Via Sapientiae: The Institutional Repository at DePaul University
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Addressing the Crisis of Masculinity: The Impact of a High School Counter-Hegemonic Course on Adolescent Male Identity and Traditional Masculinity Ideology
No full textRev. Michael Hurley, O.S.A. to Elizabeth Ann Seton, undated
Get PDFhttps://via.library.depaul.edu/seton_family_papers/1035/thumbnail.jp
Elizabeth Ann Seton to Rev. Pierre Badade, undated
Get PDFhttps://via.library.depaul.edu/seton_family_papers/1059/thumbnail.jp
Elizabeth Ann Seton to Rev. Pierre Badade, undated
Get PDFhttps://via.library.depaul.edu/seton_family_papers/1061/thumbnail.jp
That\u27s Not Happening to My Kid: Six Chicago Public Schools\u27 Families Speak Out
No full textThe purpose of this qualitative research study was to understand the experiences of six diverse families when Chicago Public Schools (CPS) failed to meet their children’s educational needs. The children attended grades k-8 in four Chicago neighborhoods. Nine family members from three generations were interviewed. They related school responses to their children’s behavior, and emphasized school failures and refusal to communicate with them and to provide and implement IEP and 504 Plans for their children. In response, family members advocated within and outside of CPS, searched for resources, used insider knowledge, bonded with other parents, and made major life changes. Fighting for their children’s needs, they described suffering emotional stress, health breakdowns, financial loss, frayed relationships, and moral injury. Despite experiencing harm, families showed resilience and became activists for their own and other children. The study revealed that school failure has a comprehensive impact on the entire family, that personal and school resources do not consistently prevent children from losing services, and that, despite suffering harm, families become empowered as they fight for their own and other children. Research shows school responses to children’s behavior often discriminates against children who are Black, Indigenous, Latinx, and have disabilities. Scholarship stresses the importance of family-school relationships to student success, but family voices are largely absent from scholarship, school decision-making, and policy. This study contributes the needed perspectives and lived experiences of families, voices are essential to create systemic and urgent change needed for Chicago Public Schools
Coming to the American Vincentian Mission in 1818: The Second Journey
No full textThree letters from Francesco Cellini, a Vincentian novice, and his confrere, Filippo Borgna, a Vincentian student with vows, are given or summarized here. In 1818, Cellini and Borgna made an eighty-eight-day voyage from Livorno, Italy, to the United States. Cellini wrote an account to a friend in Rome, and Borgna largely copied this in his letter, perhaps to ensure that one of their texts would survive the trip back to Italy. These are the only known detailed records of the Vincentians’ second journey to the US and reinforce records kept by Felix De Andreis and Joseph Rosati, who came two years before. These accounts all detail storms at sea and observe the US’s religious liberty and pluralism. The Cellini letters discuss the beauty of American landscapes and nature. John Rybolt adds, “Cellini’s emphasis on the saints as protectors and the devil as the source of the problems during their journey is unique to his account. Borgna’s letter adds valuable information on their travel arrangements after arriving in the New World. Additionally, the accounts of the first and second voyages clearly depict the challenges of reaching the new American mission on its western frontier.” Biographical information about both Vincentians is provided
The impact of temperature induced vertebral anomalies on C-start swimming performance in Astyanax mexicanus (Teleostei: Characidae)
No full textThis study investigates the impact that temperature-induced vertebral anomalies have on the C-start escape response of Astyanax mexicanus, a model species in evolutionary developmental biology. Employing three temperature treatments to induce varying degrees of skeletal anomalies, we assessed their effects on key swimming performance metrics including, C-start time, the curvature coefficient, head displacement distance, and displacement velocity. Through the use of linear mixed models (LMMs) and generalized linear mixed models (GLMMs), our results reveal that specific anomalies such as vertebral fusions and anomalous haemal and neural spines affected the curving ability of c-start escape responses, however, these did not negatively impact other performance parameters, with velocity, distance, and response time showing no significant impacts from any anomaly types, when assessed individually. This suggests a complex interplay between structural deformities and compensatory physiological mechanisms that maintain functional performance. Other variables measured had a stronger and significant impact on swimming performance, including standard length (SL), vertebral number, and temperature treatment, which influenced escape speed, curving ability, and overall locomotor performance. Our findings challenge conventional perceptions about the debilitating impact of vertebral anomalies, indicating that many affected fish can still effectively perform escape maneuvers, which is critical for survival. This study underscores the importance of considering morphological resilience in conservation strategies for Neotropical freshwater ecosystems facing environmental and anthropogenic pressures
1 Herpes Simplex Virus Type 1 and Apolipoprotein-E in Alzheimer’s Disease: Virus Entry and Innate Immunity
No full textHerpes simplex virus type 1 (HSV-1) is a neurotropic virus that has been detected in brains affected by Alzheimer’s Disease (AD), the leading global cause of cognitive decline. In vitro and epidemiological studies support a role for HSV-1 in AD. The strongest genetic risk factor for late-onset AD is the E4 allele of APOE, which codes for apolipoprotein-E (ApoE), a protein that mediates brain cholesterol homeostasis. Previous work has suggested that ApoE can affect HSV-1 entry into cells; however, APOE has three alleles (E2, E3, and E4) and allelespecific effects of ApoE on HSV-1 entry remain undetermined. We hypothesized that ApoE-E4 enhances HSV-1 entry into cells by incorporating into virus particles and promoting host cell attachment via heparan sulfate. This hypothesis was tested using a virus-cell binding assay, a virus entry assay, and a virus incorporation assay. While an allele-specific effect of ApoE on HSV-1 entry into cells was unable to be fully elucidated, ApoE was not found to incorporate into HSV-1 particles produced by murine astrocytes, indicating that this model of ApoE-E4-enhanced HSV-1 entry was unlikely. Chronic neuroinflammation is a hallmark of AD, and HSV-1 infection induces robust immune signaling. Therefore, a second hypothesis was formulated that HSV-1 infection contributes to AD development by synergizing with APOE4 genotype to elicit elevated immune responses. To explore the impact of APOE genotype on the innate immune response to HSV-1, primary cultures of murine astrocytes humanized for APOE3 or APOE4 were exposed to virus, and cytokine expression was characterized by qRT-PCR. HSV-1 infection stimulated increased CCL-2, CXCL2, and IL-6 mRNA in APOE4 astrocytes compared to APOE3 astrocytes. This finding supports a model in which virus-induced innate immunity contributes to the elevated AD risk associated with HSV-1 infection and APOE4 genotype