İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
Not a member yet
1249 research outputs found
Sort by
Toward green and sustainable zinc-ion batteries: The potential of natural solvent-based electrolytes
No full textZinc-ion batteries (ZIBs) are emerged as a promising alternative for sustainable energy storage, offering advantages such as safety, low cost, and environmental friendliness. However, conventional aqueous electrolytes in ZIBs face significant challenges, including hydrogen evolution reaction (HER) and zinc dendrite formation, compromising their cycling stability and safety. These limitations necessitate innovative electrolyte solutions to enhance ZIB performance while maintaining sustainability. This review explores the potential of natural solvent-based electrolytes derived from renewable and biodegradable resources. Natural deep eutectic solvents (DES), bio-ionic liquids, and biomass-derived organic compounds present unique advantages, including a wider electrochemical stability window, reduced HER activity, and controlled zinc deposition. Examples include DESs based on choline chloride (ChCl), glycerol-based systems, and biomass-derived solvents such as γ-valerolactone (GVL) and aloe vera, demonstrating improved cycling stability and dendrite suppression. Despite their promise, challenges such as high viscosity, cost, and scalability remain critical barriers to commercialization. This review underscores the need for further research to optimize natural solvent formulations, enhance Zn anode compatibility, and integrate these systems into practical applications. By addressing these challenges, natural solvent-based electrolytes can pave the way for safer, high-performance, and environmentally sustainable ZIBs, particularly large-scale energy storage systems
Phase-selective synthesis of nanoshell hollow V2O3 and V3O5 microspheres as high-performance cathodes for aqueous Zn-ion batteries
No full textDivanadium trioxide (V2O3) microspheres having nano-sized shells were produced by a facile and cost-efficient solvothermal method. Thermal treatment of V2O3 yielded trivanadium pentoxide (V3O5) microspheres. After the synthesis, the structural and electrochemical characterizations were performed in detail. Cathodes produced with the V2O3 and V3O5 materials reached specific capacities of 388 and 320 mAh g− 1 , respectively, at a current density of 0.1 A g− 1 . Aqueous zinc-ion batteries (ZIBs) fabricated with V2O3 and V3O5 cathodes demonstrated high-rate capability and capacity retention. The V2O3 microspheres, which possess a rhombohedral corundum type structure, showed outstanding rate capability (412 mAh g− 1 at 0.1 A g− 1 ; 149 mAh g− 1 at 20 A g− 1 ) and notable cycling stability (95.6 % capacity retention after 1200 cycles at 2 A g− 1 ; 80 % retention at the 2400th cycle at 5 A g− 1 ). Conversely, monoclinic V3O5 provided a comparable initial capacity (374 mAh g− 1 at 0.1 A g− 1 ) but faced rapid capacity decline at high current (26 % retention after 6000 cycles at 5 A g− 1 ). These results emphasize the significance of crystal structure in achieving stable and high-rate Zn2+ storage. In summary, the rhombohedral V2O3 phase exhibits superior Zn2+ transport kinetics and mechanical strength compared to the monoclinic V3O5, which accounts for the differences observed in their electrochemical performance
Berrak hücreli akantom ile skuamöz hücreli karsinoma in situ ayırıcı tanısında reflektans konfokal mikroskopi
No full textBackground and Design: There are few reports on the in vivo reflectance confocal microscopy (RCM) features of clear cell acanthoma (CCA). This study aimed to evaluate the diagnostic ability of RCM in CCAs that are difficult to diagnose clinically and to compare the RCM findings with those observed in squamous cell carcinoma in situ (SCCIS) lesions, which exhibit similar clinical morphology. Materials and Methods:We searched our database and identified three cases of CCA with atypical features and three cases of SCCIS with common morphological features. We described the clinical, dermoscopic, RCM, and histopathological characteristics of these cases. Results: Both lesion groups showed prominent epidermal hyperplasia on RCM; however, atypia in epidermal cells in CCAs was not as pronounced as that in SCCISs. The general architecture was preserved in the CCAs. In SCCISs, epidermal basal cells were increased in size, and prominent pleomorphism and atypia were observed in the full-thickness epidermis, whereas basal cells in CCAs were normal in pattern and appearance. Conclusion: We suggest that differentiating CCA from SCCIS on RCM is possible, even in atypical cases, by careful evaluation of the general architecture of the tumor and determination of the degree of epidermal disarray, nuclear features of the epidermal cells, presence of uniformity or pleomorphism of the epidermal cells, and features of the basal cells. A comparison of normal skin and tumor areas may also help in better evaluation.Amaç: Berrak hücreli akantomun (BHA) in vivo reflektans konfokal mikroskopi (RKM) özelliklerine ilişkin sınırlı sayıda rapor bulunmaktadır. Bu çalışmada, klinik olarak tanı koymanın zor olduğu BHA’ların RKM tanı yeteneğini değerlendirmeyi ve klinik morfoloji açısından benzer olan in situ skuamöz hücreli karsinom (SHKIS) lezyonlarında görülen RKM bulgularıyla karşılaştırmayı amaçladık. Gereç ve Yöntem: Veritabanımızda arama yaparak atipik özelliklere sahip 3 BHA vakası ve bu BHA’larla ortak morfolojik özellikler taşıyan 3 SHKIS olgusu bulduk. Olguların klinik, dermoskopik, RKM ve histopatolojik özelliklerini tanımladık. Bulgular: Her iki lezyon grubunda da RKM’de belirgin epidermal hiperplazi gözlendi, ancak BHA’lardaki epidermal hücrelerdeki atipi SHKIS’lerde görüldüğü kadar belirgin değildi. BHA’larda genel mimari korunmuştu. SHKIS’lerde epidermal bazal hücreler boyut olarak artmış, belirgin pleomorfizm ve atipi tam kat epidermiste görülmüştü, buna karşın BHA’lardaki bazal hücreler normal bir patern ve görünümdeydi. Sonuç: Atipik olgularda bile, tümörün genel mimarisinin dikkatli bir şekilde değerlendirilmesi, epidermal düzensizliğin derecesinin, epidermal hücrelerin çekirdek özelliklerinin, üniformluk veya pleomorfizm varlığının ve bazal hücrelerin özelliklerinin belirlenmesi yoluyla BHA ile SHKIS’i RKM’de ayırt etmenin mümkün olduğunu öne sürmekteyiz. Normal deri ile tümöral alanların karşılaştırılması da daha iyi bir değerlendirme yapmaya yardımcı olabilmektedir
Examination of sleep disturbances in parkinson’s disease and other movement disorders
No full textFrom Bedside to Diagnosis: Practical Competencies in Movement Disorders, Volume 10 in the International Review of Movement Disorders, highlights new advances in the field, with this new volume presenting interesting chapters on important topics such as Movement Disorder Examination: Hypokinetic Disorders, Clinical Approach to Abnormal Facial Movements, Advancing Movement Disorder Education: From Courses to Curriculum, Movement Disorder Examination: Hyperkinetic Disorders
In vitro evaluation of methyl methacrylate (MMA) release from different temporary denture base materials
No full textINTRODUCTION: Residual methyl methacrylate (MMA) released from temporary denture base materials is of clinical concern due to its potential biological effects. Recently, light polymerized and 3D-printed denture base resins have emerged as alternatives to conventional cold-polymerized acrylics. This study aimed to compare the in vitro MMA release levels of three clinically relevant temporary denture base materials. MATERIALS AND METHODS: Three materials were tested: cold-polymerized acrylic resin, light-polymerized baseplate resin, and 3D-printed denture base resin. Ten samples were prepared for each group (n=10), standardized to 0.05 g per specimen. Samples were immersed in 2 mL and 5 mL of artificial saliva and incubated at 37°C. MMA release was quantified using high-performance liquid chromatography (HPLC) at 15 minutes, 30 minutes, 1 hour, and 24 hours. Data distribution was analyzed with the Shapiro-Wilk test; the effects of time, material, and saliva volume were assessed using two-way ANOVA and Tukey post-hoc tests (p<0.05). RESULTS: No MMA release was detected before 24 hours in the 3D-printed and light-polymerized groups. The cold polymerized acrylic group showed progressive MMA release starting from 15 minutes, with a significant increase over time (p<0.001). At 24 hours, it exhibited the highest MMA levels among all groups. A significant difference between 2 mL and 5 mL saliva volumes was observed only in the cold-cure group. The 3D-printed resin showed the most stable performance across all time points. CONCLUSION: Temporary denture base materials should be selected with consideration of residual monomer release. The results support the biocompatibility of 3D-printed resins for short-term clinical applications, especially when early MMA release and toxicity are of concern
Europlanet machine learning working group: A year of progress
No full textThe rapid advances in machine learning (ML) present unprecedented opportunities for planetary science. We have established a dedicated working group (WG) focused on the application of ML in this field to harness these technological advancements, address complex scientific questions, and enhance our understanding of planetary systems. The Europlanet Machine Learning Working Group held its kick-off meeting during the EPSC 2024 in Berlin, September 2024. The discussion focused on launching the group for exchanging ideas and opportunities with people within and outside of Europlanet’s membership for the first year of its launch. Some of the main goals established were to create a knowledge-sharing platform for members to share their research and invite collaboration, form sub-groups within the WG to expand on current research focus, and foster new collaborative research opportunities within or outside of Europlanet with new funding
Fluid biomarkers in atypical Parkinsonism: Current state and future perspectives
No full textDiagnosing Atypical Parkinsonian Syndromes (APS) may be challenging due to overlapping clinical features of Parkinson’s disease (PD), and the lack of pathognomonic diagnostic tests. Fluid biomarkers can be useful tools that make it easier to identify and track diferent APS. Objectives: this narrative review aim to update the current state of fuid biomarker research in APS and their potential implications in clinical practice. A comprehensive literature search was conducted in PubMed and Scopus using the following terms: “Aβ42 amyloid beta with 42 amino acids’’, “ alpha-synuclein’’, “Atypical Parkinso nian Syndromes’’, “corticobasaldegeneration’’, “C reactive protein’’, “cerebrospinal fuid’’, “dementia with Lewy bodies’’, “multiple system atrophy’’, “neuroflament light, oligomericαsyn, phosphorylated α –syn’’, “tau phosphorylated at threonine 181’’, “progressive supranuclear palsy’’, “Seeding Amplifcation Assay’’, “t-tau; total tau”. The lack of high-afnity α-syn antibodies and ligands may contribute to α-syn’s low efcacy as a diagnostic biomarker of APS. Cerebrospinal fuid (CSF) biomarkers refecting Alzheimer pathology, axonal damage (neuroflament light chain) add valuable diagnostic and prog nostic information in the neurochemical characterization of APS. Infammatoryand microRNAs markers need to be further validated before their clinical use. Seeding Amplifcation Assays (SAA), despite their high sensitivity and specifcity, are at this point used only as a research tool, and they are not quantitative or refective of disease severity. Biomarker research for early identifcation and prognosis of APS patients requires multicenter collaboration, validation, and AI-based diagnostics, despite immature biological classifcation systems
Kafeinin sporcular kası üzerindeki epigenetik etkileri
No full textObjective: Caffeine is one of the most common ergogenic aids known to increase endurance, strength, and reaction time in athletes. Although its effects are generally thought to be mediated by adenosine receptor antagonism and its stimulatory role in calcium release, recent studies have revealed that caffeine may also influence epigenetic regulatory mechanisms. Epigenetic mechanisms are biochemical processes that alter gene activity without any changes to the DNA sequence, and these processes include DNA methylation, histone acetylation, and microRNA regulation.Amaç: Kafein, sporcularda dayanıklılık, kuvvet ve tepki süresini artırdığı bilinen en yaygın ergogenik desteklerden biridir. Genellikle etkisini adenozin reseptör antagonizması ve kalsiyum salınımı üzerindeki uyarıcı rolüyle gösterdiği düşünülse de son yıllarda yapılan araştırmalar kafeinin epigenetik düzenleme mekanizmalarını da etkileyebileceğini ortaya koymuştur. Epigenetik mekanizmalar, DNA dizisinde herhangi bir değişiklik olmadan gen aktivitesini değiştiren biyokimyasal süreçlerdir ve bu süreçler arasında DNA metilasyonu, histon asetilasyonu ve mikroRNA düzenlemesi yer alır
A comprehensive morphological and morphometric study of the spinoglenoid notch and ligament/ membrane: Possible clinical relevance of suprascapular nerve entrapment
No full textObjective: This study aimed to determine the anatomical fea tures and clinical significance of the spinoglenoid notch and spinoglenoid ligament-membrane as well as the branches of the suprascapular nerve to the infraspinatus muscle as these struc tures may cause compression of this nerve. Material and Methods: Fifty sides (25 right and 25 left) were studied on 26 fixed cadavers belonging to the Department of Anatomy, İstanbul University, İstanbul Faculty of Medicine. The suprascapular nerve branches to the infraspinatus muscle and spinoglenoid ligament-membrane were examined in cadavers, and the spinoglenoid notch was investigated in 50 dry scapulae. Result: The suprascapular nerve had two branches to the in fraspinatus muscle in 22 cadavers on 37 sides (74%) and three branches to this muscle in 11 cadavers on 13 sides (26%). On 31 sides the spinoglenoid membrane and on 19 sides the spinoglenoid ligament were observed. Related to the spinoglenoid notch, the mean width was 17.17±2.17 mm, and the mean depth was 17.45±2.03 mm in calliper measurements on dry bones, while the mean width was 16.99±1.88 mm, the mean depth was 17.73±2 mm and the mean area was 282.04±55.27 mm² in com puted tomography measurements. Conclusion: The presented data regarding the spinoglenoid notch in which the suprascapular nerve is frequently compressed and the branches of the suprascapular nerve to the infraspinatus muscle may guide the surgical treatment of the related entrap ment syndrome.Amaç: Bu çalışmada, spinoglenoid çentik ve spinoglenoid ligament-membran ile supraskapular sinirin infraspinatus kasına giden dallarının anatomik özellikleri ve klinik öneminin belirlenmesi amaçlanmıştır, çünkü bu yapılar bu sinirin sıkışmasına neden olabilir. Gereç ve Yöntem: İstanbul Üniversitesi İstanbul Tıp Fakültesi Anatomi Anabilim Dalı'na ait 26 fikse kadavra üzerinde elli taraf (25 sağ ve 25 sol) çalışıldı. Kadavralarda infraspinatus kasına giden supraskapular sinir dalları ve spinoglenoid ligament membran incelendi ve 50 kuru skapulada spinoglenoid çentik araştırıldı. Bulgular: Supraskapular sinir, 37 taraftaki 22 kadavrada (%74) in fraspinatus kasına iki dal, 13 taraftaki 11 kadavrada (%26) ise bu kasa üç dal verdi. 31 tarafta spinoglenoid membran ve 19 tarafta spinoglenoid ligament gözlendi. Spinoglenoid çentik ile ilgili olarak kuru kemik üzerinde yapılan dijital kaliper ölçümlerinde ortalama genişlik 17,17±2,17 mm, ortalama derinlik 17,45±2,03 mm iken, bilgisayarlı tomografi ölçümlerinde ortalama genişlik 16,99±1,88 mm, ortalama derinlik 17,73±2 mm ve ortalama alan 282,04±55,27 mm² olarak bulundu. Sonuç: Supraskapular sinirin sıklıkla sıkıştığı spinoglenoid çen tik ve supraskapular sinirin infraspinatus kasına giden dalları ile ilgili sunulan veriler, ilgili tuzak sendromunun cerrahi tedavisine rehberlik edebili