Czasopisma Uniwersytetu Przyrodniczy w Lublinie
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SİGARA KULLANAN KADINLARIN GEBELİK PLANLARINDA SİGARA BIRAKMA ÖNGÖRÜLERİNİN BELİRLENMESİ
No full textAraştırma sigara kullanan kadınların gebelik planlarında sigara bırakma öngörülerinin belirlenmesi amacıyla yapılmıştır. Tanımlayıcı türde olan araştırma, 182 doğurganlık çağındaki kadın ile yürütülmüştür. Veriler, Google Formlar üzerinden oluşturulan online anketin sosyal medya platformlarından (WhatsApp, facebook, instagram, twitter vb.) kadınlara iletilmesiyle toplanmıştır. Araştırma verilerinin toplanmasında kişisel tanıtım formu ve Sigara Bırakma Başarısı Öngörü Ölçeği (SBBÖÖ) kullanılmıştır. Araştırmada SBBÖÖ puan ortalaması arasında fark olduğu saptanan değişkenler ile kurulan çoklu doğrusal regresyon modelinde; sigara içme miktarının (?-coefficient= -0.324; p=0.001), daha önceki gebelikte sigara içme durumunun (?-coefficient= 0.192; p=0.037) ve gebelikte sigara içmenin gebelik ve bebek üzerinde olumsuz etkisi olduğunu bilmenin (?-coefficient= -0.181; p=0.041) sigarayı bırakma başarısı öngörüsünde önemli yordayıcılar olduğu saptanmıştır (p<0.05). Sağlık profesyonellerinin, gebelikte sigarayı bırakma başarısını etkileyen faktörleri dikkate alarak, sigara içen kadınlara tütün ürünlerini bırakma konusunda eğitim ve danışmanlık vermesi önerilmektedir
Health and Attitudes Toward Bribery: Summaries of 11 Studies
No full textThis chapter summarizes the results of 11 studies that were conducted on the relationship between health and attitude toward bribery. Additional summaries will be published in the second volume of this series, The Ethics of Bribery: Country Studies. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Breathing better: A tech-monitored study of positive expiratory pressure and reading aloud for chronic obstructive pulmonary disease
No full textBackgroundBreathing exercises, such as diaphragmatic breathing and positive expiratory pressure (PEP), relieve breathlessness in people with chronic obstructive pulmonary disease (COPD).AimThis study aimed to investigate the effects of breathing exercises with PEP and reading aloud on vital signs, fatigue level, severity of dyspnoea and respiratory function parameters in patients with COPD.DesignThe study followed a randomized controlled trial of COPD patients from a single hospital in eastern Turkey.MethodsThe study included 103 patients who were randomly assigned to receive pre-reading exercises, breathing exercises with a PEP device or no intervention for 8 weeks.ResultsThe use of a PEP device improved oxygen saturation, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) values and reduced fatigue and dyspnoea severity. Reading aloud lowered the mean arterial pressure and reduced fatigue and dyspnoea severity.ConclusionThe study concludes that PEP devices and reading aloud can improve respiratory function in patients with COPD. Additionally, reading aloud is an accessible, easy-to-implement and economically feasible method for treating COPD symptoms. What is already known about this topic?Chronic obstructive pulmonary disease (COPD) causes cough, shortness of breath, fatigue and impaired exercise capacity. The most common symptoms are dyspnoea and fatigue.The treatment and prognosis of COPD require skilled nursing care. Breathing exercises guided by nurses relieved the symptoms.Information technologies are increasingly used for COPD monitoring and therapy. Remote patient monitoring, especially the use of wearables, can improve patient outcomes and reduce healthcare expenditures.What this paper adds?Reading aloud and positive expiratory pressure (PEP) breathing exercises can improve vital signs and lung function in patients with COPD, with the latter being more effective.Wearable technologies for remote patient monitoring can help manage COPD and improve patient outcomes.The implications of this paper:Wearable technologies for remote patient monitoring can support COPD management and improve patient outcomes.Pulmonary exercise devices improve oxygen saturation, forced expiratory volume in 1 s (FEV1) and FEV1/forced vital capacity (FVC) in COPD patients while reducing fatigue and dyspnoea. These devices help patients with COPD breathe easily.Reading aloud reduces fatigue, dyspnoea and mean arterial pressure. COPD patients can benefit from reading newspapers, magazines and novels aloud.The authors are grateful to all the patients for their participation in this study.The authors are grateful to all the patients for their participation in this study
DİN EĞİTİMİNDE ANAKRONİZM PROBLEMİ
No full textÖrgün ve yaygın din eğitiminin içeriklerinde karşılaştığımız anakronizm probleminin ele alındığı bu çalışmada, “bir şeyin, bir kavramın veya olayın gerçek tarihsel bağlamı dışına çıkartılması ve geçmişin temel özellikleriyle günümüzden farklı olduğunun göz ardı edilmesi” şeklinde tanımlanan bu kavram ışığında, din eğitiminin içeriğini oluşturan dinî kavramlar başta olmak üzere, eğitime konu edilen diğer konuların ve süreçlerin bağlamından kopartılarak tüm zamanların yegâne bilgisi ve doğrusu şeklinde sunulması ya da söz konusu içeriklerin oluştuğu zamanla olan ilişkisinin göz ardı edilmesi şeklinde tezahür eden bu yaklaşımın muhtemel sebepleri ve yol açtığı sorunlar tartışılmaktadır. Araştırmanın verileri, nitel araştırma türlerinden olan doküman analizi yöntemi kullanılarak elde edilmiştir. Örgün ve yaygın din eğitiminin içeriğini oluşturan tefsir, hadis, fıkıh ve siyer gibi kaynakların yanı sıra özellikle DKAB ders kitaplarında seçilen örnek metinler üzerinde yapılan analizlerde, temel metinlerin okunmasında, dinî referansların kullanılma biçiminde, rivayete dayalı bilgilerin aktarımında ve eğitim süreçlerinde kullanılan dilde anakronik yaklaşımın sebep olduğu çeşitli ifadelerin ve değerlendirmelerin yer aldığı görülmektedir. Literal okuma, dil ve tarih bilgisi yetersizliği, tarafgirlik, düşüncede bağnazlık gibi etkenlerle meydana gelen bu sorunun aşılabilmesi için örgün ve yaygın din eğitimi süreçlerinde derinlikli bir alan bilgisine, analitik ve eleştirel düşünceye, ileri düzeyde bir genel kültür bilgisine ihtiyaç duyulduğu anlaşılmaktadır. Özellikle öğretmenlerin her türlü anakronizme karşı temkinli olmalarının ve öğrencilerini de bu konuda duyarlı ve donanımlı hale getirmelerinin önem arz ettiği anlaşılmaktadır
Income Level and Attitudes Toward Bribery: Summaries of 18 Studies
No full textThis chapter summarizes the results of 18 studies that were conducted on the relationship between income level and attitude toward bribery. Additional summaries will be published in the second volume of this series, The Ethics of Bribery: Country Studies. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2023
Water-soluble N-heterocyclic carbene precursors bearing benzimidazole core: synthesis, characterization, in vitro antioxidant and anticancer studies
No full textBenzimidazole is an important member of the nitrogen-containing heterocyclic ring system since it confers surprisingly good biological properties in medicinal chemistry such as anticancer drug applications. Keeping this in mind, a new series of asymmetrical 1,3-disubstituted benzimidazolium salts were designed and reported. The compounds were synthesized by the reaction of 1-alkylbenzimidazoles with 2-(2-bromoethyl)-1,3-dioxane. The structures of all the compounds were determined using FT-IR, H-1 and C-13 NMR spectroscopy, LC-MS, and elemental analysis. The compounds were used for their antioxidant capacity by commercial kit assay. Further, these were screened for their cytotoxic effect against cell lines including MCF-7, A-549, and L929 using cisplatin as a reference drug. It resulted that the total antioxidant capacity values of the compounds were found to be quite low compared to the trolox equivalent. On the other side, most importantly, two compounds showed remarkable anticancer activity against MCF-7 and A-549 with IC50 values of 18.06 and 20.44 mu g/cm(3), respectively, in comparison with cisplatin (IC50 = 83.11 and 87.80 mu g/cm(3)). Furthermore, most of the compounds were found to be safe on normal L929 fibroblast cells compared to cancer cells (IC50 values for healthy fibroblasts were 142.70-268.37 mu g/cm(3)). Taken together, the newly synthesized compounds containing benzimidazole core can be readily constructed and used as an attractive class of anticancer agents.{graphical abstracts
Impact of thermal pasteurization and thermosonication treatments on black grape juice (Vitis vinifera L): ICP-OES, GC-MS/MS and HPLC analyses
No full textGrape juice is a widely consumed fruit due to its bioactive compounds, minerals, and aroma components. Our objective was to investigate ultrasound treatment of black grape juice affects its bioactive components due to using response surface methodology (RSM) and artificial neural network (ANN) optimization. At the same time, mineral components, sugar components, organic acids, and volatile aroma profiles were compared in black grape juice treated with thermal and ultrasound pasteurization. ANN showed superior predictive values (>99%) to RSM. Optimal combinations were obtained at 40 degrees C, 12 min, and 65% amplitude for thermosonication. Under these conditions, phenolic, flavonoid, antioxidant activity, and anthocyanin values were 822.80 mg GAE/L, 97.50 mg CE/L, 24.51 mmol Trolox/L, and 368, 81 mg of mv-3-glu/L, respectively. Thermosonicated grape juice (TT-BGJ) was tested against black grape juice (P-BGJ) produced with conventional thermal methods. This study investigated the effects of thermal pasteurization and thermosonication on black grape juice bioactive compounds and minerals, aroma profile, and sensory evaluation. Thermosonication affected the aroma profile less, 329.98 mu g/kg (P-BGJ) and 495.31 mu g/kg (TT-BGJ). TT-BGJ was detected to contain seven different mineral elements (Mn, K, Fe, Mg, Cu, Zn, and Na). Thermosonication caused an increase in Fe, Zn, Mn, and K minerals. Panelists generally liked the TT-BGJ sample. These results suggest that the thermosonication process may potentially replace the traditional black grape juice processing thermal process
Characterization and production of sert carbon from some tree leaves and usage in energy storage
No full textEnerji yaşamın temeli olup insan ihtiyaçlarının üretilmesinde en temel unsur olmuştur. Son yıllarda özellikle küresel ısınma sonucu karbondioksit üretimine karşı fosil yakıtların kullanımına kısıtlamalar ön plana çıkmaktadır. Büyük otomotiv firmaları yakın gelecekte elektrik enerjisi kullanan modellerin geliştirilmesini yönelik malzeme üretimine büyük önem vermeye başlamışlardır. Bu konuda önemli adımlar atılmaya başlanmasına rağmen enerji depolamada ve şarj edilebilme sıklığı ve süresiyle ilgili olarak sıkıntılar henüz aşılmamış durumdadır. Lityum iyon piller dünyadaki lityumun rezervi nedeniyle yeni arayışlara neden olmuştur. Aktif karbon temelli kapasitörler ve sodyum iyon pillerin kullanımı için yoğun çalışmalar yapılmakta olup sert karbonun sodyum iyon pillerde kullanımı ön plana çıkmaya başlamıştır. Bu tez kapsamında biyokütle olarak üç farklı ağaç (meşe, kayısı ve kiraz) yaprağından sert karbon üretimi, karakterizasyonu ve enerji depolama özelliğinin (sodyum iyon pil ve/veya kapasitör) incelenmiştir. Öncelikle yeşil yapraklar biyokütle kaynağı olarak kullanılmış olup ağaç üzerindeki yapraklar toplandıktan sonra temiz su ile yıkanarak laboratuvar ortamında toz haline getirilmiştir. Aynı işlem basamakları sonbahar da ağaçlardan dökülmüş yapraklar için de yapılmıştır. Öğütülmüş tüm örneklerin kül tayinleri yapılmış olup ham örnekleri FTIR, XRD ve SEM analizleri ile karakterizasyonları yapılmıştır. Öğütülmüş yaprak numunelerinin üç bölge ısıtmalı silindirik fırında quartz cam boru içerisine alınarak, 900, 1100 ve 1100oC sıcaklıklarda inert azot atmosferinde 5oC/dakika ısıtma hızlarında sert karbon üretimleri yapılmış, karakterizasyonu ve enerji depolama özelliği detaylıca incelenerek Na-İyon batarya üretilmiştir. Anahtar Kelimeler: Yaprak, sert karbon, enerji depolamaEnergy is the basis of life and has been the most basic element in the production of human needs. In recent years, restrictions on the use of fossil fuels have come to the fore, especially against the production of carbon dioxide as a result of global warming. Large automotive companies have started to attach great importance to the production of materials for the development of models that use electrical energy in the near future. Although important steps have been taken in this regard, the problems related to energy storage and the frequency and duration of charging have not been overcome yet. Lithium-ion batteries have led to new searches due to the reserves of lithium in the world. Intensive studies are being carried out for the use of active carbon-based capacitors and sodium ion batteries, and the use of hard carbon in sodium ion batteries has begun to come to the fore. In this thesis, sert carbon production, characterization and energy storage properties (sodium ion battery and/or capacitor) from three different tree leaves (oak, apricot and cherry) as biomass were investigated. First of all, green leaves were used as a source of biomass, and after the leaves on the tree were collected, they were washed with clean water and turned into powder in the laboratory environment. The same process steps were performed for the leaves that fell from the trees in autumn. Ash determination of all ground samples was made and raw samples were characterized by FTIR, XRD and SEM analyses. The ground leaf samples were taken into a quartz glass tube in a cylindrical furnace with three zone heating, and hard carbon was produced at temperatures of 900, 1100 and 1100oC in an inert nitrogen atmosphere at heating rates of 5oC/minute, characterization and energy storage properties were examined in detail and Na-ion batteries were produced. Keywords: Leaf, sert carbon, energy storag
An Outbreak of Vancomycin-Resistant Enterococci in a City Hospital Intensive Care Unit: Molecular Characterization of Resistance
No full textBackground and Objectives: Vancomisin-resistant Enterococci (VRE), is a resistant microorganism that colonizes and causes infections in hospitalized patients. The aim of this study was to show the spread of vancomycin-resistant Enterococcus faecium (VREfm) step-by-step in all intensive care units, which started with the growth of VREfm on 2 December 2021 in the blood culture of a patient hospitalized in the anesthesia intensive care unit of our hospital and was found to have reached epidemic size in the surveys. Materials and Methods: Rectal swab samples were taken from all patients hospitalized in intensive care units, VRE colonization was determined, the VanA and VanB resistance genes associated with the vancomycin resistance of VREfm isolates were determined by PCR method, and clonal association analysis was performed by Arbitrarily Primed-PCR (AP-PCR) and PFGE (pulsed-field gel electrophoresis). Results: In our study, VRE were detected in 61 of 2601 rectal swab samples. In total, fifty-four (85.52%) of the VRE isolates were Enterococcus faecium, three (4.91%) was Enterococcus faecalis, three (4.91%) was Enterococcus gallinorum, and one (1.63%) was Enterococcus casseliflavus. It was determined that all of the 54 VREfm isolates, which were the most detected among all VRE isolates, carried the vanA gene. In the clonal association analysis of the isolates by AP-PCR and PFGE methods, it was found that they had 12 different genotypes, 48 of them were included in any cluster, the clustering rate was 88.8%, and the largest cluster was the genotype 1 cluster, with 36 isolates. Of the 54 patients with VREfm isolated recently, 18.51 percent of the clinical samples were isolated before the survey, and 9.25% were isolated after the survey. It was determined that 100% of VREfm isolates were resistant to ampicillin, levofloxacin, ciprofloxacin, high-level gentamicin, trimethoprimsulfamethoxazole, and teicoplanin, 7.4% to tigecycline, and 1.85% to linezolid. Conclusions: In our study, in the clonal association analysis performed by isolating VREfm in rectal swab samples, it was found that 88.8% of the samples were indistinguishably similar, and that the increase in the number of VREfm infections after the index case in our hospital was associated with the epidemic. VREfm infections cause long-term hospitalization, costs and also deaths, which shows the seriousness of the event, and the importance of the combination of epidemiological and molecular analysis in epidemic research
Synthesis, in vitro, and in silico studies of novel poly-heterocyclic compounds bearing pyridine and furan moieties as potential anticancer agents
No full textThirteen novel poly-heterocyclic compounds containing pyridine and furan moieties were synthesized and fully characterized by H-1 NMR, 1(3)C NMR, FTIR, and elemental analysis. The optimized geometry of the most stable conformation of the synthesized compounds was determined at the DFT/B3LYP level of theory. Frontier molecular orbitals, molecular electrostatic potential, and atoms in molecules analysis were performed to better understand the electronic properties, reactivity, and intermolecular interactions. The cytotoxicity of all compounds was assessed In vitro against MCF-7 and A-2780 cell lines using the MTT assay. Among them, compounds 2c, 3c, 3d, 4a, and 4c at 0.1 mu M concentration showed more potent cytotoxicity against the MCF-7 cells than the reference drug docetaxel. On the other hand, compounds 2c, 3a, 3c, and 4c are more cytotoxic against the A-2780 cell line compared to the standard at the same concentration. The docking studies revealed an excellent affinity for the active site of the human topoisomeraseII ss enzyme, which may explain the promising cytotoxicity of these classes of molecules. The in silico evaluation of ADMET parameters indicated good pharmacokinetic properties of all the investigated compounds. (c) 2022 Elsevier B.V. All rights reserved.MESRS (Ministere de l'Enseignement Superieur et de la Recherche Scientifique, Algeria); DGRSDT (Direction Generale de la Recherche Scientifique et du Developpement Technologique, Algeria); Inonu University, Malatya, TurkeyWe would like to thank MESRS (Ministere de l'Enseignement Superieur et de la Recherche Scientifique, Algeria) and DGRSDT (Direction Generale de la Recherche Scientifique et du Developpement Technologique, Algeria), for financial support, as well as the HPC resources of UCI-UFMC (Unitede Calcul Intesif of the university Freres Mentouri Constantine 1) for the computational resource used. The authors are grateful also for the financial support from Inonu University, Malatya, Turkey