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Токсиколого-гигиеническая оценка наночастиц оксида селена изолированно и в комбинации с наночастицами оксида меди
Get PDFЦель исследования - токсиколого-гигиеническая оценка безопасности наночастиц оксида селена при изолированной экспозиции и в комбинации с наночастицами оксида меди в условиях экспериментов in vitro и in vivo
Placenta previa: risk factors, maternal and perinatal outcomes
Get PDFThe aim of the study is to study the features of the anamnesis, pregnancy and childbirth outcomes for the mother and fetus with placenta previa, and to identify the main risk factors for this pathology.Цель исследования – выделить основные факторы риска предлежания плаценты на основании изучения особенностей анамнеза, исходов беременности и родов для матери и плода
Совершенствование метода немедленной имплантации у пациентов с отсутствием премоляров верхней челюсти
Get PDFЦель исследования. Усовершенствовать метод немедленной имплантации в области премоляров верхней челюсти с использованием индивидуализированных конструкций, смоделированных и изготовленных с применением аддитивных технологий
Natural human Bet v 1- specific IgG antibodies recognize non- conformational epitopes whereas IgE reacts with conformational epitopes
Get PDFBackground: The nature of epitopes on Bet v 1 recognized by natural IgG antibodies of birch pollen allergic patients and birch pollen- exposed but non- sensitized subjects has not been studied in detail.Objective: To investigate IgE and IgG recognition of Bet v 1 and to study the effects of natural Bet v 1- specific IgG antibodies on IgE recognition of Bet v 1 and Bet v 1- induced basophil activation. Methods: Sera from birch pollen allergic patients (BPA, n = 76), allergic patients without birch pollen allergy (NBPA, n = 40) and non- allergic individuals (NA, n = 48) were tested for IgE, IgG as well as IgG1 and IgG4 reactivity to folded recombinant Bet v1, two unfolded recombinant Bet v 1 fragments comprising the N- terminal (F1) and C- terminal half of Bet v 1 (F2) and unfolded peptides spanning the corresponding sequences of Bet v 1 and the apple allergen Mal d 1 by ELISA or micro- array analysis. The ability of Bet v 1- specific serum antibodies from non- allergic subjects to inhibit allergic patients IgE or IgG binding to rBet v 1 or to unfolded Bet v 1- derivatives was assessed by competition ELISAs. Furthermore, the ability of serum antibodies from allergic and non- allergic subjects to modulate Bet v 1- induced basophil activation was investigated using rat basophilic leukaemia cells expressing the human FcεRI which had been loaded with IgE from BPA patients. Results: IgE antibodies from BPA patients react almost exclusively with conformational epitopes whereas IgG, IgG1 and IgG4 antibodies from BPA, NBPA and NA subjects recognize mainly unfolded and sequential epitopes. IgG competition studies show that IgG specific for unfolded/sequential Bet v 1 epitopes is not inhibited by folded Bet v 1 and hence the latter seem to represent cryptic epitopes. IgG reactivity to Bet v 1 peptides did not correlate with IgG reactivity to the corresponding Mal d 1 peptides and therefore does not seem to be a result of primary sensitization to PR10 allergen- containing food. Natural Bet v 1- specific IgG antibodies inhibited IgE binding to Bet v 1 only poorly and could even enhance Bet v 1- specific basophil activation. Conclusion: IgE and IgG antibodies from BPA patients and birch pollen- exposed non-sensitized subjects recognize different epitopes. These findings explain why natural allergen- specific IgG do not protect against allergic symptoms and suggest that allergen-specific IgE and IgG have different clonal origin
Malignant neoplasms of the skin in different age periods
Get PDFThe purpose of the study is to analyze the dynamics of the incidence of malignant skin neoplasms among the population of the Sverdlovsk region in different age periods.Цель исследования – проанализировать динамику заболеваемости злокачественными новообразованиями кожи среди населения Свердловской области в разные возрастные периоды
Neurotoxic effects of lead oxide nanoparticles in rats after subchronic intranasal exposure
Get PDFThe purpose of the study -evaluation of the neurotoxic effect of PbO NPs on rats after subchronic intranasal exposure.Цель исследования – оценка нейротоксического действия наночастиц оксида свинца на крыс после субхронического интраназального введения их крысам
Clinical case of combined eye injury: penetrating corneoscleral wound with concussion of the third degree. Advanced surgical approach to treatment
Get PDFThe purpose of the study is to present a clinical case of severe combined injury of the eyeball: penetrating corneoscleral injury, concussion of the III degree, as well as an advanced surgical approach to the treatment of this pathology.Цель исследования – представить клинический случай комбинированной травмы глазного яблока: проникающее корнеосклеральное ранение, контузия III степени, а также расширенный хирургический подход к лечению данной патологии
Development of interactive dialogue simulator for studying functional disorders of children's digestive organs
Get PDFThe purpose of the study is the article is devoted to the development of an interactive simulator for the study of children's FDDS.Цель исследования. Статья посвящена разработке интерактивного диалогового тренажера для изучения ФРОП у детей
Environmental factors affecting posture disorders in children
Get PDFThe purpose of the study is to identify environmental factors in the organization of the educational process and lifestyle factors that adversely affect the formation of posture in children.Цель исследования - выявить факторы окружающей среды при организации учебного процесса и факторы образа жизни, неблагоприятно влияющие на формирование осанки у детей
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