İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Evaluation of posterior segment changes in pediatric asthma patients with and without inhaled corticosteroid therapy
No full textThis study aimed to evaluate and compare changes in the posterior segment of pediatric asthma patients, potentially associated with asthma or inhaled corticosteroids. A retrospective analysis was conducted on children aged 7–17 diagnosed with atopic asthma. The participants were categorized into groups: Group 1 (no inhaled corticosteroids) and Group 2 (inhaled corticosteroid treatment). A control group of healthy children was also included. Demographic data, clinical findings, and laboratory results (e.g., eosinophil count, IgE, CRP levels) were collected. Optical coherence tomography (OCT) and OCT angiography (OCTA) were used to measure posterior segment parameters. Asthma patients demonstrated a statistically significant reduction in subfoveal choroidal thickness, the superficial capillary plexus in the superior and nasal quadrants, the choriocapillaris in the foveal quadrant, and the peripapillary vascular density in the inferior and superior quadrants compared to controls. Inflammation markers such as eosinophil count and CRP showed significant correlations with changes in vascular density. Asthma, as a chronic inflammatory and hypoxic condition, can significantly affect posterior segment parameters, leading to potential visual function impairments in children. Regular monitoring with OCT and OCTA can help detect early microvascular changes, allowing for timely interventions to preserve visual health
The impact of unplanned pregnancy on prenatal attachment and subjective happiness
No full textObjective: Unplanned pregnancies are a major public health problem that causes undesirable socio‐ economic and psychological consequences for women, children and families in both developed and developing countries. This study was carried out to evaluate the impact of unplanned pregnancy on prenatal attachment and subjective happiness. Methods: This analytical cross‐sectional study was conducted with 342 pregnant women who attended the Obstetrics and Gynecology outpatient clinic of a university hospital between July 2022 and October 2022. Data was collected using the Demographic Information Form, London Unplanned Pregnancy Determination Scale, Prenatal Attachment Inventory, and Subjective Happiness Scale. The data was evaluated using descriptive statistics, as well as pearson correlation and regression analyses. Results: Age, number of pregnancies, pregnancy week, feelings experienced upon learning of the pregnancy, and previous pregnancy loss status all appear to have a statistically significant effect on the prenatal attachment and subjective happiness scale (p<.001). Regression analysis results show that prenatal attachment and subjective well being have a statistically significant effect on the London Unplanned Pregnancy Determination Scale (R2 =0.495). Conclusion: It has been found that unplanned pregnancies negatively affect early maternal behavior and individual happiness before birth. Therefore, it is considered important to provide counseling and psychosocial support to all pregnant women in order to bond with motherhood and ensure subjective happiness, along with prenatal education
Aloe vera ve ayva çekirdeği müsilajı içeren aljinat türevli biyobozunur filmlerin üretimi ve karakterizasyonu
No full textBu çalışma, biyobozunur ve fonksiyonel film üretimi amacıyla ayva çekirdeği musilajı ve aloe vera jeli içeren sodyum aljinat bazlı biyopolimer filmlerin sentezini ve karakterizasyonunu kapsamaktadır. Ayva çekirdeği, yüksek viskozite sağlayan doğal polisakkarit içeriği ile film matrisine mukavemet kazandırırken, aloe vera jeli antimikrobiyal ve antioksidan özellikleriyle biyolojik aktiviteyi güçlendirmektedir [1, 2]. Sodyum aljinat, biyouyumluluk ve film oluşturma kabiliyeti yüksek bir hidrojel olması nedeniyle temel taşıyıcı polimer olarak seçilmiştir [3]. Bu çalışma kapsamında, dört farklı hidrojel film formülasyonu hazırlanmıştır. Her bir formülasyon, sodyum aljinat, aloe vera, ayva çekirdeği, selüloz hidroksi etil selüloz (HEC) ve gliserol bileşenlerinin belirli oranlarda karıştırılmasıyla oluşturulmuştur. Film yapısında bulunan bileşenlerin birbirleriyle olan kimyasal ve fiziksel etkileşimleri, malzemenin mekanik ve fonksiyonel özelliklerini belirlemektedir. Film üretiminde solvent dökme yöntemi uygulanmış ve karakterizasyon aşamasında mekanik dayanım, su buharı geçirgenliği, biyobozunurluk ve antibakteriyel aktivite parametreleri değerlendirilmiştir. Fourier Dönüşümlü Kızılötesi Spektroskopisi (FTIR), UV-Vis Spektroskopisi ve Termogravimetrik Analiz (TGA) ile kimyasal yapı ve termal stabilite analizleri gerçekleştirilmiştir. Biyobozunurluk testleri, filmlerin çevresel koşullarda zamanla parçalanabilir olduğunu gösterirken, antibakteriyel testler inhibisyon etkisini doğrulamıştır. Elde edilen sonuçlar, ayva çekirdeği ve aloe vera içeren biyopolimer filmlerin sürdürülebilir ve çevre dostu bir alternatif sunduğunu göstermektedir. Bu bulgular, organik çözücü ve yüksek sıcaklık kullanmaksızın, biyobozunur malzemeler üzerine yapılan araştırmalara katkı sağlaması hedeflenmektedir
Molecular perspective on gemcitabine resistance in PANC-1 and PANC-1GemR pancreatic cancer cells: The potential role of polyphenolic cocktail (PFK5120) in overcoming chemoresistance
No full textMolecular perspective on gemcitabine resistance in PANC-1 and PANC-1GemR pancreatic cancer cells: The potential role of polyphenolic cocktail (PFK5120) in overcoming chemoresistance
The validity and reliability of the Turkish version of the patient’s knee implant performance (PKIP) questionnaire-preoperative and postoperative
No full textThe Patient’s Knee Implant Performance (PKIP) Questionnaire is a short and easy-to-complete questionnaire developed to assess the performance of total knee arthroplasty (TKA) more comprehensively. The aim of this study was to investigate the validity and reliability of the Turkish version of the PIKP questionnaire before (PKIP PreOp) and after (PKIP PostOp) TKA. The study included 162 patients referred for TKA and 154 patients who had undergone the surgery at least 3 months prior. Cronbach alpha, intra class correlation coefficient, and item-total correlation values were calculated to assess the reliability of the PIKP questionnaire. Validity was determined using exploratory and confirmatory factor analysis. To determine parallel scale validity, the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), The Short Form-36 (SF-36) Quality of Life Scale performance score were used. The mean age of the participants was 66.39 ± 7.65 years. Cronbach alpha and intra-class correlation coefficient values of the PKIP were acceptable (0.723 and 0.985, respectively). The item-total correlation values of each item of the PKIP was also acceptable (lowest ranged from 0.335 to 0.621). Confirmatory and exploratory factor analysis revealed that the both PKIP PreOp and PKIP PostOp studies had sufficient fit. The PKIP PreOp and PKIP PostOp was moderately to strongly correlated with the Western Ontario and McMaster Universities Osteoarthritis Index and Short Form-36 score (P < .001). Patients undergoing TKA had a significantly higher PKIP PostOp score than PKIP PreOp score. The Turkish version of the PKIP is valid, reliable, and sensitive to assess in performance in patients undergoing TKA
The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease
No full textMetabolic dysfunction-associated fatty liver disease (MAFLD) affects over one-fourth of the global adult population and is the leading cause of liver disease worldwide. To address this, the Asian Pacific Association for the Study of the Liver (APASL) has created clinical practice guidelines focused on MAFLD. The guidelines cover various aspects of the disease, such as its epidemiology, diagnosis, screening, assessment, and treatment. The guidelines aim to advance clinical practice, knowledge, and research on MAFLD, particularly in special groups. The guidelines are designed to advance clinical practice, to provide evidence-based recommendations to assist healthcare stakeholders in decision-making and to improve patient care and disease awareness. The guidelines take into account the burden of clinical management for the healthcare sector
Regülatör ağırlıklarının motor performansına etkisi
No full textDizel motorlar, yakıt dönüşüm verimlilikleri ve yüksek tork kapasiteleri sebebiyle farklı sektörlerde birincil güç kaynağı olarak tercih edilmektedir (Pachiannan ve diğ., 2025). İçten yanmalı motorlarda genellikle hidrokarbon içeren yakıt ile havanın yanması sonucunda enerji açığa çıkmaktadır (Görmez, 2020). Bu yanma olayı kumandalı (kontrollü) yanma, tutuşma gecikmesi ve ani yanma olarak 3 farklı aşama halinde ele alınmaktadır. Yanma aşamasının başlamasını sağlayan önemli parametrelerden biri ateşleme gecikmesidir (Miron ve diğ., 2021). Yakıtın püskürtülmeye başladığı zamandan silindir basıncının yüksek hızda arttığı zamana kadar geçen süreye ateşleme gecikmesi denilmektedir
Effects of the COVID-19 pandemic on the health of nursing staff: Qualitative research
No full textPurpose: To explore the effects of the COVID-19 pandemic on the physical, psychological, social, and spiritual health of nursing team members and to identify the coping measures adopted by them. Methods: This is a descriptive study with a qualitative approach. The study involved 42 Brazilian nursing professionals. Data were collected between June and July 2022 and analyzed through content analysis. Results: Three themes identified: (I) Effects of the pandemic on the health of nursing professionals, (II) Major difficulties faced by nursing professionals during the pandemic, and (III) Protection measures adopted by nursing professionals during the pandemic. Also, eleven sub-themes emerged. Participants stated that the COVID-19 pandemic affected their physical, psychological/mental, social, and spiritual health. The lack of material and human resources, increased demand and professional devaluation, social distancing, facing death, insufficient information and the lack of social commitment were cited as the main problems faced by the participants. Nursing professionals resorted to different measures to protect their health. Conclusion: The health of nursing professionals was significantly impacted during the COVID-19 pandemic. It was determined that nursing professionals and health institutions need to be better prepared to face crises. Continuing education should be developed to train nursing staff for future outbreaks better. Health administrators and nurse managers play key roles in safeguarding the physical and psychosocial health of nursing staff by ensuring adequate and high-quality personal protective equipment, offering occupational health training, and establishing psychosocial support programs.Amaç: Araştırmanın amaçları, COVID-19 pandemisinin hemşirelik ekibi üyelerinin fiziksel, psikolojik, sosyal ve ruhsal sağlıkları üzerindeki etkilerini belirlemek ve benimsedikleri başa çıkma önlemlerini ortaya çıkarmaktır. Yöntem: Bu, nitel bir yaklaşımla yapılan tanımlayıcı bir çalışmadır. Çalışma, 42 Brezilyalı hemşirelik profesyonelini içermektedir. Veriler Haziran-Temmuz 2022 tarihleri arasında toplanmış ve içerik analizi yöntemi kullanılarak analiz edilmiştir. Bulgular: Üç tema ortaya çıktı: (I) Pandeminin hemşirelik profesyonellerinin sağlığı üzerindeki etkileri, (II) Pandemi sırasında hemşirelik profesyonellerinin karşılaştığı ana zorluklar ve (III) Pandemi sırasında hemşirelik profesyonelleri tarafından benimsenen başa çıkma yöntemleri. Ayrıca on bir alt tema belirlenmiştir. Katılımcılar, COVID-19 pandemisinin fiziksel, psikolojik/zihinsel, sosyal ve ruhsal sağlıklarını nasıl etkilediğini bildirdi. Donanım ve insan kaynağı eksikliği, artan talep ve profesyonel devalüasyon, sosyal mesafe, ölümle karşı karşıya kalma, yetersiz bilgi ve sosyal taahhüt eksikliği, katılımcıların karşılaştığı başlıca sorunlar olarak belirtilmiştir. Hemşirelik profesyonelleri sağlıklarını korumak için farklı yöntemlere başvurmuşlardır. Sonuç: Hemşirelik profesyonellerinin sağlığı, COVID-19 salgını sırasında büyük ölçüde etkilenmiştir. Hemşirelik profesyonellerinin ve sağlık kurumlarının krizlere karşı daha hazırlıklı olmaları gerektiği belirlenmiştir. Hemşirelik profesyonelleri gelecekteki salgınlar için daha iyi yetiştirmek için sürekli eğitim geliştirilmelidir. Sağlık yöneticilerinin ve yönetici hemşirelerin, yeterli ve kaliteli kişisel koruyucu donanım sağlayarak, iş sağlığı konusunda eğitim vererek ve psikososyal destek programları geliştirerek hemşirelerin fiziksel ve psikososyal sağlığını korumada kilit rollere sahip oldukları unutulmamalıdır
Kalıcı mıknatıslı senkron motorun modellemesi ve kontrolü
No full textElektrikli araçlar (EV’ler), enerji verimliliği, çevreci ulaşım ve performans beklentilerini karşılamak amacıyla içten yanmalı motorlara alternatif olarak gelişmiştir. Kalıcı mıknatıslı senkron motorlar (PMSM), yüksek verimlilik, kompakt yapı ve geniş hız aralığı avantajları sayesinde EV uygulamalarında tercih edilmektedir. Tesla Model 3’te kullanılan İçten Mıknatıslı PMSM (IPMSM) yapısı, düşük hızda yüksek tork ve yüksek hızda verimli çalışma imkânı sunmaktadır
Diaphragmatic dysfunctions and their treatment: Neural therapy and manual medicine as effective approaches
No full textDiaphragmatic dysfunctions are a medical issue whose relevance is often underestimated. They manifest in respiratory and systemic symptoms such as dyspnea, sleep disturbances, chronic fatigue, gastroesophageal reflux, and even heart failure. As the primary respiratory muscle, the diaphragm is pivotal in maintaining trunk stability and regulating intra-abdominal pressure, making its dysfunction capable of exerting profound impacts on overall health. Causes and Pathophysiology of Diaphragmatic Dysfunctions: Diaphragmatic dysfunctions can arise from a variety of factors, including: Chronic stress, which increases tension in the diaphragm and surrounding fascia, Myofascial trigger points, which impair muscle contraction and mobility, Scar tissue, which limits fascial mobility, Trauma, surgeries, or mechanical stress, which may irritate or impair the function of the phrenic nerve. The phrenic nerve, which innervates the diaphragm, plays a crucial role in the functionality of this muscle. Irritation or damage to the phrenic nerve can significantly impair diaphragmatic movement, leading not only to breathing difficulties but also to dysregulation of the autonomic nervous system and organ functions. Treatment Approaches: The combination of neural therapy and manual medicine has proven to be particularly effective in treating diaphragmatic dysfunctions. Injections targeting myofascial trigger points and segmental therapy can support diaphragmatic function. Manual diagnostics play a critical role in identifying segmental dysfunctions and fascial adhesions