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Recuperación cardíaca y respuesta cronotrópica tras pruebas de esfuerzo submáxima y máxima en personas con bronquiectasias.
No full textIntroduction: Cardiac autonomic dysfunction is related with greater disease severity and worse prognosis in diverse respiratory diseases; however, its impact in patients with bronchiectasis is still unknown.
Objectives: To explore the presence of cardiac autonomic dysfunction and identify clinical determinants during and after submaximal (6-minute walk test, 6MWT) and maximal (incremental shuttle test, ISWT) exercise testing in people with bronchiectasis; as well as to examine possible changes in cardiac autonomic function after 12 months of follow-up.
Methods: A longitudinal study recruiting adults with stable bronchiectasis was conducted. Initially, sociodemographic and clinical variables were collected and participants performed both exercise tests, the 6MWT and the ISWT. The same clinical variables were recorded and the PM6M was repeated after 12-month follow-up. The heart rate recovery after the first and second minute (HRR1, HRR2) after the exercise tests, as well as chronotropic response (CR) to exercise were the indicators selected to analyse the cardiac autonomic function. The cutoff of ≤ 14 beats was established to define the presence of a slowing HRR1. Regression models were used to identify clinical determinants related to HRR1 and CR.
Results: We enrolled 104 participants with a mean (standard deviation, SD) age of 64 (13), being the 26% classified as mild, 42% as moderate, and 32% as severe. A slower decrease in HRR1 was observed in the 36% of participants after the 6MWT; this subgroup also showed a decrease in the HRR2 and CR, as well as were classified as severe and walked less distance compared to those who presented a normal HRR1. Distance walked and baseline HR were the independent determinants of HRR1, whereas distance walked was the only predictor of CR in the 6MWT. The 18% of participants (n=8) who performed the ISWT (n=45) presented a HRR1≤ 14 beats; this subgroup also showed lower HRR2 and CR after the ISWT compared to those with normal HRR1. More severe patients presented lower values of final HR, HRR1, HRR2, baseline and final SpO2 and walked less distance in the ISWT. The only clinical determinant identified in the ISWT was the distance walked for CR. A total of 56 participants completed the follow-up, identifying that 20% had a slowing of HRR1 only at the initial assessment, 7% only at the final assessment and 12% at both assessments. The change in muscle fatigue was identified as the only determinant of the change in the HRR1, while change in distance walked and muscle fatigue were the determinants of change in the CR after the follow-up.
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Conclusion: The 36% and 18% of participants who completed the initial 6MWT and ISWT showed a slow decrease of the HRR1; these participants also showed lower values of HRR2 and CR. These findings were similar after the follow-up period. Distance walked is the determinant most concurrent with cardiac autonomic function in people with stable bronchiectasis.Introducción: En diversas patologías respiratorias se ha demostrado que la disfunción autonómica cardiaca se relaciona con una mayor severidad de la enfermedad y peor pronóstico; sin embargo, se desconoce su impacto en pacientes con bronquiectasias.
Objetivos: Explorar la presencia de disfunción autonómica cardíaca y sus posibles determinantes clínicos durante y tras una prueba de ejercicio submáxima (prueba de marcha de los 6 minutos, PM6M) y máxima (prueba de lanzadera incremental, ISWT) en personas con bronquiectasias, así como examinar posibles cambios en la función autonómica cardiaca tras 12 meses de seguimiento.
Métodos: Se realizó un estudio longitudinal reclutando adultos diagnosticados de bronquiectasias en periodo de estabilidad clínica. Inicialmente se registraron variables sociodemográficas, clínicas y se realizó la PM6M y el ISWT. Tras 12 meses, se registraron las mismas variables clínicas y se volvió a realizar la PM6M. La recuperación cardíaca tras el primer y segundo minuto (FCR1, FCR2) de recuperación tras las pruebas, así como la respuesta cronotrópica (RC) al ejercicio fueron los indicadores seleccionados para analizar la función autonómica cardiaca. Se estableció el límite de ≤ 14 pulsaciones para definir la presencia de una ralentización de la FCR1. Se utilizaron modelos de regresión para identificar determinantes clínicos relacionados con la FCR1 y la RC.
Resultados: Se reclutaron 104 participantes con una edad media (desviación estándar, DS) de 64 (13), clasificándose el 26% como leves, 42% moderados y 32% severos. El 36% de los participantes presentaron una ralentización de la FCR1 tras la PM6M inicial, junto con una menor FCR2 y RC disminuida, así como eran más severos y recorrieron menos distancia respecto aquellos que recuperaron normalmente. La distancia recorrida y la FC basal fueron los determinantes independientes de la FCR1, mientras que la distancia recorrida fue el único predictor de la RC en la PM6M. El 18% de los participantes (n=8) que realizaron el ISWT inicial (n=45) presentaron una ralentización de FCR1, junto con una menor FCR2 y RC tras la prueba en comparación al grupo con una FCR1 normal. Los pacientes más severos presentaron una menor FC final, FCR1, FCR2, SpO2 basal y final, así como recorrieron menor distancia en el ISWT. El único determinante clínico que se identificó en el ISWT fue la distancia alcanzada para la RC. Un total de 56 participantes completaron el seguimiento, identificando que el 20% presentó una ralentización de la FCR1 solo en la evaluación inicial, el 7% únicamente en la final y el 12% en ambas valoraciones. El cambio de la fatiga muscular se presentó como único determinante del
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cambio de FCR1, mientras que el cambio en la distancia caminada y la fatiga muscular fueron los determinantes del cambio en la RC tras el seguimiento.
Conclusión: El 36% y el 18% de los participantes que completaron la PM6M y el ISWT inicial presentó una ralentización de la FCR1, relacionándose con una menor FCR2 y RC. Estos hallazgos fueron similares tras el periodo de seguimiento. La distancia recorrida es el determinante independiente más concurrente de la función autonómica cardíaca en bronquiectasias
Eficacia de la radiofrecuencia como terapia complementaria a una intervención convencional en deportistas con desgarro muscular en los isquiotibiales. Un protocolo de ensayo clínico aleatorio
No full textIntroducción: Las roturas de los isquiotibiales son uno de los trastornos más prevalentes en el mundo del deporte. Puede ser una amenaza en la carrera de profesionales y aficionados a causa de su importante riesgo de recaída si no se trata de manera adecuada. Para complementar una terapia fisioterapéutica convencional, existen varias tecnologías interesantes de estudiar para determinar sus efectos. La radiofrecuencia es una de estas tecnologías que puede mostrarse importante en la reducción del tiempo de recuperación.
Objetivo: Evaluar el aporte de la radiofrecuencia como terapia complementaria a una intervención convencional en la mejora de varios aspectos biomecánicos así como en la reducción del tiempo necesario antes de regresar a la actividad deportiva (RTP). Metodología:
Tratamos de un protocolo de un ensayo clínico aleatorizado por bloques y estratificados por sexo, edad y tipo de deporte. Tenemos a dos grupos, uno de control que recibe sesiones de terapia convencional y sesiones placebo de radiofrecuencia, y un grupo experimental que recibe sesiones de terapia convencional junto con sesiones activas de radiofrecuencia. Resultados esperados:
El uso de radiofrecuencia disminuye el tiempo necesario para cumplir un RTP, aumentando la fuerza muscular, el ROM y disminuyendo el dolor y el riesgo de recaídas. Conclusión: El tratamiento con radiofrecuencia permite un RTP más temprano y mejorar varios aspectos biomecánicos del músculo. Se debería pensar en usarlo más en el mundo del deporte profesional. Sin embargo, futuros estudios confirmatorios y analizando más variables podrían ser interesantes.Introduction: Hamstring injuries are one of the most prevalent disorders in the world of sports. It can pose a threat to both professionals and amateurs due to its significant risk of recurrence if not treated properly. To complement conventional physiotherapy, there are several interesting technologies to study in order to determine their effects. Radiofrequency is one of these technologies that may prove important in reducing the recovery time. Objective: To evaluate the contribution of radiofrequency as a complementary therapy to conventional intervention in improving various biomechanical aspects as well as reducing the time required before returning to sports activity (Return-To-Play, RTP). Methodology: We conducted a protocol for a randomized controlled trial stratified by sex, age and type of sport. We have two groups, one control group receiving sessions of conventional therapy and placebo radiofrequency sessions, and one experimental group receiving sessions of conventional therapy along with active radiofrequency sessions. Expected Results: The use of radiofrequency reduces the time required to achieve RTP, increases muscle strength, range of motion (ROM), and decreases pain and the risk of recurrence.
Conclusion: Radiofrequency treatment should enable earlier RTP and improve various biomechanical aspects of the muscle. it should be considered using it more in the world of professional sports. However, future confirmatory studies analyzing more variables could be interesting
Análisis de la secuenciación completa de los genomas de una familia con un miembro afectado por la enfermedad rara KAT6A
No full textEl sindrome del KAT6A es una enfermedad rara que se da cuando ocurren mutaciones dentro del gen KAT6A. No se conoce mucho sobre ella y son pocas las personas que la sufren que han sido estudiadas, siendo además muy difícil hacerlo debido a la gran variabilidad de la enfermedad. Estos estudios se han llevado a cabo mediante la secuenciación de exomas. El objetivo de este proyecto es realizar un pipeline optimizado para el estudio de las variantes, así como el análisis de estas, de las muestras de una persona afectada por la enfermedad y sus familiares. En este caso la secuenciación llevada a cabo ha sido la del genoma completo, siendo esta la primera vez que se utiliza este tipo de secuenciación para estudiar esta enfermedad. Con la pipeline aquí realizada, hemos sido capaces de comparar las variantes de los familiares y de detectar la mutación causante de la enfermedad en el niño.KAT6A syndrome is a rare disease that occurs when mutations happen within the KAT6A gene. Not much is known about it, and only a few affected individuals have been studied, this is also particularly challenging due to the wide variability of the disease. These studies have been done through exome sequencing. The aim of this project is to create an optimized pipeline for variant analysis, as well as to analyse samples from a person affected by the disease and their family members. In this case, whole genome sequencing has been performed, marking the first time this type of sequencing has been used to study the disease. With the pipeline carried out here, we have been able to compare the variations of the family members and detect the mutation causing the disease in the child
Impacto de antioxidantes en el sistema inmune fetal de embarazadas con esclerosis múltiple y tratamiento Glatiramer
No full textChanges in Baropodometric Evaluation and Discomfort during the Workday in Assembly-Line Workers
No full textProlonged standing at work is associated with health risks. The appearance of lower-limb and lower-back discomfort is one of the most prevalent factors in prolonged standing workers. The aim of this research was to evaluate the effect of an eight-hour workday on foot pressure and musculoskeletal discomfort in standing workers. Thirty-six assembly-line workers (six women) were recruited to participate in a cross-sectional study to assess foot pressure and surface, foot, knee, and lower-back discomfort before and after a real workday. Baropodometry outcomes (surface and pressure) were evaluated by the pressure platform SensorMedica and musculoskeletal discomfort was evaluated by Cornell’s Musculoskeletal Discomfort Questionaire. Total foot surface (p = 0.01) and foot discomfort (p = 0.03) increased significantly at the end of the workday. Prolonged standing during 8 h workday increased the foot discomfort and total foot surface in assembly-line workers. No foot pressure variable (forefoot, rearfoot, or total) was significantly modified after the workday in assembly-line workers
Changes in Baropodometric Evaluation and Discomfort during the Workday in Assembly-Line Workers
No full textProlonged standing at work is associated with health risks. The appearance of lower-limb and lower-back discomfort is one of the most prevalent factors in prolonged standing workers. The aim of this research was to evaluate the effect of an eight-hour workday on foot pressure and musculoskeletal discomfort in standing workers. Thirty-six assembly-line workers (six women) were recruited to participate in a cross-sectional study to assess foot pressure and surface, foot, knee, and lower-back discomfort before and after a real workday. Baropodometry outcomes (surface and pressure) were evaluated by the pressure platform SensorMedica and musculoskeletal discomfort was evaluated by Cornell’s Musculoskeletal Discomfort Questionaire. Total foot surface (p = 0.01) and foot discomfort (p = 0.03) increased significantly at the end of the workday. Prolonged standing during 8 h workday increased the foot discomfort and total foot surface in assembly-line workers. No foot pressure variable (forefoot, rearfoot, or total) was significantly modified after the workday in assembly-line workers
Physical Therapist Interventions Versus or Combined with Surgical Treatment in Nontraumatic Degenerative Meniscal Pathology: A Systematic Review and Network Meta-Analysis (UNCORRECTED MANUSCRIPT)
Get PDFObjective
This study aimed to synthesize the evidence from randomized clinical trials (RCTs) in people with nontraumatic degenerative meniscal pathology, comparing physical therapist interventions versus or combined with arthroscopic partial meniscectomy (APM).
Methods
Seven electronic databases were searched. Methodological quality was evaluated using the Physiotherapy Evidence Database scale. Data synthesis was performed with random-effects network meta-analysis, and results were summarized using the standardized mean differences.
Results
From 2103 studies, 10 RCTs comprising 1411 individuals were included. Ninety percent of the selected RCTs were classified as good quality according to the Physiotherapy Evidence Database scale. All interventions (physical therapist interventions, APM, and APM plus physical therapist interventions) showed reduced pain and physical impairments at 3 months follow-up. However, when a physical therapist intervention was included, greater reductions in pain at rest (APM versus physical therapist interventions: 0.73 [95% CI = 0.20 to 1.26]; APM versus APM plus physical therapist interventions: 0.59 [95% CI = 0.15 to 1.03]) and greater increases in the strength of knee extensor muscles (APM versus physical therapist interventions: 0.44 [95% CI = 0.07 to 0.80]; APM versus APM plus physical therapist interventions: 0.73 [95% CI = 0.29 to 1.16]) were observed at 3 months. In contrast, no differences were found between treatments beyond 3 months.
Conclusions
Physical therapist interventions based on exercise programs demonstrate superior short-term outcomes in pain reduction and knee extensor strength compared to surgical treatment.
Impact
For nontraumatic degenerative meniscal pathology, conservative treatment utilizing a physical therapist intervention approach should be prioritized as the first choice over surgical treatment. It offers comparable or superior short-term pain reduction and strength improvements, with a lower risk of side effects. In cases where surgery is deemed necessary, including postsurgical physical therapist interventions are highly recommended to enhance muscle strength and alleviate pain
Audiovisual distribution of branded content through Youtube: "Learning Together"
Get PDFYouTube is one of the most popular platforms to produce and distribute audiovisual content. Thus, brands take advantage of its potential to develop branded content projects. This paper addresses the case of “Aprendemos Juntos” by BBVA. The research aims to describe the distribution model and analyse the content to understand its key elements. The methodology is based on que quantitative analysis of the channel’s production (2019-2023) and a qualitative content analysis of the most relevant videos
Resumen del Seminario de Investigación en Traducción Literaria Aurora Bernárdez 26-28 de Abril de 2023
Get PDFDurante el seminario se abordó la traducción literaria desde la investigación académica y desde la profesionalidad de quienes se dedican a investigar, enseñar y/o traducir obras literarias, se dio voz a quienes llevan años entre páginas de libros y sus traducciones para que nos contasen su experiencia investigadora y/o profesional. Asimismo, se contó con la presencia de quienes llevan años desentramando la figura de Aurora Bernárdez
Forma, construcción y restauración de bóvedas tabicadas en el Monasterio de Santa María de Piedra, Nuévalos (zaragoza)
Get PDFThis paper aims to document the constructive solution applied to cover the staircase space executed
during the 16th-century expansion of the Monastery of Santa María de Piedra, through the execution
of timbervaults. We present a study on the constructive development of the solution employed, as well
as a formal analysis of the geometric model that had to be intervened upon to recover and rehabilitate
the staircase space. Compared to stone vaults, the efficiency of timbervaults is evident in aspects such
as economy of means, speed of execution, and lightness. All of this has led to this system being valued
and implemented in various periods of construction history.Este artículo pretende documentar la solución constructiva aplicada para cubrir el espacio de la escalera
ejecutada durante la ampliación del siglo XVI del monasterio de Santa María de Piedra, empleando
bóvedas tabicadas. Presentamos un estudio sobre el desarrollo constructivo de la solución empleada,
así como un análisis formal del modelo geométrico sobre el que hubo que intervenir para recuperar y
rehabilitar el espacio de la escalera. En comparación con las bóvedas realizadas en cantería, la eficacia
de las tabicadas es patente en cuestiones como la economía de medios, la rapidez de ejecución o
la ligereza y todo ello ha supuesto que este sistema sea valorado y puesto en práctica en diversos
periodos de la historia de la construcción