İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Effectiveness of mandala coloring in reducing anxiety in women with early-stage breast cancer receiving chemotherapy for the first time
No full textContext: Many people with cancer experience fear or anxiety when starting chemotherapy for the first time. Mandala coloring is an art therapy approach commonly used for anti-stress therapy. Objective: To assess whether mandala coloring reduces the anxiety experienced by women with early-stage breast cancer during their first chemotherapy session. Design: A quasi-experimental controlled study with pretest/posttest design. Setting: The study was conducted in the outpatient chemotherapy unit of the Istanbul University Institute of Oncology between March 2017 and May 2018. Participants: Eight-four women with early-stage breast cancer who presented for their first session of chemotherapy were included, 41 in the intervention group and 43 in the control group. Intervention: Patients in the intervention group were asked to color a mandala for 30 min while receiving premedication prior to chemotherapy. No intervention was applied to the control group. Main outcome measures: Levels of distress and anxiety were assessed before and after premedication using the distress thermometer and State–Trait Anxiety Inventory. Results: The sample group consisted primarily of women who had primary school education, were married, and were homemakers. Average distress levels were low in both the intervention and control group before premedication, and state anxiety scores did not differ statistically between the groups before or after premedication. However, patients in the intervention group who had high distress levels before premedication showed a significant decrease in state anxiety score after premedication, while patients in the control group showed no decrease
Ovarian stimulation and oocyte cryopreservation in females with cancer
No full textPurpose of review: We reviewed the most recent developments including the safety and effectiveness data and success rates in individualized ovarian stimulation protocols for adult and postpubertal females with cancer. Recent findings: In women with breast cancer, aromatase inhibitor- and tamoxifen-supplemented stimulation protocols increase the margin of safety by limiting estrogen exposure. The outcomes of ovarian stimulation appear similar between cancer and noncancer populations, even with the recently developed random-start protocols, which allow initiation of ovarian stimulation anytime during the menstrual cycle. Based on lower anti-Mullerian hormone levels and primordial follicle density, carriers of BRCA pathogenic variants (BRCApv) have decreased ovarian reserve in comparison to women without those variants and may lose larger portion of their ovarian reserve post chemotherapy. Oocyte cryopreservation is also emerging as a suitable fertility preservation approach for selected postpubertal girls as young as 12 years of age. Summary: Individualized ovarian stimulation approaches combined with improvements in cryopreservation techniques increased the success and safety margin to preserve fertility with oocyte freezing. Women with BRCApv, on the other hand, may be at disadvantage as they have lower ovarian reserve and may lose larger portion of their ovarian reserve post chemotherapy compared to women who do not carry these variants.NICHD HD053112 to KO
Saberes plurais e educação em saúde: ação, reflexão e transformação
No full textAlém de exercer funções relacionadas ao cuidado, à gestão e à pesquisa, o profissional de enfermagem tem um importante papel como educador. A função de educador do enfermeiro é ampla e voltada para toda a comunidade. Ao desenvolver suas funções, a enfermagem deve atentar para as diferentes necessidades e origens culturais dos indivíduos. Portanto, os saberes tradicionais de saúde devem ser integrados ao cuidado e à educação em saúde
Dikey büyüme paterni olan sınıf III hastalarda sınıf III elastiklerle hibrit hyrax-mentonplak tedavisi sonrası iskeletsel ve dental yapıların retrospektif olarak 3 boyutlu değerlendirilmesi: Bir pilot çalışma
No full textObjective: The aim of the present study is to evaluate the skeletal and dental changes three-dimensionally in patients with skeletal Class III malocclusion and vertical growth pattern treated with hybrid hyrax-mentoplate and Class III elastic combination. Materials and Methods: In this retrospective study, conebeam computed tomography images of 6 patients (5 females and 1 male; Mean age: 11.9±0.9 years) who had undergone an orthopedic treatment with hybrid hyrax-mentoplate and Class III elastic combination were retrieved from the archive of Marmara University, Department of Orthodontics. Initial and post-protraction skeletal and dental parameters were investigated by using 3D SLICER version 5.0.2 software (www.slicer.org). Statistical significance was set at p0.05). There were no significant changes in vertical skeletal parameters except significant decreases in FH-OP and SN-OP angles of 5.28° and 5.18°, respectively. In terms of dental changes, while a significant decrease was found in LI-OP angle (8.82°), significant increases in LI-MP angle and in overjet change were found (5.27°, 3.75 mm, respectively) (p0.05). A significant increase was found in both SN-16M and SN-26M (5.79 mm, 4.10 mm, respectively) (p0,05). Vertikal iskeletsel değerlendirmede FH-OP ve SN-OP açılarında sırasıyla 5,28° ve 5,18° anlamlı azalma gözlenirken (p0,05). Dental değerlendirme parametrelerinden, LI-OP açısında 8,82° anlamlı azalma, LI-MP açısında 5,27° artış ve overjet değişiminde 3,75 mm anlamlı artış gözlenmiştir (p0,05). Hem SN-16M hem de SN-26M’de (sırasıyla 5,79 mm ve 4,10 mm) (p<0,05) anlamlı artış bulunurken, MP-36M ve MP-46M ölçümlerinde (sırasıyla 1,62 mm ve 2,29 mm) (p<0,05) anlamlı azalma gözlenmiştir. Sonuç: Hibrit hyrax-mentonplak ve Sınıf III elastik kombinasyonu uygulaması ile iskeletsel Sınıf III maloklüzyonlu ve artmış vertikal büyüme paternli hastalarda, yüz yüksekliğinde değişiklik olmaksızın ve mandibular ve palatal düzlemde rotasyon gözlenmeksizin sagittal yönde ortopedik düzeltme sağlanabilmektedir
Model and photographic analysis in orthodontics
No full textOrtodontide teşhis ve tedavi planlamasında modeller ve dental fotoğrafların önemi yadsınamaz. Bu yöntemler; dişler, kemikler ve yumuşak dokular hakkında kapsamlı bilgiler verebildiği gibi, aynı zamanda tüm kayıt yöntemleri arasında en noninvaziv yöntem olmaları yönünden de değerlidirler. Günümüzde üç boyutlu teknolojilerin gelişmesiyle birlikte her alanda olduğu gibi ortodontide de hem bu kayıt yöntemlerinde hem de analiz yöntemlerinde önemli gelişmeler yaşanmaktadır. Bu derlemenin amacı, günümüz ortodontisinde kullanılan diyagnoz yöntemlerinden model ve fotoğraf analiz yöntemlerini ve dijital teknolojideki gelişmelerin bu analizlere katkılarını incelemektir.The significance of models and dental photographs in the diagnosis and treatment planning within orthodontics cannot be overstated. They offer comprehensive information about teeth, bones, and soft tissues, and they are particularly valuable because they are noninvasive recording methods. In recent times, with the advancements in three-dimensional technologies, substantial progress has been made in both recording and analysis methods in orthodontics, as is the case in many other fields. This review aims to explore model and photographic analysis methods, which are among the diagnostic techniques employed in contemporary orthodontics, and the enhancements brought about by developments in digital technology to these analyses
Depremzedelerin optimal sağlığı için besinsel takviyelerin önemi
No full text(Dünya Sağlık Orgütü, doğal afeti "dış yardım gerektirecek kadar büyük ve ani ekolojik fenomen" olarak tammlamaktadır. Yer kabuğunda ani olarak ortaya çıkan enerjinin dalgalar halinde yer yüzeyini sarsmasıyla görülen dep-remler, can kapplarmın yanı sıra ciddi ekonomik kayıplara da neden olan önemli doğal afetlerdendir (Bao ve ark, 2021). Afet hazırlığı içerisinde yer alan "afet beslenmesi" kavramı 2000'li yıllarda geliştirilen yeni bir kavramdır (Koenig ve Schultz, 2010). Doğal afet sırasında gıda ve beslenme yönetimi ise afetin evresine göre farklılık göstermektedir ("Euboyama-Kasaoka ve Pur-ba, 2014)
The effect of dental biofilm induced gingivitis treatment on patients' taste perceptions
No full textGiriş ve Amaç: Tat algısı, genetik, yapısal ve çevresel pek çok faktöre bağlıdır. Kronik inflamasyonun, tat bozukluklarında etken faktörlerden biri olduğu düşünülmektedir. Bu çalışmada, dental biyofilme bağlı, inflamatuar karakterde bir dişeti hastalığı olan gingivitisli hastaların, tedavi sonrası tat algılarındaki değişiminin değerlendirilmesi amaçlandı. Gereç ve Yöntem: Çalışmada hastaların başlangıç periodontal durumu Quigley-Hein plak indeksi (Turesky modifikasyonu), gingival indeks, sondalamada kanama ve sondalanabilir cep derinliğini içeren periodontal indeks ve ölçümlerle; tat algıları, 6-n propiltiourasil (PROP) (0.32 mmol/l) ve NaCl (0.1 mol/l) solüsyonları ile ağız çalkalatılıp Etiketli Büyüklük Skalası kullanılarak değerlendirildi. Çalışmaya dahil edilen orta ve şiddetli gingivitisi olan hastalara Faz I tedavi uygulandı. Periodontal değerlendirmeler ve tat algısı değerlendirmeleri 1. haftada ve 1. ayda tekrarlandı. Veriler IBM SPSS 21.0 programı ile istatistiksel olarak değerlendirildi. Bulgular: Çalışma grubu; 16’sı kadın (27.88 ± 0.93 yaş ort.) ve 15’i erkek (28.6 ± 1.3 yaş ort.) 31 hastadan oluştu. Demografik verilerde istatistiksel olarak bir farklılık bulunmadı. Hastaların başlangıca göre 1. hafta ve 1. ayda değerlendiren tüm klinik parametrelerinde istatistiksel anlamlı düzeyde iyileşme gözlendi (p <0.05). PROP ve NaCl solüsyonları ile değerlendirilen tat algılarında, yine başlangıca göre tedavi sonrası 1. hafta ve 1. ay değerlendirmelerinde anlamlı düzeyde artış gözlendi (p <0.001). Sonuç: Çalışmada periodontal tedavi sonrası orta ve şiddetli gingivitis hastalarında klinik parametrelerdeki iyileşme ile korele olarak tat algılarında anlamlı düzeyde artış gözlendi. Kısıtlı bir popülasyonda yapılan bu çalışmanın hastalardan geri bildirimin alındığı, proinflamatuar sitokin değişimlerinin de değerlendirildiği daha kapsamlı çalışmalarla desteklenmesine ihtiyaç vardır.Aim: Taste perception depends on many genetic, structural, and environmental factors. Chronic inflammation is one of the causative factors in taste disorders. The study aimed to evaluate the post-treatment change in taste perceptions of patients with gingivitis, an inflammatory gum disease caused by dental biofilm. Material and Methods: The periodontal status of the patients with moderate and severe gingivitis was determined by periodontal indices and measurement; including Quigley-Hein plaque index (Turesky modification), gingival index, bleeding on probing and probing depth. Taste perceptions were asseslutions. Periodontal and taste perception evaluations were done at baseline and one week and one month after Phase I therapy. The data were statistically evaluated with the IBM SPSS 21.0 program. Results: The study group consisted of 31 patients; 16 female (27.88 ± 0.93 mean age) and 15 male (28.6 ± 1.3 mean age). No statistical difference was found in demographic data. A statistically significant improvement was observed in all clinical parameters (p <0.05) and a significant increase was observed in taste perceptions (p <0.001) evaluated with PROP and NaCl solutions in the first-week and first-month compared to baseline. Conclusion: A significant increase in taste perception was observed in patients with moderate and severe gingivitis after periodontal treatment, in correlation with the improvement in clinical parameters. This study needs to be supported by more comprehensive studies in which feedback from patients and proinflammatory cytokine changes are also evaluated
Intraabdominal infections and minimally invasive approaches
No full textİntraabdominal enfeksiyonlar (İAE) periton zarının ve intraperitonal kavitenin mikrobiyal kontaminasyonuna bağlı gelişirler ve peritonit olarak adlandırılırlar. İntraabdominal enfeksiyonlar nedenlerine göre dört sınıfa ayrılırlar; primer, sekonder ve tersiyer peritonitler ile karın içi abseler. İAE tedavileri de etyolojilerine göre değişmektedir. Medikal tedaviden cerrahi yöntemlere kadar farklı tedavi yöntemleri vardır. İAE çoğu zaman acil müdahale gerektirmekle birlikte zamanında ve uygun tedavi yapılmazsa morbiditesi ve morbiditesi yüksek oranda olan patolojilerdir. Günümüzde minimal invazif yaklaşımlar cerrahinin bir çok alanında kullanıldığı gibi intraabdominal enfeksiyona neden olan patolojilerin tedavisinde de sıklıkla kullanılmaktadır. Bu bölümde intraabdominal enfeksiyonlara neden olan ve acil cerrahi müdehale gerektiren patolojiler ile bunların tedavisinde kullanılan minimal invazif yöntemler anlatıldı.Intraabdominal infcctions (1A1) also named as peritonitis, occur duc to the microbio-logical contamination of peritonium and intraperitoncal cavity. Intraabdominal infcctions, according to thcir cthiologics, are classified into four groups; primary, secondary, tertiary peritonitis and in-traabdominal abecss. Treatment of 1A1 varies according to their cthiologics. Thcrc are different trcat-mcnt modalities ranging from medical treatment to surgical prosedures.1A1 usually require emergency intervention. They are pathologies with high morbidity and mortality if they are not treated appropri-atcly. Today, minimally invasivc approaches arc used in many areas of surgery as well as in the treat-ment of pathologies that cause intraabdominal infcctions. In this chapter, pathologies that cause intraabdominal infcctions requiring urgent surgical intervention and their minimally invasive treat-ment methods arc discussed
Determination of Rh type and gender using circulating cell-free fetal DNA in early pregnancy of Rh negative women in Turkey
No full textIntroduction: Choosing the right clinical approach for early and reliable diagnosis/screening is becoming more important day by day. The aim of the study was to determine the early RhD type with cff-DNA obtained from maternal plasma, especially in the light of recent developments. In this way, it is aimed to apply Rh Ig only to mothers who are determined to have RhD (+) fetuses and to prevent unnecessary further tests that may possess a risk for RhD (-) fetuses. Methods: Prediction of fetal gender and RH genotype was performed by using RT-qPCR method. With simultaneous amplification of sequences of SRY, DYS14 and RH genes (exon 7 and exon 10). Fetal gender and RhD were determined in 30 RHD (-) pregnant women with cfDNA. Results: As a result of genotyping, the gender of 67% (20/30) fetuses was determined as male; the gender of 33% (10/30) fetuses was determined as female in a sample group of 30 pregnancies. It was determined that the DYS14 100% (20/20) gene was more sensitive than the SRY 97% (18/20) gene in gender determination after examining prenatal and postnatal results. As a result of the analysis, the presence of 17% (5/30) RhD (-) fetuses and 83% (25/30) RhD (+) fetuses were determined which is 100% compatible with postnatal results. Discussion: Detecting fetal RhD gene in maternal plasma made an important contribution to its use in non-invasive prenatal screening. This study shows that unnecessary intervention and cost can be avoided with successful genotyping analysis performed with RT-qPCR
GQoSMT: On guaranteeing the quality of service requirements of simultaneous multithreading processors
No full textGuaranteeing the quality of service of a running thread on a Simultaneous Multithreading processor is one of the most challenging issues since these processors allow sharing of many datapath resources, including the Issue Queue, the Reorder Buffer, the Load/Store Queue, the branch prediction circuit, and multiple levels of the caches among multiple threads. In this study, we apply machine learning techniques to accurately predict the instant quality of service of a target thread so that we can transfer just a sufficient amount of shared resources to keep its quality of service stable at an expected level. Our test results show that our proposed prediction model gives only around 3% deviation from the target quality of service level, on average, whereas an earlier prediction model gives more than a 13% deviation