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Tratamiento tributario del ingreso mínimo vital
No full textEn el presente trabajo se a analizan las obligaciones tributarias derivadas de la percepción del ingreso mínimo vital, determinando las deficiencias que su regulación presenta, como punto de partida para proponer las modificaciones que, de lege ferenda, se deberían acometer
The Evolution of Cooperation in Spatial Public Goods Game with Tolerant Punishment Based on Reputation Threshold
No full textPÉREZ BELTRÁN, Carmelo (ed.). Dinámicas de protestas en el mundo árabe. Desafiando a los orígenes autoritarios
No full textAnálisisis de Riesgos - Actividad 1.5
No full textTodo el material para el conjunto de actividades de este curso ha sido elaborado y es propiedad intelectual de José Luis Romero Béjar. Todos los materiales están protegidos por la Licencia Creative Commons CC BY-NC-ND que permite "descargar las obras y compartirlas con otras personas, siempre que se reconozca su autoría, pero no se pueden cambiar de ninguna manera ni se pueden utilizar comercialmente".El objetivo de esta tarea es realizar un análisis y discusión del concepto de Quantitative
Risk Management (QRM), abordando los siguientes aspectos clave:
- Definición y fundamentos del QRM.
- Aplicaciones en la gestión del riesgo financiero.
- Modelos y metodologías utilizadas.
- Ventajas y desafíos del enfoque cuantitativo.
- Discusión sobre su relevancia en el contexto actual.The objective of this task is to analyze and discuss the concept of Quantitative Risk Management (QRM), addressing the following key aspects:
- Definition and fundamentals of QRM.
- Applications in financial risk management.
- Models and methodologies used.
- Advantages and challenges of the quantitative approach.
- Discussion on its relevance in the current context
Hydroxytyrosol N-alkylcarbamate conjugates as antitrypanosomal and antileishmanial agents
No full textNovel lipophilic hydroxytyrosol N-alkylcarbamate conjugates were synthesized by coupling several alkyl isocyanates
of different chain lengths with the primary hydroxy group of this natural phenol. These N-alkylcarbamate
conjugates were tested as antitrypanosomal and antileishmanial agents, and their cytotoxicity was
evaluated against the human MRC-5 and THP-1 cell lines. Five of these N-alkylcarbamate derivatives showed
submicromolar IC50 concentrations against Trypanosoma brucei brucei, with values ranging from 0.2 to 0.8 μM,
and three other hydroxytyrosol conjugates showed IC50 values below 5 μM. Data for the five most active Nalkylcarbamate
derivatives indicate a gain in activity relative to hydroxytyrosol of between 115- and 460-fold,
and selectivity indices for control/human MRC-5 cells relative to T. b. brucei parasites of between 47- and 140-
fold. These N-alkylcarbamate derivatives were also tested against the intracellular amastigote form of Leishmania
donovani in infected THP-1 macrophages, where five compounds had IC50 values less than or equal to 10 μM,
with selectivity indices relative to L. donovani of between 3- and 25-fold in MRC-5 cells and between 8- and 60-
fold in THP-1 cells. In all of these derivatives, the ortho-diphenolic groups were free. When the hydroxytyrosol
derivatives had ortho-diphenolic groups protected by benzyl groups, cytotoxicity against T. b. brucei and L.
donovani showed significantly higher IC50 values, with most cases exceeding 20 μM.Se sintetizaron nuevos N-alquilcarbamato conjugados lipofílicos de hidroxitirosol mediante el acoplamiento de varios isocianatos de alquilo, de diferentes longitudes de cadena, con el grupo hidroxilo primario de este fenol natural. Estos N-alquilcarbamato conjugados se ensayaron como agentes anti-tripanosómicos y anti-leishmánicos, y se evaluó su citotoxicidad frente a las líneas celulares humanas MRC-5 y THP-1. Cinco de estos N-alquilcarbamato derivados mostraron concentraciones IC50 submicromolares frente a Trypanosoma brucei brucei, con valores que oscilaban entre 0.2 y 0.8 μM, y otros tres conjugados de hidroxitirosol mostraron valores IC50 inferiores a 5 μM. Los datos de los cinco N-alquilcarbamato derivados más activos mostraron una ganancia de actividad, en relación con el hidroxitirosol, de entre 115 y 460 veces y unos índices de selectividad para las células control/humanas MRC-5, en relación con los parásitos de T. b. brucei, de entre 47 y 140 veces. Estos N-alquilcarbamato derivados también se ensayaron frente a la forma amastigote intracelular de Leishmania donovani en macrófagos infectados THP-1, donde cinco de estos compuestos presentaron valores de IC50 inferiores o iguales a 10 μM, con índices de selectividad frente a L. donovani de entre 3 y 25 veces en células MRC-5 y de entre 8 y 60 veces en células THP-1. En todos estos derivados, los valores de IC50 fueron inferiores o iguales a 10 μM, con índices de selectividad frente a L. donovani de entre 3 y 25 veces en células MRC-5 y entre 8 y 60 veces en células THP-1. En todos estos derivados, los grupos orto-difenólicos estaban libres. Cuando los derivados del hidroxitirosol tenían grupos orto-difenólicos protegidos por grupos bencilos, la citotoxicidad frente a T. b. brucei y L. donovani mostró valores de IC50 significativamente más altos, superando en la mayoría de los casos la concentración de 20 μM.FQM-13
Uterus didelphys: the first case report on molecular profiling of endometrial tissue from both uterine cavities
No full textBackground A didelphic uterus represents a unique and infrequent congenital condition in which a woman
possesses two distinct uteri, each with its own cervix. This anomaly arises due to partial or incomplete merging of the
Müllerian ducts during the developmental stages in the womb. Accounting for uterine malformations, a didelphic
uterus is a relatively rare condition, affecting approximately 0.5–2% of the population and is considered one of the
more uncommon types of uterine abnormalities.
Methods This case report aims to study the physical separation in uterine didelphys and its impact on endometrial
microbiome and inflammation, and the patterns of endometrial receptivity observed.
Results Endometrial receptivity analyses revealed a similar receptive state in both uteri, both in the early receptive
phase. Differential markers of chronic endometritis, including CD138, and MUM1-positive cells, were observed
when comparing endometrial biopsies from both uteri. The right uterus exhibited a higher prevalence of these
positive cells. Regarding the microbiome, significant differences were found between the uteri, notably in the right
uterus, a clear non-dominance of lactobacilli and the presence of genera such as Staphylococcus, Streptococcus,
and Acinetobacter. Additionally, the right uterus presented a less ‘favourable’ microenvironment, a characteristic
that was also reflected in the right cervix; both sites presenting less lactobacilli than the left side samples. A distinct
metabolomic signature associated with the physical separation of the uteri contributed to the differences in
endometrial milieu.
Conclusions Our study revealed that physical separation, among other factors in uterus didelphys, affects the
endometrial microbiome, metabolome, and inflammatory state, with significant microbiome variation observed
between the uteri, although similar endometrial receptivity patterns were noted.Projects Endo-Map PID2021-12728OB-I00, ROSY
CNS2022-135999 funded by MICIU/AEI/10.13039/501100011033 and by
FEDER, EU, and Enterprise Estonia (grant EU48695 and project RE.5.02.22–019
ReadUteru)Becas Fundación Ramón Areces para
Estudios Postdoctorales – Convocatorias XXXV and XXXVI, respectively, para
Ampliación de Estudios en el Extranjero en Ciencias de la Vida y de la MateriaPlan de Recuperación, Transformación y resiliencia, Ayudas
para la recualificación del sistema universitario español, Ayudas Margarita Salas para la formación de jóvenes doctores – Universidad de MurciaHorizon Europe (NESTOR, grant no. 101120075) of the European
Commission and the Estonian Research Council (grant no. PRG1076
Masculinity in Caregiving: Impact on Quality of Life and Self-Stigma in Caregivers of People with Multiple Sclerosis
No full textBackground/Objectives: This study aims to examine the impact of the caregiving role on quality of life, perceived burden, gender dissonance, and self-stigma among male caregivers of individuals with multiple sclerosis (MS) in Andalusia, Spain. Methods: A total of 44 male caregivers participated, completing questionnaires on sociodemographic and functional characteristics of the persons with MS (PwMS) they cared for. Measures included the Caregiving Tasks in Multiple Sclerosis Scale (CTiMSS), the Zarit Burden In- terview (ZBI), quality of life (WHOQOL-BREF), gender perception, and self-stigma. Data analysis employed ANOVA and regression analyses to assess the relationship between perceived burden and quality of life. Results: Male caregivers experienced significant burden, particularly in instrumental and social–practical caregiving tasks, with a mean score of 23.9 on the ZBI. Perceived burden was inversely related to quality of life, notably impacting physical and psychological health. Sixteen percent of caregivers reported cogni- tive self-stigma, though without affective or behavioral manifestations. Gender dissonance was observed, as men often perceived certain caregiving tasks as feminine; however, many integrated this role within their masculine identity. Conclusions: Male caregivers of PwMS face the dual burden of caregiving demands and traditional gender expectations. While gender dissonance and low levels of self-stigma were observed, most caregivers adapted by integrating caregiving into their identity. These findings highlight the need for tailored interventions to address their unique challenges and enhance their well-being.SEJ 208: Estudios Socioculturales Aplicado
La predictibilidad de la motivación de los estudiantes de inglés como lengua extranjera a través de la credibilidad y la autoeficacia de los profesores
No full textTo boost students’ motivation, educators have a noteworthy impact on this
progress, and various aspects associated with teachers such as their traits and beliefs in their
abilities. For a long time, it has been broadly acknowledged that self-efficacy is an essential
element of motivation that impacts how students engage with their studies. Also, another
element is the credibility of the teacher, which pertains to how much the students believe
in the teacher. As a result, this study was carried out to inspect the impact of EFL teachers’
self-efficacy and credibility on learners’ motivation. Accordingly, 316 English as a Foreign
Language (EFL) learners participated in the research. Three scales were given to the students
and the gathered information was analyzed using structural equation modeling (SEM). The
findings indicated that both teachers’ credibility and self-efficacy have been proven to impact
learners’ motivation in the EFL educational field. 68% of changes in the EFL students’ motivation
can be predicted by their teachers’ credibility, and about 71% of changes in the EFL
learners’ motivation can be predicted by their teachers’ self-efficacy. The outcomes of the
study and their implications for teaching stakeholders were presented to consider teacher-related
factors, namely teachers’ credibility and self-efficacy in boosting learners’ motivation,
and finally, suggestions for future studies were also provided.Para aumentar la motivación de los estudiantes, los educadores tienen un impacto
notable en este proceso, y diversos aspectos asociados a los profesores como sus rasgos
y creencias en sus capacidades. Durante mucho tiempo, se ha aceptado ampliamente que
la autoeficacia es un elemento esencial de la motivación que influye en cómo los estudiantes
se involucran con sus estudios. También, otro elemento es la credibilidad del profesor, que se
refiere a cuánto creen los estudiantes en el profesor. Como resultado, este estudio se realizó
para examinar el impacto de la autoeficacia y la credibilidad de los profesores de inglés como
lengua extranjera (EFL) en la motivación de los alumnos. En consecuencia, 316 estudiantes
de inglés como lengua extranjera (EFL) participaron en la investigación. Se les entregaron
tres escalas a los estudiantes y la información recopilada se analizó mediante el modelado
de ecuaciones estructurales (SEM). Los resultados indicaron que tanto la credibilidad como la autoeficacia de los profesores han demostrado tener un impacto en la motivación de los
alumnos en el campo educativo de EFL. El 68% de los cambios en la motivación de los
estudiantes de EFL pueden ser predichos por la credibilidad de sus profesores, y alrededor
del 71% de los cambios en la motivación de los alumnos de EFL pueden ser predichos por la
autoeficacia de sus profesores. Se presentaron los resultados del estudio y sus implicaciones
para las partes interesadas en la enseñanza para considerar los factores relacionados con los
docentes, es decir, la credibilidad y la autoeficacia para impulsar la motivación de los alumnos
y, finalmente, también se proporcionaron sugerencias para estudios futuros
The Processional Throne of the discord: historical artistic evolution of the Canopy Passage of the Virgin of Consuelo from Antequera (1928-2024)
No full texthttps://epsir.net/index.php/epsir/article/view/1347Introducción: Entre 1928 y 2017, la Virgen del Consuelo de Antequera ha tenido cuatro tronos procesionales, con variaciones en el palio a lo largo de los años, incluyendo un palio negro de estilo antequerano y dos palios rojos. El palio rojo representó una ruptura en la tradición local, convirtiéndose en un sistema complejo de valores identitarios. Metodología: El estudio se basa en una metodología documental, utilizando documentación de archivo y prensa histórica para analizar la evolución histórico-artística del diseño del paso procesional de la Virgen del Consuelo desde 1928 hasta la actualidad. Resultados: El objetivo es categorizar las diferentes fases evolutivas del diseño del paso procesional, documentar los diseños y sus contextos históricos, y identificar la autoría de los diseños y los artesanos involucrados en su creación. Discusión: Este análisis permite comprender cómo el diseño del paso procesional ha cambiado a lo largo del tiempo, reflejando tanto la evolución estética como los cambios en los valores culturales y tradicionales de Antequera. Conclusiones: La publicación ofrece una visión integral de la evolución del paso procesional de la Virgen del Consuelo, destacando su relevancia como símbolo de identidad local y su relación con los contextos históricos y artísticos.Introduction: Between 1928 and 2017, the Virgen del Consuelo de Antequera has had four processional thrones, with variations in the pallium over the years, including a black Antequera-style pallium and two red palliums. The red pallium marked a true break from local tradition, becoming a complex system of identity values. Methodology: The study is based on a documentary methodology, using archival documentation and historical press to analyze the historical-artistic evolution of the design of the processional step of the Virgen del Consuelo from 1928 to the present day. Results: The aim is to categorize the different evolutionary phases of the design of the processional step, document the designs and their historical contexts, and identify the authorship of the designs and the artisans involved in their creation. Discussion: This analysis helps to understand how the design of the processional step has changed over time, reflecting both aesthetic evolution and changes in the cultural and traditional values of Antequera. Conclusions: The publication offers a comprehensive view of the evolution of the processional step of the Virgen del Consuelo, highlighting its relevance as a symbol of local identity and its relationship with historical and artistic contexts
