İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Osseous anatomy of the distal radius: A morphometric analysis of external groove and bony ridge
No full textPurpose: This study aimed to investigate the presence and morphological and morphometric characteristics of the distal radius's external groove (EG) and bony ridge, which play a potential role in the pathogenesis and treatment difficulties of De Quervain's tenosynovitis. Methods: The osseous anatomy of the distal radius was analyzed in detail on a total of 103 dry bone specimens (49 left and 54 right) obtained from the Department of Anatomy, Istanbul University, Turkiye. The frequency and morphology of the EG were analyzed. The EGs were categorized as Type 1, Type 2, and Type 3 with two EGs, one EG with depth, and an additional EG without depth, respectively. Finally, flat areas without clear groove boundaries were classified as Type 4. Results: The analyses showed variations in the morphology and dimensions of the EG and bony ridge. A total of 110 EGs were detected in 103 radii examined. Type 1, Type 2, Type 3 and Type 4 EGs were reported in 30 bones (30%), 38 bones (38%), 12 bones (12%) and 23 bones (23%), respectively. The depth of the EG of Type 1 was 0.26 ± 0.23 mm and 0.22 ± 0.16 mm on the lateral and medial sides, respectively. Also, the depth of the Type 2 was calculated as 0.49 ± 0.37 mm. Conclusion: The osseous variations of the distal radius are critical anatomical factors contributing to the pathogenesis of De Quervain's tenosynovitis and difficulties in the treatment process. It is essential to recognize these variations to improve diagnostic accuracy and optimize therapeutic interventions
Is digital anesthesia a viable alternative for pain and anxiety control in pediatric dentistry?
No full textBackground: Pain and anxiety during dental procedures remain major challenges in pediatric dentistry, particularly during local anesthesia administration. Aim: This study compared the effectiveness of digital anesthesia systems versus conventional infiltration and mandibular block techniques in managing pain, anxiety, and behavioral responses in pediatric dental patients. Design: Seventy-nine children aged 6–12 were randomly assigned to receive anesthesia via digital anesthesia system (DAS), infiltration, or mandibular block. Pain was assessed using the Wong-Baker Faces Pain Rating Scale (WBFRPS), anxiety via the Modified Child Dental Anxiety Scale (MCDAS), and behavioral responses through the FLACC scale. Statistical analyses included ANOVA, Kruskal–Wallis, and chi-square tests (p<0.05). Results: Children in the DAS group reported significantly lower pain scores during needle insertion, anesthetic delivery, and treatment. Post-treatment MCDAS scores decreased significantly in the DAS group, especially for items related to “tooth exami nation,” “filling,” and “gingival injection.” FLACC results also indicated more favorable behavioral responses—such as relaxed facial expressions and absence of crying—in the digital group (p<0.05). Conclusion: Digital anesthesia appears to be a highly effective alternative to conventional techniques for minimizing pain, reducing dental anxiety, and improving behavioral cooperation in pediatric patients, supporting its broader implementation in clinical practice
8. sınıf öğrencilerinde algılanan anne baba tutumları ile sınav kaygısı arasındaki ilişkinin incelenmesi
No full textThis study aimed to examine the relationship between perceived parenting styles and test anxiety levels among 8th grade students. The research was designed within the framework of the relational survey model, one of the quantitative research methods, and the sample consisted of 318 students studying in 10 public secondary schools in Eyüpsultan district of Istanbul during the 2024–2025 academic year. Data were collected through the Parental Consent Form, Demographic Information Form, Parental Attitude Scale (PAS), and Westside Test Anxiety Scale (WTAS). The collected data were analyzed using SPSS 25.0, and independent samples t-test, one-way ANOVA, Pearson correlation analysis, and multiple linear regression tests were conducted. The results revealed that female students experienced significantly higher levels of test anxiety compared to male students. Correlation analysis showed significant negative relationships between test anxiety and the dimensions of acceptance-interest and psychological autonomy. Multiple regression analysis indicated that only the psychological autonomy dimension was a significant predictor of test anxiety. No significant differences were found in test anxiety levels according to different types of 3 parental attitudes. These findings demonstrate that students’ test anxiety is significantly associated with the psychological autonomy and acceptance they perceive from their parents. The results are consistent with previous studies in the literature, showing that democratic parenting styles and psychologically supportive approaches have a reducing effect on test anxiety. In this regard, the study contributes to the understanding of psychosocial factors influencing test anxiety. Based on the findings, it can be suggested that strengthening guidance and counseling services, expanding parental awareness programs, and encouraging teachers to collaborate with families are crucial steps in reducing students’ test anxiety. Furthermore, parents adopting approaches that provide greater psychological autonomy and acceptance may help students cope more effectively with test anxiety.Bu araştırma, 8. sınıf öğrencilerinin algıladıkları anne-baba tutumları ile sınav kaygısı düzeyleri arasındaki ilişkiyi incelemek amacıyla gerçekleştirilmiştir. Nicel araştırma yöntemlerinden ilişkisel tarama modeli kullanılarak yapılandırılan çalışmada, İstanbul ili Eyüpsultan ilçesindeki 10 devlet ortaokulunda öğrenim gören toplam 318 öğrenci örnekleme dâhil edilmiştir. Veriler; Veli Onam Formu, Demografik Bilgi Formu, Anne-Baba Tutum Ölçeği (ABTÖ) ve Westside Sınav Kaygısı Ölçeği (WSKÖ) kullanılarak toplanmıştır. Elde edilen veriler SPSS 25.0 programı ile analiz edilmiş, bağımsız örneklem t-testi, tek yönlü ANOVA, Pearson korelasyon analizi ve çoklu doğrusal regresyon testleri uygulanmıştır. Araştırma sonucunda, kız öğrencilerin erkek öğrencilere göre anlamlı düzeyde daha yüksek sınav kaygısı yaşadığı bulunmuştur. Korelasyon analizinde, sınav kaygısı ile kabul-ilgi ve psikolojik özerklik boyutları arasında negatif yönlü anlamlı ilişkiler tespit edilmiştir. Çoklu regresyon analizinde, sadece psikolojik özerklik boyutunun sınav kaygısının anlamlı bir yordayıcısı olduğu bulunmuştur. Elde edilen bulgular, öğrencilerin sınav kaygısı ile ebeveynlerinden algıladıkları psikolojik özerklik ve kabul düzeyleri arasında anlamlı ilişkiler olduğunu göstermektedir. Bu sonuçlar, mevcut alanyazında yer alan çalışmalarla paralellik göstermekte; özellikle demokratik ebeveyn tutumlarının ve psikolojik destekleyici yaklaşımların sınav kaygısını azaltıcı etkisinin daha önceki araştırmalarla da desteklendiği görülmektedir. Çalışma, bu bağlamda sınav kaygısını etkileyen psikososyal etmenlerin anlaşılmasına katkı sağlamaktadır. Bulgular doğrultusunda; öğrencilerin sınav kaygısının azaltılmasına yönelik rehberlik hizmetlerinin güçlendirilmesi, ebeveynlere yönelik bilinçlendirme programlarının yaygınlaştırılması ve öğretmenlerin de ailelerle iş birliği içinde çalışmasının önem taşıdığı söylenebilir. Ayrıca, ebeveynlerin çocuklarına daha fazla psikolojik özerklik ve kabul sağlayacak yaklaşımlar geliştirmeleri, öğrencilerin sınav kaygısı ile daha etkili baş etmelerine katkı sağlayabilir
Taze kadavralarda willis halkasının ön bölümündeki varyasyonların kapsamlı sınıflandırılması
No full textObjective: The goal of our study is to evaluate and classify the variations of the anterior communicating artery (AComA) on fresh cadavers from the Türkiye population. Methods: In this study, 182 fresh cadavers were analysed and classified according to the number, shape and course of the AcomA. Results: In our study, typical AcomA was the most common with a rate of 86 (47.25%), while variations of the AcomA were found in the remaining 96 (52.75%) cases. Among these variations, in 11.46% (11/96) of cases, AcomA variations were identified as distal and proximal duplications according to the number of branches they represented; 68.75% (66/96) of cases were identified by their shape (X-shaped, single/double fenestration, hypoplasia, or aplasia); and, in 19 cases, it was characterized by course (median artery or oblique course). The rate of variations was 65% (26/40) in females and 49.29% (70/142) in males. In our study, the X-shaped and single fenestration variations were recorded as the most common. Conclusions: The results of the study are important for cerebrovascular surgery and radiological interventions. It emphasises the importance of recognising and considering variations. The study will contribute to the understanding of cerebrovascular diseases and the development of treatment strategies.Amaç: Bu çalışmanın amacı, Türk popülasyonuna ait taze kadavralar üzerinde arteria communicans anterior’un (AcomA) varyasyonlarını tanımlamak ve sınıflandırmaktır. Yöntemler: Bu çalışmada toplamda 182 taze kadavra incelendi ve AcomA’nın sayısı, şekli ve seyrine göre sınıflandırılması gerçekleştirildi. Bulgular: Çalışmamızda, tipik AcomA %47,25 oranıyla en sık görülürken, geri kalan 96 olguda AcomA’un varyasyonlarına rastlandı. Bu varyasyonlar arasında 11/96 olguda distal ve proksimal duplikasyon, 66/96 olguda şekline göre (X-şekilli, fenestrasyona sahip, hipoplazik veya aplazik) ve 19 olguda seyrine göre (median arter veya oblik seyir) AcomA varyasyonları tespit edildi. Varyasyon oranı kadınlarda 26/40 ve erkeklerde 70/142 idi. Çalışmamızda, X şekilli ve tek fenestrasyon gösteren varyasyonları en sık görülen varyasyonlar olarak kaydedildi. Sonuçlar: Çalışmanın sonuçları serebrovasküler cerrahi ve radyolojik girişimler için önemlidir. Varyasyonları tanımanın ve dikkate almanın önemini vurgulamaktadır. Çalışma, serebrovasküler hastalıkların anlaşılmasına ve tedavi stratejilerinin geliştirilmesine katkıda bulunacaktı
Comparison of short- and long-term outcomes of diode laser vs. crystallized phenol treatment for pilonidal sinus disease: A propensity score-matched multicentre study
No full textAim: Pilonidal sinus disease (PSD) primarily affects young adults; rapid recovery is essential and yet lacks a standardized treatment approach. While excisional techniques delay recovery, minimally invasive options like laser ablation and phenol application are gaining interest, yet comparative long-term evidence is scarce. This study compared short- and long-term outcomes of laser versus phenol treatment in PSD. Method: In this multicentre retrospective cohort study (Nov. 2017–Sep. 2024), patients treated with laser or phenol were included. 1:3 propensity score matching using the nearest neighbour algorithm was performed based on age, gender, prior surgical history and year of operation. Categorical variables were analysed using chi-squared or Fisher's exact tests, whereas continuous variables were compared using Student's t-test or Mann– Whitney U test depending on distribution normality. Results: Out of 897 eligible patients, 644 were included (median age: 26 years, body mass index [BMI]: 26.2 kg/m2 , male-to-female ratio: 4:1). The number of sinuses/pits was 2–3 in both groups. Operating time was significantly longer in the laser group. Complications occurred in 6.8% of laser patients, whereas none were reported in the phenol group. Pain scores were higher in the laser group (2 [1–3] vs. 1 [0–2]). Median follow-up was 45 months (laser) and 40 months (phenol). Return to daily activities was delayed in the laser group, whereas complete healing was slower in the phenol group. Readmission, recurrence and recovery rates were comparable (85%–86%). Conclusion: Both treatments demonstrated low complication and recurrence rates with high recovery rates. Laser favoured faster healing and fewer sessions, whereas phenol allowed for shorter procedures and earlier return to daily life
Use of facial analysis systems in food and nutrition sciences
No full textTeknolojinin son yıllarda hızla gelişmesi sağlık sektörüne de yansımış olup bu kapsamda hizmet alan ve veren kişilerin hayatını kolaylaştıran birçok dijital sağlık hizmeti gündeme gelmiştir. Bu hizmetlerden biri de yüz morfometrisinin ve ifadesinin değerlendirilmesiyle kişilerin beslenme durumları ve gıdaya yaklaşımlarının analizidir. Bu çalışmanın amacı, yüz morfometrisi ve yüz ifadesi analizi gibi yapay zeka temelli dijital ölçümleme tekniklerinin gıda ve beslenme bilimlerinde kullanım olanaklarını incelemektir. Bu amaçla Pubmed, Web of Science ve Google Akademik’de yayımlanan makaleler incelenerek konu potansiyel etkinlik, güvenilirlik ve etik açıdan değerlendirilmiştir. Yüz morfometrisi, yüz yapısının dijital olarak modellenmesini sağlayan; belirli anatomik noktalar üzerinden bireyin beslenme örüntüsüne dair ipuçları sunan bir tekniktir. Bu analizin özellikle fiziksel erişimi zor bölgelerde ikamet eden malnutrisyon riski yüksek kişilere uzaktan beslenme taraması yapabilme potansiyeli mevcuttur. Yüz ifadesi analizi ise gıda endüstrisindeki ürün geliştirme süreçlerinde tüketicilerin ürünlere yönelik duygusal yanıtlarının objektif ölçümünde kullanılabilmektedir. Böylece üreticiler, ürünleri piyasaya sunmadan önce potansiyel tüketici tepkilerini öngörerek duygusal yanıt temelli stratejik kararlar alabilirler. Özellikle nöropazarlama alanında kullanımı oldukça yaygınlaşan bu sistem sayesinde ürün tasarımı, ambalaj seçimi, gıdanın duyusal bileşenleri ve pazarlama stratejilerinin optimizasyonu sağlanabilmektedir. Ancak, bu analizlerde yaş, etnik köken, büyüme dönemleri, yüz kılları, estetik operasyonlar gibi beslenme durumundan büyük ölçüde etkilenen karıştırıcı faktörlerin dikkate alınması gerekmektedir. Ayrıca veri gizliliği, etik ilkeler ve analizlerin ticarileşme potansiyeline dair tartışmalar da bu süreçte dikkate alınması gereken önemli unsurlar arasındadır. Bu sebeple daha stabil ve güvenli dijital uygulamalara ve bu uygulamaları test edecek ileri çalışmalara ihtiyaç duyulmaktadır. Gelecekte, yüz analizi gibi dijital biyogöstergelere dayalı yaklaşımların yaygınlaşarak gıda bilimi ve tüketici davranışı araştırmalarında beslenme problemlerinin tanı ve teşhisinin yanısıra kişiselleştirilmiş beslenme uygulamalarına katkı sağlaması beklenmektedir.The rapid development of technology in recent years has also affected the healthcare sector, leading to numerous digital health services that facilitate the lives of both healthcare providers and recipients. One of these services is the analysis of individuals’ nutritional status and approaches to food through the evaluation of facial morphometry and expression. This study aims to examine the usage possibilities of artificial intelligence-based digital measurement techniques such as facial morphometry and facial expression analysis in food and nutrition sciences. For this purpose, articles published in PubMed, Web of Science, and Google Scholar were reviewed, and this approach was evaluated in terms of potential effectiveness, reliability, and ethical considerations. Facial morphometry is a technique that enables the digital modeling of facial structure and provides clues about an individual’s dietary pattern through specific anatomical landmarks. This analysis can perform remote nutritional screening, especially for individuals at high risk of malnutrition living in physically inaccessible regions. Facial expression analysis can be utilized in the food industry to measure consumers’ emotional responses during product development processes objectively. This way, producers can anticipate consumer reactions and make strategic decisions based on emotional data. This system is commonly used in neuromarketing and supports optimizing product design, packaging, sensory properties, and marketing strategies. However, confounding factors such as age, ethnicity, growth phases, facial hair, and aesthetic surgeries, which may be influenced by nutritional status, should be considered. Moreover, potential data privacy issues, ethical principles, and commercialization must be addressed. Therefore, more stable and secure digital applications, as well as further studies to validate these tools, are needed. In the future, digital biomarker-based approaches like facial analysis are expected to gain prevalence and contribute to the diagnosis and management of nutritional issues and advancements in personalized nutrition and consumer behavior studies
Comparing the effects of halloysite nanotubes and precipitated calcium carbonate nanoparticles on the environmental stress cracking resistance and mechanical properties of polycarbonate
No full textPolycarbonate (PC) is a versatile and amorphous engineering thermoplastic used in various areas due to its exceptional me-chanical and thermal properties. However, its susceptibility to environmental stress cracking limits its industrial application inchemically aggressive environments. This study investigates the effects of incorporating surface-modified halloysite nanotubes(HNTs) and precipitated calcium carbonate (PCC) as nanofillers on the mechanical properties and environmental stress cracking(ESC) resistance of PC. PC nanocomposites were prepared with varying filler concentrations (1%, 3%, and 5% by weight) usingtwin-screw extruder and injection molding devices. Comprehensive mechanical characterization, including three-point bending, Charpy impact toughness, and Shore D hardness tests, revealed that introducing 1 wt% of HNT optimally balances stiffness,toughness, and ESC resistance. PCC, on the other hand, significantly improved processability but demonstrated poor ESC perfor-mance, with samples failing within an hour in methanol immersion tests. ESC resistance testing in methanol and sodium laurylether sulfate (SLES) solutions confirmed the superior performance of HNT-reinforced PC nanocomposites. Scanning electronmicroscopy (SEM) analyses provided insights into filler-matrix interactions and crack propagation mechanisms. These findingsoffer valuable guidance for the development of PC nanocomposites tailored for automotive, electronics, and chemical processingindustries
Optimization of VA-NADES-ME for the one-step separation and determination of rhodamine B and rhodamine 6G in red pencil samples
No full textAn environmentally friendly and simple method was developed for the simultaneous separation and determination of Rhodamine B (RhB) and Rhodamine 6 G (Rh6G) in red pencil samples by vortex assisted microextraction using NADES (Natural Deep Eutectic Solvent). A two-phase system was established using lactic acid-based DES (Deep Eutectic Solvent) and tetrahydrofuran (THF) for the extraction of RhB and Rh6G. In method optimization, sample amount, pH, DES type, DES volume, solvent type and solvent volume parameters were investigated. Limit of detection (LOD) and limit of quantification (LOQ) values were 4.13, 5.03 and 12.5, 15.3 µg/mL for RhB and Rh6G, respectively. The correlation coefficients obtained at concentrations ranging from 1–12 µg/mL are 0.9973 and 0.9985. Red pencil samples were spiked at two different concentrations (3–5 µg/mL). The recovery values obtained were in the range of 84.7%-107.4%. The relative standard deviation (RSD) values of the developed method are in the range of 2.77%-5.45%, indicating that the method is reproducible. The results showed that the developed microextraction method can be success fully applied for the separation and determination of RhB and Rh6G from red pencil samples
Quantification of agnuside in human plasma with a novel high-performance liquid chromatographic method and pharmacokinetic study
No full textThis study presents a combination of High Performance Liquid Chromatography (HPLC) and ultraviolet (UV) detection that provides the quantification of agnuside in human plasma specimens. Reverse-phase chromatographic separation was carried out with C18 column (150 mm × 4.6 mm × 5 μm), at 25°C with isocratic elution of the mobile phase containing methanol: 0.1% formic acid (35:65 v/v) at 0.6 mL/min flow rate. Experiments were carried out at a wavelength of 258 nm. The retention time of the analyte is 9.70 ± 0.01 min. The developed technique was validated based on the International Conference on Harmonization guideline. The correlation coefficient of the technique was 0.9915, and the calibration range was 5–125 μg/mL. The recovery value of the proposed method was found to be 101.4%, and the precision of the method was calculated as 6.35 with the highest RSD% value. A pharmacokinetic study was performed by administering agnuside to a healthy volunteer
In-depth analysis of the demographic landscape and clinical outcomes of assisted reproductive technologies in Türkiye: A comprehensive survey for the years 2020 and 2021
No full textObjective: To investigate patient characteristics and outcomes of assisted reproductive technology (ART) cycles conducted in Türkiye during the coronavirus disease-2019 (COVID-19) pandemic (2020-2021). Material and methods: ART centers in Türkiye were invited to participate in this survey. The questionnaire focused on patient demographics and performance outcomes and was sent to center directors via anonymous Qualtrics™ links. Results: The survey was sent to 167 centers and data were collected from 15 centers in 2020 and 24 centers in 2021. The clinical pregnancy rate from intrauterine insemination (IUI) procedures remained similar, with 15.1% in 2020 (1,245 IUI cycles) and 14.5% in 2021 (2,023 IUI cycles), while successful delivery rates were 12.5% and 11.5%, respectively. For ART treatments, the clinical pregnancy rate from fresh embryo transfers increased from 45.1% in 2020 (3,119 transfers) to 50.4% in 2021 (8832 transfers), with similar live birth rates, 34.2% vs. 34.4%. Frozen embryo transfers resulted in clinical pregnancy rates of 47.8% in 2020 (2,498 transfers) and 51.9% in 2021 (12,015 transfers), with live birth rates rising from 39.8% to 42.7%. Preimplantation genetic testing cycles resulted in clinical pregnancy rates of 64.2% in 2020 (271 transfers) and 60.8% in 2021 (2,102 transfers), with live birth rates of 53.5% and 48.2%, respectively. Regarding techniques for fertility preservation in females, 11 prepubertal and 61 postpubertal ovarian tissue cryopreservation procedures were reported, alongside 1,346 cycles performed within the same period. In males, 144 post-pubertal testicular tissue, 871 epididymal and 2,480 ejaculated sperm cryopreservations were reported. During the two years, six ovarian tissue transplantations followed by ART were performed, with 96 women using cryopreserved oocytes. In addition, 40 testicular tissue, 298 epididymal, and 238 ejaculated sperm samples were used for ART purposes. Conclusion: This survey provides a comprehensive overview of ART practices in Türkiye for 2020 and 2021, establishing a long-term, nationallevel analysis while highlighting the challenges posed by the COVID-19 pandemic. The longitudinal analysis established a foundation for future annual reports and offers critical insights into emerging trends over these two years