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[Incidental Detections Suggestive of COVID-19 in Asymptomatic Patients Undergoing 68Ga-DOTATATE and 68Ga-PSMA-11 PET-CT Scan for Oncological Indications] [COVID-19 Zufallsbefund bei asymptomatischen Patienten mit 68Ga-DOTATATE und 68Ga-PSMA-11 PET-CT-Untersuchung aufgrund onkologischer Indikation]
Get PDFInvestigating the stress management status in middle-aged women in bushehr based on a transtheoretical model
No full textAims The present study aimed to investigate the relationship between self-efficacy, decision-making balance, and change processes with stress management in middle-aged women. Instrument & Methods This cross-sectional study was performed in 2019 on 600 middle-aged women covered by Bushehr Comprehensive Health Services Centers. The method of sampling was stratified. Data was gathered by demographic questionnaire and TTM based questionnaire, including self-efficacy, decisional balance (perceived barriers and benefits), processes of change, and stage of changes. Data were analyzed using ANOVA and Tukey post hoc test in SPSS 20 software. Findings The lowest and highest mean stress management scores were in the women in pre-contemplation (13.64±3.79) and maintenance (22.58±4.10), respectively. The mean score of self-efficacy in the women during the stages of change from pre-contemplation (15.71±6.80) to maintenance (33.06±5.09) was upward, and this average score in the stages of pre-contemplation, contemplation, and preparation was significantly lower than the stages of action and maintenance (p<0.001). Regarding processes of change, consciousness-raising, dramatic relief, environmental reevaluation, self-evaluation, social liberation, self-liberation, stimulus control, counter conditioning, helping relationships, and reinforcement management are significantly lower pre-contemplation and contemplation than action and maintenance (p<0.001). Conclusion The results indicate the importance of TTM constructs in advancing individuals to higher levels of change. Based on this, it is recommended to design and implement educational interventions based on TTM to improve stress management behaviors. Copyright© 2021, the Authors | Publishing Rights, ASPI. This open-access article is published under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material) under the Attribution-NonCommercial terms
Familial Cases of Trichophyton benhamiae Infection Transmitted from a Guinea Pig in Iran
No full textTrichophyton benhamiae is a zoophilic dermatophyte mainly transmitted to humans from guinea pigs. This zoophilic species can also cause dermatophytosis as reported by human contact with other animals, such as rabbit, cat, and fox. Here, we report the tinea faciei and tinea corporis cases: a 12-year-old girl and her 53-year-old father, with no history of immunodeficiency and underlying disease, caused by T. benhamiae transmitted from a guinea pig in Iran. Dermatological examination revealed several erythematous, round, scaly, and approximately 1–4-cm-diameter lesions in both patients. The girl had seven skin lesions, and her father presented two skin lesions on the front side of his neck. The girl’s lesions had started 3 weeks before and her father’s lesions appeared 7 days after the first clinical appearance of the lesions in the daughter. The girl had daily close contact with a guinea pig, while her father did not have any direct exposure to the pet. Examination of the lesions scraping with 10% potassium hydroxide (KOH 10%) revealed hyaline septate hyphae and arthroconidia. The dermatophyte isolated in culture was identified as T. benhamiae using molecular analysis. The patients were successfully treated using topical sertaconazole nitrate 2% cream twice a day for 4 weeks
Occurrence and distribution of microplastic particles and the concentration of Di 2-ethyl hexyl phthalate (DEHP) in microplastics and wastewater in the wastewater treatment plant
No full textWastewater treatment plant (WWTP) is one of the significant sources of Microplastics (MPs) release to the environment. Di 2-ethyl hexyl phthalate (DEHP) is used as an additive for more flexibility of plastics. In this study, we determined the number, size, shape, and color distribution of MPs as well as the concentration of DEHP in MPs and wastewater during the wastewater treatment process in WWTP. Samples were collected from 4 stations of different treatment stages of WWTP. The microplastic particles and the concentration of DEHP were detected via the fluorescence and polarized light microscopy and GC/MS instrument, respectively. The number of MPs decreased from 9.2 (station 1) to 0.84 MP/L (the final treated effluent) during the wastewater treatment process. Also, the size of MPs at the last station was smaller than the other stations. The mean concentrations of DEHP in MPs in stations 1, 2, 3 and 4 had the respective values of 83.3, 61.05, 30.62 and 17.49 μg/g, while the mean concentrations of DEHP in wastewater in stations 1, 2, 3 and 4 were 30.08, 25.07, 9.56, and 8.13 μg/L, respectively. This study shows that despite the removal of high amounts of MPs and DEHP in the final effluent of WWTP, due to the high volume of this effluent (2.828 × 108 L/d), significant amount of MPs (2.419 × 107 MP/day) and DEHP enter the aquatic environment daily, which may threaten the health of the fish and aquatic organisms and ultimately on the health of the local population
The role of Nrf2 in neural stem/progenitors cells: From maintaining stemness and self-renewal to promoting differentiation capability and facilitating therapeutic application in neurodegenerative disease
No full textNeurodegenerative diseases (NDs) cause progressive loss of neurons in nervous system. NDs are categorized as acute NDs such as stroke and head injury, besides chronic NDs including Alzheimer's, Parkinson's, Huntington's diseases, Friedreich's Ataxia, Multiple Sclerosis. The exact etiology of NDs is not understood but oxidative stress, inflammation and synaptic dysfunction are main hallmarks. Oxidative stress leads to free radical attack on neural cells which contributes to protein misfolding, glia cell activation, mitochondrial dysfunction, impairment of DNA repair system and subsequently cellular death. Neural stem cells (NSCs) support adult neurogenesis in nervous system during injuries which is limited to certain regions in brain. NSCs can differentiate into the neurons, astrocytes or oligodendrocytes. Impaired neurogenesis and inadequate induction of neurogenesis are the main obstacles in treatment of NDs. Protection of neural cells from oxidative damages and supporting neurogenesis are promising strategies to treat NDs. Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a transcriptional master regulator that maintains the redox homeostasis in cells by provoking expression of antioxidant, anti-inflammatory and cytoprotective genes. Nrf2 can strongly influence the NSCs function and fate determination by reducing levels of reactive oxygen species in benefit of NSC survival and neurogenesis. In this review we will summarize the role of Nrf2 in NSC function, and exogenous and endogenous therapeutic strategies in treatment of NDs
Retraction Note: Ambient particulate matter concentration levels of Ahvaz, Iran, in 2017 (Environmental Geochemistry and Health, (2019), 41, 2, (841-849), 10.1007/s10653-018-0182-0)
Get PDFThe Editor-in-Chief has retracted this article because it contains material that substantially overlaps with another published article [1]. Sina Dobaradaran agrees to this retraction. Gholamreza Goudarzi, Sahar Geravandi, and Mohammad Javad Mohammadi do not agree to this retraction. Nadali Alavi, Ahmad Reza Yari, Farzaneh Aslanpour Alamdari, Majid Farhadi, Hamed Biglari, Maryam Dastoorpour, and Bayram Hashemzadeh have not responded to any correspondence from the publisher about this retraction
Sars-cov-2 and covid-19, basic and clinical aspects of the human pandemic: A review
No full textIn the last two decades, we have witnessed three major epidemics of the coronavirus human disease namely, severe acute respiratory syndrome (SARS), Middle Eastern respiratory syndrome, and more recently an ongoing global pandemic of coronavirus disease 2019 (COVID-19). Iran, a country of nearly 84 million, in the Middle East, severely in-volved with the COVID-19 disease. A documented multidimensional approach to COVID-19 disease is therefore man-datory to provide a well-balanced platform for the concerned medical community in our county and beyond. In this review, we highlight the disease status in Iran and attempt to provide a multilateral view of the fundamental and clinical aspects of the disease including the clinical features of the confirmed cases, virology, pathogenesis, epidemiology, and laboratory methods needed for diagnosis
Clinical, immunologic and molecular spectrum of patients with immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome: A systematic review
No full textBackground: Immunodeficiency, centromeric instability and facial dysmorphism (ICF) syndrome is a rare autosomal recessive immune disorder presenting with hypogammaglobulinemia, developmental delay, and facial anomalies. The ICF type 1, type 2, type 3 and type 4 are characterized by mutations in DNMT3B, ZBTB24, CDCA7 or HELLS gene, respectively. This study aimed to present a comprehensive description of the clinical, immunologic and genetic features of patients with ICF syndrome. Methods: PubMed, Web of Science, and Scopus were searched systemically to find eligible studies. Results: Forty-eight studies with 118 ICF patients who met the inclusion criteria were included in our study. Among these patients, 60% reported with ICF-1, 30% with ICF-2, 4% with ICF-3, and 6% with ICF-4. The four most common symptoms reported in patients with ICF syndrome were: delay in motor development, low birth weight, chronic infections, and diarrhea. Intellectual disability and preterm birth among patients with ICF-2 and failure to thrive, sepsis and fungal infections among patients with ICF-1 were also more frequent. Moreover, the median levels of all three immunoglobulins (IgA, IgG, IgM) were markedly reduced within four types of ICF syndrome. Conclusion: The frequency of diagnosed patients with ICF syndrome has increased. Early diagnosis of ICF is important since immunoglobulin supplementation or allogeneic stem cell transplantation can improve the disease-free survival rate
Socialization During the COVID-19 Pandemic: The Role of Social and Scientific Networks During Social Distancing
No full textIn the COVID-19 era, while we are encouraged to be physically far away from each other, social and scientific networking is needed more than ever. The dire consequences of social distancing can be diminished by social networking. Social media, a quintessential component of social networking, facilitates the dissemination of reliable information and fighting against misinformation by health authorities. Distance learning, telemedicine, and telehealth are among the most prominent applications of networking during this pandemic. Additionally, the COVID-19 pandemic highlights the importance of collaborative scientific efforts. In this chapter, we summarize the advantages of harnessing both social and scientific networking in minimizing the harms of this pandemic. We also discuss the extra collaborative measures we can take in our fight against COVID-19, particularly in the scientific field
Comparison of Secreted Frizzled-Related Protein -4 & -5 Promoter Methylation in Patients with Acute Myeloblastic Leukemia and Healthy Individuals
Get PDFBackground: DNA methylation patterns are often changed in cancer cells. Many
of the tumor inhibitor genes are silenced by methylation, such as CDKN2B, p73,
and the suppressor of cytokine signaling in patients with acute myeloblastic
leukemia (AML). Secreted frizzled-related protein -4 and -5 (SFRP4, 5) are
negative regulators of the Wnt signaling pathway. We aimed to evaluate the
methylation status of SFRP4 and SFRP5 genes in patients with AML.
Methods: Blood samples were isolated from 60 patients with AML and 30
healthy controls. DNA was exploited, treated with sodium bisulfite, and tested
utilizing methylation-specific polymerase chain reaction with specific primers
for methylated and unmethylated sequences of the SFRP4 and SFRP5 genes.
Results: The frequency of unfit hypermethylation of SFRP4 and SFRP5 genes
in patients with AML was characterized to be 50% (30/60) and 40% (24/60),
respectively. Moreover, for all the subjects in the control group, methylation of
SFRP4 and SFRP5 genes was negative. The spread of SFRP4 and SFRP5 promoter
methylation in patients with AML was higher than the control population.
Conclusion: Hypermethylation was seen in SFRP4 and SFRP5 genes in patients
with AML