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UJI AKTIVITAS KOMBINASI EKSTRAK AIR LIDAH BUAYA ( Aloe vera L.) DAN AKAR MANIS (Glycyrrhiza glabra L.) SEBAGAI PENYUBUR RAMBUT
Get PDFAloe vera (Aloe vera L.) contains amino acids, vitamins, folic acid, and liquorice (Glycyrrhiza glabra L) containing glisirizin, and flavonoids, which have properties as fertilizer hair. This study aims to obtain a combination of extracts with activity most optimal fertilizer hair, made 3 combination with a combination of 1 (the water extract of liquorice concentration of 2.5% and 7.5% aloe vera), a combination of 2 (the water extract of liquorice concentrations of 2, 5% and 2.5% aloe vera), and combinations of 3 (the water extract of liquorice concentration of 5% and 7.5% aloe vera). Testing the activity of hair growth is done by measuring the rate of hair growth, hair growth acceleration and weight of rabbit hair for 28 days. Rabbit hair growth results showed the combination 1 has an average length of the largest hair with hair growth rate value of 2.97 cm, accelerated hair growth amounted to 0.15 cm / day on day 7 and weighing 0.13 gram hair
ANALISIS ADVERSE DRUG REACTIONS OBAT ANTI RETROVIRAL PADA PENGOBATAN PASIEN HIV/AIDS DI RSUD GUNUNG JATI CIREBON TAHUN 2013
Get PDFAcquired Immunodeficiency Syndrome (AIDS) is a disease caused by infection with Human Immunodeficiency Virus (HIV). The pharmacology treatment for the infection was antiretroviral therapy. The problem from the use of antiretroviral drugs (ARV) is the emergence of unwanted drug reactions (adverse drug reaction). The purpose of this study was to identify and analyze the incidence of adverse drug reactions from the use of antiretroviral drugs in the treatment of patients with HIV / AIDS that occurred in RSUD Gunung Jati Cirebon. This study involves 122 patients. Data were obtained from medical records and patient interview form. The data were evaluated with a descriptive analysis of demographic profile of patients and the percentage of adverse drug reaction (ADR) The results showed an adverse drug reaction (ADR) on the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon. ARV regimens are the most widely used is the combination of Zidovudine + Lamivudine + Nevirapine / Efavirenz (AZT + 3TC + EFV) as much as 31.2% (38 people). Duration of therapy ARV in Seroja Clinic RSUD Gunung Jati Cirebon most is> 2 years - 4 years 28.7% (35 people). Types of adverse drug reaction (ADR), which occurs in the use of antiretroviral drugs in the treatment of patients with HIV / AIDS in RSUD Gunung Jati Cirebon include: headache (22.1%), fatigue (6.8%), anemia (9.3%), itching (14.4%), nausea / vomiting (20.1%), diarrhea (7.2%), lipodystrophy (2.0%), rash (11.3%), skin discoloration (1.6%), neuropathy (1.6%) and sleep disorders (3.6%)
PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN KELOR (Moringa oleifera L.) TERHADAP AKTIVITAS ANALGESIK DAN ANTIINFLAMASI MELALUI EKSPRESI ENZIM SIKLOOKSIGENASE
Get PDFKelor (Moringa oleifera L.) contains flavonoid as a major of bioactive constituent. Quercetin as a flvonoid group inhibits COX-2 in inflammatory process. This study aimed to determine the effect of etanol extract of the kelor leaves on the analgesics and antiiinflamatory in mice. Etanol extract of the kelor leaves were evaluated for analgesics activity through writhing assay test at doses of 12.5; 25 and 50 mg/kgBW using  Swiss albino mice. On the other hand antiinflammatory assay was performed by carrageenan induced paw edema of the etanol extract of the kelor leaves at 35; 70 and 140 mg/kgBW. Aspirin and sodiumdiclofenac were employeed as a standard for analgesic and antiinflammatory studies respectively. The result of the analysis show that etanol extract of the kelor leaves at doses 25 and 50 mg/kgBW decrease the number of writhing so that it have an analgesic power of 76.41±2.73% and 80.41±5.20%. Etanol extract of the kelor leaves at dosage 140 mg/kgBW show 24.30±2.960% antiinflammatory power and 46.37±6.434% on decreased COX-2 expression
UJI ANTIOKSIDAN EKSTRAK ETANOL DAUN DAN KULIT BATANG MANGGIS Garcinia mangostana L.
Get PDFAntioxidant was a compound which possessed an activity as scavenger of free radicals. This study was aimed to examine the antioxidant activity of ethanolic extract from leaves and skin barks of Garcinia mangostana. Antioxidant activity were evaluated by using DPPH method for ethanolic extract in serial concentration of 800, 400, 200 and 100ug/mL. The result found that ethanolic extract of leaves and skin barks of Garcinia mangostana showed antioxidant activity with IC50 value of 674.947 ug/mL and 565.759 ug/ml, they were eleven and ten times weaker than d-α-tocopherol (IC50 57,114 ug/mL) which were used as a control. In conclusion, EE from leaves and skin barks of Garcinia mangostana exhibited an activity as scavenger of free radicals from DPPH
AKTIVITAS ANTIMIKOSIS EKSTRAK ETANOL DAUN SIRSAK (Annona muricata L.)
Get PDFPrevalence of Candidiasis is still in high level. Some antimycosis have been less effective so it needs to explore novel sources of antimycosis, one of candidate is the soursop leaves (Annona muricata L.) The aims of this study to observe antimycosis activity of the ethanol extract of soursop leaves at concentration of 15 %, 30 %, and 60 % against Candida albicans ATCC 10231 with agar diffusion method . The results showed that all of the ethanol extract of soursop leaves have exhibited antimycosis activity which concentration-dependent
STUDI KINETIKA ADSORPSI Al-MCM 41 TERHADAP METILEN BIRU
Get PDFThe synthesis and kinetics studies of Al-MCM 41 of the methylene blue adsorption have been done. The observations of the adsorption kinetics are very important parameter in the adsorption process. This is the higher of adsorption kinetics tend to faster adsorption process. The results of characterization of Al-MCM 41 have a wall thickness is 15.173 Å, Pore Volume Pore is 0.584 cm3/g, Pore Diameter is 30.446 Å, Surface Area is 995.513 m2/g. The results of the adsorption kinetics of Al-MCM 41 to methylene blue adsorption follows pseudo second order with coefficient of determination (r2) value of 0.999 and the value of adsorption rate constant of Al-MCM 41 is 10-2 g.mg-1.min-1
Efektivitas ekstrak etanol daun ungu (Gratophyllum pictum (L.)) untuk menurunkan kadar TNF-α dan NO
Get PDFEthanol extract of Gratophyllum pictum L (G. pictum L). leaves contain phytochemical compounds such as alkaloids, tannins and flavonoids, which have antibacterial activity against Staphylococcus aureus. This study aims to prove the effectiveness of ethanol extract of G. pictum L. to reduce the level of TNF-α and NO in Swiss mice infected with S. aureus.The study treated 30 Swiss mice divided into 5 groups, consist of: K (-) normal mice ; K (+) mice were infected with S. aureus ; P1, P2, P3 were infected with S. aureus and given the ethanol extract of G. pictum leaves,75,150, and 300 mg/kgBW/day for 7 days . Mean levels of TNF-α of group K(-), K (+), P1, P2, P3 were 300.29; 550.29; 390.34; 517.67; 327.55 pg / mL respectively. One Way ANOVA test showed that there were significant differences between all treatment groups (p = 0.001), LSD Post Hoc test revealed P1 and P3 groups different significantly with K (+) with p= 0.013 and p = 0.001. Mean levels of NO of group K (-), K (+), P1, P2, P3 were 1.32; 3.56; 2.50; 2.64; and 1.56 μM/mL respectively. Kruskal WallisTest showed that the levels of NO not significantly different, although NO levels at 300 mg/kgBW/day similar with to the levels of NO group K(-). Spearman correlation test showed that there were correlations between TNF-α and NO with the variation results on each treatment groups. Ethanol extract of G. pictum leaves at 300 mg/kgBW/day for 7 days is regarded as the effective dose to reduce TNF-α and NO levels in Swiss mice infected by S. aureus
Uji sitotoksisitas dan antiproliferatif ekstrak etanol daun leunca (Solanum Nigrum,L) terhadap sel raji
Get PDFLeunca (Solanum nigrum,L.) is one of the medicinal plant which used society for traditional medication as antipyretic, hypotensive and anticancer. The aim of this research was to know an anticancer activity of ethanol extract of leunca leaves, emphasized on an ability to inhibit the growth Raji cell. Ethanol extract took from leunca leaf powder that epitomized using ethanol solvent by Soxhlet instrument. Citotoxicity test was done by incubating Raji cell at a density of 2x104 with treatment using ethanol extract from leunca (Solanum nigrum L.) leaf in several concentration 500; 250; 125; 62,5; 31,25; 15,62; 7,81 and 3,90 µg/ml. A test was done by MTT method and the percent of cell mortality was calculated. The LC50 values were calculated using probit analysis. The research continued with antiproliferation test on treatment sample concentration 50; 25 µg/ml with cell control for 24, 48, and 72 hours.The result of research indicate that ethanol extract of leunca leaves had cytotoxic effect towards Raji cell with LC50 values 59,22 µg/ml. The result of antiproliferation test showed that there were the growth of inhibitation on treatment sample with doubling time values 69,56 hour at concentration 50 µg/ml; 60,00 hour at concentration 25 µg/ml, and doubling time cell control is 44,98 hour
Potensi ekstrak etanol 70% akar saluang balum (Lavanga sarmentosa blume kurz) terhadap kualitas dan viabilitas sperma mencit
Get PDFThe present study tried to investigate potency of L. sarmentosa root extract on quality and viability of mice sperm.This study used 25 Swiss male mice were randomly divided into five experimental groups of 5. The ethanolic extract of L. Sarmentosa (100, 200, 400 mg/kg b.w/days), control and X-gra were administered orally for 14 days. The animals were evaluated for sperma quality (sperm count and sperm motility) and viability at 14 days treatment. The results showed that administration of L.sarmentosa roots extract significantly increasing the sperm count (970x106cell/mL) at 400 mg/kg b.w/days (P 0.0040). The extract dose of 200 mg/Kg b.w and 400 mg/Kg b.w had the highest motility values (95%). Viability of sperm are 83.8%; 96.0%; 87.8% respectively at a dose of 100 mg/kg b.w, 200 mg/kg b.w and 400 mg/kg b.w. Present finding oral administration of L. sarmentosa roots extract has a potency of the quality and viability of mice sperm
UJI AKTIVITAS PENYUBUR RAMBUT KOMBINASI EKSTRAK AIR TEH HIJAU DAN HERBA PEGAGAN
Get PDFHair fertilizer was used to stimulate hair growth that is used topically on the scalp. Natural materials are expected to be used as fertilizer hair is green tea leaves and herb gotukola. Because the green tea leaves contain a chemical polyphenol compounds that are flavonoids and their derivatives and herb gotukola contain lead compound triterfenoid saponin that are asiatikoside, flavonoids, phytosterols, madecassid acid, madecassoside, asiatic acid and amino acids are thought to have properties as fertilizer hair. This study was conduced to determine whether the combination of the water extract of green tea leaves and herb gotukola has activity as a hair fertilizer and combination which has the most optimum activity. Test hair fertilizer activities include the rate of hair growth, hair growth acceleration and the weight of the hair. In this study used three combinations are combination 1 ( the water extract of green tea leaves and 5% water gotukola herb extract 2.5%), combination 2 (the water extract of green tea leaf extract 7.5% and 2.5% water gotukola herb) and combination 3 (the water extract of green tea leaves and 5% water gotukola herb extract 7.5%). The results showed the combination of the water extract of green tea leaves and water extract herb gotukola has activity as fertilizer hair and extract the most optimum combination is a combination of 1 with a concentration of water extract of green tea leaves (5%) and water extract of the herb gotukola (2.5%) the rate of hair growth 2.689 cm in 28 days, accelerated hair growth 0.128 cm / day and the hair weighs 0.1938 grams in 28 days