Majalah Kedokteran Andalas
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Correlation Of Neutrophil Lymphocyte Ratio And Platelet Lymphocyte Ratio With Severity Of COVID-19
Full text linkThe neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) tests are simple tests can be done before a COVID-19 patient hospitalized. This examination is useful for determining the diagnosis and prognostic of the patient. The aim of the study was to determine the correlation between NLR and PLR with the severity of COVID-19. This research was an analytical study with a cross-sectional approach using secondary data from 289 medical records of patients with confirmed COVID-19 for the period June-August 2021. The total sampling technique was used and processed with the chi-square test. Most of the research subjects were in the range of 26-45 years (28.4%). More than half of the subjects were female (61.6%). There were 99 patients (34.3%) with severe conditions. Less than half of the patients had abnormal leukocyte and platelet examination results, namely 64 (22.1%) and 56 (19.4%). Patients with abnormal NLR and PLR examinations were 135 (46.7%) and 123 (42.6%). There was a significant correlation between NLR and the severity of COVID-19 inpatients (p<0.001, OR=9.452). There is a significant correlation between PLR and the severity of COVID-19 inpatients (p<0.001, OR=7.268). This study concludes a significant correlation between NLR and PLR with the severity of COVID-19
Diet tinggi asam lemak jenuh menyebabkan infertilitas pada pria: peran aksis usus-testis
Full text linkTujuan : Memaparkan efek diet tinggi asam lemak jenuh terhadap infertilitas pada pria melalui aksis usus-testis. Metode: Â Studi literatur. Hasil: Peran aksis usus-testis telah terbukti mempengaruhi kesuburan pria. Pusat aksis ini adalah mikrobiota usus. Dalam kondisi eubiosis terdapat hubungan simbiosis antara mikrobiota usus dan testis. Sedangkan pada kondisi disbiosis, salah satunya akibat diet tinggi asam lemak jenuh, terjadi peningkatan endotoksin berupa lipopolisakarida (LPS) serta penurunan asam lemak rantai pendek (SCFA) yang berperan sebagai antiinflamasi. Kondisi ini menyebakan hilangnya integritas epitel usus, sehingga terjadi translokasi bakteri dan sitokin inflamasi kedalam sirkulasi sistemik. Inflamasi tingkat rendah disistemik merusak integritas barier darah-testis, sehingga mengganggu spermatogenesis dan menekan kualitas semen. Mengembalikan kondisi eubiosis usus dapat memperbaiki integritas barier darah-testis sehingga meningkatkan kualitas semen. Kesimpulan: Diet tinggi lemak jenuh menyebabkan inflamasi tingkat rendah kronis yang dapat menyebabkan infertilitas pada pria
Anemia Defisiensi Besi Berat pada Remaja
Full text linkIron deficiency anemia (IDA) is anemia caused by a reduced body iron reserve to form red blood cells. During periods of rapid growth, such as the first year of life and adolescence, the need for iron increases, leading to an increased incidence of iron deficiency anemia during these periods. Deficiency of iron can lead to concealed intestinal bleeding. This case report discusses a 10-year and 7-month-old male patient with a diagnosis of severe iron deficiency anemia accompanied by occult bleeding. The patient received a blood transfusion due to a very low Hb level of 3.9 g/dl. The transfusion was administered gradually with a target Hb of 6 g/dl and was followed by iron supplementation. The blood transfusion provided was in the form of red cell packs, administered slowly in sufficient amounts to raise the Hb to a safe level
Hubungan Ekspresi PD-L1 dengan Stadium Patologis dan Grading Karsinoma Urotelial Kandung Kemih
No full textObjective: To determine the relationship between Programmed Cell Death-Ligand 1 (PD-L1) Â Â expression with histopathological variants, and staging of papillary thyroid carcinoma. Methods: This study is an observational research with a cross-sectional study. The sample consisted of papillary thyroid carcinoma cases from the Pathological Anatomy Laboratory of Dr. M. Djamil Padang General Hospital, spanning from January 2022 to December 2022, totaling 37 cases. Pathological stages of invasive urothelial carcinoma of bladder were assessed based on the TNM system WHO 2022 classification, and grades were evaluated according to the WHO 2022 classification. PD-L1 expression was assessed through immunohistochemical staining. Bivariate analysis was conducted using the Chi-square test, with statistical significance set at p < 0.05. Results: The study revealed a positive PD-L1 expression rate of 32.5%. Statistical analysis showed a significant association between PD-L1 expression and pathological stages of invasive urothelial carcinoma of bladder (p=0.019). High stages exhibited higher levels of PD-L1 expression. However, the study did not find a significant relationship between PD-L1 expression and grades of invasive urothelial carcinoma of bladder (p=0.152). Conclusion: There is an association between PD-L1 expression and pathological stages. PD-L1 expression is not associated with the grades of invasive urothelial carcinoma of bladder
Anosmia pada Rinitis Virus dan Rinitis COVID-19: Sebuah Tinjauan Naratif
Full text linkLatar Belakang: Anosmia adalah gejala khas pada rinitis akibat infeksi virus dan sering dilaporkan menonjol pada rinitis terkait COVID-19. Memahami perbedaan angka kejadiannya penting untuk penapisan klinis, keputusan isolasi, dan komunikasi risiko pada pasien. Tujuan: untuk melihat bagaimana anosmia pada rinitis virus dan rinitis COVID-19. Metode: penelitian ini merupakan suatu tinjauan naratif yang menggunakan metode PRISMA berdasarkan kriteria inklusi dan eksklusi. Hasil: anosmia yang disebabkan oleh rinitis COVID-19 memiliki angka kejadian yang lebih tinggi dibandingkan rinitis yang disebabkan oleh virus lain. Kesimpulan: angka kejadian anosmia lebih tinggi terjadi pada rinitis COVID-19 daripada rinitis virus. Anosmia dapat menjadi gejala alarm untuk mencurigai seseorang mengalami rinitis COVID-19
Biscuit Formulation With Substitution Of Mackerel Fish Meal (Rastrelliger Sp.) And Black Rice Flour (Oryza Sativa L. Indica) As An Alternative Snack For Diabetes Mellitus Sufferers
No full textObjective: This research aims to develop a biscuit formulation with the substitution of mackerel fish flour and black rice flour as an alternative snack for diabetes mellitus sufferers.Method: This research was an experiment with a Completely Randomized Design (CRD) consisting of four treatments, namely 0% (F0), 25% (F1), 50% (F2), and 75% (F3). Organoleptic tests were carried out on 7 trained panelists. The organoleptic test data was tested for normality using the Shapiro Wilk test. The results of the data distribution are normally distributed, so to determine whether there are real differences in each treatment, the data is processed using the ANOVA test at the 5% level, if it is known that there are significant differences (p value <0.05), followed by the Duncan New Multiple Range Test (DNMRT) at the 5% level to see which treatments are different. Results: The biscuits selected based on organoleptic tests were F1 biscuits with a water content of 3.1%, ash 1.5%, protein 5.2%, fat 3%, magnesium 117 gr, anthocyanin 14.88 mg. Conclusion: Biscuits substituted for mackerel fish flour and black rice flour can be used as an alternative snack for diabetes mellitus sufferers.Keywords: diabetes mellitus, biscuits, mackerel flour, black rice flourÂ
Hubungan Pengetahuan dan Sikap Terhadap Perilaku Masyarakat Dalam Upaya Pencegahan COVID-19 Di Kelurahan Bangkala Kecamatan Manggala Kota Makassar Tahun 2021
Full text linkObjective: to determine the relationship between knowledge and attitudes towards community behavior in efforts to prevent COVID-19 in Bangkala Village, Manggala District, Makassar City in 2021.Methods: The type of research used is an observational quantitative analytic study with a cross-sectional approach. The sampling technique used was accidental sampling. The sample was obtained by distributing online questionnaires in the form of a google form link that was distributed through social media, namely via whatsapp to the entire community of Bangkala Village, Manggala District, Makassar City, amounting to 376 people. Data analysis used Chi-square statistical test.Results: Based on the results of the chi-square test analysis, the p value on knowledge = 0.000 (<0.05) and the p-value on attitude = 0.000 (<0.05). This shows that there is a relationship between the level of knowledge and attitudes towards community behavior in efforts to prevent COVID-19.Conclusion: There is a relationship between knowledge and behavior of people in Bangkala Village, Manggala District, Makassar City towards efforts to prevent COVID-19. There is a relationship between attitudes towards community behavior in Bangkala Village, Manggala District, Makassar City towards efforts to prevent COVID-19.Â
Hubungan Komorbid dengan Outcome Pasien Terkonfirmasi COVID-19 Di RSUP M. Djamil Padang Tahun 2020
Full text linkTujuan : Penelitian bertujuan Untuk mengetahui hubungan komorbid dengan outcome pasien terkonfirmasi COVID-19 di RSUP. M. Djamil Padang tahun 2020. Metode : Penelitian bersifat analitik observasional dengan pendekatan cross sectional. Data dikumpulkan dan diolah dengan menggunakan teknik total sampling , yaitu semua pasien terkonfirmasi COVID-19 yang dirawat di RSUP M.Djamil Padang berdasarkan kriteria inklusi dan ekslusi . Jumlah sampel penelitian sebanyak 468 pasien terkonfimasi COVID-19 yang dirawat pada periode Maret – Desember 2020. Analisis yang digunakan adalah analisis bivariat berupa Chi-Square . Hasil: Hasil penelitian menunjukkan terdapat hubungan yang signifikan antara komorbid dengan outcome pada pasien terkonfirmasi COVID-19 (p=0,010) di RSUP. M.Djamil Padang. Kesimpulan : Berdasarkan hasil penelitian dapat diartikan bahwa terdapat hubungan antara komorbid dengan outcome pada pasien terkonfirmasi COVID-19
Kemampuan Berpikir Kritis dan Kecerdasan Emosional pada siswa SMA di Kota Pontianak
Full text linkTujuan : Mengetahui hubungan kemampuan berpikir kritis dan kecerdasan emosional pada siswa sekolah menengah atas (SMA) di Kota Pontianak. Metode : Penelitian ini menggunakan studi analitik observasional dengan pendekatan cross-sectional, dengan populasi 100 siswa SMA dari 6 kecamatan di Kota Pontianak yang mengisi kuesioner dan dianalisis menggunakan program komputer, cara pemilihan sampel menggunakan teknik probability sampling dengan cluster sampling. Hasil : Hasil analisis dengan teknik Spearman menunjukkan korelasi positif searah antara kemampuan berpikir kritis dan kecerdasan emosional pada variabel pengendalian diri sebesar 0,405 dan pada variabel empati menunjukkan korelasi sebesar 0,272. Kesimpulan: Terdapat hubungan antara kemampuan berpikir kritis dan kecerdasan emosional yang dapat berpengaruh terhadap pemecahan masalah dan pengambilan keputusannya pada masa depan. Kata kunci: Remaja, Perbaikan Kurikulum 2013, Kemampuan berpikir kritis, Kecerdasan emosional
Effect of Dadih Probiotics on Malondialdehyde Levels in Diabetic Mellitus Rats With Alloxan Induction
No full textObjective : This research aims to analyze the effect of dadih probiotics on MDA levels in alloxan-induced diabetic rats. Methods : This study used an experimental design with a post-test-only control group. Wistar strain white rat samples were divided into 4 groups. The negative group was not given any treatment, K(+), P1, and P2 were induced by alloxan 150 mg/kg BW on the first day. Groups P1 and P2 were given dadih probiotic doses of 1.87 g/200 gBW and 3.74 g/200 gBW on days 4 to 17. Results : Measurement of MDA levels was carried out on the 18th day. Data were analyzed with One Way Anova and a post-hoc test. The research results are statistically significant if p-value <0.05. The average levels of MDA K- 2.29 nmol/mL, K+ 3.77 nmol/mL, P1 2.97 nmol/mL, and P2 2.53 nmol/mL. Based on statistical tests, there was an effect of dadih probiotics on MDA levels as evidenced by a p-value < 0,05. Conclusion : Dadih probiotic doses of 1.87 g/200gBW and 3.74 g/200gBW can reduce MDA levels in rats