İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Video-assisted learning on youtube in dentistry education: The impact of overdenture videos on dentistry students
No full textOBJECTIVES: This study aimed to evaluate the effectiveness of video-assisted learning on the knowledge and perceptions of dental students regarding implant-supported overdentures, which represent a challenging but essential aspect of prosthodontic treatment. The increasing use of digital platforms for educational purposes motivated this research. MATERIALS-METHODS: A prospective pretest–posttest intervention study was conducted involving 4th- and 5th-year dental students at Istanbul Health and Technology University. Participants initially completed a 15-item multiple-choice test designed to assess their baseline theoretical knowledge of implant supported overdenture procedures. Students watched the selected educational video demonstrating key clinical steps, including implant positioning, abutment selection, impression-taking techniques, and prosthesis fitting. After the video session, students completed the same knowledge test to evaluate knowledge gain, as well as a 10-item Likert-scale survey to assess their perceptions about the video’s clarity, educational value, engagement, and motivational impact. Data were statistically analyzed using paired t-tests for knowledge score comparisons and descriptive statistics for survey results.Students complete the survey via Google Forms. RESULTS: Analysis revealed a statistically significant increase in post-intervention test scores, indicating an improvement in students’ understanding of overdenture concepts and clinical procedures. Survey responses reflected positive student attitudes toward video-assisted learning, highlighting increased clarity, engagement, and confidence in managing implant-supported overdentures. Most students expressed a preference for integrating similar video modules into their formal prosthodontic education. CONCLUSION: Video-assisted learning through widely accessible platforms such as YouTube serves as an effective supplementary educational tool in dental training. It enhances both theoretical knowledge and practical confidence in complex prosthodontic procedures like implant-supported overdentures. Incorporating such multimedia resources into dental curricula is strongly recommended to enrich student learning experiences and outcomes
Individualized oral hygiene home visits for children with special needs
No full textObjective: This study aims to evaluate the 6-month effects of an applied oral hygiene education program delivered through homevisits for children with special needs in Istanbul. Additionally, the study seeks to establish an individualized oral health monitoringprogram and promote non-cariogenic dietary habits.Methods and Results: The study included 279 children with special needs aged 1–8 years. Participants’ oral hygiene practices,dietary habits, and dental health status were compared before and after the education program. Plaque levels were assessed usingthe Silness-Löe Plaque Index, and Streptococcus mutans (S. mutans) levels were measured using the Saliva-Check Mutans test kit.After the intervention, the proportion of children brushing twice daily increased from 13.8% to 33% (p < 0.05), while the percentageof children with moderate plaque levels decreased from 40.1% to 26.5%. Additionally, the proportion of children with S. mutanslevels exceeding 105 CFU/mL decreased significantly from 91.3% to 68.0% (p < 0.005).Conclusion: Individualized oral hygiene education was found to be effective in improving oral health in children with specialneeds. Significant reductions in plaque levels and S. mutans concentrations were observed, along with increased parentalawareness. Future multidimensional educational programs incorporating home visits may play a crucial role in maintaininglong-term oral hygiene habits in children with special needs.This study was supported by Istanbul Kalkinma Ajansi (TR10/16/ÇGE/0062).
Bu çalışma İstanbul Kalkınma Ajansı (TR10/16/ÇGE/0062) tarafından desteklenmiştir
Hereditary breast, ovarian, pancreatic and prostate cancer syndrome: Multigene testing, multiomics, and risk management
No full textHereditary breast, ovarian, pancreas and prostate cancer (HBOC/HBOPC) syndromes remain a major global health concern, with BRCA1, BRCA2 and other high- or moderate-risk homologous recombi nation repair (HRR) gene variants driving a significant share of familial cancer risk. Beyond breast and ovarian sites, these mutations increase susceptibility to prostate, pancreatic, and other solid tumors, high lighting the syndromic nature of HBOPC. Advances in multigene panel testing (MPT), AI-supported variant classification, and polygenic risk scores (PRS) now enable more precise risk estimation, while functional reclassification and population-specific founder mutation mapping reduce uncertainty in un derrepresented groups. Emerging epigenetic and non-coding RNA biomarkers further strengthen early detection and treatment stratification. However, large-scale validation is still needed to translate these tools into equitable care. Risk-reducing surgeries, tailored surveillance, and targeted therapies—includ ing PARP inhibitors, immunotherapy, and homologous recombination deficiency (HRD)-based regi mens—have transformed management but require equitable access and culturally sensitive counseling to address psychosocial barriers and family communication challenges. Real-world data (RWD) and cross border variant databases are essential to bridge gaps between guidelines and practice, especially where founder effects and mosaicism complicate standard criteria. This review integrates current evidence on the genetic and molecular foundations, organ-specific management, evolving therapies, and ethical di mensions of HBOPC care. By combining multidisciplinary insights with AI, functional analyses, and real-world implementation strategies, this review highlights how next-generation precision oncology can deliver equitable, high-quality, and locally adapted prevention and treatment for families worldwide
Harnessing GPT technology for clinical decision support in retinal detachment
No full textAim: Considering the increasing incorporation of artificial intelligence (AI) in healthcare, it is crucial to comprehend the advantages and constraints of these technologies within ophthalmologic settings for their secure and efficient clinical utilization. This study aims to comprehensively assess the efficacy of three leading Generative Pre-trained Transformer (GPT) -based platforms in providing clinical decision-support for retinal detachment (RD). Methods: This cross-sectional comparative study was conducted between April 2024 and May 2024. Fifty questions were created based on the American Academy of Ophthalmology “Retina Book”, specifically targeting RD. The answers were produced by three different platforms and assessed by three independent reviewers who used Likert scales to evaluate their comprehensiveness and accuracy. Six readability metrics, including the Flesch-Kincaid Grade Level (FKGL) and Flesch Reading Ease Score (FRES), average words per sentence, average syllables per word, total sentence count, and total word count, were assessed. Results: Gemini earned the most outstanding results for comprehensiveness (4.11±0.72) and accuracy (1.49±0.61), followed by ChatGPT and Copilot. ChatGPT had superior readability metrics, achieving an FKGL of 15.62±2.85 and a FRES of 62.54±12.34, establishing it as the most accessible platform. ChatGPT demonstrated significantly higher performance compared to other platforms in the metrics of average syllables per word (p=0.0421) and total word count (p=0.0115). At the same time, no significant differences were found among the platforms in the metrics of average words per sentence (p=0.0842) and total sentence count (p=0.1603). Intraclass correlation coefficient (ICC) values indicated strong inter-rater agreement for comprehensiveness (ICC >0.74) and moderate to-high agreement for accuracy (ICC >0.56). Conclusion: Gemini’s detailed and accurate responses position it as a robust tool for professional use, while ChatGPT’s superior readability makes it suitable for patient education. These findings emphasize the synergistic advantages of AI platforms in research and development management and show the necessity for hybrid systems that integrate accessibility with accuracy
Falx cerebri'nin fenestra perspektifinden değerlendirilmesi ve olası klinik sonuçları
No full textObjective: The human falx cerebri is an important anatomical structure due to the hemispheres it is adjacent to and the dural venous sinuses it contains. It is also an important landmark in determining the midline in the interhemispheric transcallosal ap proach for lateral and third ventricular tumours in neurosurgical practises. Thus, the goal of this cadaveric study was to investi gate the existence, number, and topography of fenestra on the falx cerebri in the Turkish population. Material and Methods: For this study, 60 adult Turkish cadaveric dura maters were examined. The number of falx cerebris and the existence and topography of fenestra on the falx cerebri was de termined. The length and width of the fenestra were measured using a digital compass. Result: All falces cerebrum were single, and no double or triple falx cerebri were observed. There was fenestra on the falx cerebri in five cases (8.3% of all cases), and two of them included multi ple foramina (%40 of all fenestrae). In addition, one fenestra was on the middle part of the falx cerebri, whereas the other was placed on the posterior part of this partition. The mean length and width of these fenestrae were 23.3x7.5 mm. Conclusion: The novel findings documented in this study may be important to increase the success rate of diagnostic and op erative procedures of the falx cerebri or adjacent structures and to minimise intraoperative complications during neurosurgical applications.Amaç: İnsan falx cerebri’si, komşu olduğu hemisferler ve içer diği dural venöz sinüsler nedeniyle önemli bir anatomik yapıdır. Ayrıca, nöroşirürji uygulamalarında lateral ve üçüncü ventrikül tümörleri için interhemisferik transkallozal yaklaşımda orta hat tın belirlenmesinde önemli bir landmarktır. Bu nedenle, mevcut kadavra çalışmasının amacı, Türk toplumunda falx cerebri üze rindeki fenestra varlığını, sayısını ve topografyasını araştırmaktı. Gereç ve Yöntem: Bu çalışma için 60 yetişkin Türk kadavra dura mater’i incelendi. Falx cerebri sayısı, falx cerebri üzerinde fe nestra varlığı ve fenestranın topografyası belirlendi. Fenestranın uzunluğu ve genişliği dijital kaliper kullanılarak ölçüldü. Bulgular: Falces cerebrorum'un tamamı tekli olup, ikili veya üçlü falx cerebri gözlemlenmedi. Beş olguda (tüm olguların %8,3'ü) falx cerebri üzerinde fenestra vardı ve bunların ikisinde çoklu foramenler (tüm fenestraların %40'ı) vardı. Ayrıca fenestralardan biri falx cerebri'nin orta kısmında, diğeri ise bu bölümün arka kısmında yer alıyordu. Bu fenestraların ortalama uzunluğu ve genişliği 23,3x7,5 mm idi. Sonuç: Bu çalışmada belgelenen yeni bulgular, falx cerebri veya komşu yapılara yönelik tanısal ve operatif prosedürlerin başarı sını artırmak ve nöroşirürji uygulamaları sırasında intraoperatif komplikasyonları en aza indirmek için önemli olabilir
A subjective multi-criteria assessment of the lean and green production by using hesitant fuzzy sets
No full textLean Production, which has been implemented in a wide range of areas for many years, mainly aims to meet customer satisfaction while reducing waste and keeping efficiency at the maximum level. The Green Production tries to minimize the negative impact of production on environment while to increase the efficient utilization of natural resources. The analogy of these two concepts may sometimes encourage the joint application. Analysis of the factors affecting the success of Lean and Green production requires a multi-dimensional evaluation of experts as either researchers or practitioners. In this way, the problem on hand becomes a typical multi-criteria decision making problem and also contains uncertainty inherent in subjective evaluation of decision makers. Due to this reason, this study presents a fuzzy multi-criteria evaluation methodology by using hesitant sets. A real life application of the approach which considers the case of Türkiye is also presented
Testing the performance of cross-correlation techniques to search for molecular features in JWST NIRSpec G395H observations of transiting exoplanets
No full textCross-correlations techniques offer an alternative method to search for molecular species in James Webb Space Telescope (JWST) observations of exoplanet atmospheres. In a previous article, we applied cross-correlation functions for the first time to JWST NIRSpec/G395H observations of exoplanet atmospheres, resulting in a detection of CO in the transmission spectrum of WASP-39b and a tentative detection of CO isotopologues. Here, we present an improved version of our cross-correlation technique and an investigation into how efficient the technique is when searching for other molecules in JWST NIRSpec/G395H data. Our search results in the detection of more molecules via cross-correlations in the atmosphere of WASP-39b, including H2O and CO2, and confirms the CO detection. This result proves that cross-correlations are a robust and computationally cheap alternative method to search for molecular species in transmission spectra observed with JWST. We also searched for other molecules (CH4, NH3, SO2, N2O, H2S, PH3, O3, and C2H2) that were not detected, for which we provide the definition of their cross-correlation baselines for future searches of those molecules in other targets. We find that that the cross-correlation search of each molecule is more efficient over limited wavelength regions of the spectrum, where the signal for that molecule dominates over other molecules, than over broad wavelength ranges. In general, we also find that Gaussian normalization is the most efficient normalization mode for the generation of the molecular templates.This work is based on observations made with the NASA/ESA/CSA JWST. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in As tronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programme JWST-ERS-01366. Support for program JWST-ERS-01366 was provided by NASA through a grant from the Space Telescope Science Institute. This work was supported by grant JWST-ERS-01366.033-A. EE-B and EP acknowledge funding from the Spanish Ministry of Economics and Competitiveness through project PGC2018-098153-B-C31. EE B acknowledges financial support from the European Union and the State Agency of Investigation of the Spanish Ministry of Science and Innovation (MICINN) under the grant PRE2020-093107 of the Pre-Doc Program for the Training of Doctors (FPI-SO) through FSE funds. JK acknowledges financial support from Imperial College London through an Imperial College Research Fellowship grant. CC acknowledges support by ANID BASAL project FB210003. LD acknowledges support from the KU Leuven IDN grant IDN/19/028 and the MC-ITN CHAMELEON grant. This research was supported by the Excellence Cluster ORIGINS which isfunded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) un der Germany’s Excellence Strategy – EXC-2094 – 390783311. GM acknowledges financial support from the Severo Ochoa grant CEX2021-001131-S and from the Ramon´ y Cajal grant RYC2022- 037854-I funded by MCIN/AEI/1144 10.13039/501100011033 and FSE+. This material is based upon work supported by the Na tional Aeronautics and Space Administration under Agreement No. 80NSSC21K0593 for the programme ‘Alien Earths’. The results reported herein benefited from collaborations and/or information exchange within NASA’s Nexus for Exoplanet System Science (NExSS) research coordination network sponsored by NASA’s Science Mission Directorate. J-MD acknowledges the research programe VIDI New Frontiers in Exoplanetary Climatology with project number 614.001.601, which is (partly) financed by the Dutch Research Council (NWO).
Bu çalışma, NASA/ESA/CSA JWST ile yapılan gözlemlere dayanmaktadır. Veriler, NASA'nın JWST için NAS 5-03127 sayılı sözleşmesi kapsamında, Astronomi Araştırmaları Üniversiteleri Birliği tarafından işletilen Uzay Teleskobu Bilim Enstitüsü'ndeki Mikulski Uzay Teleskopları Arşivi'nden elde edilmiştir. Bu gözlemler, JWST-ERS-01366 programıyla ilişkilidir. JWST-ERS-01366 programına destek, Uzay Teleskobu Bilim Enstitüsü'nden alınan bir hibe aracılığıyla NASA tarafından sağlanmıştır. Bu çalışma, JWST-ERS-01366.033-A hibesiyle desteklenmiştir. EE-B ve EP, İspanya Ekonomi ve Rekabet Bakanlığı'nın PGC2018-098153-B-C31 projesi aracılığıyla sağladığı fonu kabul etmektedir. EE B, Avrupa Birliği ve İspanya Bilim ve İnovasyon Bakanlığı Devlet Araştırma Ajansı'ndan (MICINN), Doktorların Eğitimi için Doktora Öncesi Programı (FPI-SO) kapsamında FSE fonları aracılığıyla PRE2020-093107 hibesi kapsamında mali destek aldığını kabul eder. JK, Imperial College London'dan Imperial College Araştırma Bursu hibesi aracılığıyla mali destek aldığını kabul eder. CC, ANID BASAL projesi FB210003'ün desteğini kabul eder. LD, KU Leuven IDN hibesi IDN/19/028 ve MC-ITN CHAMELEON hibesinden destek aldığını kabul eder. Bu araştırma, Almanya'nın Mükemmellik Stratejisi - EXC-2094 - 390783311 kapsamında Deutsche Forschungsgemeinschaft (DFG, Alman Araştırma Vakfı) tarafından finanse edilen Mükemmellik Kümesi ORIGINS tarafından desteklenmiştir. GM, Severo Ochoa hibesi CEX2021-001131-S ve MCIN/AEI/1144 10.13039/501100011033 ve FSE+ tarafından finanse edilen Ramon y Cajal hibesi RYC2022-037854-I'den aldığı mali desteği kabul etmektedir. Bu materyal, Ulusal Havacılık ve Uzay Dairesi tarafından "Uzaylı Dünyalar" programı için 80NSSC21K0593 sayılı Anlaşma kapsamında desteklenen çalışmalara dayanmaktadır. Burada bildirilen sonuçlar, NASA'nın Bilim Misyon Müdürlüğü tarafından desteklenen NASA'nın Gezegen Dışı Sistem Bilimi Bağlantısı (NExSS) araştırma koordinasyon ağı içindeki iş birliklerinden ve/veya bilgi alışverişinden yararlanmıştır. J-MD, Hollanda Araştırma Konseyi (NWO) tarafından (kısmen) finanse edilen 614.001.601 proje numaralı VIDI Gezegen Dışı İklim Biliminde Yeni Sınırlar araştırma programını takdir etmektedir
Viewpoints of nurse auditors regarding the profession: A qualitative study
No full textAbstract Purpose – This study aims to understand the experiences of Brazilian nurse auditors in the practice of their profession, exploring the importance, challenges, rewards and strategies related to the occupation. Design/methodology/approach – This is a qualitative descriptive study conducted with 44 nurse auditors. An online, open-ended questionnaire was used. Thematic content analysis was performed. Findings – Five themes were identified: (1) functions of a nurse auditor; (2) skills required for a nurse auditor; (3) learning to be a nurse auditor; (4) advantages of being a nurse auditor and (5) challenges faced by a nurse auditor. Also, a total of 16 subthemes were presented. Research limitations/implications – The study critically examined essential aspects of auditing through the lens of nurse auditors, addressing a relevant topic. However, limitations must be acknowledged, including the use of self-report questionnaires, regional representation disparities, the scarcity of international articles on the topic and potential researcher bias. Practical implications – The study underscores the importance of increasingly integrating nurse auditors into the workforce while emphasizing the need to enhance the capacitation of these professionalsthrough theoretical and practical education. It highlights the significance of educating other multidisciplinary team members about the nurse auditor’s crucial role in fostering teamwork and ensuring the quality of healthcare services. Originality/value – To the best of the author’s knowledge, this is the first study conducted with Brazilian nurse auditors, exploring crucial aspects of auditing from the perspective of these professionals. Understanding the critical role of nurse auditorsinmaintaining and improving healthcare quality can enhance public trust in healthcare systems
Investigation of the effects of melatonin on granulosa cell proliferation and DNA methylation
No full textMelatonin, a pineal hormone with antioxidant and regulatory functions, has emerged as a key modulator of ovarian physiology. Its presence in fol licular fluid suggests important roles in granulosa cell function, follicle devel opment, and reproductive outcomes. However, its effects on granulosa cell tumour (GCT) biology and epigenetic regulation remain insufficiently defined. This study aimed to investigate the effects of melatonin on proliferation and global DNA methylation in human granulosa tumour cells (COV434) com pared with healthy endothelial controls (HUVECs). COV434 and HUVEC cells were treated with melatonin at 1, 10, 100, and 1000 µM. Cell viabil ity and proliferation were assessed using the MTT [3-(4.5-dimethylthiazol-2- yl)-diphenyl tetrazolium bromide] (Cambridge, UK) assay and xCELLigence RTCA system (Roche), while DNA methylation was quantified with a 5-mC ELISA kit (Epigentek Group Inc, USA). Experimental groups included nega tive, sham, melatonin-treated, and positive controls. Melatonin showed a cell type-dependent effect. In COV434 cells, proliferation was significantly inhib ited, with an IC50 of 10.55 µM, whereas HUVECs displayed increased prolifer ation at higher doses. DNA methylation levels decreased in both cell types in a dose-dependent manner, reaching the highest significance in COV434 cells at 1000 µM (p < 0.001). In conclusion, melatonin demonstrated a dose-dependent inhibitory effect on COV434 cell proliferation while simultaneously reducing global DNA methylation levels