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"Las Meninas" in the clinical description of genetic disorders
Full text linkIntroduction: Las Meninas (The Family of Philip IV) continues being a topic of active research in the field of Medical Sciences. In this painting, three distinct planes can be differentiated, the foreground features the Infanta and her ladies-in-waiting and two court jesters along with a mastiff; and in the background, we find the image of the Monarchs reflected in a mirror.Objectives: To analyze the characters portrayed in the foreground of "Las Meninas", using contemporary clinical genetics concepts. Additionally, it seeks to explore the potential genetic significance of the reflection of the royal couple in the mirror, highlighting its relevance in the era of Genomic Medicine.Methods: A documentary research was conducted, identifying 47 documents through three independent searches in the following databases: PubMed/Medline, Google Scholar and OMIM. Moreover, recommendations from experts in the field were incorporated. Subsequently, two researchers scrutinized independently the articles in their entirety, and both concurred on the recommendation of the inclusion of 32 articles. After conducting a qualitative evaluation, a comprehensive review was generated.Results: Within this painting, there are depicted clinical signs that are sufficient to suggest diagnoses of achondroplasia, Laron syndrome and McCune-Albright syndrome. Furthermore, it serves as an illustrative tool to distinguish the characteristics associated with autosomal dominant inheritance in the Habsburg Syndrome; the observation of this artwork provides an invaluable exercise for honing clinical skills.Conclusions: In the foreground of the painting "Las Meninas," discernible clinical signs in the depicted characters lead us to propose dysmorphic disorders of genetic origin as potential diagnostic hypotheses.The visual observation of Velázquez\u27s genius, captured in this artwork is still decisive as part of the clinical examination in the diagnostic process, especially in the era of Genomic Medicine
Enhancing Business Competitiveness through Accounting Digitalization
Full text linkIntroduction: Amid rapid changes in the external and internal environment of modern business, more and more companies are turning to the introduction of the latest digital technologies to improve their accounting systems. This helps to increase the efficiency and accuracy of processes, as well as reduce the cost of routine work. However, the use of modern digital tools in accounting also involves certain risks and limitations, as well as raises questions about the ability to use the data for further management decision-making. Given the proven relevance of the topic, the purpose of the study can be defined as identifying key digital tools for the development and improvement of accounting to ensure the competitiveness of modern business in the long term. Methods: To obtain the results, the author used general scientific methods of analysis, synthesis, systematisation, processing of statistical material, generalisation and specification, as well as a specific method of hierarchy analysis, which allowed to identify the most optimal areas of accounting optimisation for a modern enterprise. Results: The study identified the main digital tools that can be used in the field of accounting and their impact on the system of accounting procedures in the company. The possibilities of applying various digital tools were identified and it was found that they are necessary to increase competitiveness in the long term. Conclusions: By applying the hierarchy analysis method, it is determined that the most promising for the development of the accounting system may be the tools for processing big data and using digital twins
The Impact of Post-Traumatic Stress Disorder on the Psychological and Physical Health of Military Personnel
Full text linkIntroduction: Given that PTSD is a complex problem in military personnel, it is important to characterize its impact on both mental and physical health. Objectives: The purpose is to analyze the impact of post-traumatic stress disorder on the psychological and physical health of military personnel based on the consideration of illustrative clinical cases. Methods: The methods of systematic literature analysis, thematic analysis, comparison and observation were used. The latter was expressed in 2 forms: clinical and everyday observation. Based on a strict selection of scientific sources (10 inclusion criteria were formed), the most relevant and relevant literature was selected. Results: The results showed that symptoms can include agitation, reflective feelings, flashbacks to painful events. Conclusions: The paper summarizes that PTSD can manifest itself at different stages, starting with acute acute PTSD (from 1 to 3 months), chronic PTSD (more than 3 months) to delayed PTSD (after 6 months) and complex PTSD. It can lead to cardiovascular problems, digestive problems, headaches, fibromyalgia, etc. Thus, it has been established that the impact of PTSD is multifaceted, as it includes both mental and physical health problems
History of the Formation of Ethnic Minority Organisations at the Beginning of Ukraine\u27s Independence
No full textUkraine\u27s progress in European integration requires understanding the specifics of ethnic policy under current conditions. Therefore, the issue of historical retrospectives of the formation and activities of ethnic minority organizations in the early 1990s as one of the factors of state-building remains relevant. This study aims to analyze the historical context and peculiarities of the institutionalization of ethnic minority structures in Ukraine at the initial stage of the restoration of Ukrainian state independence. The research object is ethnic minority organizations, primarily those that focused their activities on national and cultural revival. The methodological framework includes the principles of historicism, tolerance, scientific impartiality, and impartiality. The formation of ethnic community organisations and the main vectors of their activities during the specified period have been traced in detail. Despite many common historical, cultural, and socio-political backgrounds, the formation of such organisations for different communities could have its peculiarities. For example, for Jewish organizations, the demographic issue was acute due to emigrant sentiments in the Jewish community. As for ethnic minorities like Hungarians and Romanians, they had close ties with their historical homelands. This fact also influenced their organizational structure in Ukraine. The Georgian minority built their organizations emphasizing cooperation between Ukraine and Georgia. Germans also sought to maintain ties with their historical homeland. For Poles, the religious factor was significant. Overall, in Ukraine, there were quite favorable conditions for the full development and activities of ethnic minorities despite the complex political and economic situation of the early 1990s. Nowadays, the issue of organizational development of ethnic communities is a matter of focus for state authorities both at the legislative level and at the level of local communitie
Current Advertising Approaches in Tourism: Effects on Consumer Behaviour and the Advancement of Tourism Activities
Full text linkIntroduction: The relevance of the research topic is the need to adapt tourism enterprises to rapid changes in the advertising industry under the influence of digital technologies. In the context of the development of the modern advertising market, there is an active implementation of digital strategies, which allows to engage the audience more effectively and take into account changes in its behaviour. Objective: The study considers the following advertising strategies: content marketing, targeted advertising on social platforms, contextual advertising and personalised offers. Methods: The research methods included generalisation, synthesis, comparative analysis of the types of advertising strategies and statistical processing of quantitative data. A stratified sample of representatives of the tourism industry was used. Secondary data from consumers of different age groups were analysed. Statistics on modelling consumer behaviour were used to analyse the data. The article identifies effective advertising strategies in the digital environment. Results: The study results showed that companies invest 2 times more in personalised advertising and targeting. In 2023–2024, native advertising strategies and an individual approach will prevail, and it is predicted that media tools on social networks will become widespread in the coming years. Social platforms and personalised advertising have become critical factors in attracting new customers. Conclusions: Prospects for further research include a detailed analysis of the impact of automation on advertising campaigns
Strategic Plan for The Professional Drivers Union Cantón Pallatanga, Province of Chimborazo
Full text linkIn recent years, the Professional Drivers Union of the Pallatanga Canton, located in the Province of Chimborazo, has faced a growing demand for the implementation of strategic planning. This need arises with the objective of directing the established goals towards sustainable economic development. This research focuses on the formulation of a Strategic Plan that promotes economic growth and quality improvement in the Union during the period from 2023 to 2027.To carry out this research, a methodology was established that combines qualitative and quantitative approaches. A non-experimental and transversal design was chosen, which allows obtaining information in the real environment without altering the data, within a specific period of time. The population under study was the institution\u27s staff, and field activities were carried out to collect information. The techniques used included interviews directed at the general secretary of the Union, as well as surveys administered to employees.The results obtained revealed that the organization does not have a formal strategic plan. More than half of the employees surveyed are unaware of fundamental aspects such as the mission, vision, values, principles and institutional policies. However, a notable commitment is evident in management focused on the well-being of the Union\u27s collaborators, students and dependents.The main conclusion of the research is that planning within the institution is presented as an informal process, with poorly defined goals. Given this situation, it is proposed to develop a strategic plan that includes various strategies aimed at improving the operational efficiency of the Union. This approach not only seeks internal strengthening, but also the generation of a positive impact on the economic development of the communit
The Perspectives of Physical Education on Global Development: Integrating Traditional Practices with Modern Wellness Approaches
Full text linkThis research looks at how to combine old and new wellness methods in physical education. This research focuses on utilizing hobbies, games, and technology to address issues related to students\u27 lack of interest. We used a systematic review approach to analyze 12 qualitative research articles published between 2011 and 2024. We used standard databases like PubMed, Science Direct, Academic Search Complete, ERIC, Web of Science, CINAHL, SAGE, and SPORTDiscus to look for terms and synonyms that were related to old-fashioned physical games, new health programs, and technological advances in physical education. The searches took place from May 2024 to October 2024. Specifically, the inclusion criteria used were the presence of empirical research, methodological variety, and the study’s relevance to the research objectives. Twelve articles met the inclusion criteria for the review. We thematically analyzed the data to identify trends, issues, and opportunities in physical education.Researchers found that traditional games support cultural experiences and teamwork, while new-age strategies like mindfulness, exercise, and project-based learning relate to motivation and whole-person well-being. Researchers found that intelligent vision systems and serious games can help students learn. Technology can help make learning more fun and less difficult. When developing physical education programs, there is also a focus on revisiting the mental and emotional aspects of the learners, emphasizing the importance of mindfulness and flexible learning theories.So, mixing traditional ways of doing things with modern ideas about health and fitness makes activities more accessible to everyone and opens up new ways to teach about physical education
Innovations in Public Administration and Management for Implementing Effective Strategies and Tools
Full text linkIntroduction: The current global dynamics and the European integration course of Ukraine\u27s development transform the requirements for forming a public administration paradigm. At the same time, the transfer of innovations is seen as a key element in ensuring the efficiency of the management system and complementarity with the requirements of modern society. Methods: Publications indexed in leading scientific databases were utilised. The inclusion and exclusion criteria for publications were based on spatial-temporal indicators and the level of information reliability. Among the methods used to assess the risk of bias in the included studies was the brainstorming method. Additionally, general scientific methods were employed.Results: It identifies the main directions of innovative development of public administration systems in the European community. The emphasis is placed on the functionality of digitalisation tools and information and communication technologies that automate a significant part of public administration processes and improve public service quality. Several economic indicators representing the tendency to increase efficiency are presented. A comparative analysis of the indicators of e-government development in different countries and the global context is carried out. Practical concepts and practical tools for integrating innovations into public administration in the context of sustainable development are substantiated. Conclusions: The study proves that e-governance, analytical tools, artificial intelligence, digital interaction platforms, and geographic information systems allow today to implement successful concepts of public-private partnerships and increase the efficiency of public administration. The concepts of transparency, adaptability and innovation are complementary to the requirements of society and allow for addressing the complex challenges of our time
Failure behavior of Strengthen reinforced concrete columns under effect of static load
Full text linkIntroduction: This study aimed to present a rapid and effective repair method using Cempatch and carbon fiber-reinforced polymer (CFRP) for reinforced concrete (RC) columns affected by seismic events.Methods: The study included both experimental and theoretical components. The experiment involved casting and testing thirteen 900 mm long reinforced concrete columns with identical longitudinal steel reinforcement and a cross-section of 200 x 200 mm. An axial compressive load (N) was applied to all specimens, starting from zero and increasing until failure. The columns were divided into four groups, each containing a control column. Three damaged columns in each group were repaired with Cempatch and different levels of CFRP. The theoretical analysis utilized ANSYS software (version 14) for simulation.Results: The experimental results showed that the failure pattern shifted from the repaired areas to the unrepaired ones as the number of CFRP layers increased. This indicates that the restoration materials efficiently deflected stress and enhanced the load-bearing capacity of the columns. Finite element analysis results showed strong agreement with the experimental findings, with final load differences of 17.3% and 0.9%, respectively. The tests demonstrated a 148.7% increase in ultimate load with additional CFRP layers, and a 30.3% rise in the number of repaired faces. However, repairs near the center of the columns yielded less favorable outcomes than those at the top.Conclusions: The study confirms that using Cempatch and CFRP significantly improves the seismic resistance of RC columns, with optimal repair outcomes achieved with CFRP layers applied near the top of the columns
The philosophical dimensions of cultural dynamics in society\u27s evolution
Full text linkIntroduction: Philosophical and cultural research is positioned to study culture\u27s structure, function, and role. At the same time, the philosophy of the cultural phenomenon focuses on identifying the main evolutionary cultural trends and understanding the causes of crisis phenomena.Objective: This research implements a scientific inquiry into the cultural aspects of societal development in the context of philosophical knowledge. A systematic analysis of the societal and cultural development stages was carried out to comprehend these processes according to the established periodisation in philosophical teachings.Methods: A number of theoretical research methods were used, including historical, philosophical and philosophical-cultural methods, holistic and systemic analysis, synthesis, methods of comparison, generalization, and others.Results: It is substantiated that the synergy of philosophy and culture forms a unique reflective-conceptual framework for the cultural development of society, endowing it with integrity and orderliness and enabling the rationalisation of individual elements within the social system. It has been proven that the model of philosophical knowledge within the traditional cognitive and cultural paradigm, which correlates with order, balance, stability, and determinism, does not correspond to the realities and challenges of the modern world with its chaos, imbalance, instability, and volatility. The study found that the ideas of synergism have not lost their paradigmatic significance to this day.Conclusions: Thus, it is demonstrated that the essence of the philosophical nature of cultural aspects is positioned as the development of the human position in the philosophical-cultural dimension in a historical-temporal context