İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
Not a member yet
1249 research outputs found
Sort by
Neural therapy as a key modulator in non-specific low back pain
No full textBackground: Non-specific low back pain (NSLBP) is a widespread musculoskeletal disorder with multifactorial origins, including postural dysfunctions, myofascial imbalances, autonomic dysregulation, and psychosocial influences. Differentiating between functional and degenerative causes is crucial for treatment planning. Conventional therapies often fall short, particularly in chronic cases. This study evaluate the efficacy of neural therapy as a regulatory, minimally invasive treatment option for NSLBP. Methods: This retrospective analysis includes 1,242 patients treated at the Natural Health Clinic between 2017 and 2024. Patients underwent neural therapy targeting modulation of the autonomic nervous system (ANS), resolving interference fields, and treating myofascial trigger points. Treatment duration, symptom severity (VAS, ODI), and functional improvement were assessed, with stratification by age and chronicity. Results: Neural therapy led to complete symptom resolution in 29% of cases and marked improvement in 35%, with only 2% reporting worsening symptoms. Most patients required between 2 and 4 sessions; fewer than 10% needed over 12 sessions. Age and symptom duration correlated with treatment intensity—older and long-term chronic patients often needed more sessions. Combined with manual medicine, neural therapy enhanced outcomes by addressing vegetative dysfunctions, neurogenic inflammation, and segmental restrictions. Conclusion: Neural therapy offers a compelling integrative approach for both functional and degenerative NSLBP. Its ability to regulate autonomic dysfunctions, reduce chronic inflammation, and address underlying interference fields positions it as a practical component of multimodal pain management. The retrospective data from over 1,200 patients underscores its clinical relevance, especially for middle-aged and older adults with chronic symptoms
Comparative gastric microbiota profiles in non-ulcer dyspepsia and peptic ulcer patients
No full textBackground Recent evidence suggests that the human stomach hosts a diverse microbiota beyond Helicobacter pylori, and that shifts in microbial composition may influence gastric health. In particular, oral-origin bacteria may dominate the gastric niche in the absence of H. pylori, yet their specific roles in different gastroduodenal disorders remain unclear. This study aimed to profile and compare the gastric microbiota composition in Turkish patients with non-ulcer dyspepsia (NUD) and peptic ulcer disease (PUD), in order to better understand microbial profiles potentially associated with gastroduodenal disease. Methods Ninety-eight patients underwent endoscopic evaluation and were divided into two groups according to the presence or absence of ulcers. Group 1 (n=52) included individuals with NUD, while Group 2 (n=46) comprised patients with PUD. Gastric biopsy samples from both groups were analyzed for the relative abundance of H. pylori using quantitative real-time PCR (qPCR), and next-generation sequencing was employed for a comprehensive analysis of the gastric microbiota. Results In total, H. pylori DNA was detected in 71.4% (70/98) of the samples, with a significantly higher prevalence in PUD patients (82.6%) compared to NUD patients (61.5%) (p=0.02). Distinct microbial profiles were observed based on H. pylori status. In NUD patients, Alloprevotella showed significantly higher relative abundance in H. pylori negative samples (p<0.05). Among PUD patients, the absence of H. pylori was associated with increased levels of Porphyromonas and Neisseria compared to NUD patients without H. pylori (p<0.05). These genera, typically associated with the oral cavity, appeared to expand opportunistically when H. pylori was absent. Conclusions The absence of H. pylori in gastric disorders was linked to a notable shift in microbiota composition, with increased representation of oral-origin bacteria such as Alloprevotella, Porphyromonas, and Neisseria. These findings, observed in a Turkish patient cohort, may reflect a potentially compensatory or opportunistic microbial shift in H. pylori-negative gastroduodenal disease. As exploratory findings, this study represents the first analysis from Türkiye comparing gastric microbiota profiles in NUD and PUD patients and provides novel regional insight into gastric microbial ecology.This work was supported by Istanbul Aydın University Scientific Research Projects Coordination Unit, Project number: 2018/05.
Bu çalışma, İstanbul Aydın Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi tarafından 2018/05 proje numarasıyla desteklenmiştir
Polyherbal ointment with bromelain for chronic diabetic wounds: Insights from a clinical case series
No full textPurpose Chronic diabetic wounds are characterized by prolonged inflammation and impaired healing. This study evaluates a novel polyherbal ointment, W Cura D Plus®, which contains Azadirachta indica oil, Hypericum perforatum oil, and bro melain from Ananas comosus. After initial debridement with W Cura D Plus®, treatment continued with W Cura G Plus®. To our knowledge, this is the first clinical report examining this specific combination in the treatment of chronic diabetic wounds. Methods A single-center clinical case series was conducted in 13 diabetic patients with Wagner grade 2–3 diabetic foot ulcers of at least 4 weeks’ duration. All patients were on standard type 2 diabetes therapy (oral agents and/or insulin) and routine wound care prior to enrollment. W Cura D Plus® was applied daily for 7 days to promote debridement, followed by W Cura G Plus® until complete closure or no further reduction in ulcer size for two consecutive weeks. Clinical endpoints included wound area, closure percentage, and recovery time. White blood cell (WBC) and C-reactive protein (CRP) levels were monitored. Results Fourteen wound observations were analyzed. Mean wound area decreased from 25.07±24.56 cm² at baseline to 7.38±5.15 cm² (p=0.0103), and mean closure rate was 64.15±0.23% (p=0.0108), surpassing the 50% benchmark for clini cally meaningful improvement. Recovery time averaged 97.7 days compared to baseline (initial status prior to treatment). WBC and CRP significantly declined (p<0.0001). No adverse events were reported. Conclusion This polyherbal formulation may represent a safe adjunct to standard care, but larger controlled trials are needed to confirm efficacy
Association of body mass index with orbital fat volume in lower eyelid blepharoplasty
No full textThe manuscript was language-edited with the assistance of an AI-based tool (ChatGPT 4o, OpenAI).
El yazması, yapay zeka tabanlı bir araç (ChatGPT 4o, OpenAI) yardımıyla dil açısından düzenlendi.Purpose To investigate the relationship between body mass index (BMI) and the volume of orbital fat excised during lower eyelid blepharoplasty. Methods This retrospective cross-sectional study included 58 patients who underwent bilateral transconjunctival lower eyelid blepharoplasty between January and December 2024. Total orbital fat volume was measured intraoperatively using a graduated cylinder. BMI was calculated from preoperative height and weight and classified according to World Health Organization criteria. Statistical analyses included Pearson correlation, one-way ANOVA with Tukey’s post-hoc test, and univariate and multivariable linear regression. Results The mean age of the patients was 49.2±11.6 years, and the mean BMI was 24.5±3.8 kg/m². The mean total orbital fat volume excised was 2.08 ± 0.94 cc. Fat volume differed significantly across BMI categories (p<0.001), with obese and overweight patients having greater excised fat than normal-weight individuals. Pearson correlation demonstrated a strong positive association between BMI and fat volume (r=0.592, p<0.001). In regression analysis, BMI was the only significant predictor of orbital fat volume, explaining 35.1% of the variance (R²=0.351). Conclusion BMI is strongly associated with orbital fat volume excised during lower eyelid blepharoplasty. These findings suggest that systemic adiposity extends to the periorbital region and highlight the relevance of considering BMI in preoperative planning to optimize surgical outcomes
Effects of blending different ratios of cottonseed oil with diesel fuel in a single-cylinder diesel engine
No full textThe persistent reliance on internal combustion engines, particularly within the transportation sector, continues to pose significant environmental challenges due to the emission of exhaust gases. This issue has intensified global efforts to identify and develop alternative fuels that can mitigate greenhouse gas emissions associated with fossil fuel consumption. Concurrently, the gradual depletion of petroleum reserves and volatility in fuel prices have introduced economic sustainability concerns. In this experimental study, the impact of blending conventional diesel fuel with 10% and 20% cottonseed oil by volume on engine performance and exhaust emissions was evaluated using a single cylinder direct injection diesel engine. The results demonstrated that the addition of cottonseed oil did not significantly affect engine power output or brake specific fuel consumption. However, a notable decrease in carbon monoxide (CO) emissions was observed, accompanied by an increase in nitrogen oxides (NO) emissions with higher biodiesel ratios. These findings indicate that cottonseed oil–diesel blends up to 20% by volume can be considered a technically viable partial substitute for conventional diesel fuel in compression ignition engines, with tradeoffs in emission characteristics
Kalıcı mıknatıslı senkron motorun modellemesi ve kontrolü
No full textBu çalışmada, Tesla Model 3’te kullanılan İçten Mıknatıslı Senkron Motorun (IPMSM) matematiksel modeli oluşturulmuş ve alan yönlendirmeli kontrol (FOC) algoritması uygulanmıştır. Motorun kontrolü için klasik PI kontrol yapısı ve SVPWM (Space Vector PWM) modülasyonu kullanılarak hız ve akım regülasyonu gerçekleştirilmiştir
Design and synthesis of thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen as potential MetAP (type II) inhibitors
No full textIn the present study, a range of novel thiosemicarbazides 4a-i and 1,2,4-triazoles 5a-i derived from ibuprofen, were synthesized. Structural elucidation of these synthesized compounds was performed utilizing a variety of spectroscopic methods, including FTIR, 1 H NMR, 13C NMR and HR-MS. The synthesized compounds were tested for cytotoxicity in five different cancer cell lines (cervical cancer (HeLa), human breast cancer (MCF-7), human gastric adenocarcinoma (MKN-45), human metastatic prostate cancer (PC3) and human glioblastoma (U87)). The compounds were compared with healthy cells (NIH-3T3) and the most effective compounds were determined by means of the selectivity index. Thiosemicarbazides derived form ibuprofen 4i and 4d showed anticancer activity, while 1,2,4-triazoles derived form ibuprofen 5b, 5c, 5d, 5e, 5h, 5g showed anticancer activity in HeLa, MCF-7, MKN-45, PC3 and U87 cells. To test the stability of the protein-drug complexes all 18 compounds 4a-i and 5a-i were docked into the active site of the MetAP2 enzyme In general, computational inhibition constants values were correlated with the experimental values. The dynamic behavior of MetAP2-inhibitor complexes was analyzed using all atoms Molecular Dynamic (MD) simulations for 200 ns duration. MD revealed that the drugs bind in the active center of MetAP2 with stable RMSD and RMSF. In conclusion, in-silico results and in-vitro studies suggests that thiosemicarbazides and 1,2,4-triazoles derived from ibuprofen may be novel anticancer drug candidates for treating cervical, breast, prostate, gastric and glioblastoma. Compounds provided induction of apoptotic proteins in the cell by inhibiting MetAP2 enzyme. Furthermore, the potential antioxidant activities of the compounds were evaluated using the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity assay. Among the compounds tested, 4a, 4b, 4e, 4f, 4h, and 4i exhibited values closely resembling the DPPH activity of the standards.This study was funded by the Turkish Health Institutes Presidency (TUSEB). Project number: 4235.
Bu çalışma, Türkiye Sağlık Enstitüleri Başkanlığı (TUSEB) tarafından finanse edilmiştir. Proje numarası: 4235
Evaluation of students' perspectives on the use of haptic virtual reality simulation systems in pediatric dentistry preclinical education
No full textAmaç: Bu çalışmanın amacı, çocuk diş hekimliği preklinik eğitiminde kullanılan haptik sanal gerçeklik simülatörlerinin (HSGS) öğrenciler tarafından nasıl değerlendirildiğini incelemektir. Çalışmada özellikle cihazın eğitsel katkısı, gerçekçiliği, ergonomisi ve motor becerilere olan etkisi gibi boyutlarda öğrenci algıları ortaya konmuştur. Gereç ve Yöntem: Araştırmaya diş hekimliği fakültesinde öğrenim gören üçüncü sınıf öğrencilerinden 68 kişi katılmıştır. Katılımcılara, HSGS deneyimlerinin ardından 14 maddelik Likert tipi ölçek içeren çevrim içi bir anket uygulanmıştır. Veriler IBM SPSS v23 programı ile analiz edilmiş; normal dağılıma uygunluk Kolmogorov-Smirnov ve Shapiro-Wilk testleriyle değerlendirilmiştir. Gruplar arası karşılaştırmalarda Mann-Whitney U testi, kategorik değişkenlerde ise Fisher’s Exact testi kullanılmıştır. Ölçeğin iç tutarlılığı Cronbach’s alfa katsayısı ile incelenmiştir. Bulgular: Öğrenciler, HSGS’nin beceri gelişimi, özgüven ve öğrenmeye katkısını olumlu değerlendirmiştir. Gerçekçilik ve ergonomi boyutlarında da yüksek memnuniyet bildirilmiştir. Cinsiyete göre anlamlı fark saptanmamıştır (p>0,05). Ölçeğin Cronbach’s alfa katsayısı 0,89 bulunmuştur. Sonuç: Haptik sanal gerçeklik simülatörleri, çocuk diş hekimliği preklinik eğitiminde öğrencilerin beceri gelişimine, öğrenme motivasyonuna ve özgüvenine önemli katkılar sunmaktadır. Ayrıca, standardize edilmiş eğitim imkânı sağlaması nedeniyle geleneksel yöntemlere kıyasla güçlü bir alternatif oluşturmaktadır. Bu bulgular, HSGS’nin diş hekimliği müfredatına entegrasyonunun gerekliliğini desteklemektedir.Aim: The aim of this study was to evaluate dental students’ perceptions of haptic virtual reality simulators (HVRS) in preclinical pediatric dentistry training. Materials and Methods: A total of 68 third-year dentalstudents completed a 14-item Likert-scale questionnaire following HVRS practice. The survey assessed educational value, realism, ergonomics, and motorskills. Data were analyzed using IBM SPSS v23. Mann-Whitney U and Fisher’s Exact tests were applied, and internal consistency was measured with Cronbach’s alpha. Results: Students reported positive perceptions regarding HVRS, particularly in terms of skill development, self-confidence, and learning contribution. High satisfaction was also observed in realism and ergonomics. No significant gender differences were found (p>0.05). The Cronbach’s alpha coefficient was 0.89. Conclusion: HVRS provide a standardized and effective training tool that enhances skills and self-confidence in pediatric dentistry education. These findings support the integration of HVRS into the dental curriculum
Antihypertensive treatment of a patient with normal blood pressure: Case report and call for paying attention
No full textThe current 2024 European Society of Cardiology (ESC) guideline for the management of elevated blood pressure and hypertension defines blood pressure less than 115/65 mmHg by ambulatory blood pressure monitoring (ABPM) as nonelevated, blood pressures in-between 115–129 and 65–79 mmHg as elevated blood pressure, and hypertension as ≥130/80 mmHg. There, might be patients seeking medical attention for the symptoms, apparently nonspecific but suggestive of hypertension with optimal, or not elevated, or elevated blood pressure values. A female patient with complaints of headache and dizziness lasting for 2 months has been evaluated in cardiology outpatient clinic and assessed by ABPM. It has been told that she had previously blood pressure of 90–100/50–60 mmHg and was suffering from headache when systolic blood pressure exceeds 110 mmHg. Her 24-h ABPM revealed systolic and diastolic blood pressure as 106/63 mmHg showing nighttime decrease compared with daytime pressures (98/59 mmHg and 108/68 mmHg, respectively). Thereafter, she was instructed to keep continuing the life-style modification and given to beta-blocker (bisoprolol 5 mg) as an antihypertensive treatment. At the end of the 2 weeks of follow-up period, she was headache-free and was feeling comfortable and well with a mean home blood pressure of 98/56 mmHg. We have presented prosperous antihypertensive treatment of a female patient suffering from headache and dizziness with a numerically normal or nonelevated blood pressure. In the presence of symptoms and having not elevated or elevated blood pressure levels, patients’ history on previous measure of blood pressure might facilitate our decision-making process
The lenalidomide derivative loaded and quercetin modified MIL-100 based novel drug delivery system for breast cancer treatment
No full textLenalidomide (L0) is an immunomodulatory agent with a range of effects, including anticancer and anti-inflammatory activity, and is commonly utilized in treating multiple myeloma. A derivative of lenalidomide (L1) has been synthesized to enhance its effects and to target different cancer cell types. In this study, the lenalidomide derivative L1, with the chemical structure 1-[2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl]-3-(p-tolyl)urea, was loaded onto a novel drug delivery system (DDS), and its activity was assessed towards triple-negative breast cancer cell lines (TNBC). MIL-100, a subclass of metal-organic framework (MOF) structures, was synthesized via a microwave-assisted hydrothermal method. MIL-100 was modified with quercetin (QC) as a linker, and its drug loading capacity was optimized, achieving a 95.18 % encapsulation efficiency. Additionally, the antioxidant properties of QC contributed to enhancing the performance of the DDS. In vitro drug release studies of the final product, MIL-100@QC@L1, were successfully conducted. The cytotoxic influences of the formulation on MDA-MB-231 cells were assessed using the WST-1 assay. After treatment with 10 μg/mL of MIL-100@QC@L1 for 24 h, the cell viability decreased significantly to 47.8 %, showing superior results compared to treatments with L0 and L1 alone