İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Metabolik hastalıklara eşlik eden nöropsikiyatrik komorbidite modelleri
No full textNöropsikiyatrik komorbiditeler ve metabolik hastalıklar arasında oldukça yakın bir ilgi vardır. Son yıllarda araştırma alanı olarak ve klinikte yoğun ilgi görmektedir. Bu iki konu ile ilgili olarak çeşitli komorbidite modelleri tasarlanıp, geliştirilmiş ve çalışmalara konu olmuştur (1-4). Bu bölümde metabolik hastalıklarla seyreden nöropsikiyatrik komorbidite modellerinin ana başlıkları ve de tayları yer almaktadır
Synthesis and supramolecular architectures of novel hydrazine derivative homometallic schiff base complexes and their spectroscopic and thermal chacterization
No full textIn this study, a hydrazine-containing Schiff base (ScB) and its metal complexes with five different metals—Co (ScB Co), Cu (ScB-Cu), Pb (ScB-Pb), Mn (ScB-Mn), and Zn (ScB-Zn)-were synthesized and subsequently characterized both structurally and thermally. The ScB was synthesized via an elimination reaction between vanillin and phenylhydrazine in ethanol. Hexadentate homometallic complexes (HMCs) were then obtained by reacting the ScB with five different metal salts in tetrahydrofuran. The structural architecture of the synthesized ScB and its HMCs was elucidated using Fourier Transform Infrared (FT-IR) spectroscopy, as well as proton (1 H) and carbon (13C) Nuclear Magnetic Resonance (NMR) spectroscopy. Optical, thermal, and surface characterizations of the structurally confirmed ScB and HMCs were performed using UV-Visible spectroscopy (UV-Vis), thermogravimetric and differential thermogravimetric analyses (TG-DTG), and scanning electron microscopy (SEM), respectively. According to thermogravimetric analysis, the char yield of ScB was 28.2%, while the char yields of its metal complexes—ScB-Co, ScB-Cu, ScB-Pb, ScB-Zn, and ScB-Mn—were 5.4%, 27%, 16%, 19%, and 7.1%, respectively. These results indicate that the incorporation of metal ions into the structure reduced its thermal stability, as evidenced by the decreased residue amounts at 1000 °C
The impact of female orthodontists in 21st century research: A bibliometric analysis of the 1000 most cited articles (2000−2023)
No full textThe involvement of female orthodontists in academic research has markedly increased in the 21st century. This bibliometric analysis evaluates the 1000 most-cited orthodontic articles to assess the influence of female ortho dontists in research between the years 2000−2023. A total of 677 publications featuring at least one female ortho dontic author were identified, with 54 % being first-written by women and 4.58 % produced only by female contributions. Forty-eight percent of these publications were published in the American Journal of Orthodontics and Dentofacial Orthopedics. The United States ranked first in publications, followed by Brazil and Italy, with the University of Michigan being the most productive institution. Research trends have transitioned from root resorp tion and skeletal growth in earlier years to artificial intelligence and digital technologies in more recent times
Alzheimer hastalığında ilerlemenin manyetik rezonans görüntülerindeki subkortikal hacimlerle makine öğrenmesi kullanılarak kestirilmesi
No full textAmaç: Alzheimer hastalığının (AH) erken dönemlerinde başlayan subkortikal yapılardaki ilerleyici dejenerasyonu bilinmektedir. Bu çerçevede, AH’de ilerlemenin ön görülmesi oldukça kritik bir yere sahiptir. Bu çalışmada, makine öğrenmesi (MÖ) kullanılarak subkortikal hacimlerin hastalığın ilerleyici seyrini öngörme potansiyellerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Çalışmaya Alzheimer Hastalığı Nörogörüntüleme Girişimi (ADNI) veri tabanından elde edilen, klinik tanısı ilerleyici (progresif, n=186) ve ilerleyici olmayan (non-progresif, n=235) olarak iki sınıfa ayrılmış toplam 421 katılımcının T1 ağırlıklı anatomik manyetik rezonans görüntüleme (MRG) verileri dahil edilmiştir. Anatomik MRG verisi FreeSurfer 7.2 programıyla işlenerek standart segmentasyon aşamalarında yer alan tüm subkortikal yapılara ait toplam hacimsel değerler elde edilmiştir. Ayrıca, hippokampal alt alanlar, talamus ve amigdala alt çekirdeklerinin hacimsel değerleri de hesaplanmıştır. Hacimsel değerler, MÖ algoritmalarında kullanılmadan önce intrakraniyal hacimlerle normalize edilmiştir. Normalize edilen tüm hacim değerleri kümesine PyCaret 3.0 kütüphanesi kullanılarak öznitelik seçimi uygulanmış ve subkortikal yapıların önem sıralaması Shapley (SHAP) değerleri ile belirlenmiştir. Bulgular: Subkortikal yapıların toplam hacimlerini içeren veri kümesi kullanılarak gerçekleştirilen MÖ sonucunda, bilateral amigdala, sol hippokampus, sol nucleus accumbens ve sağ lateral ventrikül ön plana çıkarak, progresif ve non-progresif grupları birbirinden %79 oranında doğruluk ile ayırt edebilmiştir. Diğer yandan, subkortikal yapıların küçük ölçekli alt alanlarının ve çekirdeklerinin hacim değerleri kullanıldığında ise bilateral amigdala-aksesuar bazal çekirdekler, sol amigdala-lateral çekirdek, amigdala-santral çekirdek, kortiko-amigdaloid geçiş alanı ve sol hippokampus-presubikulum ön plana çıkmış ve grupları birbirinden %81 oranında doğruluk ile ayırabilmiştir. Sonuç: Otomatik MÖ algoritmaları, AH’nin ilerleyici seyrini öngörebilmek için kritik rol oynayan subkortikal yapıları tutarlı bir şekilde belirleme potansiyeline sahiptir. Ayrıca, farklı ölçekteki segmentasyon kombinasyonlarına rağmen, amigdala ve hippokampus içindeki spesifik alt yapıların tutarlı şekilde ön plana çıkması AH patolojisinin takibinde bu nöroanatomik bölgelerin kritik rolünü vurgulamaktadır. Bulgularımız, AH'nin erken tanı ve takibi için otomatik MÖ algoritmalarının klinik destek aracı olarak potansiyelini vurgulamaktadır.Bu çalışma, İstanbul Üniversitesi Araştırma Üniversiteleri Destek Programı tarafından desteklenmiştir (Proje no: TSA-2022-39128)
Therapeutic effects of mesenchymal stem cell conditioned medium in rat varicocele model
No full textPurpose: This study aimed to examine the therapeutic effects of injection of conditioned medium of adipose-derived mesen chymal stem cells (ADMSC-CM) in a surgically created varicocele model in comparison with varicocelectomy. Materials and Methods: Twenty-eight male Wistar Albino rats were randomly divided into four groups: sham group, varico cele group, varicocelectomy group, and ADMSC-CM injection group. Sperm parameters were analyzed in samples taken from the epididymis after treatment. Malondialdehyde and superoxide dismutase (SOD) levels in blood samples were exam ined by biochemical analysis. The testicular tissues were stained with hematoxylin-eosin for histological examination (John sen’s Score). Additionally, Western Blot analyzes were performed to detect Claudin-11 levels, the functional protein of the blood-testis barrier, in testicular tissues. Results: Varicocelectomy and ADMSC-CM treatments significantly improved mean sperm parameters (concentration, pro gressive motility, motility, normal sperm morphology) (p≤0.05 for all). Both treatment groups had increased SOD levels along with a decrease in malondialdehyde levels (p≤0.05 for all). No significant difference was observed between the ADMSC CM group and the varicocelectomy group in preserving normal testicular histology according to Johnsen’s Score (p=0.114). Levels of Claudin-11 were significantly higher in the varicocelectomy and ADMSC-CM groups compared to the varicocele group (p≤0.05 for all). Conclusions: The therapeutic effects of ADMSC-CM in varicocele model may involve secretion of anti-inflammatory and re generative factors from ADMSC. ADMSC-CM injection appears to be a promising new strategy in the treatment of varicocelIstanbul Medipol University - BAP22-3
Labiaplasty revision surgery with using clitoral hood flap: A case-cohort study
No full textBackground: The demand for labia minora reduction surgery has increased due to aesthetic preferences and discomfort caused by labial hypertrophy. This study aims to share experiences with labial reconstruction using clitoral hood flaps in patients who underwent aggressive trim labiaplasty. Methods: Twenty-eight patients who had previously undergone only labiaplasty surgery were included in this study. Surgical techniques focused on preserving blood supply and achieving symmetry. Postoperative care included hospitalization, wound care training, and regular follow-up visits. Complications were monitored and managed as needed. Results: All 28 patients, comprising 23 bilateral and 5 unilateral labiaplasty cases, underwent revision surgery using 49 clitoral hood flaps. Complications occurred in 6 cases, including suture dehiscence, flap necrosis, and infection, all of which were effectively managed. All flaps maintained their viability, and high patient satisfaction was reported. Conclusion: Clitoral hood flap reconstruction following aggressive trim labiaplasty is a viable technique with minimal complications and high patient satisfaction. Further multicenter, long-term studies are necessary to validate these findings and improve surgical outcomes. Level of evidence iii: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266
Psychotherapy for cancer patients
No full textThis integrative volume is designed as a full resource for the psychological issues associated with cancer. Experts in a variety of areas (oncology. psychiatry, psychology, medicine, and social work) bring their insights to bear on treatment of the complex issues of cancer treatment. A range of therapy strategies are discussed, as well as varieties of therapeutic modalities. Included are evidence-based strategies for effective care for both individual and group settings. Attention is also given to care beyond the patient, including families and care givers. This volume is a comprehensive guide to providing psychotherapy in tandem with other cancer treatments and is essential guide to the present practical concerns as well as future research directions
Complementary and integrative medicine for the treatment of tourette’s syndrome
No full textBackground: There is widespread interest in complementary and integrative medicine (CIM) among people with Tourette's syndrome (TS). Objective: To perform a systematic review of evidence on the use of CIM to reduce tics and improve tic-related quality of life. Methods: We included clinical studies of CIM in children, adolescents and adults with TS and chronic tic disorders, and assessed the change in tic severity and/or tic-related quality of life using validated scales. Risk of bias of randomized controlled trials was assessed using the risk of bias tool of the American Academy of Neurology, which classifies studies into Class I, II, III or IV based on quality criteria. Results: 49 clinical studies and three systematic reviews were included. Most studies were rated Class IV and therefore at high risk of bias. Class I studies demonstrated efficacy of functional MRI neurofeedback, 5-Ling granule, Jingxin Zhidong formula, and Ningdong granule in reducing tic severity. Class II studies suggest efficacy of mindfulness-based intervention for tics, acupuncture combined with atlantoaxial joint bone setting therapy, and art therapy. Systematic reviews summarizing the Chinese literature on acupuncture, acupuncture with herbal medicine and massage therapy suggest greater reduction in tics compared to conventional treatments but there is low confidence in the evidence due to poor methodological quality of included studies. Conclusions: Evidence to support the use of complementary and integrative medicine for TS is limited in methodological quality and widespread applicability. These limitations prohibit evidence-based recommendations for general use among individuals with TS
Effect of magnification and press-on force on resin composite polishing
No full textObjective To evaluate surface roughness (Ra) and gloss (GU) of two resin composites after polishing with two systems, using a novel press-on force guided (PFG) polishing simulator. Materials and methods Eighty specimens were prepared using Essentia Universal (EU) and G-aenial Universal Injectable (GUI) composites. Surface roughness and gloss were assessed by a profilometer (Marsurf Ps10), and a glossmeter (Novo-Curve). They were polished with Sof-Lex and Twist Dia systems with or without magnification and PFG. Each polishing material was used for 30 s. Ra1 and GU1 measurements were repeated by the same operator. Data were analyzed using One-way ANOVA, Three-way ANOVA, and Robust ANOVA with Bonferroni Correction for multiple comparisons and Spearman’s rho Correlation Coefficient (<0.050). Results Higher Ra values were observed in GUI group for Twist Dia (0.33±0.05z ) compared to SofLex (0.22±0.08y ). Roughness was higher when PFG was uncontrolled (0.31±0.07x ), compared to the controlled (0.25±0.09w). No Ra difference was observed in EU group between SofLex (0.33±0.04) and Twist Dia (0.29±0.04)(P=.440). Uncontrolled PFG provided higher gloss for GUI and EU composites (69.7±2.91x , 54.63±18.68x , respectively). Twist Dia presented higher gloss for GUI and EU composites (72.3±2.57z ,58.88±13.73z , respectively). Magnification did not affect the roughness or gloss for both composites (P≥.05). A moderate negative correlation was found between roughness and gloss in GUI (r=-.546)(P<.001), while no correlation was observed in EU (r=-.110)(P=.449). Conclusion Higher surface roughness and gloss were observed with uncontrolled (not constant) press-on force. Even though SofLex may provide a lower surface roughness, Twist Dia can generate a greater surface gloss regardless of the composite type. 3.5X loupe magnification was not effective on surface roughness and gloss within a limited polishing time. Clinical Relevance Press-on force is an important factor affecting the composite polishing quality. Spiral polishing wheels can be advantageous for composite restoration polishing, as they better preserve the secondary and tertiary anatomies and provide a higher gloss. The effect of magnification on composite polishing can be related to the time spent using it
Diagnostic value of leukocyte count, c-reactive protein, and procalcitonin in pediatric liver transplant patients during the first week postoperative: A longitudinal study from a tertiary center and a new diagnostic method for predicting systemic infection
No full textBackground/Objectives: Infection is a major complication during the early postoperative period following pediatric liver transplantation (LT). Prompt diagnosis and treatment are essential to prevent death. We aimed to assess the diagnostic value of procalcitonin (PCT), white blood cell count (WBC), and C-reactive protein (CRP) levels for detecting bacterial infection and SIRS within the first week after LT. Methods: Demographic data, vital signs, laboratory results (PCT, CRP, WBC), and culture findings on the 1st, 4th, and 7th days between January 2010 and 2024 were collected retrospectively. Results: The study included 88 patients. Seventy-two percent had cirrhotic liver disease. SIRS was present in 17% (n = 15), and bacterial growth was detected in 20% (n = 18). Bacterial growth was found in 80% of patients with SIRS (n = 12/15) and in 8% of SIRS-negative patients (n = 6/73). PCT levels were significantly elevated on days 1, 4, and 7, and CRP lev els on days 4 and 7 in patients with SIRS. PCT elevation was significant on days 1, 4, and 7, while WBC increase was noted on day 7 in patients with bacterial growth. Body temperature ≥ 37.1 ◦C and PCT ≥ 5.1 ng/dL on the first day together showed a sensitivity of 72.2% and specificity of 84.3% for bacterial growth. Similarly, body temperature ≥ 37.1 ◦C and PCT ≥ 9.2 ng/dL on the first day yielded 73% sensitivity and 95% specificity for diagnosing SIRS. Cirrhotic patients exhibited limited or no WBC response to bacterial growth. Conclusions: PCT, CRP, and WBC alone are insufficient for diagnosing infection. Combined assessment of body temperature changes and PCT elevation may serve as more accurate indicators. Nonetheless, close monitoring of culture results and clinical signs, with serial physical exams, can aid timely infection management or prevent unnecessary antibiotic adjustments