Journal for ReAttach Therapy and Developmental Diversities (JRTDD)
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Anticancer Activity Of Nanosuspension Of Extract Of Malaxis Acuminata On Breast Adenocarcinoma Cell Line (MCF-7 Cell Line) And Hepatocellular Carcinoma Cell Line (Hep G2 Cell Line) – An In Vitro Study
No full textThe cytotoxic activity of Malaxis Acuminata Nanosuspension (MANS) was evaluated using the MTT assay on two cancer cell lines: MCF-7 (breast adenocarcinoma) and Hep G2 (hepatocellular carcinoma). The study measured cell viability at various concentrations of Malaxis Acuminata Nanosuspension and compared it to the standard chemotherapeutic agent Doxorubicin. For MCF-7 cells, the IC50 value of Malaxis Acuminata Nanosuspension was 63.97 µg/mL, indicating a moderate cytotoxic effect, while Doxorubicin had an IC50 value of 1.81 µg/mL, demonstrating a higher efficacy. Similarly, for Hep G2 cells, Malaxis Acuminata Nanosuspension exhibited an IC50 value of 71.6 µg/mL, compared to Doxorubicin\u27s IC50 value of 2.23 µg/mL. The results suggest that MANS shows considerable cytotoxicity in both breast and liver cancer cell lines, though Doxorubicin was more potent. Malaxis Acuminata Nanosuspension holds promise as a potential therapeutic agent for cancer treatment, particularly as a natural-based alternative
Screening of Secondary metabolites of Endophytic fungi Alternaria alternata Isolated from Microstachys chamaelea (L) Muell.Arg.
No full textEndophytes are the treasure biopotential sources for the active biocompounds which can be used as pharmaceuticals and agrochemicals. In the current study, endophytic fungi Alternaria alternata isolated from Microstachys chamaelea was investigated. Ethyl acetate extract of the endophytic fungal metabolite was screened by Gas Chromatography - Mass Spectrometry technique. The identified biocompounds are Phthalic acid-cyclobutyl tridecyl ester, Phthalic acid-cyclobutyl isobutyl ester, Phthalic acid- 4-bromophenyl octyl ester, Phthalic acid- 4-cyanophenyl nonyl ester, Phthalic acid- 6-ethyl-3-octyl butyl ester, Phthalic acid- cyclobutyl tetradecyl ester, Phthalic acid- 4-nitrophenyl octyl ester, Phthalic acid- cyclobutyl hexyl ester, Phthalic acid-cyclobutyl heptyl ester and Phthalic acid-heptyl pentyl ester. These findings suggest that only Pthalic acid derivative secondary metabolites were found in the isolated Endophytic fungi Alternaria alternata from Microstachys chamaelea. These bioactive compounds could be used in the development of antimicrobial agents
Development And Characterization Of Liposomes Containing Relugolix
No full textResearch study investigates the formulation and characterization of Relugolix-loaded liposomes using a systematic approach involving various analytical methods. Relugolix, an BCS IV anticancer, was assessed for its physical properties, melting point, and solubility across multiple solvents, revealing optimal solubility in ethanol. UV spectroscopy established the absorption maxima at 247 nm, facilitating the development of a calibration curve in phosphate buffer pH 6.8. Fourier Transform Infrared Spectroscopy (FTIR) and Differential Scanning Calorimetry (DSC) provided insights into the drug\u27s chemical interactions and thermal behavior, respectively. Liposomes were prepared using the solvent evaporation method, and their formulation was optimized through a Box-Behnken design focusing on soya lecithin, cholesterol, and rotational speed. The optimized formulation (F8) exhibited a drug content of 97.56% and an entrapment efficiency of 95.78%, alongside promising in vitro drug diffusion profiles reaching 96.87% over 12 hours. Stability studies demonstrated that these parameters remained consistent over one month. Overall, this research highlights the potential of Relugolix-loaded liposomes for effective drug delivery, paving the way for future in vivo efficacy studies
Exploring Social Skills Among Students And Its Effects On Teachers
No full textProficient social skills significantly contribute to students’ well- being, help them understand the environment around, foster meaningful relationships. This challenge requires a multi-faceted approach with an obvious involvement of teachers; despite of all the tactics being played, some internal and external factors hinder students from honing this skill. Teachers often encounter a myriad of challenges when students lack adequate social skills. This chapter explores the attitude of the students towards social skills, and look into the under lying factors contributing the deficits in students, how this inability of the students is affecting the teachers’ mental health
Digital Marketing Strategies for Private and Public Hospitals: A Comparative Analysis
No full textFor hospitals to connect and communicate with their patients in the quickly changing healthcare industry, digital marketing has become a crucial tool. In this research report, the digital marketing strategies used by public and private hospitals are compared. This research examines the efficacy of these strategies utilizing a facts analysis-primarily based have a look at with a sample size of 250 respondents, targeting factors which includes social media presence, search engine marketing, email advertising and marketing, and patient interaction. The results highlight important areas where public healthcare organizations fall short and provide insight into how private hospitals use digital platforms more successfully than public hospitals. The study also emphasizes how telemedicine services and online patient reviews are becoming more and more significant in influencing patient decision. Both industries may enhance their outreach and service delivery to the digitally informed people by comprehending these strategies
State Livelihood and Trible Community: A Cross-sectional Sociological Study
No full textThis research article explores the intersection of state livelihood programs and tribal communities, focusing on their socio-economic conditions and the challenges they face in accessing state support. Tribal communities in India, despite constitutional protections and numerous welfare initiatives, remain one of the most marginalized groups. The study delves into various government schemes like MGNREGA, the Forest Rights Act, and the National Rural Livelihood Mission, assessing their impact on the livelihoods of tribal populations. By analyzing case studies from Odisha, Chhattisgarh, and Jharkhand, this article highlights the barriers to effective implementation, such as bureaucratic inefficiencies, geographical isolation, and cultural dissonance. Through a sociological lens, the paper examines how development-induced displacement, loss of traditional livelihoods, and systemic exclusion hinder the long-term sustainability of these programs. The article concludes by proposing participatory development strategies, strengthening legal protections, and ensuring sustainable livelihood models tailored to the specific needs of tribal communities, aiming for an inclusive approach to development
Analysis Of Impact Of Quality Of Life Among Depressed Teenagers
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Depression among teenagers is an increasingly prevalent mental health issue, significantly affecting their quality of life (QoL). This study aims to explore the impact of depression on the quality of life among adolescents, focusing on key dimensions such as emotional, social, physical, and psychological well-being. Depression in teenagers often leads to a negative spiral, with detrimental effects on academic performance, social interactions, family relationships, and physical health. This research examines how the various aspects of QoL are impaired, specifically addressing the emotional instability and social withdrawal commonly observed in teenagers with depression. Using a mixed-method approach, the study involves quantitative analysis through self-reported QoL surveys and qualitative interviews to capture the depth of emotional experiences. A sample of 200 teenagers, aged 13-19, diagnosed with clinical depression is analyzed, providing insights into the multifaceted impact depression has on their day-to-day lives. The study highlights that depressed teenager often experience a lower perception of self-worth, chronic fatigue, poor physical health, and difficulty maintaining social relationships, leading to isolation. Furthermore, the study finds that poor QoL exacerbates depressive symptoms, creating a vicious cycle that hinders recovery. The findings emphasize the need for targeted interventions aimed at improving QoL through comprehensive mental health support. These include therapeutic counseling, peer support programs, family-based interventions, and lifestyle changes promoting physical and emotional well-being. Enhancing the QoL for depressed teenagers not only aids in managing depression but also contributes to their overall development and future well-being. This research underscores the critical importance of addressing QoL in therapeutic frameworks for teenagers with depression to break the cycle of emotional and psychological distress.
Baboona (Matricaria Chamomilla): A Comprehensive Review of Its Unani And Modern Therapeutic Potential.
No full textBaboonah (Matricaria chamomilla), commonly known as chamomile, is a widely used medicinal plant in Unani Medicine for its calming, anti-inflammatory, and digestive properties. This review explores its botanical characteristics, traditional Unani uses, pharmacological activities, and current scientific evidence supporting its therapeutic applications. Matricaria chamomilla has shown promising potential in various conditions, including gastrointestinal disorders, sleep disturbances, and inflammatory diseases. This study aims to bridge traditional knowledge and modern pharmacological research, providing insights into its potential integration into contemporary therapeutic practices
Aspirations For Identity In Bama "Sangati” And Toni Morrison "Beloved"
No full textThe term “identity” encompasses a wide array of elements integral to one\u27s sense of self, including rights, equality, dignity, access to equal opportunities in both work and education, and the fundamental right to receive fair pay for one\u27s contributions. Postcolonial literature extensively delves into the multifaceted concept of identity, shedding light on how historical narratives, cultural contexts, and entrenched ideological frameworks intersect within both alien and native societies, intricately weaving themselves into the lives of the central characters. The pervasive sense of disorientation and isolation experienced by these protagonists emanates from the incessant questioning they face from those around them, probing into their origins and demanding answers to questions like ‘who are you? Where are you from?’ The inherent complexities arising from the juxtaposition of conflicting binaries create a profound identity crisis, where individuals find themselves grappling with the intricate puzzle of defining who they truly are amidst the competing societal expectations and self-perceptions. It becomes evident that identity is not a fixed, inherent trait but rather a nuanced and dynamic process that is shaped by a combination of external influences and personal agency. One\u27s sense of self is a composite tapestry of both bestowed attributes and consciously constructed facets, continually evolving and adapting in response to the complex interplay of personal experiences and societal constructions
In-Vitro Investigation Of Antioxidant And Antidiabetic Properties Of Plant Extracts
No full textMedicinal plants have consistently served as key sources of medicine around the world. India possesses a vast heritage of traditional medicinal plant resources and is home to diverse plant and animal species. Free radicals are implicated in numerous conditions such as diabetes, inflammation, and cancer, which has increased the interest in antioxidant therapies. Diabetes, a metabolic disorder caused by insufficient insulin or its improper metabolism, has seen a global rise in prevalence, with projections indicating further increases in future generations. Among the various therapeutic approaches to manage diabetes, regulating blood glucose levels through different mechanisms is critical.
This study focus on the In-Vitro investigation of the antioxidant and antidiabetic potential of plant extracts. Phytochemical analysis identified the presence of alkaloids, glycosides, carbohydrates, steroids, and flavonoids in both extracts. Physical properties such as solubility, melting point, ash values, loss on drying (LOD), and extractive values were also examined. The antioxidant activity of the extracts was measured using DPPH and H₂O₂ assays. Additionally, glucose production was assessed through the inhibition of the α-amylase enzyme. Our results demonstrated that Saraca asoca extracts exhibited significant in-vitro antioxidant and antidiabetic activity, indicating that these extracts warrant further investigation in pharmacological studies