92516 research outputs found
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Desarrollo e investigación en torno a una narrativa ilustrada y animada
No full textEste TFM trata de generar un contenido narrativo desde cero, mediante un proceso de pre-producción, realizando una gran cantidad de concept art, centrado en el diseño de personajes, además de una investigación entorno a los distintos formatos y las necesidades narrativas, así como el proceso de creación de cada uno de ellos. Pasando además por los procesos de producción de cualquier álbum o animación, diseño de escenarios, personajes, storyboard, producción, montaje y por último la movilización de contenido. El tema central de la historia es el de aprender a cuidar, en este caso metafóricamente a una planta, la comparativa entre el niño y su abuela, la cual ya tiene cierto recorrido de aprendizaje. El desarrollo del personaje que, mediante el juego, las emociones y el aprendizaje, adquiere la capacidad de poder hacer florecer eso que tanto ama. Esta historia tiene distintas formas de ser entendida, el amor por la naturaleza, la salud mental, la infancia y creer en uno mismo, son valores que quiero transmitir mediante mis ilustraciones. Todo ello adaptado a un público infantil en el caso del álbum ilustrado, y en forma de animación un pequeño teaser sobre el encuentro y emociones de los personajes que se ven envueltos en la historia.This TFM tries to generate narrative content from scratch, through a pre-production process, carrying out a large amount of concept art, focused on character design, in addition to research into the different formats and narrative needs and the creation process of each of them. Also going through the production processes of any album or animation, set design, characters, storyboard, production, assembly and finally the mobilization of content. The central theme of the story is learning to take care of, in this case metaphorically a plant, the comparison between the child and his grandmother, who already has a certain learning journey. The development of the character who, through play, emotions and learning, acquires the ability to make what he loves so much flourish. This story has different ways of being understood, love for nature, mental health, childhood and believing in oneself, are values that I want to transmit through my illustrations. All of this, adapted to a children's audience in the case of the illustrated album, and in the form of animation a small teaser about the meeting and emotions of the characters who are involved in the story.Universidad de Granada. Máster en Dibujo: Ilustración, Cómic y Creación Audiovisual. Trabajo Fin de Máster. Curso académico 2024-202
Fh15 Reduces Colonic Inflammation and Leukocyte Infiltration in a Dextran Sulfate Sodium-Induced Ulcerative Colitis Mouse Model
No full textUlcerative colitis (UC) is the most prevalent inflammatory bowel disease (IBD) in the USA. Current treatments present clinical limitations, underscoring the need for innovative therapeutics that promote an anti-inflammatory immune response. This study evaluates the anti-inflammatory potential of Fh15, a recombinant Fasciola hepatica fatty acid binding protein, in a DSS-induced UC mouse model. Our results demonstrated that Fh15 treatment significantly ameliorated the severity of colitis by reducing the disease activity index (DAI) and histopathological scores. Moreover, Fh15 also decreased the serum levels of myeloperoxidase (MPO) and chitinase-3-like protein 1 (CHI3L1), and the expression of S100A9, a calcium and zinc binding protein, which is an important marker for the pathogenesis of UC. Furthermore, Fh15 downregulated pro-inflammatory cytokines TNFα and IL-1β in the distal colon, suggesting modulation of macrophage activity. Immunohistochemistry analysis revealed significantly reduced neutrophil and macrophage infiltration in UC Fh15-treated mice. These findings highlight the therapeutic potential of Fh15 for UC, as it modulates inflammatory responses, reduces leukocyte infiltration, and preserves colon integrityDepartment of Microbiology and Medical Zoology, University of Puerto Rico-Medical Sciences Campus, San Juan, PR 00936, USA
Mouse Histology & Phenotyping Laboratory, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA
Institute of Biotechnology, Department of Parasitology, University of Granada, 18071 Granada, Spai
Práctica Docente: Estudio de variabilidad climática mediante el análisis de componentes principales en modo S y T
No full textEl Judaísmo: la Misnah, el Talmud, Pentateuco, Salmos, Profetas. La Qábala y el Zohar
No full textNotas sobre conferencia impartida e Seminario sobre religionesGrupo de Investigación HUM-165: Patrimonio, Cultura y Ciencias Medievales
librosEPCCM
"Manuel Espinar Moreno". Centro Documental del Marquesado del Cenete,
Departamento de Historia Medieval y CCTTH
Taxonomic, functional diversity and emergence patterns of Plecoptera: a long‑term study in a Dinaric karst biodiversity hotspot
No full textA long-term study was conducted in a tufa barrier located in a barrage-lake system in the Dinaric Western Balkan Ecoregion, with the main aim of increasing our knowledge about Plecoptera ecology, i.e. their taxonomic and functional diversity, microhabitat preferences and emergence patterns. With six pyramidal emergence traps anchored to the streambed, a total of 8191 adult specimens of 12 plecopteran species were recorded. Nemoura cinerea was the dominant, and Isoperla oxylepis the rarest species. Emergence was seasonal and influenced by water temperature. Some species emerged mostly in spring/early summer (Nemouridae), and some in autumn/early winter (most Leuctridae). Plecoptera preferred microhabitats with pebbles, mosses and higher water velocity. New data on species-level preferences, such as Leuctra albida selecting similar conditions, improve our understanding of plecopteran ecological requirements in Dinaric karst tufa barriers. Plecoptera assemblage metrics were comparable among the three hydrological periods identified during the study, and among the 14 years of the study, indicating resilience of the recorded species to the effects of ongoing climate change.KLIMA4-HR (KK.05.1.1.02.0006)University of Zagreb, Plitvice Lakes NP (FEN-PLI-106-F19-00081)Ministry of Science, Education and Sports (MZOS-119-1193080-3076)German Academic Exchange Service (DAAD) - Short-Term Research Grant, 2019 (57440917
La traducción decolonial y posthumanista de voces caribeñas en la era de la IA: un caso práctico
No full textLa colección Monográficos Vertere de Traducción e Interpretación de la
Universidad de Valladolid ha sido acreditada en el año 2024 con el Sello de
Calidad en Ediciones Académicas CEA-APQ, promovido por la Unión de
Editoriales Universitarias Españolas (UNE) y avalado por la Agencia Nacional
de Evaluación de la Calidad y Acreditación (ANECA) y la Fundación Española
para la Ciencia y la Tecnología (FECYT), obteniendo la «Mención Especial de
Internacionalidad».Este capítulo examina cómo herramientas de IA (DeepL y ChatGPT) pueden integrarse —sin sustituir— en una metodología de traducción literaria decolonial y poshumanista. A partir de un caso práctico de traducción colectiva (UGR, 2023/2024) de relatos de Love’s Promise (2017) de la autora jamaicana Opal Palmer Adisa, el texto articula un marco teórico poscolonial/decolonial (Spivak, Bhabha, Wynter, Mignolo, Rivera Cusicanqui) y lo cruza con debates poshumanistas sobre la relación humano-tecnología. El análisis muestra, mediante ejemplos comentados, cómo la IA resulta útil para definir, sugerir y explorar opciones léxicas, pero no resuelve por sí sola la carga connotativa, ética y estilística del original: ahí entra la lectura hermenéutica, la investigación cultural y la reescritura. La propuesta culmina defendiendo una traducción híbrida y situada, que preserva oralidad y heteroglosia mediante decisiones creativas (incluida la adopción estratégica de rasgos del español caribeño) y reafirma el papel irreductible de la traductora como intérprete crítica.This chapter explores how AI tools (DeepL and ChatGPT) can be integrated—without replacement—into a decolonial and posthumanist methodology for literary translation. Drawing on a practical case study of collective translation (University of Granada, 2023/2024) of short stories from Opal Palmer Adisa’s Love’s Promise (2017), it combines postcolonial/decolonial approaches (Spivak, Bhabha, Wynter, Mignolo, Rivera Cusicanqui) with posthumanist debates on human–technology relations. Through commented examples, the chapter shows that AI can be useful for generating, testing, and mapping lexical options, but cannot by itself resolve the text’s ethical, connotative, and stylistic density—which requires hermeneutic reading, cultural research, and creative rewriting. The proposal ultimately argues for a situated, hybrid practice that preserves orality and heteroglossia through deliberate translational choices (including the strategic use of Caribbean Spanish features), reaffirming the translator’s irreducible role as a critical interpreter
Discovery of core genes for systemic lupus erythematosus via genome-wide aggregated trans-effects analysis
No full textThe “omnigenic” hypothesis postulates that the polygenic effects of common variants on a typical complex trait coalesce on
relatively few core genes through trans-effects on their expression. Our aim was to identify core genes for systemic lupus
erythematosus (SLE) by testing for association with genome-wide aggregated trans-effects (GATE) scores for gene expression in a
large genetic dataset (5267/4909 SLE cases/controls). SLE was strongly associated with upregulation of expression of eight
interferon-stimulated genes driven by shared trans-effects. We estimate that trans-effects on interferon signaling account for 9% of
the total genetic effect on SLE risk. Outside this pathway, GATE analysis detected twenty putative core genes for SLE. Direct protein
measurements for these genes were strongly associated with SLE in UK Biobank. Two putative core genes (TNFRSF17, TNFRSF13B)
encode receptors (BCMA, TACI) expressed on B cells; their ligands (BAFF, APRIL) are targeted by drugs licensed or in development
for SLE. Four genes (PDCD1, LAG3, TNFRSF9, CD27) encode receptors that have been characterized as immune checkpoints, and
three (CD5L, SIGLEC1, CXCL13) are biomarkers of SLE disease activity. These results provide genetic support for existing drug targets
in SLE (interferon signaling, BAFF/APRIL signaling) and identify other possible therapeutic targets including immune checkpoint
receptors.UK Biobank Resource
(Application No. 23652)Academy of Medical Sciences, Wellcome Trust, UK Government Department of Business, Energy and Industrial Strategy, British Heart Foundation, y Diabetes UK
(Springboard Award SBF006/1109)Medical Research Council (MRC)
(Cross Disciplinary Fellowship Programme - MC_FE_00035)Consejería de Universidad, Investigación e Innovación — Junta de Andalucía
(EMERGIA Grant 30BM280101)EU/EFPIA Innovative Medicines Initiative Joint Undertaking
(PRECISESADS, Grant No. 115565
El caballo se mueve en L
No full textFinanciado por Diputación Provincial de Jaén y
Grupo de Investigación INCREAS (HUM-654)Monografía complementaria a la exposición "El caballo se mueve en L", de Jesús Montoya Herrera, Francisco José Sánchez Montalbán y Rafael Peralbo Cano, en el Centro cultural Baños Árabaes, Palacio de Villardompardo, Jaén, septiembre a noviembre de 2025. Exposición a partir de la obra teatral El público de Federico García Lorca.Complementary monograph to the exhibition "El caballo se mueve en L" (The Horse Moves in L), by Jesús Montoya Herrera, Francisco José Sánchez Montalbán, and Rafael Peralbo Cano, at the Baños Árabes Cultural Center, Villardompardo Palace, Jaén, September to November 2025. Exhibition based on the play “El Público” (The Audience) by Federico García Lorca.Diputación Provincial de JaénGrupo de Investigación INCREAS (HUM-654
Sourdough Breads Made with Selected Lactobacillus Strains and Spelt Flour Contain Peptides That Positively Impact Intestinal Barrier
No full textCereal grains have been dietary staples for millennia, providing essential nutrients alongside their primary carbohydrate content. Recently, the search for sustainable, nutrient-rich
alternatives has drawn attention to spelt (Triticum aestivum ssp. spelta L.), a low-input crop
with promising nutritional properties. Spelt supplies a higher content of unsaturated fatty
acids and minerals, such as iron, zinc, and magnesium and exhibits lower levels of phytic
acid compared to common wheat. This study explores the nutraceutical potential of fermented bakery products made from spelt and wheat flours using sourdough fermentation,
a process driven by lactic acid bacteria (LAB) and yeasts. Breads produced with baker’s
yeast were included for comparison. Specifically, this manuscript focuses on the generation
of bioactive peptides (BPs), which have demonstrated anti-oxidant, anti-inflammatory, and
gut-protective effects by modulating oxidative stress and inflammatory signaling pathways.
By comparing aqueous extracts from breads prepared with varying flours and fermentation
methods, optimal conditions for producing functional baked goods could be defined. The
findings may offer new avenues for developing bakery products that potentially increase
intestinal health while promoting sustainable agriculture through the use of spelt.University of Florence, Italy (RICATEN24)Ministry of Science, Innovation and Universities, Spain (PID2023-151294OB-I00, OMA
Effect of Alveolar Process and Basal Bone Features on Post-Extraction Dimensional Changes
No full textAim: To evaluate the effect of specific phenotypical and anatomical features of the alveolar process and basal bone on post-extraction
dimensional changes.
Materials and Methods: Patients requiring the extraction of a single maxillary non-molar
tooth were enrolled. A
comprehensive
panel of baseline anatomical characteristics, including sagittal root position (SRP) class, was recorded.
Linear and volumetric bone changes and the need for ancillary bone augmentation (NBA) were assessed after a 14-week
healing period.
Results: Records from 65 patients were included. Facial bone thickness (FBT) ≤ 1 mm was associated with significantly greater
dimensional changes and greater NBA compared to sites presenting FBT > 1 mm (88.46% vs. 35.13%; p < 0.002). Bone remodelling
and NBA were highest in SRP Class IV (100%), with lower frequencies in Class I (60%) and Class II (43.5%). Sites with roots
outside the bony housing showed significantly more remodelling and NBA (89.47% vs. 43.18%; p < 0.001). Sites with a basal bone
width narrower than the alveolar processes exhibited significantly greater bone remodelling and a higher prevalence of NBA
compared to sites where the basal bone was wider (88.89% vs. 50%; p = 0.09). Socket entrance dimensions, distance from the coronal
aspect of the facial bone to adjacent boundaries and root volume showed a comparable trend towards increased dimensional
changes and grafting.
Conclusions: Certain site-specific
features appear to significantly affect post-extraction
alveolar ridge remodelling and the subsequent
NBA to facilitate implant therapy.University of Iowa College of Dentistry
Department of PeriodonticsUniversity of Bern, Department
of Oral Surgery & Stomatology, School of Dental Medicin