International Journal of Research Development and Technology
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Therapeutics of Nipha virus: Recent Development and Advances
Get PDFThe Nipah virus (NiV) is a virus with high fatality rate causes mortality. Historically afflicted many developing countries. Several countries with developing economies, including Future outbreaks are likely to threaten Thailand, Cambodia & Madagascar, according to Centres for Disease Control & Prevention (CDC). Little has been accomplished in nearly 20 years since 1st case of NiV was reported in terms of developing a treatment & vaccine. Since many underdeveloped countries lack capacity to combat epidemic, it is imperative to properly educate health systems. An epi demiological back-drop, comprehension of how this lethal virus is transmitted, how it appears & methods of diagnosis & prevention are among aims of this review. The emergence of novel viruses & diversity of viruses are occurring at an alarming rate. Due to the sudden emergence of the (NiV), serious concerns have been raised over its immediate management using conventional medical treatments & testing processes. When (NiV) enters host cell via a cell surface receptor, syncytium is created. The virus is discharged into circulation & spreads to other organs as syncytium gradually breaks down. By targeted tagging & blocking action of viral surface proteins, NiV infection can be selectively detected & neutralised with aid of nanotechnology. Creating a targeted nano-system against these expressed pro-teins may also aid in preventing spread of viral infection because NiV-infected cells also produce these viral surface proteins, which aid in creation of the syncytium
Development & Optimization of Anthelmintic Activity of Herbal Formulation
Get PDFVarious Asian traditional writings refer to Azadirachta indica leaves and Trichosanthes dioica seeds as herbal medication used for anthelmintic purposes ethno pharma-cologically. The goal of current study was to produce a herbal formulation including A. indica leaves & T. dioica seeds and evaluate its anthelmintic activity in order to determine the optimal dose for pronounced efficacy. For the development of the formulation as tablets, preformulation investigations were carried out. Experiments were conducted on nematodes & Ascaridia galli in order to assess & improve anthelmintic efficacy of formulations F1, F2 & F3. The medication albendazole was prescribed frequently. For each formulation as well as the standard, amount of time needed for worm paralysis & death (lethal time) was documented. The findings showed that A. galli was significantly paralyzed & killed by treatment with all formulations. By showing quickest paralysis & fatal times, F1 formu-lation (1:1 ratio of both plant extr-acts) proved highest effectiveness as an ant-helmintic
Development Optimization of Anthelmintic Activity of Herbal Formulation
Get PDFVarious Asian traditional medical systems have reported the use of Azadirachta indica leaves and Trichosanthes dioica seeds as herbal remedies for anthelmintic purposes in ethnopharmacology. The present study aimed to develop a herbal formulation containing A. indica leaves and T. dioica seeds and to evaluate its anthelmintic activity in order to determine the optimal dose for maximum efficacy.
For tablet formulation, preformulation studies were conducted. Experimental investigations were carried out on nematodes and Ascaridia galli to assess and compare the anthelmintic efficacy of three formulations (F1, F2, and F3). Albendazole was used as the standard reference drug. For each formulation and the standard, the time required for worm paralysis and death (lethal time) was recorded.
The results demonstrated that A. was significantly paralyzed and killed by all tested formulations. Among them, formulation F1, containing a 1:1 ratio of both plant extracts, showed the highest anthelmintic activity by exhibiting the shortest paralysis and lethal times