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The AhR Ligand, TCDD, Regulates Androgen Receptor Activity Differently in Androgen-Sensitive versus Castration-Resistant Human Prostate Cancer Cells
Get PDFThe reported biological effects of TCDD include induction of drug metabolizing enzymes, wasting syndrome and tumor promotion. TCDD elicits most of its effects through binding the aryl hydrocarbon receptor (AhR). TCDD induced degradation of AhR has been widely reported and requires ubiquitination of the protein. The rapid depletion of AhR following TCDD activation serves as a mechanism to modulate AhR mediated gene induction. In addition to inducing AhR degradation, TCDD has been reported to induce degradation of hormone receptors. The studies reported here, evaluate the effect of TCDD exposure on androgen receptor (AR) expression and activity in androgen-sensitive LNCaP and castration-resistant C4-2 prostate cancer cells. Our results show that TCDD exposure does not induce AhR or AR degradation in C4-2 cells. However, both AhR and AR are degraded in LNCaP cells following TCDD exposure. In addition, TCDD enhances AR phosphorylation and induces expression of AR responsive genes in LNCaP cells. Our data reveals that TCDD effect on AR expression and activity differs in androgen-sensitive and castration-resistant prostate cancer cell models
Morris Brown College Catalog 1940-1941
No full textThe Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Council on Library and Information Resources (CLIR) in supporting the processing and digitization of a number of historic collections as part of the project: Our Story: Digitizing Publications and Photographs of the Historically Black Atlanta University Center Institutions
Reading achievement: oral language proficiency and biographical data of third grade students of Atlanta, Georgia, 1986
No full textThis study examined the relationship between oral language proficiency and reading achievement, between birth order and reading achievement, between parent income and reading achievement, between sex and reading achievement, between parent type and reading achievement of third grade students in the Atlanta Public School System of Atlanta, Georgia. Test instruments used were the California Achievement Test and the Paradigmatic-Syntagmatic Language Inventory Scale Biographical data was obtained from school records. The data analysis techniques utilized was the Pearson Correlation Coefficient. The findings showed significant correlation between birth order and reading achievement, between oral language proficiency and reading achievements. The correlation between parent income and reading achievement, between parent type and reading achievement had a positive relationship. There was a low negative relationship between sex and reading achievement
Spelman College Bulletin 1951-1952
Get PDFThe Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Council on Library and Information Resources (CLIR) in supporting the processing and digitization of a number of historic collections as part of the projectOur Story: Digitizing Publications and Photographs of the Historically Black Atlanta University Center Institutions
Catalogue of the Officers and Students of Atlanta University, 1876-77
No full textThe Atlanta University Center Robert W. Woodruff Library acknowledges the generous support of the Council on Library and Information Resources (CLIR) in supporting the processing and digitization of a number of historic collections as part of the project: Our Story: Digitizing Publications and Photographs of the Historically Black Atlanta University Center Institutions.</em
A study of the academic success of the Booker T. Washington High School students entering Morehouse College during the years 1945-1953, 1958
No full textA study of the organizational trends and program practices of five councils of social agencies from 1938-1948, 1948
No full textAn experimental study of the relative effectiveness of two methods of teaching information concerning breakfast foods, 1951
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An exploratory descriptive study of the perceptions of elderly African American men and women on social support systems, 1998
No full textThe objective of this study was to determine if there was a difference between the perceptions of elderly African American men and women regarding social support systems. To obtain this objective the researcher conducted an exploratory descriptive research design. A self-administered 31 item questionnaire was given to fifteen elderly African American men and fifteen African American women in rural North Carolina. A non-probability convenience sample was used for this population. The null hypothesis of this study were rejected at the .05 level of significance. The results of this study revealed that the elderly had a strong perception of social support systems. They felt loved by and involved with family, friends and others. The study did not reveal any statistical significant difference between the two groups of elderly