leaves have alkaloid, flavonoids, tannins, saponins, and compound. The results showed that the total death toxicity testing at a concentration of 1000 ppm 83%, at a concentration of 100 ppm 67%, at a concentration of 10 ppm 47% and at a concentration of 1 ppm 30%. The higher the concentration of soursop leaf extract, the higher the mortality from shrimp larvae and the LC50 value of 12.57 ppm. Based on the LC50 value , it can be concluded that soursop leaf extract has the potential as an anticancer candidate and is very toxic because had an LC50 which < 30 ppm
Antioxidant Activity Test of Ethanol Extract of Sylissa carteri from the Waters of Poopoh Village, Minahasa Regency
No full textSponges are one of the marine biota that has great potential to produce active compounds. The metabolic process of the Stylissa carteri sponge can produce secondary metabolites. Secondary metabolite compounds produced by sponges have many benefits, one of which is as an antioxidant. This study aims to determine the antioxidant activity of the ethanol extract of the sponge Stylissa carteri obtained from the waters of Poopoh Village Minahasa Regency. The Stylissa carteri sponge was extracted by maceration method and using a solvent, namely ethanol. Testing of antioxidant activity was carried out using the DPPH (1,1-diphenyl-2- pikrihydrazyl) method which was measured using a UV-Vis Spectrophotometer. The results showed that the Stylissa carteri sponge extract had antioxidant activity with the highest inhibition percentage at a concentration of 100 ppm that is 78,2%
Uji Aktivitas Antioksidan Ekstrak Etanol Spons Aaptos aaptos yang Diperoleh dari Pantai Selatan Kabupaten Minahasa
Full text linkSpons Aaptos aaptos merupakan salah satu biota laut yang sangat prospektif dan memiliki kemampuan menghasilkan senyawa bioaktif yang potensial untuk dijadikan sebagai sumber obat-obatan baru. Antioksidan adalah zat yang bisa mencegah terjadinya proses oksidasi, karena itu antioksidan sangat bermanfaat bagi kesehatan. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dari ekstrak etanol yang dihasilkan oleh spons Aaptos aaptos dengan menggunakan metode DPPH (1,1-difenil-2-pikrilhidrazil). Jenis penelitian ini adalah penelitian eksperimen laboratorium. Hasil analisis data %inhibisi yang didapat adalah 52,6% (25 ppm); 72,5% (50 ppm); 82,9% (75 ppm); dan 87,4% (100 ppm). Ekstrak etanol spons Aaptos aaptos yang diperoleh dari Pantai Selatan Kabupaten Minahasa memiliki aktivitas antioksidan tertinggi pada konsentrasi 100 ppm yaitu 87,4%.
Kata kunci: Aaptos aaptos, aktivitas antioksidan, DPPH, Kabupaten Minahas
Pengaruh Pelayanan Kefarmasian terhadap Kepuasan dan Loyalitas Pasien Rawat Jalan di Instalasi Farmasi RSUD X
Full text linkPelayanan kefarmasian yang diberikan oleh tenaga kesehatan sangat penting dalam upaya meningkatkan kepuasan dan loyalitas pada pasien. Pelayanan kefarmasian yang baik dapat meningkatkan kepuasan pada pasien yang kemudian akan mengciptakan loyalitas pasien yang tinggi. Tujuan penelitian ini untuk mengetahui tingkat kepuasan dan loyalitas pasien di Instlasi Farmasi RSUD X, serta melihat apakah ada pengaruh dari pelayanan kefarmasian terhadap kepuasan dan loyalitas pasien di Instalasi Farmasi RSUD X. Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan pendekatan deskriptif. Hasil penelitian menunjukan 75% pasien di Instalasi Farmasi menyatakan puas dan 22,7% menyatakan cukup puas dengan pelayanan kefarmasian. 45,5% pasien menyatakan loyal dan 47,7% meyatakan cukup loyal terhadap Instalasi Farmasi di RSUD X. Kesimpulan dari penelitian ini adalah pelayanan kefarmasian memiliki pengaruh secara signifikan terhadap kepuasan dan loyalitas pasien di Instalasi Farmasi RSUD X.
Kata kunci: Pelayanan kefarmasian, kepuasan, loyalita
Liosina paradoxa sponge ethanol extract's antioxidant activity test taken from Poopoh Village's Southern Beach
No full textLiosina paradoxa sponge is one of the Indonesian marine biota that contains compounds that have strong bioactivity. This study was conducted with the intention to determine the antioxidant activity contained in Liosina paradoxa sponge. This research is a laboratory experimental research where this test uses DPPH method. The results showed that Liosina paradoxa sponge has antioxidant activity with the highest concentration having a percentage reaching 75%
Investigating the antibacterial activity of sponge extract Callyspongia aerizusa from the waters of Parentek Beach, Lembone East District, Minahasa Regency
No full textCallyspongia aerizusa is one type of sponge that grows in the waters of Indonesia, like sponges in general, this species has a porous body and a hard surface like stone. In addition, C. aerizusa can also absorb oxygen from water through the diffusion process. This study aims to determine whether there is antibacterial activity of C. aerizusa sponge extract from Parentek Beach Waters, East Lembean District, Minahasa Regency. This study uses the agar diffusion method (Kirby Bauer diffusion dics) and will see the inhibition zone that will be generated based on its category. Based on the results of the research, C. aerizusa sponge extract has a diameter of inhibition zone produced, namely on Staphylococcus aureus bacteria 8 mm in a concentration of 250 ug and for Eschericia coli bacteria it has no inhibition zone produce