Indian Journal of Research in Homoeopathy
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Potency dependent angiogenic effect of Bellis perennis on in ovo chick chorioallantoic membrane assay
No full textBackground: Hormesis is the biological response of an organism for a particular dosage of a substance. The lower dose stimulates and higher dose inhibits. J Compton Burnett, an eminent homeopath, prescribed Bellis perennis for breast and uterine tumours, which suggests it could be due to the antiangiogenic property or angiogenic inhibiting property and clinically also it is used for healing of fractured bone and wound healing which may be due to angiogenic promoting property. This experiment deals with the dose dependent effect of Bellis perennis on In Ovo Chick Chorioallantoic Membrane Assay. Objective: To evaluate the Hormesis effect of Bellis perennis 12X, 6CH, 30CH by assessing the angiogenic effect in chorioallantoic membrane assay (CAM). Methods: CAM assay was done following the standard protocol and the antiangiogenic and angiogenic effect of Bellis perennis in 12X, 6CH, and 30CH was assessed by counting the number of vessels and densitometry study using Image J software at 24 h, 48 h, and 72 hours(h). Histological study was carried out under light microscopy for tissue thickening. Results: Bellis perennis had antiangiogenic property in 12X and angiogenic property in 6CH and 30CH. Conclusion: Bellis perennis shows potency dependent angiogenic activity
Individualised homoeopathic treatment of menstrual distress in adolescent girls- A case series
No full textIntroduction: Menstrual distress is a broad term describing the constellation of physical, emotional, and behavioural symptoms that occur about menstruation and cause discomfort or disruption to daily life. These symptoms can include abdominal cramps, backache, breast tenderness, mood swings, irritability and sleep disturbances. This complex impact ex tends beyond pain alone and reflects the multifaceted burden that menstruation may impose. This case series brings forth eight adolescent girls suffering from menstrual distress, who were successfully treated with individualised Homoeopathy. Case summary: The results of this case series demonstrate a mean reduction in total Menstrual Distress Questionnaire (MEDI-Q) score from baseline to six months from 15.4 to 0.0. Complete recovery of dysmenorrhoea, physical or/and psychological distress associated with menstruation was seen in all eight cases. Causal relationship between homoeo pathic intervention and clinical outcome was done using Modified Naranjo Criteria (MONARCH). Further, randomised controlled trial of larger sample size are needed to validate the results
Evaluation of oral administration of \u3ci\u3eCalendula officinalis\u3c/i\u3e among the centesimal potencies in acute wound healing in male wistar rats
No full textBackground: Calendula officinalis (Calendula) is used in Homoeopathy to treat various wounds. The presence of bioactive compounds results in pharmacological properties like wound healing, antioxidants, and anti-inflammatory properties. Hence, clinicians use different centesimal potencies (6C, 30C, 200C) to heal wounds. Objective: To compare the wound-healing potential of Calendula dilutions (6C, 30C, 200C) through oral administration in a pre-clinical acute wound model. Materials and Methods: The study involved administering Calendula centesimal potencies (6C, 30C, 200C) orally. Male wistar rats aged eight to ten weeks were involved in the experiment. Every animal had full-thickness excisional wound created on its back and assigned into four groups: vehicle control (VC) group and three treatment groups receiving oral doses of dispensing alcohol, Calendula 6C, Calendula 30C, and Calendula 200C, respectively. Each animal received treatment twice daily for seven days, with six-hour interval between doses. Wound photographs, taken at regular intervals, were used to observe the rate of wound closure. Animals were sacrificed on 8th and 14th days to collect samples for histopathology and immunohistochemistry. Results: Analysis of variance assessed the statistical significance of the group differences. The study showed that wound healing was significantly higher in Calendula-treated groups than in VC. The results indicate that wound closure, epidermal thickness, collagen deposition, and the proliferative marker antigen Kiel-67 (Ki-67) expression levels were significantly higher (p \u3c 0.01) in the Calendula 30C-treated group compared with other groups. Conclusion: Among the Calendula centesimal potencies tested for wound contraction, 30C proved to be the most effective for wound healing
अध्ययन, अध्यापन, अनुसंधान: Celebrating 270 years of Homoeopathy and Scientific Integration
No full textThe World Homoeopathy Day (WHD) 2025 convention, held on 10th–11th April 2025 at Mahatma Mandir, Gandhinagar, commemorated the 270th birth anniversary of Dr. Samuel Hahnemann, the founder of Homoeopathy. Organized by the Central Council for Research in Homoeopathy (CCRH), the National Commission for Homoeopathy (NCH), and the National Institute of Homoeopathy (NIH), under the Ministry of Ayush, the event witnessed an unprecedented gathering of 8,651 delegates, making it the largest-ever congregation of homoeopathic professionals, students, and researchers. Centered on the theme
अध्ययन, अध्यापन, अनुसंधान (Education, Teaching, and Research), the event emphasised the integration of scientific research, clinical practice, and education in Homoeopathy. Over two days, a total of 25 thematic sessions, including three panel discussions, were conducted across six parallel halls, covering a diverse spectrum of topics such as public health, clinical innovations, agro-Homoeopathy, veterinary Homoeopathy, and the emerging role of artificial intelligence in biomedical research
Role of bowel nosode Bacillus morgan in the management of post-infective irritable bowel syndrome: An evidence-based case report
No full textBackground: Irritable bowel syndrome (IBS) is a functional disorder characterised by multifactorial causes and is classified according to Rome IV criteria into IBS-constipation, (IBS-diarrhoea prominently in post-infectious cases), and IBS-mixed symptoms. Psychological factors and certain foods fermentable oligosaccharides, disaccharides, monosaccharides, and polyols are known to aggravate the condition. The morbidity rate of IBS is a global concern as it negatively impacts the patient’s quality of life, leading to psychological distress, financial losses, and reduced work efficiency. Case Summary: This case report highlights a 69-year-old female patient who experienced a (acute) sudden onset of IBS symptoms, that is., an urgent need to defecate, increased frequency of evacuation, abdominal bloating, sour eructations, and heartburn on eating, developing over 4–5 days which heightened her health anxiety. Physical examination revealed epigastric tenderness and associated headache, vertigo, and cough leading to a diagnosis of post-infective IBS. Regular follow-ups were taken to conceptualise Kent’s twelve observations for all the prescriptions. The patient received Carbo vegetabilis, Natrum carbonicum, and Lycopodium clavatum in tandem with Bowel Nosode, Bacillus morgan as the patient related the onset of her complaints to her suffering from “Swine flu” in 2009. The patient’s assessment was done using the IBS-36 questionnaire, IBS symptom severity index, and the MONARCH tool, demonstrating clinical improvement and enhanced quality of life. This evidence-based case report illustrates the usefulness of Homoeopathy in managing post-infective IBS by reducing symptom intensity and episode frequency. The treatment protocol involved ascending potencies of the prescribed medicines, demonstrating a beneficial approach to patient care
Therapeutic response of homoeopathic medicines in management of nicotine dependence and withdrawal: A case series
No full textIntroduction: On discontinuing or decreasing nicotine use, nicotine-dependent individuals, often smokers, may experience withdrawal symptoms such as irritability, frustration, anxiety, depression, difficulty concentrating, restlessness and insomnia. These symptoms can significantly impact their quality of life, affecting physical health, psychological state, social relationships, personal beliefs and daily activities. The most commonly recommended conventional treatment for nicotine withdrawal is nicotine replacement therapy (NRT), which aims to reduce cravings and ease symptoms. However, NRT can be habit-forming and has been associated with a variety of adverse effects.
Cases Summary: We report four cases of nicotine dependence managed solely with homoeopathic interventions for withdrawal symptoms. At baseline, two of the cases exhibited markedly severe behavioural rating of nicotine withdrawal symptoms, whereas the other two demonstrated moderate severity, as assessed by the Minnesota Nicotine Withdrawal Scale-Self-Report/Observer-rating. The individualised homoeopathic treatment resulted in positive outcomes with notable clinical improvement and no adverse effects. For the initial phase of withdrawal management, homoeopathic medicines Ignatia amara, Lycopodium clavatum, Arsenicum album and Tabacum were prescribed based on the symptoms of the patients. Treatment outcomes were evaluated using the Minnesota Nicotine Withdrawal Scale–Improvement Index Score. The causal attribution was assessed using Modified Naranjo Criteria for Homeopathy (MONARCH). To further validate the utility of homoeopathic treatment in such cases, well-designed and rigorous clinical trials are warranted
Urinary bladder and bilateral renal calculi expelled through the homoeopathic medicine Nux vomica – A case report
No full textIntroduction: Urolithiasis is one of the most common urological problems that one comes across in a general outpatient clinic. The usefulness of homoeopathic medicines in the expulsion of urinary calculus is well-reported. However, this case is unique due to an advanced case of urolithiasis, where complications had begun to appear, as also the expulsion of all calculi using the homoeopathic medicines. Case Summary: A 34-year-old male patient was diagnosed with a large, mobile urinary bladder calculus and small bilateral renal calculi, with hydronephrosis, hydroureter, and mild oedema at ureterovesical (U-V) junction. He presented with recurrent episodes of mild to moderate dull aching pain, as well as sudden onset of severe, sharp pain on both sides of the flank and in the back. He also experienced the urge to urinate frequently. Based on the characteristic symptoms, repertorial analysis, and individualisation, Nux vomica 30C and 200C were prescribed. The treatment proved effective in facilitating the expulsion of all calculi and reducing oedema at the U-V junction. The Modified Naranjo Criteria for Homeopathy, a tool for causal attribution, was used to assess the relationship between the homoeopathic treatment and the outcome. The MONARCH score for this case was +8. This case demonstrates that a single medicine prescribed based on symptom totality was successful in the expulsion of large urinary bladder calculi which may not pass spontaneously and usually require surgical intervention. The bilateral renal calculi were expelled, and pathological changes in the urinary system were also resolved. The patient showed significant improvement in mental and physical symptoms as well
Effectiveness of individualised Homoeopathy in hypertrophied adenoids in pediatric population: A single-arm, prospective pilot study
No full textBackground: Adenoid hypertrophy is the most common cause of upper airway obstruction in children. Objective: The primary objective was to determine the reduction in hypertrophied adenoids in children after homoeopathic treatment, using nasal endoscopic assessment. The secondary objectives were to identify the changes in symptoms of hypertrophied adenoids in children after administration of homoeopathic medicines using “Four-point clinical rating scale for adenoidal symptoms (FPCR)” and to find out the utility of homoeopathic medicines in reducing the frequency of upper respiratory tract infections (URTI) in children with hypertrophied adenoids. Materials and methods: Thirty children between 3–14 years of age, with signs and symptoms of hypertrophied adenoid were screened from the outpatient department of National Homoeopathy Research Institute in Mental Health, Kerala, India, in 2019. It was a single-arm-prospective study. The treatment effect was analysed by evaluating the endoscopic grading of hypertrophied adenoids, reducing the frequency of URTI, and the FPCR scale for adenoidal symptoms. Results: Nasal endoscopy at the end of one year of homoeopathic treatment revealed no further increase in size of the adenoids in 19 cases, whereas in 11 cases the size increased. There was a statistically significant reduction in the FPCR scale (z = 4.724, p \u3c 0.001). The frequency of URTI reduced from six episodes in six months to less than four episodes in twelve months. Conclusion: The study shows a probable role of homoeopathic medicines in reducing the size of adenoid hypertrophy and reducing the frequency of upper respiratory tract infections in children