İstanbul Sağlık ve Teknoloji Üniversitesi Kurumsal Akademik Arşivi
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Jinekolojik kanser hastaları için yapılandırılmış psiko-eğitimsel müdahalenin etkinliği: Randomize kontrollü çalışma
No full textThis randomized controlled trial aimed to evaluate the effects of a structured psychoeducational program on illness perception, coping skills, psychological adjustment, and emotional distress in women diagnosed with gynecological cancer. A total of 49 patients with stage I–III gynecological cancer were randomly assigned to either the psychoeducation intervention group (n=22) or the control group receiving standard oncological care (n=27). The six-week group-based intervention was adapted from the Fawzy and Fawzy model and included cancer education, stress management, cognitive restructuring, emotional expression, and coping skills training. Pre- and post-intervention assessments were conducted using validated Turkish versions of the Mental Adjustment to Cancer Scale, Profile of Mood States, Hospital Anxiety and Depression Scale, Beck Depression Inventory, Illness Perception Questionnaire, and Stress Coping Styles Inventory. Non-parametric statistical analyses were employed. The intervention group demonstrated significant improvements in fighting spirit, problem solving, seeking social support, personal control, illness coherence, and mood, as well as significant reductions in helplessness, anxious preoccupation, avoidance coping, fatalism, anxiety, depression, emotional distress, and negative illness perceptions (all p<.05), with medium-to-large effect sizes. No significant changes were observed in the control group. The structured psychoeducational intervention effectively enhances psychological adjustment, reduces distress, and promotes adaptive coping and illness perceptions, suggesting its integration into routine oncology care may improve psychosocial outcomes
Transgenerational effect of nicotine consumption on the TCF7l2 signalling pathway and glucose metabolism
No full textTransgenerational Effect of Nicotine Consumption on the TCF7L2 Signalling Pathway and Glucose Metabolis
Sustainable human resource management: A proposal of comprehensive model
No full textThe significance of human resource management (HRM), which positively impacts the organization’s strategical development and sustainability, has progressively increased and has undergone a transformation throughout time. It is important to highlight that whereas literature emphasizes the role and goals of human resources for fostering sustainability, there is no widely accepted approach. Aside from considering the organization’s competitive advantages, it also takes into consideration social and environmental aspects while considering all its stakeholders. In doing so, it must also ensure its financial sustainability. Despite the existence of several fundamental methods, the absence of a comprehensive approach that encompasses every component leads to the ongoing discussions in the literature on sustainable HRM. Furthermore, the sustainable human resources literature lacks to address the impact of institutional pressures, resulting in an insufficient approach. In this study, many core approaches and alternative perspectives in literature have been evaluated from a comprehensive perspective, leading to the development of a recommended approach which institutional pressures were added
Anatomical investigation of levator palpebrae superioris muscle and the distribution pattern of oculomotor nerve
No full textPurpose This study aims to evaluate the morphological features of the levator palpebrae superioris muscle (LPS) and the variations in the distribution of the oculomotor nerve in the muscle. Methods 100 bilateral orbits from 50 cadavers were included in our study. In our study, the medial, lateral, and middle length, width, and thickness of the LPS were measured from 3 different points and recorded. In addition, the number of branches of the oculomotor nerve entering the LPS muscle was calculated. Results The medial, lateral, and middle length of LPS were 34.85±5.30 mm, 34.62±5.67 mm, 35.77±5.31 mm on the right side and 33.66±4.74 mm, 33.81±4.83 mm, 34.54±5.14 mm on the left side, respectively. The width of the muscle was seen to expand from proximally to distally. It was noted that the middle 1/3 thickness of the LPS was the thickest part of the muscle compared to the other parts. A total of 239 oculomotor branches entered the LPS. The middle 1/3 of the LPS was reached by 151 oculomotor nerve branches. It was noted that the largest number of oculomotor nerves entered the middle 1/3 part of LPS. Conclusion The morphometric and morphological findings of LPS and branches of the oculomotor nerve may be useful in surgical planning for the LPS and levator aponeurosis and in preventing complications during surgical interventions
Long-term effects of neural therapy in fibromyalgia – A retrospective multicenter analysis effectiveness of neural therapy in patients with fibromyalgia
No full textBackground: Fibromyalgia syndrome (FMS) is a chronic pain condition associated with widespread musculoskeletal discomfort, persistent fatigue, and diminished quality of life. Many patients show limited response to conventional treatments. Neural therapy (NT), a core modality of regulatory medicine, aims to restore autonomic balance and modulate inflammatory reflexes through targeted injections of local anesthetics. Objective: This retrospective multicenter study evaluates the long-term effectiveness of NT in 565 patients with treatment resistant fibromyalgia who previously failed to respond adequately to standard therapies. Methods: Data were collected from five neural therapy clinics between 2017 and 2024. Standardized outcome measures were assessed at baseline, immediately post-treatment, and at 3, 6, and 12 months: Pain intensity: Visual Analog Scale (VAS) Disease burden: Fibromyalgia Impact Questionnaire (FIQ) Quality of life: Short Form-36 (SF-36), including subdomains (physical function, pain, energy/fatique, social function, general health perception) Statistical analysis employed the Friedman test for repeated measures. Results: VAS scores dropped from a mean of 8.5 to 1.9 post-treatment and remained below 3.0 over 12 months. FIQ scores decreased from a baseline mean of 78.1 to 18.6 and remained significantly improved (mean 24.9 at 12 months). SF-36 physical function increased from 33.5 to 82.0, with sustained gains at all follow-ups. Social functioning, general health perception, pain and vitality domains showed similar sustained improvements. The treatment completion rate was 92.9%, indicating high tolerability and patient satisfaction. Conclusion: Neural therapy produced significant and sustained improvements in pain, physical functioning, energy, and social participation in fibromyalgia patients. Its multimodal effects—autonomic modulation, anti-inflammatory action, and improved microcirculation—support its use in integrative and regulatory pain medicine. This study presents strong evidence for neural therapy as an effective, safe, and cost-efficient option in patients with resistant fibromyalgia. Further randomized controlled trials are needed to confirm these findings and establish standard treatment protocols
Regenerative strategies in pediatric dentistry: A comprehensive overview of tissue engineering from past to future
No full textTissue engineering in pediatric dentistry focuses on regenerating damaged dental tissues in children, aiming to restore their natural functions and address challenges associated with immature teeth. This field applies interdisciplinary biological principles to repair and regenerate tissues, using biomaterials, stem cells, and growth factors. Current advancements emphasize the regeneration of the dentin-pulp complex and tooth development through the use of biomaterials such as collagen, which offers structural support for cell growth and favorable interactions in tissue engineering. Additionally, various growth factors like FGF, TGF-β, BMP, and VEGF play vital roles in tissue regeneration by regulating signaling mechanisms in the dentin-pulp complex. Stem cells, particularly dental-derived ones such as DPSCs, SHEDs, and PDLSCs, have shown great potential in regenerating dental tissues in pediatric patients. These multipotent cells are capable of differentiating into various lineages, including odontoblasts, and are essential for the regeneration of both soft and hard dental tissues. While gene therapy, scaffolding techniques, and advanced technologies like three-dimensional (3D) bioprinting hold promise for tissue engineering, challenges remain in clinical implementation due to high costs and the need for further research. However, tissue engineering has already begun revolutionizing pediatric dental treatments, particularly in regenerative endodontics, and offers a minimally invasive alternative to traditional procedures like root canal treatments for young immature teeth. The future of regenerative dentistry in pediatric care lies in improving the application of stem cell–based therapies and bioactive materials to achieve complete tissue regeneration and provide more effective, personalized care for young patients
Sahin transvaginal extracorporeal myomectomy as a novel minimally‑invasive technique for the management of uterine myomas: A retrospective cohort analysis
No full textIntroduction: Vaginal myomectomy (VM) is a minimally-invasive surgery to remove uterine fibroids; however, limited exposure, difficulties in suturing, and challenges in achieving hemostasis restrict its wider adoption. To address these limitations, the Sahin transvaginal extracorporeal (STVEC) technique was developed, allowing for complete uterine exteriorization for extracorporeal reconstruction. Aim: We aimed to evaluate the safety, feasibility, and perioperative outcomes of the STVEC technique in women undergoing surgery for symptomatic uterine myomas. Materials and methods: This retrospective cohort included 200 consecutive patients who underwent VM using the STVEC technique between February 2021 and October 2024. Demographic characteristics, myoma features according to the International Federation of Gynecology and Obstetrics (FIGO) classification, operative variables, postoperative outcomes, and complications were analyzed. The complications were graded using the Clavien–Dindo system. Conversion to laparotomy was performed when safe continuation of the STVEC approach was not feasible. Results: Mean (SD) age of the study cohort was 39.1 (6.5) years and mean (SD) body mass index was 27.5 (5.8) kg/m². Mean (SD) myoma count was 1.8 (1.4; range: 1–5) and mean (SD) diameter was 6.7 (2.4; range, 5–10) cm. Intramural myomas (FIGO type 2–5) were the most common (55%). Conversion to laparotomy occurred in 8 patients (4%) due to adenomyotic uteri, adhesions, prior vaginal surgery, or altered cervical anatomy. Median (interquartile range [IQR]) hemoglobin decrease was 1.7 g/dl, median (IQR) estimated blood loss was 180 ml, and mean (SD) operative time was 71.9 (19.5) minutes. Blood transfusion was required in 18 patients (9%). Early complications occurred in 7 participants (3.5%), and all were minor. Conclusions: The STVEC technique appears safe and feasible, offering good bleeding control, low complication rates, and rapid recovery. Further multicenter studies are needed to confirm our findings
Sports drinks may affect salivary parameters in adolescent footballers
No full textFCT – Fundação para a Ciência e a Tecnologia, I.P./ Foundation for Science and Technology, I.P., Grant/Award Number UIDB/04748/2020 Life Quality Research Center (Centro de Investigação Qualidade de Vida)
FCT – Bilim ve Teknoloji Vakfı, F.İ.P./ Bilim ve Teknoloji Vakfı, F.İ.P., Hibe/Ödül Numarası UIDB/04748/2020 Yaşam Kalitesi Araştırma MerkeziMany adolescent athletes turn to sports supplements (SS) to improve their performance. Still, the growing use of these products raises questions about how they might affect oral health in the long run. While most studies focus on adult athletes and link sports drink consumption to dental issues like erosion and decay, it is worth asking whether these problems could begin much earlier, during the teenage years. This study explored how supplement use may influence salivary characteristics and early signs of oral health changes in adolescent football players
CFD simulation analysis of a diesel generator exhaust muffler and performance-based optimization
No full textThis study addresses a gap in the literature by simultaneously optimizing noise reduction and structural integrity in silencer design. A novel silencer model offering advan tages over conventional designs was developed. In the first phase, the initial optimization model was developed to minimize noise levels while considering environmental con straints. CFD analyses using NEC Acostix and Ex-Tuner calculated noise, temperature, and pressure, followed by validation in SimScale. The results demonstrated improved efficiency in reducing pressure loss and noise. A silencer with Ø 800 mm diameter, 3000 mm length, and Ø 355.6 mm exhaust connection was manufactured and tested, achieving 96 dB(A) at 1 m, with front and side measurements of 85.1 dB(A) and 74.4 dB(A), respectively. In the second phase, fastener durability in silencer support plates was optimized using tensile tests and FEA in Ansys R19.2. Parametric analyses for M4-M20 bolts were conducted, and regression analysis in Minitab (Minitab Statistical Software Version 21.1) showed 97.74% accuracy. An objective function was developed using curve fitting. The second optimization problem, incorporating design constraints, was solved using the interior point and Lagrange multipliers methods. This study provides a foundation for silencer design, ensuring both structural reliability and noise control. Future research will explore performance eco-friendly solutions across varying generator power levels
Evaluation of mesiodistal tip accuracy in mandibular anterior teeth following incisor extraction with clear aligners
No full textIntroduction: Single mandibular incisor extraction is sometimes necessary in clear aligner treatment, yet the accuracy of mesiodis tal tooth positioning in such cases remains unclear. This retro spective study evaluates the discrepancy between predicted and achieved mesiodistal movements of the remaining mandibular an terior teeth in Invisalign (Align Technology, Santa Clara, CA) treat ments. Additionally, it examines the effects of aligner attachments and change frequency on movement accuracy. Material and Methods: A total of 40 Invisalign patients with single mandibular incisor extraction were retrospectively analyzed. Geomagic Control X (3D Systems, Rock Hill, SC) was used to mea sure pretreatment positions, predicted movements, and achieved outcomes. Predicted and actual mesiodistal tip movements were compared. Results: Regression analysis revealed significant discrepancies (P 0.05). However, incisors were less likely than canines to follow the predicted movement direction (P = 0.025). Conclusion: A significant discrepancy exists between predicted and achieved mesiodistal movements after single mandibular in cisor extraction with Invisalign. The number of aligners, wear dura tion, and attachments do not significantly influence accuracy. Fur ther research is needed to optimize treatment planning and im prove predictability in clear aligner therapy