Pharmaciana
Not a member yet
486 research outputs found
Sort by
PENINGKATAN STABILITAS KURKUMIN MELALUI PEMBENTUKAN KOMPLEKS KURKUMIN-ï¢-SIKLODEKSTRIN NANOPARTIKEL DALAM BENTUK GEL
No full textCurcumin is a compound derived from turmeric. This compound is practically insoluble inwater and has poor stability. To improve the benefit of curcumin as a potential active compound in agel preparation, better stability are requested. Encapsulation was performed by freeze drying methodsand all evaluation data confirmed that curcumin included in the ï¢-cyclodextrin forming curcumin-ï¢-cyclodextrin nanoparticle. The formula showed particle size of 156.8 ± 38.3 nm, polydispersity indexof 0.174 ± 0.026, and zeta potential of -17.3  0.2 mV. The gelling agents used for formulation of gelbase were HPMC, CMC-Na, carbopol 940, water-soluble chitosan, and viscolam. Viscolam showedbest stability of pH and viscosity after storage at 25 and 40 oC for 28 days. The inclusion complex andcurcumin were incorporated into gel. Both of the formulas showed good stability in pH and viscosityafter storage at 25 and 40oC for 28 days, and the inclusion complex gel showed improvement in thechemical stability which is approximately 2.12-fold (p<0.01) and 1.41-fold (p<0.05), after storage at25 and 40 oC, respectively
PENGEMBANGAN PREPARASI NANOPARTIKEL THYMOQUINONE-KITOSAN DENGAN METODE KOSOLVEN MENGGUNAKAN ISOPROPIL ALKOHOL
Get PDFThymoquinone, an active compound isolated from black cumin seeds (Nigella sativa L.), has pharmacological activity as anticancer, antiinflammatory, and immunomodulator. This compound has a volatile nature, easily oxidized, and low melting point, leading to difficulties in tablet formulation. Moreover, its low solubility in water leading to low bioavailability. Therefore, it is necessary to develop nanoparticle drug delivery systems to solve these problems. Chitosan-thymoquinone nanoparticles can be formed using sodium tripolyphosphate as cross linker by cosolven method. Chitosan solution in acetate buffer pH 4 was added to thymoquinone solution in 50%, 75%, 100% isopropyl alcohol, than sodium tripoliphosphate solution in water was added slowly in a gently stirrer. The nanoparticle produced was characterized in its loading capacity (LC), particle morphology, particle size, and zeta potential, as well as the loading efficiency (LE) of nanoparticle. Factorial Design Optimization resulted that the best condistion is achieved by 75% isopropyl alcohol using thymoquinone level of 10 mg/mL and chitosan level of 10 mg/mL. In this condition, the nanoparticle has LC of 8.71%, LE of 76.29%, 609.8 nm in diameter and zeta potential of 137.9 mV. It can be concluded that isopropyl alcohol can help the formation of nanoparticles thymoquinone. The particle size and zeta potential is too big, therefore it is craved to modify the process by variation in thymoquinone, chitosan, and sodium tripoliphosphat concentration
STUDI PENGELOLAAN OBAT SEBELUM DAN SESUDAH JKN DI PUSKESMAS JETIS KOTA YOGYAKARTA
Get PDFThe effective and efficient drugs management is very crucial in the whole success of public health center management. The government hold a program called National Health Insurance (JKN) in order to achive quality and cost control which is effective and efficient. The research was aimed to know the drugs management at the public health center in Jetis Yogyakarta which includes drug plan, drug demand, drug acceptance, drug storage, drug distribution and the process of drugs recording and reporting. This study used observasional descriptif desaign. Subjects for this study was the implementation of drugs management work instruktion in public health center .The technique data collection used triangulation or the combination among stuctured observation result in the form of check list, interview with the human rosources involved of drug management and observation the drug management documentation. The technique analysis used quantative-qualitative descriptive analysis with percentage. The results showed that the drugs management at the public health center Jetis Yogyakarta at the drug plan, was included in both criteria (before JKN 100% and after JKN 100%), the drug demand was included in the criteria quite well (before JKN 63.64% and 63.64% after JKN ), the drug acceptance was included in both criteria (before JKN 100% and after JKN 100%), the drug storage was included in both criteria (before JKN 80.56% and 83.33% after JKN), the drug distribution was included in both criteria (before JKN 76, 92% and after JKN 84.62%), the drug recording and reporting was included in both criteria (prior JKN after JKN 100% and 100%). The general drug management before and after JKN at the public health center Jetis Yogyakarta was applicable standards and good criteria with the percentage of drug management before JKN amounted to 83.91% and after JKN amounted to 86.21%
GAMBARAN JUMLAH SKS MATA KULIAH PERGURUAN TINGGI FARMASI INDONESIA YANG MENDUKUNG PENGGUNAAN OBAT YANG RASIONAL
Get PDFAccording to World  Health Organization (WHO), there are two major steps as a commitment to make changes in the implementation of pharmacy practice that are national drug policy and learning system changes in pharmacy education. The aim of the research was to obtain the cummulative credit overview in college of pharmacy in Indonesia that supporting Rational Drug Use based on promotion rational drug use (PRDU) and International network  rational use of drug (INRUD). This study used a analytic descriptive design. The study was located in some colleges of pharmacy in Indonesia. Data was collected through observation of the recent curriculum used in the Indonesian college of pharmacy. Research were conducted by giving a questionnaire on the rational drug use topic in the curriculum and in-depth interviews with the dean or faculties appointed by the dean. The number of credits developed by 21 colleges of pharmacy as respondents have in between 140-158 credits. Median number of credits developed by C accreditation level are more than A and B accreditation level. Three of A accreditation level of colleges have number of credits in between 66-171 credits and a college with B accreditation level as much as 36.9 credits. Whereas in total of credits semester that support the RDU in Community and Clinical Pharmacy (CCP) interests has more than the non-CCP interests
EKSTRAK HEKSAN BIJI JINTAN HITAM (Nigella sativa L) MENINGKATKAN AKTIVITAS FAGOSITOSIS MAKROFAG TIKUS BETINA GALUR SD (Sprague Dawley) YANG DIINDUKSI DMBA (7,12Dimetilbenz(α)antrasen) SECARA IN VITRO
No full textPrevious research has shown that black cumin seed oil is as an immunomodulator, but the mechanism MBJH as an immunomodulator in DMBA-induced macrophage unknown. A study to determine the effects of EHBJH on the activities of SD rat peritoneal macrophage phagocytosis induced DMBA has been conducted. This study was conducted on 10 female Sprague Dawley rats were divided into two groups, namely 5 mice without any treatment group and 5 mice DMBA DMBA treatment groups. Once a week administration of 15 mg DMBA of mice,rats dissected and taken peritonealnya fluid for isolation of macrophages to be cultured for 24 hours. The peritoneal macrophages were given hexane BJH (Nigella sativa Lour) as much as 1 mg/mL, 5 mg/mL, 25 mg/mL, and were given a standard timokuinon for each group without induction DMBA and DMBA treatment groups. Macrophages were incubated for 2 hours back. Phagocytosis test is done by adding the latex particles on cultured macrophages and Giemsa staining. Data percentage of macrophages that eat latex and phagocytosis index were analyzed using the Kolmogorov-Smirnov test followed by ANOVA and LSD test with a 95% confidence level. The results showed that the activity and phagocytosis index DMBA -induced macrophages that is not greater than the index of activity and macrophage phagocytosis induced macrophages (p<0.05). A group of 25 mg/mL EHBJH have activity and phagocytosis index is highest when compared with the other treatment group (p<0.05). Conclusion: The study showed that the hexane BJH (Nigella sativa Lour) can improve macrophage phagocytic activity of female rats Sprague Dawley strain
PENAPISAN FITOKIMIA, PENETAPAN KADAR NAFTOKUINON TOTAL, DAN AKTIVITAS ANTIFUNGI FRAKSI TIDAK LARUT ETIL ASETAT EKSTRAK ETANOL DAUN PACAR KUKU (Lawsonia inermis L.) TERHADAP Candida albicans ATCC 10231
Get PDFCandidiasis is an infection caused by Candida albicans. Synthetic treatment against Candida albicans has been developed, but reports of resistance to antifungal agents that there continue to emerge, and cause a lot of side effects. Pacar kuku (Lawsonia inermis L.) is one of the plants that has antifungal activity. Chemical content of polyphenols inhibit candidiasis is a form of naphthoquinone. This study aimed to test the antifungal activity of ethanolic extract of insoluble ethyl acetate fraction of pacar kuku leaves against Candida albicans. The ethanol extract was obtained from the ethyl acetate extraction of previously fractionated with ethyl acetate. Identification of chemical compounds made with phytochemical screening. Test antifungal activity against Candida albicans using microdilution method. Amphoterisin B infusion in doses 250 µg/ml with the concentration of 1,50 µg/ml, 0,75 µg/ml, 0,38 µg/ml, 0,19 µg/ml, 0,09 µg/ml, dan 0,05 µg/ml were used as standard solution. The parameters in this study are the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). The concentration of the extract used in the MIC and MFC determination were 80%, 40%, 20%, 10%, 5%, 2,5% (w/v). Identification of chemical compounds was performed using test tubes and assay on anthraquinone compounds. The results showed that the MFC of the ethanol extract is 40% w/v. The MIC and MFC of amphoterisin B were 0,09 µg/ml and 0,19 µg/ml respectively. The test tubes showed that the ethanol extract contains polyphenols, saponins, and quinone. The naphtoquinone total content in the ethanol extract consecutively 7,97±0,14%
PENGARUH KITOSAN DARI CANGKANG UDANG TERHADAP RED BLOOD CELL, HEMOGLOBIN, DAN TROMBOSIT PADA MODEL RHEUMATOID ARTHRITIS YANG DIINDUKSI CFA
Get PDFThe research was conducted the effect of chitosan on rats blood alteration that induced arthtritis. In addition, the research used pre-post test group control design. than used  was divided into groups (n=6) including normal groups, positive control, negatif control, and  groups were treated by khitosan at varian 50 mg/200gBB and 100 mg/200gBB doses. Adjuvant-induced was developed using complete Freund’s Adjuvant on 1st day, than 17-47th days after treated given appropriate their groups. To evaluate did blodd counter on 0, 16th,and 47th days after treated with otomatic optic dan electronic resisten method. Than analyzed using ANOVA test and paired t-test (p<0,05). Result of the research is Chitosan 50 mg/200gBW fit to reduce of eritrocid 6,1% (p<0,05), hemoglobin 7,77% (p<0,05) and PLCR 35,29% (p<0,05), meanwhile of Chitosan 100 mg/200gBW fit to reduce of trombocyte 40,49% (p>0,05) and PLCR 35,66% (p<0,05). In additional research, khitosan 50 mg/200gBW fit to complete blood of the rheumatoid arthritic mouse well
PENGARUH UKURAN PARTIKEL BERAS HITAM (Oryza sativa L.) TERHADAP RENDEMEN EKSTRAK DAN KANDUNGAN TOTAL ANTOSIANIN
Get PDFBlack rice has been tested for its high anthocyanin content. Black rice can be one of the potential sources of anthocyanin. Particle size is one of factors which influences amount of isolated  biocompound  in maceration process. Decreasing particle size can increase the amount of isolated  biocompound and extract yield value. The high value of extract yield shows effectiveness of maceration process. In this research, particle size variation has been done maceration process for investigating its influence on black rice extract yield and total anthocyanin content of maceration  result. This study used black rice ( Oryza sativa L.) from Beringharjo market, Yogyakarta. Maceration  with solvent of ethanol 96% add ed HCl 37% until pH 1,0(1:6) is done for 6 x 24 hours, with particle  size variation: mesh 20/40, 40/60 and whole bran of black rice. Data of extract yield and total  anthocyanin content are analyzed by using one-way ANOVA with confidence level 95%. The results  revealed that extract yield and total anthocyanin content of black rice extract with particle size  variation: mesh 20/40, 40/60 and whole bran of black rice intact 6%; 16%; 11,26%; and  30,76 mg/100  g; 1167,80 mg /100 g; 322,23 mg/100 g, respectively. There is significant difference  between  tested groups (P< 0,05). We concluded that particle size of black rice influences extract yield  and total anthocyanin content of maceration result
PENGGUNAAN POTENTIALLY INAPPROPRIATE MEDICATIONS (PIMs) PADA PASIEN GERIATRI RAWAT INAP OSTEOARTHRITIS DI RS PKU MUHAMMADIYAH YOGYAKARTA
Get PDFPotentially inappropriate medications (PIMs) use among elderly is a serious public health problem because it is intrinsically linked to increased morbidity, mortality, and healthcare costs. This study aims to determine the association between number of drug prescribed, duration of hospital stay and PIMs use among elderly hospitalized patients at PKU Muhammadiyah Yogyakarta General Hospital. This study was analytic observational with cross-sectional study. Beers criteria 2012 were used to identify PIMs use among elderly hospitalized patients with osteoarthritis. Logistic regression analysis were used to determine association between number drugs of prescribed, duration of hospital stay and PIMs use. The results showed that 7 (38.9%) out of 18 hospitalized elderly patients were identified PIMs use and all of patients received atleast one PIM. The most common agents involved in PIMs were estazolam (11.1%), and metoclopramide (11.1%). Polypharmacy is a major predictor factor of PIMs use in this study
BENCANA ALAM DAN PENDIDIKAN INTERPROFESI
Get PDFHealth care provider provide first response to patients in disaster. Medical and health institutions in Indonesia which produce health professional are still in early process to develop IPE for their students. Health professional unaccustomed with team work to serve patients, therefore they are not properly prepared to response natural disasters. The aim of this article is to give understanding for health institutions about interprofessional education (IPE) concept related to natural disaster. Review article conducted by analyzing scientific article from journals and text books. IPE is a necessary step in preparing a collaborative practice ready health work force to respond in disaster and getting better patient outcomes. Patients are the primary focus of any emergency response such as disaster. In disaster team work is the crucial competency that must be think first. Team performance however may not be optimal and it is often the patient who suffers from this dysfunction. Improved inter professional practice in emergency response will lead to better patient outcomes when teams have adequate knowledge and skills. They will manage the patients each other appropriately based on their each role. Health institutions should develop IPE including module focus on disaster/emergency preparedness to optimize role of health provider. Real experience into community exercises also necessary to ensure that student involvement during actual disasters also needed as a part of local disaster management plans