KU Leuven Research Data Repository
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Replication Data for: Mapping urban gullies in the Democratic Republic of the Congo
No full textThis dataset contains information on mapped cased of urban gullies (UGs), occurring in the Democratic Republic of Congo (ii), information on how many people were likely displaced by the formation and expansion of these UGS as well as how many people live in the direct vicinity of such gullies. More specifically, the dataset includes:
(i) shapefiles of all mapped urban gullies (> 2922 in 26 cities of DRC) as mapped on the reference image, as well as on 1-4 earlier images;
(ii) files related to identifying the factors controlling the occurence of UGs and a logistic regression model to predict urban gully susceptibility at a 1-km² resolution
(iii) shapefiles and excel files related to assessing UG expansion events as well as the population displacement associated with these events;
(iv) shapefiles and excel files related to the definition of UG hazard zones and the calculation of (changes in) exposed population, living in these hazard zones
(v) files related to assessing the uncertainty on the displaced and exposed populatio
HAM GWAS Summary Statistics
No full textBackground: HTLV-1 is an enigmatic retrovirus triggering a debilitating neuroinflammatory disease, HTLV-1-associated myelopathy (HAM), with unknown pathogenesis. Both HTLV-1 infection and HAM predominantly affect women and non-white neglected populations. HAM is lacking disease-modifying treatment, as current treatment is mostly symptomatic and inspired by either HIV-1 or multiple sclerosis therapeutic strategies.
Methods: We used systems biology analyses of novel and publicly available data comprising (epi)genomics, transcriptomics, metabolomics and proteomics of multi-ancestry cohorts from a total of >2500 People Living with HTLV-1 from 5 countries (Brazil, Peru, Japan, UK, US).
Findings: Leveraging an unique admixed Brazilian cohort, genome-wide association study (GWAS) revealed African-specific variants in inflammasome sensor AIM2 with genome-wide significance (p5x10-8) corresponding to metabolic, immune and neuronal genes were validated using published Japanese GWAS. Polygenic risk score and proviral load were independent disease predictors across ancestries. Systems biology analysis revealed neuronal/synaptic signaling, monocyte count, glucose/lipid metabolism, and neurocognition/depression as genetically linked to HAM. In silico drug screening identified estrogen blocker Fulvestrant as the top hit, while also confirming existing (pre)clinical data for HDAC inhibitors and immunosuppressants. Validated GWAS genes were overexpressed in HAM patients’ whole blood and CD4 T-cells, as well as in spinal cord astrocytes, oligodendrocytes, and microglia single-cell RNAseq. We experimentally confirmed decreased ApoA1/lipid/cholesterol levels, higher monocyte levels and lower neurocognitive scores in multi-ancestry cohorts. We found striking biological similarities between retroviral Hbz/Tax overexpression, Hbz interactome and HAM multi-omics findings: enrichment for lipid/cholesterol metabolism, estrogen signaling, neurodegenerative diseases, and viral pathways including EBV, recently identified as the major driver of multiple sclerosis.
Interpretation: Our data-driven approach uncovers novel disease mechanisms and therapeutic targets, and a validated polygenic risk score allowing targeted surveillance for high-risk individuals A strong molecular overlap to other neurodegenerative/neuroinflammatory diseases reveals shared neuropathogenic pathways between unrelated viruses
Instrumental learning and behavioral persistence in children with attention-deficit/hyperactivity-disorder: does reinforcement frequency matter?
No full textThis dataset contains the raw and transformed data of an experimental study investigating instrumental learning and behavioral persistence in children with and without ADHD. In this study, children completed a free-operant instrumental learning task. The children completed the acquisition phase of the task under continuous (100%) or partial (20%) reinforcement, followed by a 4-min extinction phase. The dataset contains demographic information of the participants, as well as task performance measures for both acquisition and extinction
Replication Data for: Omnidirectional 3D Printing of PEDOT: PSS Aerogels with Tunable Electromechanical Performance: A Playground for Unconventional Stretchable Interconnects and Thermoelectrics
No full textThese data correspond to the publication: https://doi.org/10.1002/advs.202412491
The data pertain to the characterization of the materials we developed in the research and were used to draw the figures in the paper. These raw data were obtained experimentally in the lab via direct measurements or were produced automatically from commercial equipment detailed in the methodology of the cited published paper.
The file names are self-explanatory and make direct reference to the publication figures
Supplemental Material for: Translation and Valuation are Vital Antecedents of Lived Regulation: An Integrative Review on Strategic Public Procurement.
No full textWe conducted an integrative literature review. It answers the following question: What do we know about the use of policy criteria in public procurement during the pre-award stage and the awarding stage by actors inside a public administration or government or utility?
The dataset contains the supplemental material of the integrative review
Replication Data for: Hydrolysis activity measurements do not depend on the aeration conditions
No full textHydrolysis, often the rate-limiting step in waste valorization processes (e.g., anaerobic digestion), is a complex process, influenced by various factors. One of these factors is the presence of oxygen. While the effect of oxygen on hydrolysis itself is well-documented, its impact on hydrolysis activity monitoring has received less attention. This study focuses on the influence of aeration conditons on fluorescence-based, 96-well plate reader assays. More specifically the oxygen depletion rate of each well and the resulting hydrolysis activity is measured. The oxygen depletion rate was significantly higher when flushing the plate reader device with nitrogen. However, the hydrolysis activity (protease and cellulase) of both aerobic and anaerobic sludge samples, and a pure enzyme was not influenced by the aeration conditions. This result suggests that oxygen does not affect the functionality of the enzymes themselves, but may influence microbial contributors to enzyme production. These findings confirm that hydrolysis activity monitoring tools yield consistent results regardless of aeration conditions. Consequently, both aerobic and anaerobic samples can be reliably assessed under standard aerobic conditions, typical for plate reader devices, without risking overestimation of anaerobic sample activities
High-resolution fMRI reveals a dorsal brain pathway selective for conspecific vocalizations in macaques
No full textThis dataset is associated with the article titled "High-resolution fMRI reveals a dorsal brain pathway selective for conspecific vocalizations in macaques" . The dataset includes the following: High-resolution fMRI data in NIfTI format, acquired from macaques during auditory stimulation experiments. Event files in TSV format, containing the onset and duration of each stimulus presented during scanning sessions. MATLAB scripts used to generate the main results presented in the paper
Use of ketogenic diet to treat lymphoedema - the recipebundle for a clinical ketogenic diet
No full textIn the context of the proof-of-concept study on the use of ketogenic diet to treat lymphoedema, a specific recipebook for ketogenic diet has been created.
The recipebook aims to facilitate to follow this specific ketogenic diet.
The ratio of lipids over protein and carbohydrates is 4 to 1
Replication Data for: Lambrechts et al. (2025) - The relation between macro- and microscopic muscular alterations of the medial gastrocnemius in children with spastic cerebral palsy
No full textThis is a cross-sectional dataset consisting of macro- and microscopic muscle parameters of the medial gastrocnemius, for both children with cerebral palsy and typically developing peers (aged 2-9 years). Macroscopic muscle parameters were assessed through 3D freehand ultrasound and included muscle volume, anatomical cross-sectional area, muscle belly ength and echo-intensity. Microscopic parameters were collected through muscle biopsies and included fiber cross-sectional area, coefficient of variation, percentage of fiber types, capillary density and capillary to fiber ratio
Towards Adaptive Demanufacturing: A Simulation Study of a Flexible Human-Robot Cooperative Demanufacturing System
No full textThis dataset contains problem instances used for the paper titled, 'Towards Adaptive Demanufacturing: A Simulation Study of a Flexible Human-Robot Cooperative Demanufacturing System'. The problem instances represent a heterogeneous product stream of hard disk drives (HDD). The set of HDDs are based on five representative models. It contains all relevant components and possible fastner locations