International Journal of Research Development and Technology
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In-vitro Comparative Study Different Brands of Tenegliptin and Metformin HCl Prolonged Release Tablets by UV Spectroscopy
Get PDFEvaluation of the quality control standards of different generic brands of Teneligliptin & Metformin HCl extended-release tablets has been compare with the innovator Glucophage XR®. The objective of this study is to determine the dissolution data by using f1 & f2.In this dissolution test following general method using 6.8 pH phosphate buffer volume 1000 ml at 100 rpm, USP I apparatus and also by using UV spectrum at 232nm. The uniformity of weight for the Six brands of this tablet with values that compiled with I.P specification and deviated less than 5% from the mean value. Using hardness tester, the strength of the tablets determined. Hardness of the tablets was in the range of 5.60±0.13 - 7.98±0.18kg/cm2 with all brands. The result of tablet friability test of all brands tested with friability values of 0.110% to 0.821% w/w. According to I.P. no batch having friability value > 1%w/w. This study concludes the physicochemical characteristic of six brands of this tablet complied with the official IP specification for hardness, friability, weight variation and dissolution. F1 and f2 factor provide uniformity in five brands of this tablet and analysis suggest that the Ingola M brand fails the test
Formulation and Optimization of Posaconazole Nano-suspension
Get PDFA nano-suspension prepared with posaconazole was optimised via CCD. The morphological studies produced evidence of the drug\u27s amorphous state (SEM and PXRD). In vitro, there was a higher release of medicines from the nano-suspension than from the pure drugs. When the medication is prepared as a nano-suspension, its oral bioavailability is enhanced compared to the commercial version. Stability tests indicated that the formulation stayed stable for up to six months. The QbD technique was employed to examine the effects of CPPs and CMAs on CQAs, thereby augmenting the formulation\u27s safety and quality. The quantity of Tween-20, soy lecithin, and carbopol-934, as well as process variables such method PB, are critical material features. RSM\u27s CCD was used to improve the nano-suspension. Posaconazole was chosen since it is prescribed to treat oral candidiasis that is resistant to other triazole derivatives. Furthermore, the optimised nano-suspension was assessed. The lower PDI values, increased drug concentration, smooth and spherical particles with increased entrapment efficiency, and improved bioavailability all corroborate the anticipated characteristics of the nano-suspension. The results show that QbD is an effective tool for novel drug delivery systems, which is significant since it aids in the USFDA\u27s and the Indian market\u27s efforts to lower manufacturing costs, enhance safety and quality, and lessen production variability
Formulation and Evaluation of Baclofen Nano-emulsion for the Treatment of Multiple Sclerosis
Get PDFIn conclusion, the development and assessment of Baclofen nano-emulsion present a promising therapeutic avenue for addressing multiple sclerosis. This research aimed to fabricate and appraise the Nano-emulsion of Baclofen using the high-shear homogenization method. Various parameters such as Physical Appearance, pH, viscosity, % drug content, centrifugation, UV spectroscopy, and Fourier transform spectroscopy were evaluated to gauge the formulations\u27 quality. Moreover, in vitro drug release studies and stability assessments were conducted. Formulation F5 exhibited a viscosity of 5920cp, and formulation F5 demonstrated the optimal drug release rate of 98.12% within 6 hours. Stability assessments revealed minor alterations in formulations after two months at 4°C ± 2 and 75% ± 5% humidity. These findings underscore the potential of nanoemulsions as a viable vehicle for orally administering Baclofen to treat sclerosis. Leveraging nanotechnology\u27s advantages, this innovative formulation offers prospects for enhanced drug delivery, improved therapeutic efficacy, and mitigated adverse effects compared to conventional treatment modalities
A Study on Monoclonal Antibodies & their Applications
No full textFor many investigations in molecular immunology, monoclonal antibodies are crucial instruments. Monoclonal antibodies facilitate antigen profiling and macromolecular surface visualization, particularly when used in conjunction with methods like epitope mapping and molecular modeling. Furthermore, monoclonal antibodies are now essential elements of many clinical laboratory assays. Because producing monoclonal antibodies is labor-intensive and time-consuming but incredibly satisfying, they are only manufactured when necessary. This is especially true if the monoclonal antibody helps with clinical diagnosis and patient therapy, or if it can be used successfully in a standard pathology laboratory. The creation and application of monoclonal antibodies is the subject of this essay, which should improve knowledge and inspire fresh concepts in scientists and physicians
DESIGN, SYNTHESIS AND CHARACTERIZATION OF BENZOTHIAZOLE DERIVATIVE AS ANTI-BACTERIAL AGENTS
No full textBenzothiazoles have played an important role in the field of biochemistry and medicinal chemistry due to their highly pharmaceutical and biological activity. The development of synthetic processes is undoubtedly one of the most significant problems facing researchers. In this review paper, we provided recent advances in the synthesis of benzothiazole compounds related to green chemistry from condensation of 2-aminobenzenethiol with aldehydes/ketones/acids/acyl chlorides and the cyclization of thioamide or carbon dioxide (CO2) as raw materials, and the future development trend and prospect of the synthesis of benzothiazoles were anticipated
A Review on Synthesis and Biological Activity of Thiazole and it\u27s Derivatives
No full textThe continuous review gives a blueprint of the natural activities of thiazole during the earlier years. It is heterocyclic blends, Thiazole, conceivably of the most generally perceived five-membered heterocyclic compound, has a nitrogen particle at position 3 and a sulfur bit at position 1. It is a critical arrangement of a gigantic number of made compounds. Its different pharmacological development is reflected in many clinically upheld thiazolecontaining particles with, broad assortment of normal activities, similar to antibacterial, antifungal, antiviral, anthelmintic, antitumor, and quieting influences
‘‘The Effectiveness of Recreational Therapy on Dementia Patients’’
No full textTherapy for dementia patients encompasses a range of interventions aimed at improving quality of life, cognitive function, and emotional wellbeing. Nonpharmacological therapies, including cognitive stimulation, physical exercise, music therapy, and reminiscence therapy, have shown promise in enhancing memory, mood, and overall engagement. These approaches often focus on maintaining cognitive function, reducing behavioral symptoms, and fostering social interaction. Pharmacological treatments, primarily cholinesterase inhibitors and memantine, can provide symptomatic relief but do not halt disease progression. Integrative therapy models that combine pharmacological and nonpharmacological strategies offer the most comprehensive benefits. Recent advancements highlight the importance of personalized therapy plans tailored to individual patient needs, underlining the multifaceted nature of effective dementia care
’Assessing the Impact of Mindfulness-Based Interventions on Dementia Patients: A Systematic Review and Meta-Analysis
No full textDementia presents complex challenges in healthcare, necessitating innovative approaches beyond traditional pharmacological interventions. Mindfulness-based interventions (MBIs) have garnered attention for their potential benefits in addressing cognitive, emotional, and behavioral symptoms in dementia patients. This research article provides a comprehensive review and meta-analysis of existing literature to evaluate the effectiveness of MBIs on various outcomes in dementia management, including cognitive function, mood regulation, and quality of life
Studies on Hepatoprotective Properties of leaf Extracts of Azadirachta indica in 2-nitropropane Induced Hepatotoxicity
No full textThese days, there are very few hepatoprotective medications accessible to treat liver diseases. Jaundice has historically been treated using herbal remedies like Phyllanthus niruri. To determine which phytoconstituents are responsible for the hepatoprotective action, studies have been carried out on a variety of herbal plants. The goals of this study are to examine the effectiveness of ethanolic extract of Azadirachta indica and assess its hepatoprotective impact in rats that have been induced hepatotoxicity by 2-nitropropane
INVESTIGATING THE ESTROGENIC EFFECTS OF TEST ITEMS VIA ORAL ADMINISTRATION IN A FEMALE RAT OVARIECTOMY MODEL
No full textTo evaluate the effects of estrogen and estrogenic compounds on cognition in ovariectomized rats. Female Albino wistar rats (3–5 months old) weighing 250–300 g were randomly divided into seven groups: Sham, ovariectomized (OVX), OVX plus estradiol valerate, OVX plus ipriflavone, OVX plus raloxifene, OVX plus tibolone, OVX plus low-dose estradiol valerate and ipriflavone. All treatments were given orally for 3 months; whereas the drug groups received indicated drugs, the Sham and OVX control groups received saline. The escape latency of rats was tested by the Morris water maze test and the expression of amyloid precursor protein (APP) in hippocampus was determined by reverse transcription polymerase chain reaction. The level of serum estradiol and the diameter of the endometrial gland and the thickness of endometrium were also evaluated. The latency of the OVX group was noticeably longer than that of the Sham group, and the latency of all treatment groups was lower than that of OVX rats. The expression of APP mRNA in the hippocampii of OVX rats was significantly increased relative to that in Sham rats; interestingly, expression of APP in treatment groups was significantly reduced relative to OVX rats