İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Lumbar spine: Diagnosis and therapy with neural therapy
No full textThe lumbar spine, due to its topographical location and the significant load it bears, is frequently a center for chronic and acute conditions. Typical symptoms include pain and movement restrictions caused by various factors such as degeneration, postural imbalances, structural changes, or functional disorders. Neural therapy offers an effective method for both diagnosis and treatment by specifically targeting interference fields and influencing the body’s autonomic regulation. Notably, neural therapy has shown positive results in the treatment of lumbalgia, sciatica, and degenerative diseases of the lumbar spine. It supports tissue regeneration, improves circulation, and reduces pain perception by modulating the autonomic nervous system. These outcomes are achieved through precise injection techniques, such as facet joint injections and spinal nerve injections, allowing for direct and localized treatment. Neural therapy aims to activate the body’s self-healing powers and eliminate interference fields by targeted injections into the autonomic nervous system. By modulating the sympathetic and parasympathetic nervous systems, pain syndromes can be alleviated, and functional disorders corrected. The importance of comprehensive diagnosis, which considers both functional and autonomic factors, is essential to maximize the effectiveness of neural therapy and ensure holistic treatment
A quality by design study of the use of microfluidic nanoprecipitation for the generation of sub-100 nm drug nanocrystals
No full textAlthough drug nanocrystals have attracted considerable interest within the pharmaceutical industry, there remain issues with the production of nanocrystals with a size below 100 nm. The aim of the present study is to develop a stable, reproducible Canagliflozin (CFZ) sub-100 nm nanosuspension system using microfluidic nanoprecipitation and Quality by Design (QbD) techniques. By means of the circumscribed central composite design (CCCD), critical parameters of the microfluidic nanoprecipitation process and nanosuspension formula tion components were optimised. Optimal CFZ nanosuspension with Z-average of 89.52 ± 3.30 nm, PDI of 0.12 ± 0.01 and drug content of 92.49 ± 0.03 % was successfully fabricated using Soluplus as a stabiliser. An increase in saturation solubility corresponding to approximately 250 times the value of the pure CFZ in water was noted. The optimised CFZ nanosuspension was solidified by freeze-drying and electrospraying. Overall, the study has demonstrated that by using a combination of microfluidics and QbD it is promising to generate stable sub-100 nm nanocrystals with high yield, and narrow size distribution and favourable stability.The authors declare the following financial interests/personal re lationships which may be considered as potential competing interests: Yagmur Pirincci Tok reports a relationship with The Scientific and Technological Research Council of Türkiye (TUBITAK) that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Yazarlar, potansiyel çıkar çatışması olarak değerlendirilebilecek aşağıdaki mali çıkarları/kişisel ilişkileri beyan ederler: Yagmur Pirincci Tok, Türkiye Bilim ve Teknolojik Araştırma Konseyi (TÜBİTAK) ile aşağıdaki ilişkileri bildirmektedir: finansman hibeleri. Başka yazarlar varsa, bu makalede bildirilen çalışmayı etkilemiş olabilecek bilinen herhangi bir mali çıkar çatışması veya kişisel ilişkileri olmadığını beyan ederler
NiO-SnO2 nanocomposite as an adsorbent for the preconcentration of manganese ions in chamomile tea extract
No full textMatricaria chamomilla L., referred to as chamomile, is a well-known medicinal plant that is widely distributed throughout the world. In this study, a novel NiO-SnO2 nanocomposite- assisted preconcentration method was established for efficient extraction and separation of manganese ions from chamomile tea extract. This pre concentration method was coupled with flame atomic absorption spectroscopy (FAAS). NiO-SnO2 nano composites were synthesized using simple one-pot co-precipitation procedure and calcined at 650 ◦C to obtain nanoparticles with sizes below 100 nm. X-ray diffraction (XRD) analysis indicated that the crystallite size of NiO SnO2 nanocomposites was estimated to be 46.03 nm using the Monshi–Scherrer equation. The LOD (limit of detection) and linear working range were determined as 3.6 μg/L and 10–100 μg/L, respectively. The proposed method was successfully validated, and recoveries ranged from 87.2 %–117.0 %. NiO-SnO2 nanocomposites represent a promising low-cost adsorbent for the preconcentration and subsequent determination of other heavy metal ions in diverse herbal extracts
Retrospective analysis of outcomes following expandable titanium cage and iliac graft applications in patients undergoing corpectomy for cervical spinal canal stenosis
No full textIntroduction This study aimed to compare the clinical and radiological outcomes of iliac crest autografts and expandable titanium cages in anterior cervical column reconstruction among patients undergoing cervical corpectomy for cervical spinal stenosis. Methods A retrospective analysis of 93 patients who underwent anterior cervical corpectomy between 2016 and 2023 was conducted; 61 were treated with iliac grafts and 32 with expandable cages. Clinical efficacy was assessed using the modified Japanese Orthopaedic Association (mJOA) score, while radiological outcomes were evaluated by measuring cervical lordosis (C2-C7 Cobb angle), intervertebral height, and fusion status, three months post-surgery. Complications, operative duration, and revision surgery rates were also analysed. Results Both the iliac graft and cage groups demonstrated significant postoperative improvements in mJOA scores (p<0.001). The iliac graft group exhibited superior early correction of cervical kyphosis, with the Cobb angle increasing from 3.17° to 9.12° (p<0.001), compared with the cage group’s increase from 0.99° to 5.83° (p=0.025). Cervical alignment remained more stable over time in the iliac graft group. Complication rates were comparable between the groups; however, graft displacement occurred more frequently in the iliac graft group. In contrast, cage malposition occasionally necessitated revision surgery. Conclusion Both iliac grafts and expandable cages are effective for anterior cervical reconstruction, yielding comparable clinical outcomes and complication rates. Iliac grafts may be better suited for achieving immediate postoperative correction and maintaining stable long-term alignment. The choice of surgical technique should take into account specific patient needs and the distinct risk profiles associated with each method
Development of brimonidine-loaded ethosomes for glaucoma: Investigation of intraocular pressure-lowering potential in vivo
No full textBackground/Objectives: Brimonidine tartrate (BRT), a selective α2-adrenergic receptor agonist, is commonly used in the treatment of glaucoma. However, conventional eye drop formulations suffer from poor ocular bioavailability and rapid elimination. This study aimed to develop and evaluate BRT-loaded ethosomes as a nanocarrier-based alternative to enhance intraocular delivery and therapeutic efficacy. Methods: Ethosomes were prepared using the thin-film hydration method and optimized via central composite design. The optimized formulation was subjected to physicochemical characterization, in vitro release testing, and ocular irritation assessment using the Hen egg test—chorioallantoic membrane (HET-CAM) model. Additionally, the intraocular pressure (IOP)-lowering efficacy of the formulation was evaluated in a rat glaucoma model. Results: The optimized ethosomal formulation exhibited favorable physicochemical properties, including a mean particle size of 122.6 ± 0.7 nm, zeta potential of −1.8 ± 0.9 mV, and encapsulation efficiency of 87.33 ± 0.04%. In vitro release data followed Higuchi kinetics. HET-CAM analysis indicated non-irritancy. In vivo, the ethosomal BRT formulation achieved comparable IOP-lowering effects to the marketed eye drops at one-third of the dose. Conclusions: The developed BRT loaded ethosomal system demonstrated promising physicochemical stability, sustained release, and therapeutic potential. These findings suggest that ethosomes may offer a safe and effective strategy for enhancing the ocular delivery of BRT in glaucoma therapy.The project was granted internal research funding from Acibadem University Scientific Research Projects Coordination Unit (Project number: THD-2024-2211) which provides a budget that covers the expense of in vivo study.
Proje, Acıbadem Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon Birimi'nden (Proje numarası: THD-2024-2211) iç araştırma fonu almıştır ve bu fon, in vivo çalışmanın masraflarını karşılayacak bir bütçe sağlamaktadır
Novel 1-benzyl-2-indolinone indole hybrids as tyrosine kinase inhibitors: Design, synthesis, and biological activity evaluation
No full textIn the present study, new 1-benzyl-2-indolinone indole hybrids (4a-s) were synthesized and their cytotoxic ef fects were determined against human breast (MCF-7 and MDA-MB 231), lung (A549), kidney (CAKI-1 and A498), colon (HT-29 and HCT-116), and pancreas (MIA PaCa-2) cancer cells by MTT assay. Some of the tested com pounds showed significantly better inhibitory effects and safety profiles than sunitinib malate against A498 and MIA PaCa-2 cells. Compound 4s showed a selective and significant cytotoxic effect on MIA PaCa-2 cells (IC50 = 0.15 μM; SI > 666.7). Compound 4b displayed significant cytotoxic effects on both A498 (IC50 = 0.87 μM; SI > 58.3) and MIA PaCa-2 (IC50 = 0.13 μM; SI = 390.0) cells. Compound 4b in A498 cells and compounds 4a-c, 4h, and 4s in MIA PaCa-2 cells significantly decreased general tyrosine kinase activity and induced apoptosis, accompanied by reduced ERK signalings. The inhibitory activities of compounds 4a–c, 4h, and 4s against SRC, PDGFR-β, and c-MET kinases were assessed in MIA PaCa-2 cells. Compounds 4a, 4b, 4h, and 4s inhibited PDGFR β, with 4h and 4s additionally targeting c-MET, while 4a, 4b, and 4h also demonstrated SRC inhibition. In this study, lead compounds 4b and 4s were identified as selective cytotoxic agents against human pancreatic car cinoma cells through induction of apoptosis and inhibition of SRC/PDGFR-β/c-MET signaling. Notably, com pounds 4b and 4s demonstrated a significantly better safety profile than sunitinib malate against noncancerous cells, underscoring their broader therapeutic potential. To understand their potential binding modes, molecular modeling studies were performed at the ATP-binding domains of SRC, PDGFR, and c-MET kinases
The impact of infant positioning on pain and early neonatal morbidities
No full textPurpose: To investigate whether appropriate positioning, assessed using the Infant Positioning Assessment Tool (IPAT), is associated with lower pain scores and reduced incidence of early neonatal morbidities in the first week of life in premature infants. Methods: This retrospective observational study was conducted at a single center. The pre-implementation (non IPAT) group was assessed using the NPASS (Neonatal Pain, Agitation, and Sedation Scale) alone, whereas the post-implementation (IPAT) group was evaluated using both the NPASS and the IPAT. Results: The IPAT group consisted of 77 infants, and the non-IPAT group consisted of 40 infants. The mean gestational age and weight of the cases were 29.9 ± 1.2 weeks and 1350 ± 234 g, respectively. Pain scores increased in infants with intraventricular hemorrhage (IVH) (days 3 and 7) and necrotizing enterocolitis (NEC) (days 4 and 5), but decreased with IPAT use on days 5–7. IPAT scores showed a moderate negative correlation with IVH on days 1 and 6, and a strong negative correlation with NEC on day 7. Conclusion: Higher positioning quality is associated with lower pain scores and potentially fewer early morbid ities in preterm infants during the first week of life. Optimal positioning using the IPAT will help establish nursing standards and increase awareness among primary caregivers
Impact of bruxism on the mandibular angle and condylar structures: A panoramic radiographic assessment
No full textObjectives The aim of this study is to comparatively evaluate morphologic changes in the mandibular angle and condylar region, assess the mandibular cortical index (MCI), and analyze the relationships between these parameters in bruxers and non-bruxers using panoramic radiographs. Methods A total of 182 patients (364 mandibular condyle and angle), 91 bruxers and 91 non-bruxers (controls), aged between 18 and 35, were participated in this study. Three hundred sixty four mandibular angles were classifed as G0, G1, G2, G3 in terms of bone apposition and direction change. In addition, osseous changes in the mandibular condyle were determined and the endoestal edge of the basal cortex was evaluated according to the MCI classifcation. Parameters were analyzed using the Pearson’s Chi-Square test and Fisher's Exact test. A p value<0.05 was considered signifcant. Result MCI class C1, G0 class, and normal condyle type were found to be signifcantly more common in the non-bruxist group than in the bruxist group (p<0.001, p=0.025, p=0.006, respectively). It was determined that deformity and MCI-C2 class were more common in the bruxist group (p=0.006, p<0.001). Morphologic changes in the endosteal margin of the cortex and in the condylar region were observed more frequently in bruxist individuals. Conclusion For a general overview of the probable presence of bruxism, osseous changes in the mandibular condyle, and MCI can be used as auxiliary diagnostic markers
Comparative evaluation of deep learning models for the classification of impacted maxillary canines on panoramic radiographs
No full textBackground/Objectives: The early and accurate identification of impacted teeth in the maxilla is critical for effective dental treatment planning. Traditional diagnostic methods relying on manual interpretation of radiographic images are often time-consuming and subject to variability. Methods: This study presents a deep learning-based approach for automated classification of impacted maxillary canines using panoramic radiographs. A comparative evaluation of four pre-trained convolutional neural network (CNN) architec tures—ResNet50, Xception, InceptionV3, and VGG16—was conducted through transfer learning techniques. In this retrospective single-center study, the dataset comprised 694 an notated panoramic radiographs sourced from the archives of a university dental hospital, with a mildly imbalanced representation of impacted and non-impacted cases. Models were assessed using accuracy, precision, recall, specificity, and F1-score. Results: Among the tested architectures, VGG16 demonstrated superior performance, achieving an accuracy of 99.28% and an F1-score of 99.43%. Additionally, a prototype diagnostic interface was developed to demonstrate the potential for clinical application. Conclusions: The findings underscore the potential of deep learning models, particularly VGG16, in enhancing diag nostic workflows; however, further validation on diverse, multi-center datasets is required to confirm clinical generalizability
Improving nutritional quality, aroma profile and bioactive retention of rocket juice via thermosonication: A support vector regression-based optimization
No full textThis study investigates the application of thermosonication (TS) to improve the functional properties of roka (Eruca vesicaria subsp. sativia) water. Processing parameters, including time (8–16 min), amplitude (60–100%), and temperature (40–60 °C), were optimised using a comparative approach combining the response surface method (RSM) and support vector regression (SVR). The total phenolic content (TPC) increased to 86.04 mg GAE/100 mL with TS, representing an 8.1% rise compared to the control group and an 18.3% increase over pasteurization. Likewise, the total chlorophyll level reached 16.98 mmol TE/L from 9.67 g/100 mL, and β-carotene rose to 24.90 mg/100 mL (p < 0.05). Pasteurization caused losses of 15–30% in these components. In the phenolic profile, significant increases were observed in chlorogenic acid (42.05 μg/mL), caffeic acid (15.66 μg/mL), and quercetin (4.28 μg/mL). A total of 31 compounds were identified in aroma analysis; with TS treatment, levels of 3-Hexen-1-ol (15.70 μg/kg) and 1-hexanol (2.01 μg/kg) were preserved or increased. In in vitro digestion tests, the TS group demonstrated the highest bioavailability, even during the intestinal phase. For example, RSM demonstrated high compliance coefficients (R2 = 0.99), while SVR showed strong predictive performance (CV R2 = 0.84), particularly for FRAP. Overall, the results suggest that thermosonication is an innovative method for protecting and enhancing bioactive compounds in rocket juice.The author(s) declared that financial support was received for this work and/or its publication. The authors are grateful for the generous support from the Researchers Supporting Project Number (PNURSP2025R251), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia.
Yazar(lar), bu çalışma ve/veya yayınlanması için mali destek aldıklarını beyan etmiştir. Yazarlar, Suudi Arabistan, Riyad'daki Prenses Nourah bint Abdulrahman Üniversitesi'nin Araştırmacıları Destekleme Projesi (PNURSP2025R251) kapsamında sağlanan cömert destek için minnettardır