İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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A study on harmonic functions
No full textThe class of functions that have bounded boundary rotation and bounded radius rotation are the generalization of the convex and the starlike functions, respectively. The concept of such functions was introduced by L¨owner [1]. But he did not use the present terminology. It was Paatero [2,3] who systematically developed their properties and made an exhaustive study of the class of functions that have bounded boundary rotation. We will examine in this paper, the subclass of SH that is related to the class of functions that have bounded radius rotation
Clinical exome sequencing (CES) identifies a novel homozygous variant in NECTIN1 causing CLPED1
No full textClinical exome sequencing (CES) identifies a novel homozygous variant in NECTIN1 causing CLPED1European Soc Human Genetic
Hemşirelerde örgütsel bağlılığın değerlendirilmesi: Kesitsel bir çalışma
No full textThe recruitment and retention of qualified nurses are essential goals for healthcare institutions. However, various challenges can compromise nurses’ commitment. The study is a cross-sectional study conducted with 218 nurses using a sociodemographic questionnaire and an organization al commitment questionnaire and conducted through an online form. Data were analyzed using PSPP version 1.6.2-g78a33a. The sample consisted of 83.5% female participants and 43.1% were between the ages of 26-35. The proportion of singles in the sample was 46.8% and the proportion of those with postgraduate (specialist) degrees was 83.5%. Most participants had only one job (72.9%) and worked in private institutions (62.4%) in São Paulo (45.4%). The majority worked in wards (23.4%), had 1-5 years of professional experience (45.0%), and had been at their cur rent institution for 1-5 years (61.0%). Most participants work daytime shifts (67.0%) with a weekly workload of 40-48 hours (58.7%). The majority of nurses (38.5%) had no intention of leaving their jobs in the past 12 months. Most nurses showed moderate (39.4%) or high (33.9%) levels of or ganizational commitment. Nurses, who had only one job, worked during the day and had no in tention of leaving their job in the past 12 months, had higher organizational commitment scores. Although nurses maintain good levels of commitment even during crises, inadequate working conditions negatively affect this commitment. Healthcare institution administrators and nurse managers should aim to support nurses to strengthen their organizational commitment.Nitelikli hemşirelerin işe alımı ve işte tutulması, sağlık kurumları için temel hedefler arasında dır. Ancak çeşitli zorluklar hemşirelerin bağlılığını zayıflatabilir. Bu çalışmanın amacı, Brezilya’nın güneydoğu bölgesinde farklı sağlık kurumlarında çalışan hemşirelerin örgütsel bağlılık düzeyle rini belirlemektir. Araştırma, 218 hemşire ile çevrim içi bir form aracılığıyla gerçekleştirilen, sos yodemografik bir anket ve örgütsel bağlılık anketinin kullanıldığı kesitsel bir çalışmadır. Veriler, PSPP’nin 1.6.2-g78a33a sürümü kullanılarak analiz edilmiştir. Örneklem, ağırlıklı olarak kadın katılımcılardan (%83,5), 26-35 yaş aralığındaki kişilerden (%43,1), bekâr olanlardan (%46,8) ve lisansüstü (uzmanlık) derecesine sahip olanlardan (%83,5) oluşmuştur. Katılımcıların çoğunlu ğu yalnızca bir iş yerinde çalışmaktaydı (%72,9) ve São Paulo eyaletinde (%45,4) özel kurumlar da (%62,4) görev yapmaktaydı. Çoğunluk serviste çalışmakta (%23,4), 1-5 yıl arasında mesleki deneyime sahip (%45,0) olup mevcut kurumlarında 1-5 yıldır çalışmaktaydı (%61,0). Çoğu katı lımcı gündüz vardiyasında (%67,0) haftalık 40-48 saatlik (%58,7) görev yapmaktaydı. Hemşirele rin çoğu (%38,5) son 12 ay içinde işlerinden ayrılmayı düşünmediğini belirtmiştir. Hemşirelerin çoğunluğu orta (%39,4) ve yüksek (%33,9) düzeyde örgütsel bağlılık sergilemiştir. Yalnızca bir iş yerinde çalışan, gündüz vardiyasında çalışan ve son 12 ayda işten ayrılma niyeti olmayan hemşi reler daha yüksek örgütsel bağlılık puanlarına sahip olmuştur. Hemşireler, kriz anları dahi yüksek düzeyde bağlılık gösterseler de uygun olmayan çalışma koşulları bu bağlılığı olumsuz yönde et kilemiştir. Bu nedenle, sağlık kurumu yöneticileri ve yönetici hemşirelerin, hemşirelerin örgütsel bağlılıklarını güçlendirmek amacıyla destek sağlamaya yönelik adımlar atmaları gerekmektedir
Development of a sensitive spectrophotometric method for determination of the charge-transfer complex of aripiprazole in pharmaceutical formulations: Spectrometric characteristics and analytical applications
No full textThis study presents a simple, rapid, and accurate spectrophotometric method for the determination of Aripiprazole (ARP) in tablets. The determination procedure is based on the reaction of ARP with 7,7,8,8-tet racyanoquinodimethane (TCNQ), producing a colored product that was quantitated spectrophotometrically at 392 nm. Various variables affecting the reaction were optimized. The method exhibited a good linearity range with a correlation coefficient of 0.9994, observed as 0.25–3 μg/mL. The developed method was validated according to the International Council for Harmonisation (ICH) guidelines, assessing specificity, linearity, accuracy, precision, robustness, limit of detection (LOD), and limit of quantitation (LOQ). The formation of the CT-complex and the interaction sites were confirmed by elemental analysis, DSC, IR, and 1H NMR spectroscopy. The method was successfully applied to the determination of ARP in pharmaceutical preparation
Investigation of nutrition habits and meat addiction of individuals diagnosed with gastritis
No full textGastrit günümüzde sık görülen bulaşıcı olmayan hastalıklardan birisidir. Bu çalışma gastrit tanısı almış bireylerin beslenme alışkanlıklarını araştırmak ve değerlendirmek amacıyla yapılmıştır. 4 bölümden oluşan veri toplama formu hazırlanmıştır. İlk bölümde bireylerin demografik özelliklerini belirlemeye yönelik sorular sorulmuştur. İkinci bölümde Besin Tüketim Sıklığı Anketi, üçüncü bölümde Üç Faktörlü Beslenme anketi ve son bölümde Et Bağımlılığı Anketi yer almaktadır. Verilerin değerlendirilmesi için “SPSS 25.0” istatiksel veri analiz programı kullanılmıştır. Çalışma İstanbul Ümraniye Eğitim ve Araştırma Hastanesi Dahiliye polikliniği Gastroenteroloji bölümüne 1- 31 Mart 2024 tarihleri arasında başvuran ve hekim tarafından gastrit tanısı almış 90 kadın, 90 erkek toplam 180 erişkin bireyle gerçekleştirmiştir. Kadınların ağırlık ortalaması 78,57, boy ortalaması 1,67 ve beden kütle indeksi ortalaması 28,04 iken; erkeklerin ağırlık ortalaması 84,94, boy ortalaması 1,79 ve beden kütle indeksi ortalaması ise 26,37 olarak hesaplanmıştır. Üç faktörlü beslenme anketine verilen cevaplar incelendiğinde kontrolsüzlük boyutu 9,28 puan duygusal boyut 6,07 puan; duyarlılık boyutu 8,18 puan; bilinçli kısıtlama 12,58 puan ve toplam puanın 8,39 olduğu tespit edilmiştir. Cinsiyete göre et bağımlılığı ölçeği değerlendirildiğinde kadınların hazcılık, ilgi, yetki, bağımlılık ve küresel puanda erkeklere göre puanlarının düşük olduğu sonucuna ulaşılmıştır. Katılımcıların beyaz et, kırmızı et, balık eti tüketim sıklığına göre üç faktörlü beslenme anketi ve et bağımlılığı anketi ölçeklerinden aldıkları puanlar değerlendirildiğinde kadın ve erkeklere göre gruplar arasında anlamlı farklılığın bulunmadığı sonucuna ulaşılmıştır. Bu bulgulardan yola çıkılarak gastrit hastalarında beslenme faktörleri pek çok alt faktörden etkilenmektedir. Gastritli bireylerde farmakolojik ajanların kullanımı, tıbbı beslenme tedavisi ve psikolojik desteği içeren multidisipliner bir yaklaşımla olumlu değişiklikler sağlanabilir.Gastritis is one of the non-communicable but common diseases today. This study was conducted to investigate and evaluate the dietary habits of individuals diagnosed with gastritis. For this purpose, a data collection form was prepared which consists 4 sections. In the first part, questions were asked to determine the demographic characteristics of the individuals. The second section includes the Food Consumption Frequency Questionnaire, the third section includes the Three-Factor Eating Questionnaire and the last section includes the Meat Attachment Questionnaire. In order to evaluate the data, "SPSS 25.0" statistical data analysis program was used. The study was conducted with total of 180 adults; 90 females and 90 males, who applied to the Gastroenterology Department of the Internal Medicine outpatient clinic of Ümraniye Training and Research Hospital in Istanbul between March 1-31, 2024 and were diagnosed with gastritis by a doctor. Women's mean weight, height and body mass index were 78.57, 1.67 and 28.04, respectively, while men's mean weight, height and body mass index were 84.94, 1.79 and 26.37, respectively. When the answers given to the three-factor nutrition questionnaire were analyzed, it was found that the uncontrolled scale was 9.28 points; emotional scale was 6.07 score; sensitivity scale was 8.18 score; conscious restriction was 12.58 score and the total score was 8.39. When the meat attachment scale was evaluated according to gender, it was concluded that women had lower scores than men in hedonism, interest, authority, dependence and global score. When the participants' scores from the three factor eating questionnaire and meat attachment questionnaire scales were evaluated according to the frequency of consumption of white meat, red meat and fish meat, it was concluded that there was no significant difference between men and women groups. Based on these findings, nutritional factors in gastritis patients are affected by many sub-factors. Positive changes can be possible with a multidisciplinary approach including the use of pharmacological agents, medical nutrition therapy and psychological support in gastritis
Patients with gynecological malignancies are similar to other IVF patients without cancer for clinical and molecular reproductive parameters and DNA damage response pattern
No full textThis study intended to investigate if gynecological cancers compromise ovarian function and reduce the success of assisted reproduction techniques (ART). No clinical and molecular data together is available on this issue for gynecological or other organ cancers. Steroidogenic pathways and DNA damage response characteristics of the granulosa cells retrieved from the 39 gynecological cancer patients were analyzed together with their clinical ART characteristics in comparison to 31 control ART patients. Patients with gynecological malignancies were similar to the control IVF patients for the number of mature oocytes retrieved, fertilization rates and embryo development competency. Molecular analyses of the granulosa cells retrieved from these cancer patients did not detect any perturbations in gonadotropin receptor expression and response, sex steroid production, cholesterol utilization/storage and, DNA damage response pattern in comparison to control IVF patients without cancer. This study provides the first reassuring clinical and molecular combined data set that the presence of gynecological malignancy does not appear to have any detrimental effect on clinical IVF cycle characteristics and ovarian functioning at molecular level
Synthesis, cytotoxic activity evaluation and molecular docking studies of some benzimidazole derivatives
No full textIn this study, the synthesis of 2-(2-acetyl-1H-benzimidazol-1-yl)-1-arylethanone (3a-3d) and 1-methyl-3-phenylbenzo[4,5]imidazo[1,2-a]pyrazine derivatives (4a-4d) and to investigate their cytotoxic activity were aimed. APCI, IR, 1HNMR, and 13CNMR spectra were utilized to determine the structure of the synthesized compounds. The cytotoxic activity of selected compounds were detected in A549 (human lung carcinoma) and NIH3T3 (mouse embryonic fibroblasts) cell lines. Compounds 4c and 4d were found to be selectively cytotoxic against A549 and NIH3T3 cell lines. Molecular docking studies were performed using the data retrieved from the Protein Data Bank server (PDBID: 4QTX)
The therapeutic approach to fibrocystic breast disease in the MCF-10A cell culture model: Striking efficacy of polyphenol
No full textBackground and Aims: Standard treatment regimens for fibrocystic breast disease (FBD) do not provide a permanent cure and have undesirable side effects. This study aims to investigate the therapeutic potential of different honey and propolis, as well as some important polyphenols, on breast epithelial cells (MCF-10A). Materials and Methods: The effects of five honey, two propolis extracts and seven polyphenol samples on the cell viability were assessed the WST-1 assay. Content analysis of the propolis samples was performed using high performance liquid chromatography (HPLC). Results: Chestnut and cedar honey had antiproliferative effects on MCF-10A cells at all doses (1-10 μg/mL), as well as pine honey at the highest dose. However, multifloral honey had no similar effect. Chinese propolis had significant antiproliferative effects on MCF-10A cells at doses of 50-250 μg/mL and on the human periodontal ligament (hPDL) control cells at a dose of 5 μg/mL. Türkiye propolis only had an antiproliferative effect on MCF-10A cells at the highest dose (p = 0.0013). Higher levels of ferulic acid, kaempferol, caffeic acid, pinocembrin and quercetin were detected in Türkiye propolis, while Chinese propolis was rich in pinostrobin. Ferulic acid, pinostrobin and galangin showed antiproliferative properties on MCF-10A cells (p 0.05). Conclusion: The findings of the study highlight the antiproliferative effects of pinostrobin, ferulic acid and galangin on MCF-10A cells and has also confirmed the antiproliferative effects of honey and propolis samples to be due to their polyphenolic properties. Therefore, this study suggests that polyphenolic substances may have both preventive and therapeutic potential in FBD
Synergistic and dose-dependent effects of pinostrobin, pinocembrin and pinobanksin on different breast cancer cell lines
No full textIn this study, the cytotoxic and apoptotic effects of three phenolic compounds highly found in the poplar type propolis; pinostrobin (PS), pinocembrin (PC) and pinobanksin (PB), were investigated individually and in combination on hormon-positive (MCF-7) and triple negative (MDA-MB-231) breast cancer cell lines and fibrocystic breast epithelium (MCF-10A) as control. Assessment of cytotoxicity and apoptosis were performed with WST-1 and Annexin V-7AAD assays, respectively. All statistical analyses including the two-way ANOVA and multiple-t-test were performed using GraphPad Prism software. Individually, PB (P0.05). On MCF-7, the triple combination induced cytotoxic/apoptotic effects even with the 25% dose and 50% dose on MDA-MB-231(p<0.0001). Our findings clearly showed that different combinations of these phenolic substances can have synergistic cytotoxic effects and even hormetic effects in non-tumorogenic cells.This study was funded by the Scientific Projects Coordination Unit, Istanbul University (Project No. 24695 and 29818)
Hemşirelik etiği konulu yayınların eğilimleri ve gelişim süreci: Bibliyometrik bir analiz
No full textThis study aimed to analyse the current knowledge structure of publications on nursing ethics and determine the developmental process through a bibliometric analysis. This is a retrospective descriptive study. Data were gathered on September 26, 2022, from the Web of Science (WoS) and analysed using Excel and VOSviewer programs. Studies were searched by title using the following descriptors: “nurse” and “ethics”. A total of 467 studies published between 1977 and 2021 and authored by 785 individuals were examined. Approximately 73.6% of these publications were original articles, and a significant majority (95.1%) were published in English. Studies were from 52 countries and 99 distinct journals. Leading the pack in terms of productivity was the United States (n= 154). The primary keywords utilized across these studies included “ethics,” “nursing,” “nursing ethics,” “code of ethics,” and “education.” Moreover, the emergence of “COVID-19” as a prevalent keyword was observed in studies published from 2020 onwards. Nursing spans a wide array of topics, with a significant focus on imparting ethical values, a subject extensively deliberated within the realm of scientific literature. This study gives an idea about the performance of research and publications on nursing ethics. Ethics principles are essential in providing quality care, in addition to being fundamental for the appreciation of the nursing profession. The COVID-19 pandemic has brought new ethical dilemmas to the nursing profession. As nursing ethics will never be a saturated or outdated topic, it is important to encourage research on ethics in the field of nursing.Bu çalışmanın amacı, hemşirelik etiği konusundaki yayınların mevcut bilgi yapısını incelemek ve bibliyometrik bir analiz yoluyla gelişim sürecini belirlemektir. Bu çalışma retrospektif ve tanımlayıcıdır. Veriler 26 Eylül 2022 tarihinde Web of Science (WoS) üzerinden toplanmış ve Excel ve VOSviewer programları kullanılarak analiz edilmiştir. “Etik” ve “hemşirelik” anahtar kelimelerini kullanarak başlıklara göre çalışmalar taranmıştır. 1977-2021 yılları arasında yapılan 467 çalışma, 785 yazar tarafından gerçekleştirilmiş ve yayımlanmıştır. Bu yayınların %73,6’sı bilimsel makale olarak belirlenmiş ve %95,1’i İngilizce olarak yayımlanmıştır. Çalışmalar, 52 ülkeden araştırmacılar tarafından gerçekleştirilmiş ve 99 farklı dergide yayımlanmıştır. En üretken ülke Amerika Birleşik Devletleri (n= 154) olarak belirlenmiştir. En çok kullanılan beş anahtar kelime “etik”, “hemşirelik”, “hemşirelik etiği”, “etik kurallar” ve “eğitim”dir. “COVID-19” ise 2020 yılından itibaren yayımlanan çalışmalarda ortak bir anahtar kelime olarak yer almaktadır. Hemşirelikte etik, çeşitli konuları ele almaktadır ve özellikle etik değerlerin öğretimiyle ilgili konular bilimsel literatürde geniş çapta tartışılmaktadır. Bu çalışma, hemşirelik etiği konusundaki araştırma ve yayınların performansı hakkında bir fikir vermektedir. Etik prensipler, kaliteli bakım sağlamak için temel olmasının yanı sıra, hemşirelik mesleğinin değerini anlamak için de temel unsurlardır. COVID-19 pandemisinin, hemşirelik mesleğinde yeni etik ikilemlere yol açtığını vurgulamak son derece önemlidir. Hemşirelik etiği hiçbir zaman doygun veya eskimiş bir konu olmayacaktır. Bu nedenle, hemşirelik alanında etik konuları üzerine yapılan araştırmaların teşvik edilmesi büyük bir önem taşımaktadır