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    Substancje bioaktywne i właściwości lecznicze fasoli zwykłej (Phaseolus vulgaris L.)

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    The common bean (Phaseolus vulgaris L.) is an important dietary raw material due to its high content of protein, minerals, fiber and some vitamins. The bean pericarp contains glycoproteins, amino acids, choline, trigonelline, allantoin, aliphatic acids, traumatin acid and polyphenols (flavonoids, phenolic acids, tannins) and is a medicinal raw material. It is included in the group of raw materials with diuretic, antidiabetic, as well as anti-inflammatory, detoxifying, diastolic, epithelial regenerating and bactericidal effects. The extracts from the raw material of beans are further characterized by antioxidant, antimicrobial and anticancer activities. Beans are rich in antioxidants, including a variety of flavonoids, such as anthocyanins, flavonols, proanthocyanidins, tannins, glycosides, as well as a broad spectrum of phenolic acids. The content of individual bioactive components depends on the variety, growing conditions, drying technology and extraction. The raw material of beans is widely used in the treatment of diabetes mellitus, inflammation of the urinary tract, urolithiasis, rheumatic diseases, as well as gout, supports the treatment of hypertension, relieves skin ailments, among others.Fasola zwykła (Phaseolus vulgaris L.) jest ważnym surowcem dietetycznym ze względu na wysoką zawartość białka, składników mineralnych, błonnika i niektórych witamin. Owocnia fasoli ma w swoim składzie glikoproteiny, aminokwasy, cholinę, trygonelinę, alantoinę, kwasy alifatyczne, kwas traumatynowy oraz polifenole (flawonoidy, kwasy fenolowe, garbniki) i jest surowcem leczniczym. Zaliczana jest do grupy surowców o działaniu moczopędnym, przeciwcukrzycowym, a także przeciwzapalnym, odtruwającym, rozkurczowym, regenerującym nabłonek i bakteriobójczym. Ekstrakty z surowca fasoli charakteryzują się ponadto działaniem przeciwutleniającym, przeciwdrobnoustrojowym i przeciwnowotworowym. Fasola jest bogata w przeciwutleniacze obejmujące różnorodne flawonoidy, takie jak antocyjany, flawonole, proantocyjanidyny, garbniki, glikozydy, a także szerokie spektrum kwasów fenolowych. Zawartość poszczególnych składników bioaktywnych zależy od odmiany, warunków uprawy, technologii suszenia oraz ekstrakcji. Surowiec fasoli znajduje szerokie zastosowanie w leczeniu m.in. cukrzycy, stanów zapalnych dróg moczowych, kamicy moczowej, chorób reumatycznych, jak również skazy moczanowej, wspomaga leczenie nadciśnienia tętniczego, uśmierza dolegliwości skórne

    Acute kidney disease beyond day 7 after major surgery: a secondary analysis of the EPIS-AKI trial

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    Purpose: Acute kidney disease (AKD) is a significant health care burden worldwide. However, little is known about this complication after major surgery. Methods: We conducted an international prospective, observational, multi-center study among patients undergoing major surgery. The primary study endpoint was the incidence of AKD (defined as new onset of estimated glomerular filtration rate (eCFR) < 60 ml/min/1.73 m2 present on day 7 or later) among survivors. Secondary endpoints included the relationship between early postoperative acute kidney injury (AKI) (within 72 h after major surgery) and subsequent AKD, the identification of risk factors for AKD, and the rate of chronic kidney disease (CKD) progression in patients with pre-existing CKD. Results: We studied 9510 patients without pre-existing CKD. Of these, 940 (9.9%) developed AKD after 7 days of whom 34.1% experiencing an episode of early postoperative-AKI. Rates of AKD after 7 days significantly increased with the severity (19.1% Kidney Disease Improving Global Outcomes [KDIGO] 1, 24.5% KDIGO2, 34.3% KDIGO3; P < 0.001) and duration (15.5% transient vs 38.3% persistent AKI; P < 0.001) of early postoperative-AKI. Independent risk factors for AKD included early postoperative-AKI, exposure to perioperative nephrotoxic agents, and postoperative pneumonia. Early postoperative-AKI carried an independent odds ratio for AKD of 2.64 (95% confidence interval [CI] 2.21–3.15). Of 663 patients with pre-existing CKD, 42 (6.3%) had worsening CKD at day 90. In patients with CKD and an episode of early AKI, CKD progression occurred in 11.6%. Conclusion: One in ten major surgery patients developed AKD beyond 7 days after surgery, in most cases without an episode of early postoperative-AKI. However, early postoperative-AKI severity and duration were associated with an increased rate of AKD and early postoperative-AKI was strongly associated with AKD independent of all other potential risk factors. © The Author(s) 2024.Baxter International; Deutsche Forschungsgemeinschaft, DFG: KFO342-1, ME5413/1-1, ME5413/1-2, ZA428/18-1, ZA428/21-1; Deutsche Forschungsgemeinschaft, DFGOpen Access funding enabled and organized by Projekt DEAL. The study was supported by the German Research Foundation (KFO342-1, ZA428/18-1, and ZA428/21-1 to AZ and ME5413/1-1 and ME5413/1-2 to MM) and by an unrestricted research grant from Baxter (to AZ)

    Direct Detection of SARS CoV-2 by Practical Paper Based Imunoassay as an Instrument Free and Low Cost by CR3022

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    Pandemia could be emerged at any time and resulted with death in the world. Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2) caused the latest pandemia. Because of the absence of rapid diagnostic assays pandemia has surged in and caused the death of lots of people as SARS CoV-2 appeared at first time. Although reverse transcriptase polymerase chain reaction (RT-PCR) accepted as the most reliable test was used for the viral detection at first time, there are shortcomings including the need of educated personnel and difficulty of the usage of this test in undeveloped countries. For this reason, developing the rapid assays for direct recognition of virus is always eesential. Paper based immunoassays are significant among these assays and they are known as dot-blot assay (DBA). It is practical and easy to use since they are suitable for direct application of body fluids. Antibodies and aptamers are the most important reagents of diagnostic assays and it should be used having the high affinity of them. In this work, DBA was prepared by antibody-aptamer based sandwich assay and reported the suitibility of it for viral detection

    Mental Training and Anxiety: Examining the Moderating Role of Gender in Athletes

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    This study aimed to examine how gender may influence the relationship between mental training practices and anxiety levels in both individual and team athletes. Using a quantitative approach, data was gathered through convenience sampling using electronically administered questionnaires. A grand total of 348 athletes from secondary school, high school, and university teams in individual and team sports across four Turkish provinces took part in the event. The Mental Training Scale developed by Behnke et al. (2019) was used to evaluate mental training practices, while the Sports Anxiety Scale -2, created by Smith et al. (2006) and Smith, Smoll and Schutz (1990), was used to gauge levels of anxiety. The data analysis included various statistical techniques such as descriptive statistics, Cronbach's alpha for assessing scale reliability, confirmatory factor analysis, correlation analysis to explore variable relationships, and bootstrap regression analysis to investigate the potential moderating effect of gender. The results showed that the predictor variables together explained about 9% of the variation in anxiety (R-2 = .084). There was a noteworthy correlation between mental training practices and anxiety, with mental training practices showing a beneficial impact beta = .30, p < .05). Additionally, gender was found to have a significant influence in a positive direction beta = 1.58, p < .001). In addition, a noteworthy moderating effect was found, suggesting that gender plays a role in the connection between mental training and anxiety beta = -.37, p < .001). It appears that female athletes on school teams are more inclined to incorporate mental training practices into their routines, leading to better anxiety management compared to male athletes who do not engage in such practices

    Effect Of Improving Lumbar Mobility, Spinal Stability; With Core Stability Training To Achieve Personal Best Runner

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    Running consists of simple basic movements, and to achieve these simple basic movements requires good mobility and stability, because the weakening of mobility and stability of the body causes misalignment or weakness of the legs so as to interfere with the absorption or propulsion phase in leg movement while running. Apply appropriate exercise methods to improve lumbar mobility and spinal stability. One training method that can be used is the core stability training method. Core stability is an exercise model to improve the ability to control the position of trunk movement through the pelvis and legs to allow optimal motion production. This study aims to ascertain whether core stability training can improve lumbar mobility and spinal stability in running athletes. The study used an experimental method with a research pattern using a group pretest -posttest design. 10 running athletes were sampled according to the criteria to be treated in the form of core stability training for 6 weeks. The athletes were assessed before and after training using the Functional Reach Test and Unilateral Hip Bridge Endurance. This study showed that there was a significant effect between core stability training and lumbar mobility (P = 0.000) and spinal stability (P = 0.000) in athletes. The results of this study show that the application of core stability exercises can increase the ability of lumbar mobility and spinal stability, so if the core stability exercises are done properly, they can increase stability in the spine and mobility in the lumbar, which causes dynamic limb movement to be more efficient

    Relationship between parental adverse childhood experiences and the prevalence of early childhood caries

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    Objectives The aim of this study was to examine the behavioural health conditions associated with parents' retrospective adverse childhood experiences (ACEs) scores and their children's early childhood caries (ECC) in parent-child dyads. Materials and methods Parents with children younger than 72 months were included in the study. A relational screening model was used. Interaction among ACEs, ECC, nutritional habits and oral hygiene habits were evaluated. Chi-square tests and t-tests were used in the study. Multiple variables were evaluated using the artificial neural network (ANN) model. Results The mean age of the 535 children included in the study was 46.5 months, and 52% were female. Using the ANN model, there was a statistically significant relationship between the educational status of the mothers in both the ECC and severe ECC (S-ECC) groups and the socioeconomic status of the family (p < 0.05). If the number of snacks consumed daily was three or more, the risk of ECC was statistically significantly higher (chi-square test p = 0.034). The parents' ACEs scores had an impact on both ECC and S-ECC formation (p = 0.001, t-test). The higher the ACEs score, the higher the risk of S-ECC. The mean ACEs scores of the parents were also significantly higher in both the ECC and S-ECC groups compared to those of the parents of children without dental caries (p = 0.001, t-test). It was calculated that ACEs scores were effective at a rate of 18.2% on ECC (p = 0.045, ANN). Conclusions The ACEs scores of parents have an impact on the oral health of young children and ECC/S-ECC formation. Clinical relevance The long-term effects of parental ACEs are reflected in their children's oral health. Therefore, reducing the psychosocial determinants ACEs and providing parental support may help in overcoming barriers to the well-being of young children and may facilitate better oral health

    Pulmonary Physician Consultancy in Emergency Services in Turkiye (PuPCEST) - a cross-sectional multicenter study

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    Pulmonology is one of the branches that frequently receive consultation requests from the emergency department. Pulmonology consultation (PC) is requested from almost all clinical branches due to the diagnosis and treatment of any respiratory condition, preoperative evaluation, or postoperative pulmonary problems. The aim of our study was to describe the profile of the pulmonology consultations received from emergency departments in Turkiye. A total of 32 centers from Turkiye (the PuPCEST Study Group) were included to the study. The demographic, clinical, laboratory and radiological data of the consulted cases were examined. The final result of the consultation and the justification of the consultation by the consulting pulmonologist were recorded. We identified 1712 patients, 64% of which applied to the emergency department by themselves and 41.4% were women. Eighty-five percent of the patients had a previously diagnosed disease. Dyspnea was the reason for consultation in 34.7% of the cases. The leading radiological finding was consolidation (13%). Exacerbation of preexisting lung disease was present in 39% of patients. The most commonly established diagnoses by pulmonologists were chronic obstructive pulmonary disease (19%) and pneumonia (12%). While 35% of the patients were discharged, 35% were interned into the chest diseases ward. The majority of patients were hospitalized and treated conservatively. It may be suggested that most of the applications would be evaluated in the pulmonology outpatient clinic which may result in a decrease in emergency department visits/consultations. Thus, improvements in the reorganization of the pulmonology outpatient clinics and follow-up visits may positively contribute emergency admission rates

    Vaccination attitudes and practices of physicians and nurses in adult oncology settings

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    This study aimed to assess the opinions and clinical practices of oncologists and nurses about vaccination recommended for both healthcare workers and cancer patients. A cross-sectional survey study was conducted among physicians and nurses working in adult oncology settings between September 2019 and February 2022. An online survey was sent to the participants via e-mails, with two reminders at 4-week intervals for non-respondents. A total of 80 physicians and 84 nurses completed the survey. The highest vaccination rates for physicians and nurses were reported for hepatitis B, diphtheria-tetanus, and influenza vaccines. Considering the previous influenza season, only 31.25% of the physicians and 22.62% of the nurses had the influenza vaccine. Eighty-seven percent (n=70) of physicians and 57.14% (n=48) of nurses recommended adult vaccines to cancer patients. Influenza, pneumococcal, and hepatitis B vaccines were the most recommended vaccines. Thirty-seven percent of physicians and 44.05% of nurses encountered anti-vaccine attitudes among the patients. Seventeen percent of the physicians had no opinion on the timing of vaccination during conventional cytotoxic chemotherapy. Forty percent, 28.17%, and 18.31% of physicians recommended vaccination 'just before treatment', 'between treatment cycles', and 'immediately after the end of treatment', respectively. Vaccination rates of physicians and nurses working in oncology practice and the recommendation of vaccination to cancer patients are still lower than desired levels. It appears that HCPs have limited knowledge regarding vaccination time schedules in cancer patients

    Process from eyyâmu al-arous to al-fitnat al-kubrâ in Andalucia

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    İslâm toplumu Hz. Peygamber'in (s.a.v.) vefatının üzerinden henüz bir asır geçmeden vahyin mesajlarını kıtalar ötesine taşımayı başarmıştır. Tarihler M. 711 yılını gösterdiğinde Müslüman fatihler İber yarımadasına ayak basmışlardır. Yaklaşık sekiz asırlık (711-1492) bir medeniyete sahip olan Endülüs, ilmî ve mimarî eserlerinin yanında farklı tebaaya karşı kültürel, siyasî ve dinî hoşgörüsüyle de övgüye mazhar olmuştur. Endülüs, İslâm tarihi içerisinde kurmuş olduğu medeniyetle her zaman ayrı bir yere ve öneme sahip olmuştur. Bu muazzam medeniyeti yeniden gündemimize taşıma adına merceklerimizi İslâm tarihi izdüşümünde Endülüs medeniyet tarihi üzerine odakladık. Çalışmamızın ilk bölümünde Müslümanların fetih şuuru ve Endülüs topraklarına geçiş süreçlerine dair malumatlar yer almaktadır. Akabinde Müslümanların Endülüs'teki fetih amaçları ve fethi gerçekleştirecek öncü şahsiyetlerle ilgili kısaca bilgiler aktarılmıştır. Zira bir bölgenin fethini anlamak, fatihlerini tanımaktan geçer. İkinci bölümde ise Endülüs'ün tarihî dönemleriyle ilgili müktesebat arz edilmiştir. Sırasıyla; "Valiler Dönemi, Emîrlik ve Hilâfet Dönemi (Endülüs Emevî Devleti), Mülûkü't-Tavâif Dönemi, Murâbıtlar Dönemi, Muvahhidler Dönemi ve Nasrîler Dönemi" olmak üzere Endülüs'ün tarihî dönemleri altı aşamada ele alınmıştır. Konunun ana mahiyetini oluşturacak olan üç ve dördüncü bölümlerde ise Endülüs'ün "eyyâmü'l-arûs (düğün günleri)" ve "el-fitnetü'l-kübrâ (büyük fitne)" dönemleri hakkında karşılaştırmalı bilgiler aktarılmıştır. Öncelikle Endülüs medeniyeti içerisinde zirvelere ulaşılan eyyâmü'l-arûs dönemi, asr-ı saâdet günlerinin ışığında mukayeseli bir okunma yapılmıştır. Bu mukayese esnasında Endülüs tarihine damga vurmuş ve aynı ismi taşıyan üç Abdurrahman'ın biyografilerine özet şekilde değinilmiştir. Nihayetinde Endülüs Emevî Devleti'nin duraklama ve yıkılış dönemleri el-fitnetü'l-kübrâ üst başlığında konu edinilerek tarihî bilgiler aktarılmıştır. Anahtar Kelimeler: Endülüs, Asr-ı Saâdet, Eyyâmü'l-Arûs, el-Fitnetü'l-Kübrâ, I. Abdurrahman, II. Abdurrahman, III. Abdurrahman.Islamic communities have succeeded in delivering messages of revelation beyond continents that less than a century after the death of Prophet Muhammad (s.a.w.), Muslim conquerors set foot on Iberian peninsula in B.C 711. Andalous that has nearly eighy centuries old civilization, has been praised about its sciences and architectural works. Also It has been praised for its cultural, political and religious tolerance towards different peoples. Andalous has always had a special place and importance with the civilization it established in Islamic history. We are focusing our lenses that Islamic History view on the Andalous Civilization History for reunderstanding this gorgeous civilization. In the first part; our data contains Muslims' consciousness of conquests. Also, how is their transition process to Andalucian lands. Subsequently, after giving information about the Muslims' conquest aims in Andalucia, brief information was also given about the leading figures who would carry out the conquest. Because understanding the conquest of a region requires knowing its conquerors. In the second part, the acquis regarding the historical periods of Andalucia has been presented. Respectively; The historical periods of Andalucia are discussed in six stages: "Governors Period, Emirate and Caliphate Period, Mulouk at-Tavâif Period, Almoravids Period, Almohad Period and Nasrid Period" and brief information about these periods is included. In the third and fourth chapters, which will constitute the main nature of the subject, the information has been transferred about "Eyyâm al-Arous" and "al-Fitnat al-Kubra" that it has flourished in Andalucia. First, a comparative reading was made about the Eyyâm al-Arous period, which reached its peaks in the Andalucian civilization, in the light of the asr al?saadat. During this comparison, the biographies of three Abdurrahmans who left their mark on the history of Andalucia and bear the same name are briefly mentioned. Finally, historical information was conveyed by discussing the periods of stagnation and collapse of the Andalucian Umayyad State under the heading of al-Fitnat al-Kubra. Key Words: Andalucia, Asr al-Saadat, Eyyam al-Arous, al-Fitnat al-Kubra, I. Abdurrahman, II. Abdurrahman, III. Abdurrahman

    Multimodal use of kinetic typography in motion graphics: Application in motion movie posters

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    Sosyal Bilimler Enstitüsü, Grafik Tasarımı Ana Sanat DalıGörsel iletişimin önemini keşfeden ilkel insandan günümüze yazı, her zaman önemli bir konuma sahip olmuştur. Modern matbaanın gelişimi, seri üretilebilir yazının yanı sıra tipografi kavramını da matbaa tekniği olarak ortaya çıkarmıştır. Tipografi terimi, ortaya çıktığı dönemdeki anlamından günümüz dijital çağına kadar hem teknik hem de kavramsal boyutta sürekli olarak güncellenmiştir. Modern sanat akımlarıyla birlikte gelişen tipografi arayışları, bu terimi bir baskı tekniğinin ötesine taşımış ve yazıyla ilgili tüm sanatsal etkinlikleri kapsayan geniş bir disiplin haline getirmiştir. Çok modlu görsel iletişim unsurları ise mesaj-bilginin sadece yazınsal olarak değil, görsel, işitsel, hareketsel ve uzamsal kanalların birlikteliği ve bu birlikteliğin anlam yaratma sürecine etkisi ile ilgilenir. Çalışma bu bağlamda ikinci bölümde; hareketin bir ifade biçimine dönüşünü, sinema ve grafik tasarımın birlikteliği ile doğan hareketli grafik disiplinini incelemiştir. Üçüncü bölümde; çok-modluluk (multimodalite) kavramını ve semiyotik ile ilgili tanımlamaları yapmıştır. Dördüncü bölümde; tipografi teriminin günümüz konumuna gelişinde çok-modlu yapıların etkisini tipografi bağlamında örnekler ile incelemiştir. Araştırma boyunca nitel araştırma yöntemi kullanılmış ve elde edilen bilgiler betimlenmiştir. Uygulama bölümünde ise Türkiye sinemasından seçilen; Yol (1982), Yılanların Öcü (1962), Sen Aydınlatırsın Geceyi (2013), Arabesk (1988), Gemide (1998), Kosmos (2009) filmleri için hareketli afiş tasarlanmıştır. Bu afişler görsel, yazı, hareket ve artırılmış gerçeklik (uzamsal olarak) şeklinde birden fazla modu içererek; film ve anlatısını bu modlar yoluyla aktarmayı amaçlar. Bu bağlamda araştırma, dijital çağda tipografi ve hareketli afiş alanı için "anlam ve ötesi" hakkında farklı bir perspektif sunmaktadır.From the dawn of human civilization to the present day, writing has always held a significant position, recognized for its importance by early humans. The development of the modern printing press introduced the concept of typography as a printing technique and facilitated the mass production of text. The term "typography" has evolved continuously from its inception to the digital age, both technically and conceptually. With the advent of modern art movements, the exploration of typography expanded the term beyond a mere printing technique to encompass all artistic activities related to writing. Multimodal visual communication elements focus on the integration of not only textual but also visual, auditory, kinetic, and spatial channels, examining how their combination influences the process of meaning-making. This study, in its second section, explores the transformation of motion into a form of expression and the discipline of motion graphics that emerged from the fusion of cinema and graphic design. The third section addresses the concepts of multimodality and semiotics, while the fourth section examines the impact of multimodal structures on the contemporary understanding of typography, supported by relevant examples. Throughout the research, qualitative methods were employed to describe the findings. In the application section, motion posters were designed for selected Turkish films: "The Road" (1982), "Revenge of the Snakes" (1962), "Thou Gild'st the Even" (2013), "Arabesque" (1988), "On Board" (1998), and "Kosmos" (2009). These posters incorporate multiple modes such as visual, textual, kinetic, and augmented reality (spatial), aiming to convey the films and their narratives through these modalities. Consequently, this research offers a different perspective on "meaning and beyond" in the realms of typography and motion posters in the digital age

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