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Effectiveness of a training program for the acquisition of motor milestones in infants: a randomized clinical trial
Full text linkBackground In infants, the acquisition of ali motor milestones is considered an expression of correct motor development during the first months of life. An association between typical motor development of the newborn and cognitive areas has been established. Few stud ies have evaluated the efficiency of parents' knowledge of expected milestones in healthy infants.
This study aims to determine whether parents' knowledge of specific tasks can improve the achievement of ali gross motor milestones in the newborn.
Method The current study examined gross motor development in term-born infants without pathologies at 9, 12, and 15 months and the effectiveness of a training program developed for parents. The resea rch group comprised 82 full-term infants divided into an experimental group (EG) anda control group (CG) of 41 subjects each. A randomized clinica l trial study was performed. The routine follow-up program consisted of four informative sessions on the experimental group at the beginning of each trimester with information about the expected motor milestones and how to stimulate their infants to achieve them. The gross motor development of the participants was mea su red using the Al berta lnfant Motor Scale. An ANCOVA test was performed to assess the possible influence of sex, type of birth,
or the presence of siblings controlled and uncontrolled as confounding va riables on the results.
Results The initia l baseline assessment showed no statistical differences between groups (p > 0,05). After controlling confounding variables, at 9 months the EG scored 5,5 points higher than the CG (p < 0,007). At 12 months, EG scored 3,7 points higherthan CG (p < 0,007). At 15 months, EG scored 2,2 points higherthan CG (p =0,007). The experimenta l group scored significantly higher, with a 25-point higher percentile in each assessment.
Conclusion A learning program aimed at increasing parents' knowledge of their infant's gross motor development improved it. The information col lected will help professionals who support parents in monitoring their babies.
Future studies using larger sample sizes, analysing other domains of global infant development, or investigating the possible influence of other parental factors are recommended
Non-invasive brain stimulation to enhance sleep quality and architecture in Parkinson's disease: A systematic review and Bayesian network meta-analysis
Full text linkIndividuals with Parkinson's disease (PD) suffer from sleep disorders and maladaptive alterations in sleep architecture. These disorders, which increase in frequency and severity as the disease progresses, are multifactorial and clinically relevant. Sleep problems drastically reduce quality of life in these patients and are associated with faster cognitive and motor decline. Standard treatments for managing sleep disorders, which mainly include cognitive behavioral therapy and pharmacotherapy, have provided inconsistent results. Non-invasive brain stimulation (NIBS) has been proposed as another potential strategy for improving sleep quality in PD. We conducted a systematic review and Bayesian network meta-analysis (NMA) following the grading of recommendations, assessment, development, and evaluation (GRADE), to determine whether NIBS improves sleep quality and architecture in PD. Evidence from twenty-four studies, including 792 individuals with PD in the early-to-severe disease stages, was summarized. Our NMA indicated that low-frequency repetitive transcranial magnetic stimulation over the dorsolateral prefrontal cortex (rTMS; 0.54, 95 %CrI: 0.13,0.93; moderate certainty) may ameliorate subjective sleep quality compared to a control condition. Our review further suggested that rTMS may enhance objective sleep quality and sleep architecture. Our findings, which should be interpreted cautiously due to a high risk of bias, are examined in the context of sleep disorders in PD
Practical Guide for People with Pain
Full text linkVivir con dolor puede ser confuso y difícil de manejar. Muchas personas con dolor musculoesquelético, como dolor de espalda, cuello, hombros u otras articulaciones, reciben gran cantidad de consejos e información de Internet, amigos o profesionales sanitarios. Algunos son útiles, otros engañosos y muchos pueden resultar difíciles de entender. Más allá de comprender la información, a las personas a menudo les cuesta saber dónde acudir en busca de ayuda: a quién acudir, qué preguntas hacer y cómo interpretar las diferentes opiniones.
Este libro está pensado para ayudarte a ti, a tu familia y a otras personas que quieran aprender sobre el dolor. Te ayudará a comprender mejor la información sanitaria y a orientarte más fácilmente a la hora de utilizar los servicios sanitarios. Su objetivo es que te sientas más seguro a la hora de buscar ayuda, de hacer preguntas, de pensar en diferentes tratamientos y aplicar los consejos en la vida cotidiana. El objetivo de esta guía no es decirte qué hacer, sino ayudarte a aprender a pensar de forma crítica sobre el dolor y los cuidados, para que puedas tomar buenas decisiones y desempeñar un papel activo en su recuperación. Te ayudará a: Comprender el dolor y cómo manejarlo, de manera que tenga sentido para tu situación. Encontrar y acceder a fuentes fiables de atención y apoyo, tanto en Internet como en tu comunidad. Decidir qué consejos o tratamientos son fiables y cuáles son relevantes para ti. Utilizar lo que aprendes en la vida diaria, mediante pequeños pasos prácticos que te ayuden a moverse más, participar en la vida y sentirte mejor. Reflexionar y cambiar las creencias comunes sobre el dolor, para que el miedo o la frustración no te frenen.
Cada sección de este libro se centra en una de estas habilidades y ofrece breves explicaciones, ejercicios de autorreflexión y ejemplos extraídos de experiencias cotidianas. Las historias cortas que encontrarás, llamadas viñetas, muestran situaciones reales a las que se enfrentan a menudo las personas con dolor musculoesquelético: la incertidumbre sobre el ejercicio y el descanso, las dificultades para comunicarse con los profesionales sanitarios, los retos en el trabajo, la confusión sobre los resultados de las pruebas, la medicación o los objetivos personales. Estas historias no son instrucciones ni consejos médicos, sino que están pensadas para ayudarte a pensar y aprender. Cada una muestra una habilidad que se puede aprender: hacer mejores preguntas, comprender tu cuerpo, encontrar una buena atención médica o afrontar los contratiempos.Living with pain can be confusing and difficult to deal with. Many people with musculoskeletal pain — such as back, neck, shoulder, or joint pain — receive large amounts of advice and information from the internet, friends, or healthcare providers. Some of it is helpful, some misleading, and much of it can feel hard to understand. Beyond understanding information, people often struggle to find it hard to know where to go for help: who to see, what questions to ask, and how to make sense of different opinions. This book is made to help you, your family, and others who want to learn about pain. It will help you understand health information better and find your way more easily when using healthcare services. It aims to make you more confident when searching for help, asking questions, thinking about different treatments, and using advice in everyday life.
The goal of this guide is not to tell you what to do, but to support you in learning how to think critically about pain and care, so that you can make good choices and take an active role in your recovery. It will help you to: Understand pain and how to manage it, in ways that make sense for your situation. Find and access reliable sources of care and support, both online and in your community. Decide which advice or treatments you can trust and which are relevant to you. Use what you learn in daily life, through small, practical steps that help you move more, take part in life, and feel better. Think about and change common beliefs about pain, so that fear or frustration don't hold you back.
Each section of this book focuses on one of these abilities and offers short explanations, self-reflection exercises, and examples drawn from everyday experiences. The short stories you will find — called vignettes — show real situations that people with musculoskeletal pain often face: being unsure about exercising and resting, difficulties communicating with healthcare professionals, challenges at work, being confused about scan results, medication, or personal goals. These stories are not instructions or medical advice but are made to help you think and learn. Each one shows a skill that can be learned: asking better questions, understanding your body, finding good care, or coping with setbacks.Funded by the European Union. Views and opinions expressed are however those of the author(s) only and do not necessarily reflect those of the European Union or the European Education and Culture Executive Agency (EACEA). Neither the European Union nor EACEA can be held responsible for them. ERASMUS-EDU-2022-PI-ALL-INNO: Project n.10111170
Efectividad de la electrolisis percutánea en tendinopatías mediales del codo en escaladores: Protocolo de ensayo clínico aleatorizado
Full text linkIntroducción: Durante las últimas décadas la escalada ha tenido un crecimiento muy grande. El aumento de participantes se debe principalmente al aumento de rocódromos y la disminución del riesgo debido a las mejoras de la seguridad; lo que ha supuesto un incremento de las lesiones por sobreuso, siendo la tendinopatía medial del codo muy frecuente en escaladores ya que existe una fuerte demanda de la musculatura flexora del antebrazo. A pesar de que son efectivos los tratamientos conservadores la reincidencia de los síntomas es un problema, por lo que se ha considerado la electrolisis percutánea intratisular como una buena posibilidad para disminuir el dolor, incrementar la funcionalidad ya que ha resultado ser eficaz en otras tendinopatías.
Objetivo: Se pretende evaluar la efectividad de la electrolisis percutánea intratisular combinada con el tratamiento conservador en tendinopatía medial del codo en escaladores, valorando la capacidad de reducir el dolor medido a través de la escala visual analógica, incrementar la funcionalidad por medio del cuestionario abreviado del DASH (Disabilities of the Arm, Shoulder and Hand) llamado (QuickDASH) e incrementar la fuerza especifica de agarre a través del instrumento de medición específico para escaladores (Progressor de TINDEQ).
Metodología: Es un ensayo clínico aleatorizado el cual contiene una muestra de 88 escaladores. Consiste en tres grupos, el grupo 1 hace exclusivamente electrolisis percutánea intratisular, el grupo 2 tratamiento conservador y el grupo 3 realiza ambos tratamientos. Se medirá a través de las variables de dolor a través de escala visual analógica, la funcionalidad con el cuestionario QuickDASH y la fuerza de agarre específica con el Progressor de TINDEQ.
Resultados esperados: Con la electrolisis percutánea intratisular y el tratamiento conservador se prevé que el dolor disminuya, mejore la funcionalidad y la fuerza de agarre aumente.
Conclusión: El tratamiento con electrolisis percutánea intratisular junto al tratamiento conservador para la tendinopatía medial del codo en escaladores se prevé que puede ser eficaz en reducir el dolor, incrementar la funcionalidad y aumentar la fuerza de agarre
Estudio de impacto social y económico de la Universidad San Jorge (2005-2025)
Full text linkEl Estudio de Impacto Social y Económico de la Universidad San Jorge (2005-2025) refleja cómo la Universidad San Jorge ha sido un motor para el desarrollo académico, científico y económico de Aragón, además de ser uno de los actores principales en la actividad social y cultural de la comunidad autónoma y un referente institucional como uno de los mayores empleadores de la región. Pero, además, evidencian su papel como agente transformador de la sociedad a través de la educación y fomentando valores como la sostenibilidad, la responsabilidad social y el compromiso con el bienestar de las personas y la formación a lo largo de su vida
Natural Compounds as Alternative Strategy Against Antimicrobial Resistance. Analysis of their Efficacy, Synergy, and Environmental Safety as Antibiotic Adjuvants.
No full textThe widespread use of conventional antibiotics has led to escalating antimicrobial resistance and growing concerns regarding their presence in the environment and their ecotoxicological impact on non-target ecosystems. This doctoral thesis addresses these challenges by proposing and evaluating natural antimicrobial alternatives within a "One Health" framework, which integrates human health, animal health, and environmental sustainability.
We first established an environmental baseline, confirming that eight common antibiotics produce significant ecotoxic effects on aquatic and soil bioindicators, validating the need for safer alternatives. The investigation then transitioned to natural products, first evaluating Satureja montana hydrolate, a distillation by-product. While it demonstrated antimicrobial activity and circular economy potential, its moderate potency, difficulty of standardization and impact on non-target microbial communities highlighted the need for more defined and potent compounds.
This led to a focus on the hydrolate's primary bioactive constituents, thymol (THY) and carvacrol (CARV). Although both display intrinsic antimicrobial activity, their minimum inhibitory concentration (MICs) are relatively high, for example 250 μg.mL⁻¹ against Staphylococcus aureus and 125–250 μg.mL⁻¹ against Acinetobacter baumannii, making them unsuitable as monotherapies; accordingly, we evaluated them as adjuvants to commercial antibiotics. Checkerboard assays revealed potent synergistic interactions between these monoterpenoids and conventional antibiotics (e.g., gentamicin, chloramphenicol), reducing antibiotic MICs by up to 16-fold against pathogens like S.
aureus and A. baumannii. Mechanistic studies elucidated that bioactivity and synergy arise from multi-target actions, including bacterial membrane disruption, efflux pump inhibition, modulation of antibiotic-induced oxidative stress and perturbation of ATP metabolism. Crucially, these combinations significantly suppressed the emergence of antibiotic resistance, with THY–aminoglycoside pairs reducing resistance emergence by up to 32-fold in A. baumannii and 16-fold in S. aureus, while THY or CARV alone did not select for resistance.
Having demonstrated that natural product - antibiotic combinations are efficacious, we next assessed the environmental safety of THY, CARV, and their synergistic antimicrobial combinations (SACs), using standard bioindicators and river/soil microbial communities.
Both monoterpenes were acutely toxic to individual non-target indicators at low concentrations, yet river and soil communities showed minimal growth inhibition up to 100 mg L⁻¹. Synergistic antimicrobial combinations were then tested at their synergistic doses (THY or CARV paired with chloramphenicol, gentamicin, or streptomycin). They were generally less toxic than the antibiotics alone when compared at efficacious concentrations. This indicates a reduced environmental impact for the same antimicrobial effect.
In summary, this thesis proposes a compelling strategy to address antimicrobial resistance: the use of well-characterized natural compounds such as THY and CARV as antibiotic adjuvants. This approach enhances therapeutic efficacy, limits the emergence of resistance, and reduces the ecological footprint of antimicrobial treatments. As a preliminary study, it offers a promising, sustainable, and clinically translatable alternative to be further explored within the framework of a unified One Health paradigm
Parque Goya on the move. Plan de innovación en el IES Clara Campoamor Rodríguez
Full text linkEl IES Clara Campoamor Rodríguez de Zaragoza cuenta con 16 años de experiencia y se destaca por su enfoque innovador y dinámico. Entre sus programas destacan el Programa Bilingüe BRIT-MECD, el proyecto de mediación escolar Ciberayudantes y desarrollo de capacidades en Secundaria. Ciberayudantes fomenta la resolución pacífica de conflictos, el uso responsable de la tecnología y previene el ciberacoso. El centro ha implementado Chromebooks en las aulas y una versión del Aula del Futuro, combinando metodologías activas con nuevas tecnologías. Este enfoque ha sido reconocido con varios premios, reflejando el compromiso del centro con la equidad. El plan de innovación "Parque Goya on the Move", busca transformar metodologías y gestión organizativa, asegurando una educación de calidad para el alumnado.
The IES Clara Campoamor Rodríguez from Zaragoza boasts 16 years of experience and is recognized for its innovative and dynamic approach. Notable programs include the BRIT-MECD Bilingual Program, the Ciberayudantes school mediation project, and Skills Development in Secondary Education. Ciberayudantes encourages peaceful conflict resolution, the responsible use of technology, and plays a key role in preventing cyberbullying. The school has integrated Chromebooks in the classroom and implemented a version of the Future Classroom, blending active learning methodologies with cutting-edge technology. This forward-thinking approach has earned the school numerous awards, highlighting its commitment to equity. Through its innovation plan, Parque Goya on the Move, the school seeks to transform both its methodology and organizational structure, ensuring that all students benefit from a high-quality education
Development and Comparison of Reference Equations for the Six-Minute Walk Test in Spanish Healthy Adults Aged 45-85 Years
Full text linkObjectives: (i) to develop sex-specific reference equations to predict distance walked (6MWD) in the 6-minute walk test (6MWT), in healthy subjects aged 45-85 years, from different geographic areas of Spain; and (ii) to compare developed equations with previously published in a large sample of COPD patients.
Methods: First, a cross-sectional multicentre sample of randomly selected healthy subjects from 17 Spanish hospitals and universities performed two 6MWT. Linear regression and fractional polynomial modelling were used to develop the equations. Second, the developed equations were applied to 715 COPD patients from Spanish primary care centres and hospitals, and the % predicted 6MWD obtained was compared with previously published equations using Dunnett’s multiple comparisons test.
Results: 568 healthy subjects were included (51% females, mean (SD) age 62 (11) years), walked a 6MWD of 615 (113) and 557 (93) meters in males and females, respectively. The developed equations included age, weight and height, and explained 43% and 51% of the 6MWD variance for males and females, respectively. In the COPD sample (n=715, 14% females, 68 (9) years, FEV1 61 (18) % predicted, 6MWD 464 (97) meters), only 1 out of 9 previously published equations for males, and 6 out of 9 for females predicted 6MWD values similar to those of the newly developed Spanish reference equations.
Conclusions: The newly developed reference equations provide a more valid prediction of 6MWD in Spanish adults with COPD compared to previously published equations. We suggest their use in future research and clinical practice for the Spanish adult population
Effectiveness of a training program for the acquisition of motor milestones in infants: a randomized clinical trial
Full text linkBackground In infants, the acquisition of ali motor milestones is considered an expression of correct motor development during the first months of life. An association between typical motor development of the newborn and cognitive areas has been established. Few stud ies have evaluated the efficiency of parents' knowledge of expected milestones in healthy infants.
This study aims to determine whether parents' knowledge of specific tasks can improve the achievement of ali gross motor milestones in the newborn.
Method The current study examined gross motor development in term-born infants without pathologies at 9, 12, and 15 months and the effectiveness of a training program developed for parents. The resea rch group comprised 82 full-term infants divided into an experimental group (EG) anda control group (CG) of 41 subjects each. A randomized clinica l trial study was performed. The routine follow-up program consisted of four informative sessions on the experimental group at the beginning of each trimester with information about the expected motor milestones and how to stimulate their infants to achieve them. The gross motor development of the participants was mea su red using the Al berta lnfant Motor Scale. An ANCOVA test was performed to assess the possible influence of sex, type of birth,
or the presence of siblings controlled and uncontrolled as confounding va riables on the results.
Results The initia l baseline assessment showed no statistical differences between groups (p > 0,05). After controlling confounding variables, at 9 months the EG scored 5,5 points higher than the CG (p < 0,007). At 12 months, EG scored 3,7 points higherthan CG (p < 0,007). At 15 months, EG scored 2,2 points higherthan CG (p =0,007). The experimenta l group scored significantly higher, with a 25-point higher percentile in each assessment.
Conclusion A learning program aimed at increasing parents' knowledge of their infant's gross motor development improved it. The information col lected will help professionals who support parents in monitoring their babies.
Future studies using larger sample sizes, analysing other domains of global infant development, or investigating the possible influence of other parental factors are recommended
Comparación de la efectividad del uso de la rehabilitación con restricción del flujo sanguíneo (BFR) versus la rehabilitación estándar en el tratamiento de desgarros de los isquiotibiales: protocolo de ensayo clínico aleatorizado
No full textIntroducción:
Las lesiones de los isquiotibiales son comunes en los deportes ya menudo conducen a períodos de recuperación prolongados. La rehabilitación tradicional generalmente incluye ejercicios isométricos, concéntricos y excéntricos. El entrenamiento de restricción del flujo sanguíneo (BFR) ha surgido como una herramienta prometedora para mejorar la fuerza muscular y la hipertrofia durante la rehabilitación.
Objetivo:
Comparar la eficacia de la rehabilitación estándar frente a la rehabilitación BFR para mejorar la fuerza muscular de los isquiotibiales, la hipertrofia, el rendimiento funcional y los niveles de dolor después de desgarros de isquiotibiales de grado II.
Métodos:
Este ensayo controlado aleatoriamente incluyó a 60 participantes con desgarros de isquiotibiales de grado II. Los participantes fueron asignados aleatoriamente a dos grupos: rehabilitación estándar (n = 30) y rehabilitación BFR (n = 30). Ambos grupos se sometieron a protocolos de rehabilitación idénticos de 12 semanas, y el grupo BFR realizó ejercicios con una presión de oclusión arterial del 70-80 %. El resultado primario será la fuerza de los isquiotibiales, evaluada mediante dinamometría al inicio, a las 6 semanas ya las 12 semanas. Los resultados secundarios incluyeran hipertrofia muscular, rendimiento funcional y niveles de dolor.
Resultados esperados:
Se espera que, a las 12 semanas, el grupo que utiliza BFR muestra mejores resultados en las variables medidas en comparación con el grupo que sigue la rehabilitación estándar, Todo ello mientras se realizan los ejercicios con una intensidad menor.
Conclusión:
Se espera que la rehabilitación con BFR ofrezca beneficios superiores en términos de fuerza muscular, hipertrofia y resultados funcionales en comparación con la rehabilitación estándar para desgarros de isquiotibiales de grado II